Dopamine-based molecularly imprinted polymers: Synthesis strategies, biomedical applications, and future perspectives

IF 12 1区化学 Q1 CHEMISTRY, ANALYTICAL

Trends in Analytical Chemistry Pub Date : 2025-10-01 DOI:10.1016/j.trac.2025.118481

Ruilan Zhang, Zhihao Sun, Chenxu Zhu, Meiping Zhao

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Abstract

Molecularly imprinted polymers (MIPs) have emerged as powerful artificial recognition platforms in the fields of separation science, chemical sensing, drug delivery, and biocatalysis, offering unparalleled tailor-made specificity and affinity for target molecules. Among various functional materials, dopamine-based MIPs have garnered exceptional attention in recent years due to their unique combination of advantageous physicochemical properties, including facile and controllable polymerization under mild conditions; rich interfacial interactions through diverse functional groups; excellent biocompatibility and biodegradability; and versatile secondary functionalization capabilities. This comprehensive review systematically summarizes and critically analyzes the latest advances in dopamine-based MIPs, with particular focus on innovative design strategies and their cutting-edge biomedical applications. Emphasis is also placed on the long-standing challenges of dopamine in molecular imprinting, and future perspectives on next-generation materials based on dopamine-based MIPs.

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基于多巴胺的分子印迹聚合物：合成策略、生物医学应用和未来展望

分子印迹聚合物（MIPs）已成为分离科学、化学传感、药物传递和生物催化领域强大的人工识别平台，为目标分子提供无与伦比的定制特异性和亲和力。在各种功能材料中，基于多巴胺的mip由于其独特的物理化学性质组合而引起了近年来的特别关注，包括在温和条件下易于和可控的聚合；丰富的界面相互作用，通过不同的功能基团；优良的生物相容性和生物降解性；和多功能的二次功能化能力。这篇全面的综述系统地总结和批判性地分析了基于多巴胺的MIPs的最新进展，特别关注创新的设计策略及其尖端的生物医学应用。重点还放在了多巴胺在分子印迹中的长期挑战，以及基于多巴胺的mip的下一代材料的未来展望。

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来源期刊

Trends in Analytical Chemistry 化学-分析化学

CiteScore

20.00

自引率

4.60%

发文量

257

审稿时长

3.4 months

期刊介绍： TrAC publishes succinct and critical overviews of recent advancements in analytical chemistry, designed to assist analytical chemists and other users of analytical techniques. These reviews offer excellent, up-to-date, and timely coverage of various topics within analytical chemistry. Encompassing areas such as analytical instrumentation, biomedical analysis, biomolecular analysis, biosensors, chemical analysis, chemometrics, clinical chemistry, drug discovery, environmental analysis and monitoring, food analysis, forensic science, laboratory automation, materials science, metabolomics, pesticide-residue analysis, pharmaceutical analysis, proteomics, surface science, and water analysis and monitoring, these critical reviews provide comprehensive insights for practitioners in the field.