Science China Chemistry最新文献

Recent advances in exploring new blood-based biomarkers for the early diagnosis of gastric cancer

IF 10.4 1区化学

Science China Chemistry Pub Date : 2024-11-25 DOI: 10.1007/s11426-024-2189-1

Xinyu Peng, Qian Ma, Da Han

{"title":"Recent advances in exploring new blood-based biomarkers for the early diagnosis of gastric cancer","authors":"Xinyu Peng, Qian Ma, Da Han","doi":"10.1007/s11426-024-2189-1","DOIUrl":"10.1007/s11426-024-2189-1","url":null,"abstract":"<div><p>Gastric cancer (GC) is a prevalent and lethal malignancy worldwide, and the 5-year survival rate is less than 30%. The absence of distinctive symptoms often leads to late-stage diagnosis, contributing to a grim prognosis. Early detection is pivotal for improving the survival rates and outcomes of GC patients. Traditional diagnostic methods, including gastroscopy and histopathological examination, are restricted in the early diagnosis of GC. Conventional protein biomarkers, such as carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), and carbohydrate antigen 72-4 (CA72-4), exhibit insufficient sensitivity and specificity for GC screening, which diminishes their clinical value. Recently, novel circulating biomarkers, such as circulating tumor cells (CTCs), circulating tumor cell DNA (ctDNA), and circulating free RNA (cfRNA), have emerged as promising candidates in the burgeoning field of liquid biopsy due to their superior sensitivity and specificity. This review focuses on the latest research on blood-based biomarkers for GC diagnosis and examines the clinical potentials and challenges associated with these emerging biomarkers.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"68 1","pages":"35 - 45"},"PeriodicalIF":10.4,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142925659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent progress on photoactive nonprecious transition-metal complexes

IF 10.4 1区化学

Science China Chemistry Pub Date : 2024-11-15 DOI: 10.1007/s11426-024-2345-0

Zhong-Liang Gong, Hong-Jie Zhang, Yan Cheng, Jianxun Liu, Yuhan Ai, Yaqin Li, Zhihui Feng, Qiong Zhang, Shaolong Gong, Yong Chen, Chang-Jiang Yao, Yuan-Yuan Zhu, Liang-Jin Xu, Yu-Wu Zhong

{"title":"Recent progress on photoactive nonprecious transition-metal complexes","authors":"Zhong-Liang Gong, Hong-Jie Zhang, Yan Cheng, Jianxun Liu, Yuhan Ai, Yaqin Li, Zhihui Feng, Qiong Zhang, Shaolong Gong, Yong Chen, Chang-Jiang Yao, Yuan-Yuan Zhu, Liang-Jin Xu, Yu-Wu Zhong","doi":"10.1007/s11426-024-2345-0","DOIUrl":"10.1007/s11426-024-2345-0","url":null,"abstract":"<div><p>Photoactive complexes of nonprecious transition metals, mainly including those in the first-row and partially the second-row of the Periodic table of elements, have received increasing attention in view of their low cost and long-term sustainability. They are recognized as promising alternatives to noble transition metal complex congeners that have been extensively studied in optoelectronic devices, artificial photosynthesis, photocatalysis, biodiagnostics, and therapeutics, etc. This review is devoted to a comprehensive summary on the classical and recent advances on photoactive nonprecious transition metal complexes, including photoactive Zr, V, Cr, Mo, and W complexes, Mn complexes and hybrids, Fe, Co, Ni, and Cu complexes, and Zn and Cd complexes and hybrids. A particular focus is given on the molecular design, modulation of photophysical and photochemical properties, and applications of the representative and lately-developed nonprecious metal complexes. In addition, a perspective on the future development in this field is provided at the end of this review.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"68 1","pages":"46 - 95"},"PeriodicalIF":10.4,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142925745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Size-selective hybridization chain reaction for accurate signal amplification in living cancer cells

IF 10.4 1区化学

Science China Chemistry Pub Date : 2024-11-12 DOI: 10.1007/s11426-024-2294-x

Ting Chen, Xiaojiao Wang, Rongrong Gao, Meihe Yuan, Mei Chen, Xiao-Bing Zhang, Guoliang Ke

{"title":"Size-selective hybridization chain reaction for accurate signal amplification in living cancer cells","authors":"Ting Chen, Xiaojiao Wang, Rongrong Gao, Meihe Yuan, Mei Chen, Xiao-Bing Zhang, Guoliang Ke","doi":"10.1007/s11426-024-2294-x","DOIUrl":"10.1007/s11426-024-2294-x","url":null,"abstract":"<div><p>Accurate signal amplification in living cells is highly important in biomedical research and medical diagnostics. Benefiting from its enzyme-free, efficient isothermal signal amplification ability, hybridization chain reaction (HCR) plays an important role in intracellular signal amplification; however, HCR fails the accurate signal amplification in the situation when the properties of some biological targets and analogues are too similar. Particularly, their signal amplification accuracy for mature miRNAs is unsatisfactory due to the signal interference of precursor microRNAs (abbreviated as pre-miRNAs), which also contain the sequence of mature miRNAs. Herein, we develop the first example of size-selective hybridization chain reaction probe for accurate signal amplification, which achieved accurate and sensitive biosensing of mature miRNAs in living cancer cells. Our probe, termed as qTcage, consists of a DNA nanocage for size-selective responsive to mature miRNAs, as well as a quadrivalent tetrahedral DNA structure for HCR signal amplification. Benefiting from the size-selectivity of DNA nanocage, shorter mature miRNAs (19–23 nt) rather than longer pre-miRNAs (60–70 nt) could enter the cavity to release triggers strand, which activates HCR reaction for fluorescence signal recovery. The probe efficiently reduces signal interference of pre-miRNAs and improves the imaging sensitivity for intracellular mature miRNAs, which was successfully applied for mature miRNAs imaging during drug treatment. Overall, this strategy provides the hybridization chain reaction with the feature of size-selective ability, which holds promise for further accurate signal amplification in biological processes study and clinical diagnostics.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"67 12","pages":"4259 - 4266"},"PeriodicalIF":10.4,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142758036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fostering a growing chemistry community: the 2024 emerging investigator issue of Science China Chemistry

IF 10.4 1区化学

Science China Chemistry Pub Date : 2024-11-12 DOI: 10.1007/s11426-024-2414-x

Li-Jun Wan

引用次数: 0

Potential dependence in electrocatalysis: a theoretical perspective

IF 10.4 1区化学

Science China Chemistry Pub Date : 2024-11-12 DOI: 10.1007/s11426-024-2402-2

Leyu Liu, Zhaoming Xia, Zeyu Wang, Yinjuan Chen, Hai Xiao

引用次数: 0

Mechanochemistry of cyclobutanes

IF 10.4 1区化学

Science China Chemistry Pub Date : 2024-11-11 DOI: 10.1007/s11426-024-2344-0

Roberto Obregon, Junpeng Wang

引用次数: 0

Dative B-N bonds weaven toward two-dimensional purely organic materials for single crystals

IF 10.4 1区化学

Science China Chemistry Pub Date : 2024-11-06 DOI: 10.1007/s11426-024-2385-1

Wei-Lei Zhou, Siwei Wang, Yong Chen

引用次数: 0

Deciphering fungal metabolon coupling tandem inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

IF 10.4 1区化学

Science China Chemistry Pub Date : 2024-10-31 DOI: 10.1007/s11426-024-2134-0

Shuai Liu, Wen-Qiang Xu, Ying-Tong Di, Man-Cheng Tang, Ding-Kang Chen, Ming-Ming Cao, Yao-Wen Chang, Hong-Yu Tang, Chun-Mao Yuan, Jun-Bo Yang, Zhi-Li Zuo, Han Guo, Zi-Fei Xu, Ying Zeng, Yun-Dong Wu, Xiao-Jiang Hao

{"title":"Deciphering fungal metabolon coupling tandem inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids","authors":"Shuai Liu, Wen-Qiang Xu, Ying-Tong Di, Man-Cheng Tang, Ding-Kang Chen, Ming-Ming Cao, Yao-Wen Chang, Hong-Yu Tang, Chun-Mao Yuan, Jun-Bo Yang, Zhi-Li Zuo, Han Guo, Zi-Fei Xu, Ying Zeng, Yun-Dong Wu, Xiao-Jiang Hao","doi":"10.1007/s11426-024-2134-0","DOIUrl":"10.1007/s11426-024-2134-0","url":null,"abstract":"<div><p>In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase SpeF and P450 monooxygenase SpeG, is identified in the biosynthesis of spiro polycyclic alkaloids (+)-notoamide B and its diastereomer (+)-versicolamide B. Using notoamide E as a substance, SpeF/SpeG metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-mA with dienyl iminium unit. Subsequently, (+)-notoamide B and (+)-versicolamide B are produced <i>via</i> tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.\u0000</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"68 1","pages":"288 - 296"},"PeriodicalIF":10.4,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142925476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling the impacts of intermolecular interaction on morphology evolution for highly efficient organic solar cells and modules

IF 10.4 1区化学

Science China Chemistry Pub Date : 2024-10-28 DOI: 10.1007/s11426-024-2272-3

Xueqing Ma, Yingying Cheng, Yuqiang Liu, Xinming Zheng, Guangliu Ran, Hongxiang Li, Xinyue Cui, Andong Zhang, Wenkai Zhang, Pei Cheng, Wenchao Huang, Zhishan Bo

{"title":"Unraveling the impacts of intermolecular interaction on morphology evolution for highly efficient organic solar cells and modules","authors":"Xueqing Ma, Yingying Cheng, Yuqiang Liu, Xinming Zheng, Guangliu Ran, Hongxiang Li, Xinyue Cui, Andong Zhang, Wenkai Zhang, Pei Cheng, Wenchao Huang, Zhishan Bo","doi":"10.1007/s11426-024-2272-3","DOIUrl":"10.1007/s11426-024-2272-3","url":null,"abstract":"<div><p>Understanding the effect of intermolecular interaction on the growth dynamic of active layers is critical for advancing organic solar cells (OSCs). However, the diverse structure of donors and acceptors makes the research challenging. Additives with customizable structures and properties could simplify this complexity. Herein, we meticulously tailor two additives of 3,4-ethylenedioxythiophene (EDOT) and 2,5-dibromo-3,4-ethylenedioxythiophene (DBEDOT), possessing distinct intermolecular interaction features to elaborate the inherent relationship. It is found that varied interaction strengths can alter film formation processes. The enhanced intermolecular interaction between the DBEDOT and non-fullerene acceptor BTP-eC9-4F results in pre-aggregation and longer crystallization duration of BTP-eC9-4F, facilitating the formation of films with compact molecular packing and decent phase separation. Thus, exciton dissociation and charge transport become more efficient. Finally, devices processed with DBEDOT exhibit a remarkable power conversion efficiency of 19.35% in small-area OSCs and 14.11% in blade-coated 5 cm × 5 cm organic solar mini-modules. Especially, OSCs can maintain 80% of their initial efficiency after continuous annealing at 85 °C for over 2,100 h.</p><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"68 1","pages":"264 - 272"},"PeriodicalIF":10.4,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142925752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Controlled cationic ring-opening polymerization of L-lactide by organic ion pair: novel approach to isotactic-rich and crystalline polylactide

IF 10.4 1区化学

Science China Chemistry Pub Date : 2024-10-28 DOI: 10.1007/s11426-024-2370-6

Zhiqiang Ding, Mingqian Wang, Zijing Zhou, Bin Wang, Yuesheng Li

{"title":"Controlled cationic ring-opening polymerization of L-lactide by organic ion pair: novel approach to isotactic-rich and crystalline polylactide","authors":"Zhiqiang Ding, Mingqian Wang, Zijing Zhou, Bin Wang, Yuesheng Li","doi":"10.1007/s11426-024-2370-6","DOIUrl":"10.1007/s11426-024-2370-6","url":null,"abstract":"<div><p>Living/controlled cationic ring-opening polymerization (ROP) of <i>L</i>-lactide is a promising approach to isotactic-rich and crystalline poly(<i>L</i>-lactide). In contrast with the unsubstituted lactones, <i>L</i>-LA can not be polymerized by organic Lewis acids or carbenium ions, and the state of the art in this field is the cationic ROP of <i>L</i>-LA catalyzed by Brønsted acid/alcohol system <i>via</i> activated monomer mechanism. Herein, we reported the first example of controlled cationic ROP of <i>L</i>-LA by using Meerweintype ion pair [Me<sub>3</sub>O]<sup>+</sup>[B(C<sub>6</sub>F<sub>5</sub>)<sub>4</sub>]<sup>−</sup> as the catalyst. [Me<sub>3</sub>O]<sup>+</sup>[B(C<sub>6</sub>F<sub>5</sub>)<sub>4</sub>]<sup>−</sup> promoted rapid <i>L</i>-LA cationic polymerization in the absence of alcohol, producing isotactic-rich and crystalline PLLA without transesterification and epimerization side reactions. An activated chain end mechanism, involving twice S<sub>N</sub>2 substitution and configuration-inversion (<i>S</i>→<i>R</i>→<i>S</i>) with the assistance of released Me<sub>2</sub>O, was proposed and further verified by density functional theory and control experiments. This work expands the catalytic toolbox of isotactic-rich and crystalline polylactide synthesis. It represents a unique example of cationic-controlled polymerization of <i>L</i>-LA catalyzed by an organic ion pair.</p></div>","PeriodicalId":772,"journal":{"name":"Science China Chemistry","volume":"68 1","pages":"394 - 402"},"PeriodicalIF":10.4,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142925780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0