SERS probes for cancer detection: Innovations and applications

IF 12 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry Pub Date : 2025-09-17 DOI:10.1016/j.trac.2025.118467

Ya-Juan Liu , Feng Zhang , Yu-Fei Yang , Kai-Wen Ye , Li Qiu , Chao Kang , Jun Liu , Cheng Wang

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引用次数: 0

Abstract

Liquid biopsy has revolutionized cancer detection, offering a non-invasive alternative to traditional tissue biopsies and enabling early diagnosis. Recent advancements in surface-enhanced Raman scattering (SERS) technology have significantly enhanced its applicability in liquid biopsy, particularly through the development of novel nanomaterial-based substrates, enabling multiplexed detection, real-time analysis, and higher diagnostic accuracy. This review explores and compares the methodologies involved in critical stages of the SERS-based liquid biopsy workflow, including biomarker enrichment, SERS measurement, and subsequent data analysis. Emphasis is placed on the development of SERS probe, detailing advanced techniques for the design and fabrication of SERS substrates, the various types of substrates available, and the application of diverse biorecognition elements, Raman reporters, and molecular linkers. We also present and compare the applications of extracellular vesicles (EVs), circulating tumor cells (CTCs), DNA, and RNA in cancer detection, providing insights into their transformative potential for advancing precision medicine.

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SERS探针用于癌症检测：创新与应用

液体活检彻底改变了癌症检测，为传统的组织活检提供了一种非侵入性的替代方法，并使早期诊断成为可能。表面增强拉曼散射（SERS）技术的最新进展显著增强了其在液体活检中的适用性，特别是通过新型纳米材料基基底的开发，实现了多路检测、实时分析和更高的诊断准确性。本文探讨并比较了基于SERS的液体活检工作流程的关键阶段所涉及的方法，包括生物标志物富集、SERS测量和随后的数据分析。重点放在SERS探针的发展，详细介绍了SERS底物的设计和制造的先进技术，各种类型的底物，以及各种生物识别元件，拉曼报告和分子连接物的应用。我们还介绍并比较了细胞外囊泡（ev）、循环肿瘤细胞（ctc）、DNA和RNA在癌症检测中的应用，提供了它们在推进精准医学方面的变革潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Analytical Chemistry 化学-分析化学

CiteScore

20.00

自引率

4.60%

发文量

257

审稿时长

3.4 months

期刊介绍： TrAC publishes succinct and critical overviews of recent advancements in analytical chemistry, designed to assist analytical chemists and other users of analytical techniques. These reviews offer excellent, up-to-date, and timely coverage of various topics within analytical chemistry. Encompassing areas such as analytical instrumentation, biomedical analysis, biomolecular analysis, biosensors, chemical analysis, chemometrics, clinical chemistry, drug discovery, environmental analysis and monitoring, food analysis, forensic science, laboratory automation, materials science, metabolomics, pesticide-residue analysis, pharmaceutical analysis, proteomics, surface science, and water analysis and monitoring, these critical reviews provide comprehensive insights for practitioners in the field.