Recent developments and workflows of non-targeted LC-HRMS screening in the detection of veterinary drug residues in foods

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry Pub Date : 2025-05-21 DOI:10.1016/j.trac.2025.118314

Yishuang Yang , Jiaxi Chen , Guiyuan Li , Anastasios Koidis , Zhongping Yao , Hongtao Lei , Xiaoqun Wei

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引用次数: 0

Abstract

Monitoring veterinary drug residues in food is one key link to ensuring food safety. In recent years, non-targeted screening technology based on liquid chromatography-high resolution mass spectrometry (LC-HRMS) has attracted widespread attention. However, the development and application of non-targeted screening methods still face many challenges due to the constantly updated variety of veterinary drugs, the complexity of sample matrices, the large amount of data, and the cumbersome data identification process. To address the above challenges, this review systematically proposes a workflow for non-targeted screening, focusing on the research progress in sample preparation, instrument analysis, data preprocessing, and recognition strategy. In addition, it summarizes molecular formula prediction models, chemical structure prediction models, and retention time validation models, discusses the latest application of this technique in detecting veterinary drug residues in food, providing new insights to meet the challenges of non-targeted screening.

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食品中兽药残留非靶向LC-HRMS筛查的最新进展和工作流程

监测食品中兽药残留是确保食品安全的关键环节。近年来，基于液相色谱-高分辨率质谱（LC-HRMS）的非靶向筛选技术受到了广泛关注。然而，由于兽药品种不断更新，样品基质复杂，数据量大，数据识别过程繁琐，非靶向筛选方法的开发和应用仍然面临许多挑战。针对上述挑战，本文系统地提出了非靶向筛选的工作流程，重点介绍了样品制备、仪器分析、数据预处理和识别策略等方面的研究进展。此外，总结了分子式预测模型、化学结构预测模型和保留时间验证模型，讨论了该技术在食品中兽药残留检测中的最新应用，为应对非靶向筛选的挑战提供了新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Analytical Chemistry 化学-分析化学

CiteScore

20.00

自引率

4.60%

发文量

257

审稿时长

3.4 months

期刊介绍： TrAC publishes succinct and critical overviews of recent advancements in analytical chemistry, designed to assist analytical chemists and other users of analytical techniques. These reviews offer excellent, up-to-date, and timely coverage of various topics within analytical chemistry. Encompassing areas such as analytical instrumentation, biomedical analysis, biomolecular analysis, biosensors, chemical analysis, chemometrics, clinical chemistry, drug discovery, environmental analysis and monitoring, food analysis, forensic science, laboratory automation, materials science, metabolomics, pesticide-residue analysis, pharmaceutical analysis, proteomics, surface science, and water analysis and monitoring, these critical reviews provide comprehensive insights for practitioners in the field.