Microneedle wearables in advanced microsystems: Unlocking next-generation biosensing with AI

IF 11.8 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry Pub Date : 2025-02-27 DOI:10.1016/j.trac.2025.118208

Ghazala Ashraf , Khalil Ahmed , Ayesha Aziz , Muhammad Asif , Jilie Kong , Xueen Fang

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Abstract

Wearable electronics have transformed health monitoring, but the non-invasive, real-time extraction of biomarkers from interstitial fluid (ISF) remains a complex challenge. Microneedle (MN) technologies, integrated with bioelectronics and artificial intelligence (AI), provide a promising solution for continuous health monitoring and personalized therapy. This review explores the design of MN platforms and key sampling mediums, highlighting their role in advanced biosensing applications. It delves into conventional and emerging sensing modalities detailing their integration strategies. Additionally, MN-based assays for biomarkers including glucose, lactate, pH, electrolytes, nucleic acids, and proteins are examined, emphasizing their potential in early disease diagnostics. The review highlights key challenges in the clinical translation of MN-based devices and the integration of AI for improved biomarker calibration. Emerging materials and AI-driven MN platforms show promise for advancing personalized, real-time diagnostics and therapies. However, overcoming issues with ISF biomarker variability, data reliability, and scalability is crucial for their broader clinical adoption.

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先进微系统中的微针可穿戴设备：用人工智能解锁下一代生物传感

可穿戴电子设备已经改变了健康监测，但从间质液（ISF）中非侵入性、实时提取生物标志物仍然是一个复杂的挑战。微针（MN）技术与生物电子学和人工智能（AI）相结合，为持续健康监测和个性化治疗提供了一个有前景的解决方案。这篇综述探讨了MN平台和关键采样介质的设计，强调了它们在先进生物传感应用中的作用。它深入研究了传统和新兴的传感模式，详细介绍了它们的集成策略。此外，对生物标志物，包括葡萄糖、乳酸、pH值、电解质、核酸和蛋白质进行了基于mn的检测，强调了它们在早期疾病诊断中的潜力。该综述强调了基于mn的设备的临床翻译和人工智能集成以改进生物标志物校准方面的关键挑战。新兴材料和人工智能驱动的MN平台有望推进个性化、实时诊断和治疗。然而，克服ISF生物标志物可变性、数据可靠性和可扩展性的问题对于其更广泛的临床应用至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Analytical Chemistry 化学-分析化学

CiteScore

20.00

自引率

4.60%

发文量

257

审稿时长

3.4 months

期刊介绍： TrAC publishes succinct and critical overviews of recent advancements in analytical chemistry, designed to assist analytical chemists and other users of analytical techniques. These reviews offer excellent, up-to-date, and timely coverage of various topics within analytical chemistry. Encompassing areas such as analytical instrumentation, biomedical analysis, biomolecular analysis, biosensors, chemical analysis, chemometrics, clinical chemistry, drug discovery, environmental analysis and monitoring, food analysis, forensic science, laboratory automation, materials science, metabolomics, pesticide-residue analysis, pharmaceutical analysis, proteomics, surface science, and water analysis and monitoring, these critical reviews provide comprehensive insights for practitioners in the field.