Science China Chemistry最新文献

{"title":"Intramolecular twisting of cyanine dyes into compact J-aggregated nanorings for gentle light-irradiated photothermal and photodynamic synergistic therapy with antibacterial protection","authors":"Miao Li,&nbsp;Xinyue Li,&nbsp;Yang Tan,&nbsp;Le Zhong,&nbsp;Xiaoyi Jin,&nbsp;Honglei Zhan,&nbsp;Qian Li,&nbsp;Xiaojun Peng","doi":"10.1007/s11426-025-2911-8","DOIUrl":"10.1007/s11426-025-2911-8","url":null,"abstract":"<div><p>Photodynamic therapy (PDT) and photothermal therapy (PTT) synergistic treatment for hypoxic tumors, always requires high-intensity light irradiation. This study introduces an intramolecular modulation approach for achieving PDT and PTT synergy under gentle light irradiation via the formation of tightly packed J-aggregated nanorings. Specifically, cyanine dyes, designated as <b>TYA</b> and <b>TYB</b>, were synthesized and compared to investigate the influence of intramolecular and intermolecular forces on the formation of compact J-aggregates. Compared to <b>TYA</b> (14.22°, 8.58 Å), the planar quinoline moieties in <b>TYB</b> exhibit a more pronounced rotation around the methylene linker (50.21°), which facilitates intermolecular slippage and reduces the stacking distance to 4.91 Å in J-aggregated nanorings (<b>TYB J-NPs</b>). The smaller monomer separations facilitate the generation of photothermal effects under mild light irradiation. These <b>TYB J-NPs</b> generate reactive oxygen species (ROS) levels comparable to those produced by <b>TYA</b> J-aggregates, while simultaneously producing a thermal effect under near-infrared (NIR) light irradiation (35 mW/cm², 10 min, Δ<i>T</i> &gt; 20 °C). This dual functionality synergistically enables <i>in vivo</i> fluorescence and photothermal imaging, and effectively inhibits the growth and invasion of 4T1 tumors in mice. Moreover, <b>TYB J-NPs</b> demonstrate substantial antibacterial efficacy against both Gram-positive and Gram-negative bacteria, thereby offering effective antibacterial protection during tumor phototherapy. In summary, the intramolecular twisting of <b>TYB</b> effectively resolves the bottleneck associated with intermolecular repulsions at large molecular separations, thereby facilitating the formation of densely packed J-aggregates. This represents the first instance where J-aggregated nanorings enable concurrent PDT and PTT with antibacterial effectiveness under low-density NIR light irradiation. This work may significantly enhance the therapeutic potential of cyanine dyes in cancer treatment, pathogenic bacterial infections, and other diseases.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"68 9","pages":"4311 - 4325"},"PeriodicalIF":9.7,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145011729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential sensing of base modifications in RNA nucleosides for accurate cancer diagnosis","authors":"Huan Yao,&nbsp;Ze-Ping Xiao,&nbsp;Jing Guo,&nbsp;Yu Qiu,&nbsp;Song-Meng Wang,&nbsp;Qin Tong,&nbsp;Yi-Xuan He,&nbsp;Dong-Sheng Guo,&nbsp;Liu-Pan Yang,&nbsp;Li-Li Wang","doi":"10.1007/s11426-025-2771-7","DOIUrl":"10.1007/s11426-025-2771-7","url":null,"abstract":"<div><p>The sensing and discrimination of different modified nucleosides are important in various key fields, including disease diagnosis and therapy, vaccine development, and so on. Due to the highly structural similarity and diversity of modified nucleosides, it is urgent but challenging to develop a simple and efficient method for accurate discrimination. Here, the discrimination and multiplex quantitation of modified RNA nucleoside are successfully achieved via a novel tetralactam macrocycle-based fluorescent sensor array for the first time. Based on the excellent ability of the <i>endo</i>-functionalized cavity of tetralactam macrocycle to distinguish structurally similar nucleobases in nucleosides, 16 nucleosides (including 4 unmodified, 6 methylated, and 6 other chemically modified nucleosides) with similar structures can be simultaneously discriminated with 100% accuracy. Furthermore, the concentrations of individual nucleosides in ternary mixtures are quantified simultaneously by support vector machine regression with high accuracy and immunity to interference, even in complicated human urine. In addition, the accurate discrimination of simulated cancer patient urine is realized by using the 3-element sensor array, validating its great potential in cancer precision medicine.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"68 9","pages":"4264 - 4275"},"PeriodicalIF":9.7,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145011497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Operando two-dimensional solid-state NMR unravels SAPO-34 zeolite crystallization mechanism","authors":"Xingxing Wang,&nbsp;Jun Xu","doi":"10.1007/s11426-025-2854-8","DOIUrl":"10.1007/s11426-025-2854-8","url":null,"abstract":"","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"68 9","pages":"3921 - 3922"},"PeriodicalIF":9.7,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145011742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in boron chemistry","authors":"Cheng Chen,&nbsp;Zhengwei Ding,&nbsp;Yan Gao,&nbsp;Yi Jing,&nbsp;Yong-An Luo,&nbsp;Xingxing Ma,&nbsp;Xuenian Chen,&nbsp;Pengfei Li,&nbsp;Zaozao Qiu,&nbsp;Qiuling Song,&nbsp;Xiao-Ye Wang,&nbsp;Zuowei Xie","doi":"10.1007/s11426-025-2886-2","DOIUrl":"10.1007/s11426-025-2886-2","url":null,"abstract":"<div><p>Boron, positioned to the left of carbon in the periodic table with one fewer electron, exhibits unique chemical properties. Tricoordinate boron compounds are typically electron-deficient, acting as strong Lewis acids in general with electrophilic behavior. In contrast, tetracoordinate boron compounds, featuring a tetrahedral geometry, display nucleophilicity and enable transformations such as migration, transmetallation, and oxidation. Boron compounds serve as versatile synthons, reagents, and catalysts in organic reactions. Incorporating boron into conjugated systems enhances chemical diversity and modulates optoelectronic properties, while the vacant p orbital of boron imparts high electron affinity and unique stimulus-responsive characteristics. Additionally, boron forms deltahedral clusters in polyhedral (car)boranes, which are air-and moisture-stable and distinct from traditional hydrocarbon structures. This review provides an overview of the fundamental properties and diverse applications of boron compounds across various fields.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"68 9","pages":"3927 - 3995"},"PeriodicalIF":9.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145011881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A photon induced antibiotic activated by infectious microenvironment","authors":"Kun Qian,&nbsp;Zhen Cheng","doi":"10.1007/s11426-025-2857-4","DOIUrl":"10.1007/s11426-025-2857-4","url":null,"abstract":"","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"68 9","pages":"3915 - 3917"},"PeriodicalIF":9.7,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145011577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From chaos to order: electron-rich single-atom intermetallic catalysts","authors":"Xiang-Ting Min,&nbsp;Botao Qiao,&nbsp;Aiqin Wang,&nbsp;Tao Zhang","doi":"10.1007/s11426-025-2853-6","DOIUrl":"10.1007/s11426-025-2853-6","url":null,"abstract":"","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"68 9","pages":"3918 - 3920"},"PeriodicalIF":9.7,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145011531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonprecious and long-term stable MOF@POM superstructure-derived electrocatalyst for water oxidation reaction","authors":"Lei Zhang,&nbsp;Ya-Qian Lan","doi":"10.1007/s11426-025-2777-0","DOIUrl":"10.1007/s11426-025-2777-0","url":null,"abstract":"","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"68 9","pages":"3907 - 3908"},"PeriodicalIF":9.7,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145011514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stereoselective C(sp3)—H alkylation of saturated heterocycles with olefins","authors":"Wen-Cong Li,&nbsp;Jialin Ming,&nbsp;Da-Gang Yu","doi":"10.1007/s11426-025-2764-y","DOIUrl":"10.1007/s11426-025-2764-y","url":null,"abstract":"","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"68 9","pages":"3912 - 3914"},"PeriodicalIF":9.7,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145011811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redefining host-guest chemistry through amphoteric chalcogen and halogen bonding","authors":"Wei Zhou,&nbsp;Qing He","doi":"10.1007/s11426-025-2740-9","DOIUrl":"10.1007/s11426-025-2740-9","url":null,"abstract":"","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"68 9","pages":"3909 - 3911"},"PeriodicalIF":9.7,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145011731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward high-efficiency all-polymer solar cells based on polymerized small-molecule acceptors: the role of interplay between intra-chain and inter-chain couplings","authors":"Yaogang Zhang,&nbsp;Lu Ning,&nbsp;Guangchao Han,&nbsp;Yuanping Yi","doi":"10.1007/s11426-025-2717-1","DOIUrl":"10.1007/s11426-025-2717-1","url":null,"abstract":"<div><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"68 9","pages":"4115 - 4124"},"PeriodicalIF":9.7,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145011659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}