Inductively coupled plasma mass spectrometry-based immunoassay: An update from 2015 to 2025

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry Pub Date : 2025-05-22 DOI:10.1016/j.trac.2025.118317

Min Jiang , Chengchao Zhang , Yanlin Chen , Mingxia Sun , Rui Liu , Yi Lv

{"title":"Inductively coupled plasma mass spectrometry-based immunoassay: An update from 2015 to 2025","authors":"Min Jiang , Chengchao Zhang , Yanlin Chen , Mingxia Sun , Rui Liu , Yi Lv","doi":"10.1016/j.trac.2025.118317","DOIUrl":null,"url":null,"abstract":"<div><div>Inductively coupled plasma mass spectrometry (ICP-MS) has emerged as an important analytical platform in the field of biomarker detection, leveraging its exceptional sensitivity and resolution. Over the past decade, ICP-MS-based immunoassays have experienced rapid development, not only overcoming the sensitivity and multiplexing limitations of traditional optical methods but also achieving extensive applications in clinical scenarios. Elemental tags, as a core technological module of ICP-MS bioassays, serve as the critical bridge connecting biomolecular recognition and mass spectrometric signal output. Their design and performance directly influence the sensitivity, multiplexity, and throughput of the detection. Therefore, the focus of this review will be mainly on elemental tags, summarizing the latest advancements in metal ions, nanoparticles, and label-free strategies while exploring how these innovations enable ICP-MS bioassays to achieve high sensitivity, multiplexity, and high-throughput analysis. Additionally, this review also covers related bioassays based on similar principles, such as nucleic acid hybridization and aptamer-based assays.</div></div>","PeriodicalId":439,"journal":{"name":"Trends in Analytical Chemistry","volume":"191 ","pages":"Article 118317"},"PeriodicalIF":11.8000,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in Analytical Chemistry","FirstCategoryId":"1","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165993625001852","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}

引用次数: 0

Abstract

Inductively coupled plasma mass spectrometry (ICP-MS) has emerged as an important analytical platform in the field of biomarker detection, leveraging its exceptional sensitivity and resolution. Over the past decade, ICP-MS-based immunoassays have experienced rapid development, not only overcoming the sensitivity and multiplexing limitations of traditional optical methods but also achieving extensive applications in clinical scenarios. Elemental tags, as a core technological module of ICP-MS bioassays, serve as the critical bridge connecting biomolecular recognition and mass spectrometric signal output. Their design and performance directly influence the sensitivity, multiplexity, and throughput of the detection. Therefore, the focus of this review will be mainly on elemental tags, summarizing the latest advancements in metal ions, nanoparticles, and label-free strategies while exploring how these innovations enable ICP-MS bioassays to achieve high sensitivity, multiplexity, and high-throughput analysis. Additionally, this review also covers related bioassays based on similar principles, such as nucleic acid hybridization and aptamer-based assays.

查看原文本刊更多论文

基于电感耦合等离子体质谱的免疫分析：2015年到2025年的更新

电感耦合等离子体质谱（ICP-MS）凭借其卓越的灵敏度和分辨率，已成为生物标志物检测领域的重要分析平台。近十年来，基于icp - ms的免疫测定技术发展迅速，不仅克服了传统光学方法灵敏度和多路复用的局限性，而且在临床中得到了广泛的应用。元素标签作为ICP-MS生物检测的核心技术模块，是连接生物分子识别和质谱信号输出的关键桥梁。它们的设计和性能直接影响检测的灵敏度、多路复用性和吞吐量。因此，本文将主要关注元素标签，总结金属离子、纳米颗粒和无标签策略的最新进展，同时探讨这些创新如何使ICP-MS生物测定实现高灵敏度、多样性和高通量分析。此外，本文还介绍了基于类似原理的相关生物检测方法，如核酸杂交和适配体检测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Trends in Analytical Chemistry 化学-分析化学

CiteScore

20.00

自引率

4.60%

发文量

257

审稿时长

3.4 months

期刊介绍： TrAC publishes succinct and critical overviews of recent advancements in analytical chemistry, designed to assist analytical chemists and other users of analytical techniques. These reviews offer excellent, up-to-date, and timely coverage of various topics within analytical chemistry. Encompassing areas such as analytical instrumentation, biomedical analysis, biomolecular analysis, biosensors, chemical analysis, chemometrics, clinical chemistry, drug discovery, environmental analysis and monitoring, food analysis, forensic science, laboratory automation, materials science, metabolomics, pesticide-residue analysis, pharmaceutical analysis, proteomics, surface science, and water analysis and monitoring, these critical reviews provide comprehensive insights for practitioners in the field.