Chemistry - An Asian Journal最新文献

Cover Feature: In Situ Electrochemical Reduction of Imidacloprid involving a Nitroso-Intermediate-Trapped DWCNT and Its Biomimetic Cellular Oxidative Stress-Related Mediated Oxidation of Thiols (Chem. Asian J. 14/2025) 封面特征：利用亚硝基中间体捕获的小碳纳米管原位电化学还原吡虫啉及其仿生细胞氧化应激相关介导的硫醇氧化（化学）。亚洲J. 14/2025)

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-07-22 DOI: 10.1002/asia.202581403

Kandavel Preethika Andal, Annamalai Senthil Kumar

引用次数: 0

Front Cover: β1,6-Selective Enzymatic N-Acetylglucosamination Catalyzed by the Family GH84 N-Acetyl-β-D-glucosaminidase from Bacteroides thetaiotaomicron and its Glycosyl Acceptor Specificity (Chem. Asian J. 14/2025) 前封面：拟杆菌（Bacteroides thetaotaomicron） GH84家族n -乙酰-β- d -氨基葡萄糖酶催化的β1,6选择性酶n -乙酰氨基葡萄糖化及其糖基受体特异性（Chem.）。亚洲J. 14/2025)

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-07-22 DOI: 10.1002/asia.202581401

Rika Okuno, Shunsuke Nakada, Kisuke Tonomura, Yuji Aso, Daijiro Takeshita, Takayuki Ohnuma, Tomonari Tanaka

引用次数: 0

Cover Feature: Reusable Selenenyl Iodide-Initiated Cascade Cyclization of Polyenes with N-terminating Groups (Chem. Asian J. 14/2025) 封面特征：可重复使用的硒基碘化引发的含n端基团的多烯级联环化（化学）。亚洲J. 14/2025)

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-07-22 DOI: 10.1002/asia.202581402

Dr. Satoru Kuwano, Jun Kikushima, Takaaki Nakada, Dr. Shohei Sase, Prof. Dr. Kei Goto

引用次数: 0

Cover Feature: Superior Catalytic Outcomes of Dinuclear Palladium(II) NHC/PCy3 Complex Over Its Mononuclear Counterpart in Intermolecular α-Arylation of Amide (Chem. Asian J. 14/2025) 封面特征：双核钯（II） NHC/PCy3配合物在酰胺分子间α-芳基化反应中的催化效果优于单核配合物。亚洲J. 14/2025)

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-07-22 DOI: 10.1002/asia.202581404

Sneha Goswami, Kaustav Sarker, Uchchhal Bandyopadhyay, Debarati Mondal, Ankita Halder, Ramananda Maity

引用次数: 0

Charge Carrier Mobility of Phenothiazine Functionalized TCBD Derivatives of Naphthalimide. 吩噻嗪功能化萘酰亚胺TCBD衍生物的载流子迁移率。

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-07-21 DOI: 10.1002/asia.202500259

Nikhil Ji Tiwari, Tarun, Upendra Kumar Pandey, Rajneesh Misra

{"title":"Charge Carrier Mobility of Phenothiazine Functionalized TCBD Derivatives of Naphthalimide.","authors":"Nikhil Ji Tiwari, Tarun, Upendra Kumar Pandey, Rajneesh Misra","doi":"10.1002/asia.202500259","DOIUrl":"https://doi.org/10.1002/asia.202500259","url":null,"abstract":"A set of naphthalimide functionalized push-pull chromophores NPI 1-3 were designed and synthesized via Pd-catalyzed Sonogashira cross-coupling followed by [2 + 2] cycloaddition-electrocyclic ring-opening reaction. The 1,8-naphthalimide (NPI) and 1,1,4,4-tetracyanobuta-1,3-diene (TCBD) moiety acts as an acceptor unit, whereas phenothiazine (PTZ) unit acts as a donor unit. Their photophysical, electrochemical properties, and charge carrier mobilities were investigated. Density functional theory (DFT) and TD-DFT calculations were performed on NPI 1-3 to analyze the molecular geometry, frontier molecular orbitals, molecular electrostatic potentials (MEPs), and electronic transitions related to their absorption spectra. The incorporation of cyano-based strong electron acceptor TCBD in the phenothiazine functionalized naphthalimide derivatives NPI1 resulted in TCBD incorporated chromophore NPI 2-3 which exhibits red-shifted electronic absorption spectra in the near IR region. The electrochemical properties reveal that the naphthalimide derivatives NPI 1-3 exhibit multiple redox waves, attributed to the presence of NPI and TCBD acceptor units and phenothiazine donor units. The measured hole and electron mobilities for NPI 1-3 are 4.06 × 10-3 and 3.16 × 10-3 cm2 V-1 s-1, 7.5 × 10-3 and 4.48 × 10-3 cm2 V-1 s-1, 6.76 × 10-3 and 3.1 × 10-3 cm2 V-1 s-1, respectively, obtained by space-charge limited current (SCLC) measurements.","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e00259"},"PeriodicalIF":3.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Theoretical Insights into the Ni⁽⁰⁾-Catalyzed Asymmetric Hydroalkylation of Phenylbutadiene and Acetophenone: Mechanism, Selectivity, and Ligand Effect. Ni(0)催化苯丁二烯和苯乙酮不对称氢烷基化反应的理论见解：机理、选择性和配体效应。

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-07-21 DOI: 10.1002/asia.202500758

Shuwei Tang, Yufei Meng, Ying Liu, Pengfei Zhang, Zhiwei Zhang, Wanrong Guo, Song Pei, Yilong Xiao, Guowei Wang

{"title":"Theoretical Insights into the Ni(0)-Catalyzed Asymmetric Hydroalkylation of Phenylbutadiene and Acetophenone: Mechanism, Selectivity, and Ligand Effect.","authors":"Shuwei Tang, Yufei Meng, Ying Liu, Pengfei Zhang, Zhiwei Zhang, Wanrong Guo, Song Pei, Yilong Xiao, Guowei Wang","doi":"10.1002/asia.202500758","DOIUrl":"https://doi.org/10.1002/asia.202500758","url":null,"abstract":"Transition-metal-catalyzed hydroalkylation of enols/enolates with unsaturated hydrocarbons enables the functionalization via C─C and C-heteroatom bond formation. In this work, the reaction mechanisms of Ni(0)-catalyzed asymmetric hydroalkylation of phenylbutadiene and acetophenone are systematically investigated using density functional theory (DFT) calculations. The Ni(0)/Ni(II) catalytic cycle comprises oxidative addition, proton transfer, and the C(sp3)─C(sp3) bond formation via reductive elimination. The rate-determining oxidative addition step proceeds via a concerted ligand-to-ligand hydrogen transfer (LLHT) mechanism, bypassing an unstable Ni(II)-hydride intermediate. Proton transfer occurs via a ligand exchange with the enolate group within the acetophenone, and the regioselectivity arises from the preferential C(sp3)-C(sp3) bond formation via reductive elimination at the methyl-adjacent carbon in the acetophenone. Furthermore, the electron population analysis on the rate-determining transition state demonstrates that charge transfer from the Ni(0)-ligand moiety to the ─O+H σ* and ─C═C─π* antibonding orbitals facilitates the weakening of the ─O+H bond and η2-coordination of ─C═C─ bond in phenylbutadiene with the nickel center, enabling the LLHT mechanism. Additionally, the influence of ligand on the reactivity of Ni(0)-catalyzed asymmetric hydroalkylation is also explored, and the steric contour maps of percent buried volume (%Vbur) analysis confirm that the bulky ligands increase the %Vbur and enhance catalytic performance.","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e00758"},"PeriodicalIF":3.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photocatalytic Anticancer Activity of Cyclometalated Ir(III) Complexes: A Mechanistic Insight. 环金属化Ir（III）配合物的光催化抗癌活性：机理研究。

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-07-21 DOI: 10.1002/asia.202500681

Ashish Kumar Yadav, Virendra Singh, Ishwar Singh, Amit Kunwar, Biplob Koch, Samya Banerjee

{"title":"Photocatalytic Anticancer Activity of Cyclometalated Ir(III) Complexes: A Mechanistic Insight.","authors":"Ashish Kumar Yadav, Virendra Singh, Ishwar Singh, Amit Kunwar, Biplob Koch, Samya Banerjee","doi":"10.1002/asia.202500681","DOIUrl":"https://doi.org/10.1002/asia.202500681","url":null,"abstract":"Three novel cyclometalated Ir(III) complexes, Ir1-Ir3, were synthesized and thoroughly characterized. These complexes exhibited absorption in the 350-480 nm range, making them suitable candidates for visible-light-mediated photocatalytic cancer therapy. Under visible-light exposure in a DMSO:PBS (1:99 v/v) solvent system, all three photocatalysts demonstrated high efficiency in facilitating NADH oxidation, attaining turnover frequencies (TOFs) in the range of 499-698 h⁻1, exceeding the performance of most of the previously reported Ir(III)-based photocatalysts. Mechanistic studies verified the involvement of type I and type II pathways for ROS generation. Cytotoxicity studies highlighted significant photocytotoxic effects of Ir1-Ir3 in human lung adenocarcinoma cells (A549), with Ir3 emerging as the most potent under light exposure. Additionally, the negligible dark and light cytotoxicity of Ir3 against human embryonic kidney cells (HEK-293) demonstrated the safety profile of Ir3. Furthermore, the mechanistic studies in A549 cells revealed that Ir3 promoted mitochondrial membrane depolarization and activated caspase-3/7-dependent apoptotic pathways through light-triggered ROS generation and NADH oxidation. These findings highlight Ir3 as a potent dual-action cancer phototherapeutic, capable of synergistically inducing type-I and type-II anticancer activity, and efficient NADH photo-oxidation. This work presents a promising platform for developing multifunctional photocatalytic agents in cancer therapy.","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e00681"},"PeriodicalIF":3.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photocatalytic Disulfide Synthesis Using Trityl Sulfides. 三烷基硫化物光催化合成二硫化物。

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-07-21 DOI: 10.1002/asia.202500743

Keita Yamazaki, Tetsuhiro Nemoto

引用次数: 0

Benzil-Dihydrazone Based Bis-Schiff Base Dual-Sensor for Expeditious Colorimetric Detection of Ni²⁺ and Fluorometric Detection of Ag⁺: Environmental and Biological Applications. 基于苯二腙的双希夫碱双传感器快速比色检测Ni2+和荧光检测Ag+：环境和生物应用。

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-07-21 DOI: 10.1002/asia.202500779

Dishen Kumar, Srishti Dutta, Abhilash Pandey, Vanshika Sharma, Devanand Sahu, Sounik Manna, Sujata Maiti Choudhury, Goutam Kumar Patra

{"title":"Benzil-Dihydrazone Based Bis-Schiff Base Dual-Sensor for Expeditious Colorimetric Detection of Ni2+ and Fluorometric Detection of Ag+: Environmental and Biological Applications.","authors":"Dishen Kumar, Srishti Dutta, Abhilash Pandey, Vanshika Sharma, Devanand Sahu, Sounik Manna, Sujata Maiti Choudhury, Goutam Kumar Patra","doi":"10.1002/asia.202500779","DOIUrl":"https://doi.org/10.1002/asia.202500779","url":null,"abstract":"In this research, a novel dual chemosensor L has been reported. It has been characterised by FTIR, 1H-NMR, ESI-MS, elemental analyses, X-ray single crystal analysis and DFT studies. In a 1:1 methanol-water medium (v/v), the receptor L detected Ni2+ with color change from colorless to yellow and Ag+ with turn-on fluorescence enhancement. UV-vis spectroscopy, fluorescence titration, FTIR and ESI-MS have been used to analyse the response mechanisms of fluorescent colorimetric sensing. The colorimetric sensitivity for Ni2+ is 3.0 × 10-7 M and fluorometric sensitivity for Ag+ is 7.2 × 10-7 M; both the values are sufficient below the WHO permissible limits in aqueous solution. From the Job's plot measurements and the ESI-MS spectrum, 2: 1 stoichiometric complexation between L and Ni2+/Ag+ has been established. Receptor L shows remarkable detection ability in a wide pH range of 4-9 and can be successfully applied for the detection and quantification of Ni2+ ions in environmental samples, and Ag+ ions in BSA protein. At the specified doses and incubation times, L can be used as an anticancer drug and a selective sensor for bio-imaging of Ag+ ion without having any cytotoxic effects.","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e00779"},"PeriodicalIF":3.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cobalt-Catalyzed One-Pot Three-Component Cascade Annulation for the Synthesis of Highly Functionalized 3,5-Disubstituted-2,6-Dicyanoanilines at Room Temperature. 钴催化一锅三组分级联环法制备高功能化3,5-二取代-2,6-二氰苯胺。

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-07-21 DOI: 10.1002/asia.202500634

Adrija Majumdar, Subham Sau, Arunabha Thakur

{"title":"Cobalt-Catalyzed One-Pot Three-Component Cascade Annulation for the Synthesis of Highly Functionalized 3,5-Disubstituted-2,6-Dicyanoanilines at Room Temperature.","authors":"Adrija Majumdar, Subham Sau, Arunabha Thakur","doi":"10.1002/asia.202500634","DOIUrl":"https://doi.org/10.1002/asia.202500634","url":null,"abstract":"A facile one-step, three-component domino reaction has been established for the efficient synthesis of 3,5-disubstituted-2,6-dicyanoaniline derivatives, utilizing aldehydes in conjunction with aromatic, cyclic, and acyclic ketones, as well as malononitrile. This methodology employs CoCl2·6H2O as a catalyst specifically for aromatic and acyclic ketones, whereas a metal-free, base-catalyzed approach is applied for cyclic ketones. The reaction proceeds via a sequential mechanism that encompasses Knoevenagel condensation, Michael addition, and nucleophilic cyclization. Conducted at room temperature, this reaction accommodates both aromatic and aliphatic aldehydes, leveraging inexpensive and readily available substrates, thereby obviating the necessity for costly cocatalysts or ligands. It offers simple conditions, shorter reaction times, high yields, and an atom-economical, eco-friendly one-pot approach. It also provides a broad substrate scope of total 21 compounds, including 14 new compounds. The photo-physical properties, assessed via UV-vis and fluorescence spectroscopy, revealed that some compounds showed red-shifted emissions, indicating their potential as fluorescent probes for bioimaging and as dye candidates for optoelectronic applications such as OLEDs. Gram-scale synthesis confirms its industrial relevance, whereas mechanistic studies, including control experiments and Hammett analysis provide insights into the reaction pathway.","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e00634"},"PeriodicalIF":3.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144673473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0