{"title":"Cover Feature: In Situ Electrochemical Reduction of Imidacloprid involving a Nitroso-Intermediate-Trapped DWCNT and Its Biomimetic Cellular Oxidative Stress-Related Mediated Oxidation of Thiols (Chem. Asian J. 14/2025)","authors":"Kandavel Preethika Andal, Annamalai Senthil Kumar","doi":"10.1002/asia.202581403","DOIUrl":"https://doi.org/10.1002/asia.202581403","url":null,"abstract":"<p>This study electrochemically investigates imidacloprid (IMP) transformation into its toxic intermediate, IMP-NO, and its surface entrapment on a carbon nanotube-modified electrode. The system effectively mimics thiol oxidation, correlating with cellular oxidative stress mitigation. Kinetic parameters were estimated, demonstrating oxidative thiol detection, offering insights into IMP's environmental impact and biological interactions. More details can be found in article number e202401779 by Kandavel Preethika Andal and Annamalai Senthil Kumar.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":"20 14","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/asia.202581403","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Front Cover: β1,6-Selective Enzymatic N-Acetylglucosamination Catalyzed by the Family GH84 N-Acetyl-β-D-glucosaminidase from Bacteroides thetaiotaomicron and its Glycosyl Acceptor Specificity (Chem. Asian J. 14/2025)","authors":"Rika Okuno, Shunsuke Nakada, Kisuke Tonomura, Yuji Aso, Daijiro Takeshita, Takayuki Ohnuma, Tomonari Tanaka","doi":"10.1002/asia.202581401","DOIUrl":"https://doi.org/10.1002/asia.202581401","url":null,"abstract":"<p>This cover picture illustrates enzymatic glycosylation for the synthesis of the <i>O</i>-glycan core 6 disaccharide moiety, GlcNAcβ1-6GalNAc. The β1,6-selective <i>N</i>-acetylglucosamination was catalyzed by an <i>N</i>-acetyl-β-D-glucosaminidase from <i>Bacteroides thetaiotaomicron</i> with an <i>N</i>-acetyl-D-glucosamine (GlcNAc) oxazoline derivative as the glycosyl donor, resulting in disaccharides with β1,6-linked GlcNAc. More details can be found in article number e202500142 by Tomonari Tanaka, Takayuki Ohnuma, and co-workers.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":"20 14","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/asia.202581401","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dr. Satoru Kuwano, Jun Kikushima, Takaaki Nakada, Dr. Shohei Sase, Prof. Dr. Kei Goto
{"title":"Cover Feature: Reusable Selenenyl Iodide-Initiated Cascade Cyclization of Polyenes with N-terminating Groups (Chem. Asian J. 14/2025)","authors":"Dr. Satoru Kuwano, Jun Kikushima, Takaaki Nakada, Dr. Shohei Sase, Prof. Dr. Kei Goto","doi":"10.1002/asia.202581402","DOIUrl":"https://doi.org/10.1002/asia.202581402","url":null,"abstract":"<p>The cover picture illustrates reusable selenenyl iodide-initiated cascade cyclization of polyenes bearing <i>N</i>-terminal substituents. The unique soft electrophilicity of the selenenyl iodide, depicted in the upper left corner, enables efficient formation of the sequential cyclization product shown at the center. Furthermore, the selenenic acid illustrated in the upper right corner is generated via oxidative β-selenoxide elimination from the cyclized product. More details can be found in article number e202500347 by Kei Goto and co-workers.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":"20 14","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/asia.202581402","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cover Feature: Superior Catalytic Outcomes of Dinuclear Palladium(II) NHC/PCy3 Complex Over Its Mononuclear Counterpart in Intermolecular α-Arylation of Amide (Chem. Asian J. 14/2025)","authors":"Sneha Goswami, Kaustav Sarker, Uchchhal Bandyopadhyay, Debarati Mondal, Ankita Halder, Ramananda Maity","doi":"10.1002/asia.202581404","DOIUrl":"https://doi.org/10.1002/asia.202581404","url":null,"abstract":"<p>The Cover shows a combined operation of two palladium(II) centers in a dinuclear bis-NHC complex employed in the intermolecular α-arylation of 1-methyl-2-oxindole. The highly active bimetallic palladium(II) complex possessing a PCy<sub>3</sub> as an ancillary ligand <i>trans</i>-to the NHC unit and appeared to be beneficial over its corresponding mononuclear complex in terms of catalytic outcomes. More information can be found in article number e202500507 by Ramananda Maity and co-workers.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":"20 14","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/asia.202581404","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nikhil Ji Tiwari, Tarun, Upendra Kumar Pandey, Rajneesh Misra
{"title":"Charge Carrier Mobility of Phenothiazine Functionalized TCBD Derivatives of Naphthalimide.","authors":"Nikhil Ji Tiwari, Tarun, Upendra Kumar Pandey, Rajneesh Misra","doi":"10.1002/asia.202500259","DOIUrl":"https://doi.org/10.1002/asia.202500259","url":null,"abstract":"<p><p>A set of naphthalimide functionalized push-pull chromophores NPI 1-3 were designed and synthesized via Pd-catalyzed Sonogashira cross-coupling followed by [2 + 2] cycloaddition-electrocyclic ring-opening reaction. The 1,8-naphthalimide (NPI) and 1,1,4,4-tetracyanobuta-1,3-diene (TCBD) moiety acts as an acceptor unit, whereas phenothiazine (PTZ) unit acts as a donor unit. Their photophysical, electrochemical properties, and charge carrier mobilities were investigated. Density functional theory (DFT) and TD-DFT calculations were performed on NPI 1-3 to analyze the molecular geometry, frontier molecular orbitals, molecular electrostatic potentials (MEPs), and electronic transitions related to their absorption spectra. The incorporation of cyano-based strong electron acceptor TCBD in the phenothiazine functionalized naphthalimide derivatives NPI1 resulted in TCBD incorporated chromophore NPI 2-3 which exhibits red-shifted electronic absorption spectra in the near IR region. The electrochemical properties reveal that the naphthalimide derivatives NPI 1-3 exhibit multiple redox waves, attributed to the presence of NPI and TCBD acceptor units and phenothiazine donor units. The measured hole and electron mobilities for NPI 1-3 are 4.06 × 10<sup>-3</sup> and 3.16 × 10<sup>-3</sup> cm<sup>2</sup> V<sup>-1</sup> s<sup>-1</sup>, 7.5 × 10<sup>-3</sup> and 4.48 × 10<sup>-3</sup> cm<sup>2</sup> V<sup>-1</sup> s<sup>-1</sup>, 6.76 × 10<sup>-3</sup> and 3.1 × 10<sup>-3</sup> cm<sup>2</sup> V<sup>-1</sup> s<sup>-1</sup>, respectively, obtained by space-charge limited current (SCLC) measurements.</p>","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e00259"},"PeriodicalIF":3.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shuwei Tang, Yufei Meng, Ying Liu, Pengfei Zhang, Zhiwei Zhang, Wanrong Guo, Song Pei, Yilong Xiao, Guowei Wang
{"title":"Theoretical Insights into the Ni<sup>(0)</sup>-Catalyzed Asymmetric Hydroalkylation of Phenylbutadiene and Acetophenone: Mechanism, Selectivity, and Ligand Effect.","authors":"Shuwei Tang, Yufei Meng, Ying Liu, Pengfei Zhang, Zhiwei Zhang, Wanrong Guo, Song Pei, Yilong Xiao, Guowei Wang","doi":"10.1002/asia.202500758","DOIUrl":"https://doi.org/10.1002/asia.202500758","url":null,"abstract":"<p><p>Transition-metal-catalyzed hydroalkylation of enols/enolates with unsaturated hydrocarbons enables the functionalization via C─C and C-heteroatom bond formation. In this work, the reaction mechanisms of Ni<sup>(0)</sup>-catalyzed asymmetric hydroalkylation of phenylbutadiene and acetophenone are systematically investigated using density functional theory (DFT) calculations. The Ni<sup>(0)</sup>/Ni<sup>(II)</sup> catalytic cycle comprises oxidative addition, proton transfer, and the C(sp<sup>3</sup>)─C(sp<sup>3</sup>) bond formation via reductive elimination. The rate-determining oxidative addition step proceeds via a concerted ligand-to-ligand hydrogen transfer (LLHT) mechanism, bypassing an unstable Ni<sup>(II)</sup>-hydride intermediate. Proton transfer occurs via a ligand exchange with the enolate group within the acetophenone, and the regioselectivity arises from the preferential C(sp<sup>3</sup>)-C(sp<sup>3</sup>) bond formation via reductive elimination at the methyl-adjacent carbon in the acetophenone. Furthermore, the electron population analysis on the rate-determining transition state demonstrates that charge transfer from the Ni<sup>(0)</sup>-ligand moiety to the ─O<sup>+</sup>H σ* and ─C═C─π* antibonding orbitals facilitates the weakening of the ─O<sup>+</sup>H bond and η<sup>2</sup>-coordination of ─C═C─ bond in phenylbutadiene with the nickel center, enabling the LLHT mechanism. Additionally, the influence of ligand on the reactivity of Ni<sup>(0)</sup>-catalyzed asymmetric hydroalkylation is also explored, and the steric contour maps of percent buried volume (%Vbur) analysis confirm that the bulky ligands increase the %Vbur and enhance catalytic performance.</p>","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e00758"},"PeriodicalIF":3.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Photocatalytic Anticancer Activity of Cyclometalated Ir(III) Complexes: A Mechanistic Insight.","authors":"Ashish Kumar Yadav, Virendra Singh, Ishwar Singh, Amit Kunwar, Biplob Koch, Samya Banerjee","doi":"10.1002/asia.202500681","DOIUrl":"https://doi.org/10.1002/asia.202500681","url":null,"abstract":"<p><p>Three novel cyclometalated Ir(III) complexes, Ir1-Ir3, were synthesized and thoroughly characterized. These complexes exhibited absorption in the 350-480 nm range, making them suitable candidates for visible-light-mediated photocatalytic cancer therapy. Under visible-light exposure in a DMSO:PBS (1:99 v/v) solvent system, all three photocatalysts demonstrated high efficiency in facilitating NADH oxidation, attaining turnover frequencies (TOFs) in the range of 499-698 h⁻<sup>1</sup>, exceeding the performance of most of the previously reported Ir(III)-based photocatalysts. Mechanistic studies verified the involvement of type I and type II pathways for ROS generation. Cytotoxicity studies highlighted significant photocytotoxic effects of Ir1-Ir3 in human lung adenocarcinoma cells (A549), with Ir3 emerging as the most potent under light exposure. Additionally, the negligible dark and light cytotoxicity of Ir3 against human embryonic kidney cells (HEK-293) demonstrated the safety profile of Ir3. Furthermore, the mechanistic studies in A549 cells revealed that Ir3 promoted mitochondrial membrane depolarization and activated caspase-3/7-dependent apoptotic pathways through light-triggered ROS generation and NADH oxidation. These findings highlight Ir3 as a potent dual-action cancer phototherapeutic, capable of synergistically inducing type-I and type-II anticancer activity, and efficient NADH photo-oxidation. This work presents a promising platform for developing multifunctional photocatalytic agents in cancer therapy.</p>","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e00681"},"PeriodicalIF":3.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Photocatalytic Disulfide Synthesis Using Trityl Sulfides.","authors":"Keita Yamazaki, Tetsuhiro Nemoto","doi":"10.1002/asia.202500743","DOIUrl":"https://doi.org/10.1002/asia.202500743","url":null,"abstract":"<p><p>We report a photocatalytic disulfide synthesis employing trityl sulfide as the starting material. Trityl sulfide can be readily obtained from dimethoxytrityl thiol-a low-odor crystalline solid that is easy to handle-via alkyl halides or mesyl-protected alcohols. The method is broadly applicable to the synthesis of structurally diverse disulfide compounds. Notably, the reaction proceeds efficiently even under degassed conditions and constitutes a relatively underexplored transformation in which the trityl cation actively participates in the oxidation cycle of the photocatalyst.</p>","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e00743"},"PeriodicalIF":3.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Benzil-Dihydrazone Based Bis-Schiff Base Dual-Sensor for Expeditious Colorimetric Detection of Ni<sup>2+</sup> and Fluorometric Detection of Ag<sup>+</sup>: Environmental and Biological Applications.","authors":"Dishen Kumar, Srishti Dutta, Abhilash Pandey, Vanshika Sharma, Devanand Sahu, Sounik Manna, Sujata Maiti Choudhury, Goutam Kumar Patra","doi":"10.1002/asia.202500779","DOIUrl":"https://doi.org/10.1002/asia.202500779","url":null,"abstract":"<p><p>In this research, a novel dual chemosensor L has been reported. It has been characterised by FTIR, <sup>1</sup>H-NMR, ESI-MS, elemental analyses, X-ray single crystal analysis and DFT studies. In a 1:1 methanol-water medium (v/v), the receptor L detected Ni<sup>2+</sup> with color change from colorless to yellow and Ag<sup>+</sup> with turn-on fluorescence enhancement. UV-vis spectroscopy, fluorescence titration, FTIR and ESI-MS have been used to analyse the response mechanisms of fluorescent colorimetric sensing. The colorimetric sensitivity for Ni<sup>2+</sup> is 3.0 × 10<sup>-7</sup> M and fluorometric sensitivity for Ag<sup>+</sup> is 7.2 × 10<sup>-7</sup> M; both the values are sufficient below the WHO permissible limits in aqueous solution. From the Job's plot measurements and the ESI-MS spectrum, 2: 1 stoichiometric complexation between L and Ni<sup>2+</sup>/Ag<sup>+</sup> has been established. Receptor L shows remarkable detection ability in a wide pH range of 4-9 and can be successfully applied for the detection and quantification of Ni<sup>2+</sup> ions in environmental samples, and Ag<sup>+</sup> ions in BSA protein. At the specified doses and incubation times, L can be used as an anticancer drug and a selective sensor for bio-imaging of Ag<sup>+</sup> ion without having any cytotoxic effects.</p>","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e00779"},"PeriodicalIF":3.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cobalt-Catalyzed One-Pot Three-Component Cascade Annulation for the Synthesis of Highly Functionalized 3,5-Disubstituted-2,6-Dicyanoanilines at Room Temperature.","authors":"Adrija Majumdar, Subham Sau, Arunabha Thakur","doi":"10.1002/asia.202500634","DOIUrl":"https://doi.org/10.1002/asia.202500634","url":null,"abstract":"<p><p>A facile one-step, three-component domino reaction has been established for the efficient synthesis of 3,5-disubstituted-2,6-dicyanoaniline derivatives, utilizing aldehydes in conjunction with aromatic, cyclic, and acyclic ketones, as well as malononitrile. This methodology employs CoCl<sub>2</sub>·6H<sub>2</sub>O as a catalyst specifically for aromatic and acyclic ketones, whereas a metal-free, base-catalyzed approach is applied for cyclic ketones. The reaction proceeds via a sequential mechanism that encompasses Knoevenagel condensation, Michael addition, and nucleophilic cyclization. Conducted at room temperature, this reaction accommodates both aromatic and aliphatic aldehydes, leveraging inexpensive and readily available substrates, thereby obviating the necessity for costly cocatalysts or ligands. It offers simple conditions, shorter reaction times, high yields, and an atom-economical, eco-friendly one-pot approach. It also provides a broad substrate scope of total 21 compounds, including 14 new compounds. The photo-physical properties, assessed via UV-vis and fluorescence spectroscopy, revealed that some compounds showed red-shifted emissions, indicating their potential as fluorescent probes for bioimaging and as dye candidates for optoelectronic applications such as OLEDs. Gram-scale synthesis confirms its industrial relevance, whereas mechanistic studies, including control experiments and Hammett analysis provide insights into the reaction pathway.</p>","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e00634"},"PeriodicalIF":3.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}