Micropumps and microvalves for biomedical applications

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry Pub Date : 2025-03-16 DOI:10.1016/j.trac.2025.118236

Yun Zheng , Huanhuan Shi , Zhongjian Tan , Weizheng Xu , Rui Zhao , Zhengxian Dan , Zhiying Dai , Jiacong Liao , Hongwen Wu

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Abstract

This review focuses on the recent microfluidic technologies for fine manipulation of trace liquids based on functional components constructed by micropumps and microvalves and its biomedical applications. The working principle and importance of micropumps and microvalves as key components are expounded, and functional components such as enrichment, separation, mixing, extraction, purification and screening based on them are introduced. The wide applications of these functional components in wearable devices and point-of-care (POCT) devices were discussed, including real-time monitoring of human physiological indicators, rapid diagnosis of infectious diseases, early screening of cancer, etc. The significant advantages of microfluidic chips containing micropumps and microvalves in improving detection sensitivity, accuracy and efficiency are analyzed, and their important roles in personalized medicine and precision medicine are emphasized. The technical bottlenecks, limitations and possible solutions of existing microfluidic chips are discussed, and future development trends and potential breakthroughs in the biomedical field are discussed.

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来源期刊

Trends in Analytical Chemistry 化学-分析化学

CiteScore

20.00

自引率

4.60%

发文量

257

审稿时长

3.4 months

期刊介绍： TrAC publishes succinct and critical overviews of recent advancements in analytical chemistry, designed to assist analytical chemists and other users of analytical techniques. These reviews offer excellent, up-to-date, and timely coverage of various topics within analytical chemistry. Encompassing areas such as analytical instrumentation, biomedical analysis, biomolecular analysis, biosensors, chemical analysis, chemometrics, clinical chemistry, drug discovery, environmental analysis and monitoring, food analysis, forensic science, laboratory automation, materials science, metabolomics, pesticide-residue analysis, pharmaceutical analysis, proteomics, surface science, and water analysis and monitoring, these critical reviews provide comprehensive insights for practitioners in the field.