Chemistry - An Asian Journal最新文献_第2页

N-Substituted Aza-Glycine Promotes C8 CO···HN Hydrogen Bonding: A Novel Motif to Design Constrained Peptidomimetic.

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-03-15 DOI: 10.1002/asia.202500035

Bani Kanta Sarma, Anshulata Anshulata, Amar Ghosh

{"title":"N-Substituted Aza-Glycine Promotes C8 CO···HN Hydrogen Bonding: A Novel Motif to Design Constrained Peptidomimetic.","authors":"Bani Kanta Sarma, Anshulata Anshulata, Amar Ghosh","doi":"10.1002/asia.202500035","DOIUrl":"https://doi.org/10.1002/asia.202500035","url":null,"abstract":"Peptidomimetic modifications enhance their rigidity, cell permeability, and proteolytic stability of peptides, presenting significant promise for drug development. One such modification involves the isosteric replacement of the peptide backbone CαH with a nitrogen (N) atom, resulting in azapeptides. In azapeptides, there are two backbone N atoms within a single residue, with the possibility of substituting either one or both simultaneously. Previous studies have effectively mimicked the side chain substitution patterns in peptides by focusing on substituents on the nitrogen at the Cα position of azapeptides. In this study, explored the unconventional substitution at the N-terminus nitrogen by using N-substituted aza-glycine (azGly). We investigated peptide-azapeptide dimers featuring N-acetyl-proline at the N-terminus of an N-methyl azGly residue. These hybrid peptides produced turn structures stabilized by an unusual C8 CO∙∙∙HN hydrogen bond, stabilizing the proline amide in its trans conformation. Computational studies confirmed the stabilizing effect of this C8 hydrogen bond, which was further validated by NMR and CD spectroscopic studies. Overall, we provide a novel strategy for introducing non-natural C8 hydrogen bond into peptide backbone via the incorporation of N-substituted azGly, which could be leveraged to design of more rigid and stable peptidomimetics, with potential applications in drug development.","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e202500035"},"PeriodicalIF":3.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Head-group Modified Polydiacetylenes as Dual-output Optical Sensors for Environmentally Toxic-and Bio-analytes: An Update.

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-03-15 DOI: 10.1002/asia.202500219

Ankit Thakuri, Mainak Banerjee, Amrita Chatterjee

{"title":"Head-group Modified Polydiacetylenes as Dual-output Optical Sensors for Environmentally Toxic-and Bio-analytes: An Update.","authors":"Ankit Thakuri, Mainak Banerjee, Amrita Chatterjee","doi":"10.1002/asia.202500219","DOIUrl":"https://doi.org/10.1002/asia.202500219","url":null,"abstract":"Polydiacetylenes (PDAs) have emerged as a promising class of stimuli-responsive materials due to their unique blue-to-red chromatic transition and associated fluorescence turn-on effect. These optical properties arise from the topochemical polymerization of diacetylene monomers into highly conjugated π-electron systems, enabling PDAs to function as dual-mode sensors. Their colorimetric and fluorimetric responses to external stimuli, including temperature, pH, mechanical stress, and chemical or biological interactions, have been widely exploited for sensing applications. PDA-based sensors have been developed for detecting volatile organic compounds (VOCs), metal ions, and pH changes, as well as for biological sensing of proteins, enzymes, and DNA. Additionally, PDAs have been utilized for environmental monitoring, including pollutant detection and mechanical strain assessment. A key strategy for enhancing PDA sensor performance involves adequate chemical modifications of the carboxyl-functionalized headgroup, which triggers a spectral change upon selective interactions with analytes. This review attempts to cover the strategies based on PDA headgroup modifications for tuning chromatic response, optical stability, and sensor efficiency, highlighting recent advancements and challenges. By exploring these modifications, this discussion aims to provide insights into the design of next-generation PDA-based sensors with improved performance and broader applicability.","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e202500219"},"PeriodicalIF":3.5,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Transition-Metal-Catalyzed C(sp2)-H Bond Functionalization using Allyl Alcohols.

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-03-14 DOI: 10.1002/asia.202401930

Dhananjay S Nipate, Vani Dhyani, Tarun Jangir, Tharmalingam Punniyamurthy, Anil Kumar

引用次数: 0

Advances in Metal-Free Transamidation: A Sustainable Approach to Amide Bond Formation.

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-03-14 DOI: 10.1002/asia.202500327

Niharan Sivaraj, Toshifumi Dohi, Fateh V Singh

{"title":"Advances in Metal-Free Transamidation: A Sustainable Approach to Amide Bond Formation.","authors":"Niharan Sivaraj, Toshifumi Dohi, Fateh V Singh","doi":"10.1002/asia.202500327","DOIUrl":"https://doi.org/10.1002/asia.202500327","url":null,"abstract":"The amide functionalities are a crucial functional group in organic synthesis, playing a vital role in many processes that are essential for the efficient synthesis of important pharmaceutical and industrial compounds. Despite being one of the most commonly conducted reactions by researchers in both academia and industry, the synthesis of amides remains a staple in chemical research and development. Transamidation reactions enable the one-pot conversion of one type of amide into another. Additionally, this process is crucial in the complete synthesis of specific naturally occurring compounds. However, these methods have certain limitations such as using toxic and corrosive starting materials, usage of strong acid or base and metal mediated reaction, which can lead to excessive hydrolysis of the desired amide product. To overcome these challenges, more practical and efficient approaches have been developed. Metal-free transamidation reactions have emerged as a powerful and versatile synthetic methodology in organic chemistry, allowing for the direct conversion of amides into new amide products without relying on metal catalysts. In the review article, we have focused on various metal-free transamidation protocol of unactivated amides.","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e202500327"},"PeriodicalIF":3.5,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual Accessible Binding Sites in Amorphous Metal-Organic Framework for High Arsenic and Mercury Removal Efficiency.

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-03-14 DOI: 10.1002/asia.202401519

Kunlanat Sriphumrat, Preeyaporn Harnkar, Sorawich Pimu, Wiphada Jansuda, Nuttapon Yodsin, Sunatda Arayachukiat, Kanokwan Kongpatpanich

引用次数: 0

Intramolecular Halogen Bonds Assist in Activating Carbonyl Groups for the Catalytic Synthesis of Bis(indolyl)methanes. 分子内卤素键有助于活化双(吲哚基)甲烷催化合成中的羰基。

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-03-14 DOI: 10.1002/asia.202401545

Jian-Wei Han, Yingying Hou, Lin Zhu, Taiyou Liu, Limin Wang, Ruimin Wang, Ulli Englert

引用次数: 0

(Anti)aromaticity of cyclo[2n]carbons (n = 3 - 12).

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-03-14 DOI: 10.1002/asia.202500295

Marija Baranac-Stojanović

引用次数: 0

Interface Engineering for High Strength and High Toughness Ceramic Matrix Composites.

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-03-13 DOI: 10.1002/asia.202401805

Hewei Zhao, Han Zhang, Tong Li, Wenzheng Yin, Mingrui Gao, Shaojia Liu

{"title":"Interface Engineering for High Strength and High Toughness Ceramic Matrix Composites.","authors":"Hewei Zhao, Han Zhang, Tong Li, Wenzheng Yin, Mingrui Gao, Shaojia Liu","doi":"10.1002/asia.202401805","DOIUrl":"https://doi.org/10.1002/asia.202401805","url":null,"abstract":"Ceramics exhibit exceptional strength, hardness, and structural stability, rendering them indispensable as aerospace, national defense, and biomedical applications. However, the presence of robust covalent or ionic bonds within the ceramic leads to its inherent poor fracture toughness. The incorporation of toughening phases into ceramics is widely recognized as an optimal toughening strategy for ceramic matrix composites (CMCs) based on chemical means, with the interplay between toughening phase and ceramic at the interface playing a crucial role in achieving superior mechanical properties. In this review, we briefly delineate the evolution of ceramic matrix composites, emphasizing that interface engineering constitutes an efficacious approach to augmenting the fracture toughness of these composites. Furthermore, we meticulously explore the structure-activity relationship between the composition and structure of the toughening phase and the mechanical attributes of CMCs. Additionally, we comprehensively summarize the impact of innovative biomimetic structures on the mechanical properties of these composites, unveiling the beneficial effects of interface regulation on energy dissipation. Ultimately, we systematically consolidate the mechanisms underpinning the influence of interface engineering on the mechanical properties of CMCs and propose solutions to existing interface challenges, paving the way for the development of next-generation CMCs that exhibit unparalleled strength and toughness.","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e202401805"},"PeriodicalIF":3.5,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kinetic Control of Threading and Dethreading in Linked Rotaxanes via Hydrogen Bonding.

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-03-13 DOI: 10.1002/asia.202500302

Hiromichi V Miyagishi, Satoki Yamaguchi, Susumu Tsuda, Hiroshi Masai, Jun Terao

{"title":"Kinetic Control of Threading and Dethreading in Linked Rotaxanes via Hydrogen Bonding.","authors":"Hiromichi V Miyagishi, Satoki Yamaguchi, Susumu Tsuda, Hiroshi Masai, Jun Terao","doi":"10.1002/asia.202500302","DOIUrl":"https://doi.org/10.1002/asia.202500302","url":null,"abstract":"The kinetic control of macrocyclic motions is a key aspect of mechanically interlocked molecules (MIMs). Although hydrogen bonding (H-bonding) offers a high reversibility and selectivity, the use of neutral H-bonding to control the macrocyclic mobility remains limited. In this study, the effects of H-bonding on the threading and dethreading kinetics of linked rotaxanes containing a permethylated α-cyclodextrin unit and an aniline moiety were investigated. UV-Vis spectroscopy revealed significantly reduced reaction rates in H-bond acceptor solvents, such as dimethyl sulfoxide (DMSO) and dimethyl formamide. NMR titrations and FT-IR spectroscopic analyses confirmed that H-bonding between the aniline moiety and these solvents acts as a \"brake\" during threading/dethreading. Moreover, Eyring plots indicated that enthalpic losses during H-bond cleavage contribute to the increased activation barriers for these processes. Additionally, the introduction of H-bond acceptors, such as DMSO and tributylphosphine oxide, effectively modulated these rates of threading and dethreading, highlighting the potential for controlling kinetic phenomena in MIM-based systems.","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e202500302"},"PeriodicalIF":3.5,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrazonate-Based Copper(II) Metallodrugs: Insights into Solution Behavior, G-Quadruplex DNA Interaction, and Anticancer Potential.

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-03-13 DOI: 10.1002/asia.202401628

Monalisa Mohanty, Sudhir Lima, Pratikshya Das Pattanayak, Sanchita Das, Axel Buchholz, Helmar Görls, Winfried Plass, Werner Kaminsky, Rupam Dinda

{"title":"Hydrazonate-Based Copper(II) Metallodrugs: Insights into Solution Behavior, G-Quadruplex DNA Interaction, and Anticancer Potential.","authors":"Monalisa Mohanty, Sudhir Lima, Pratikshya Das Pattanayak, Sanchita Das, Axel Buchholz, Helmar Görls, Winfried Plass, Werner Kaminsky, Rupam Dinda","doi":"10.1002/asia.202401628","DOIUrl":"10.1002/asia.202401628","url":null,"abstract":"Here, two mixed-ligand mononuclear [Cu(L1)py] (1), [Cu(L2)Him] (2) and one dinuclear copper(II) complex [Cu2(L3)2(DMSO)(MeOH)] (3) were isolated in solid state and characterized through single-crystal X-ray diffraction. Herein, we highlight the solution behavior of these complexes in solution medium through HRMS and ESR. Though the complexes maintain their integrity with respect to the ligand coordination, there is solvent or co-ligand exchange and generation of both [Cu(L)(py/Him)] or [Cu(L)(H2O)] species. G-quadruplex (G4-DNA) structures in the human telomeric DNA (hTelo) and promoter regions of oncogenes (c-MYC) can behave as potential therapeutic targets for the cancer treatment. Hence, the interaction of these complexes with G4-DNA and also duplex DNA was investigated through spectroscopy and molecular docking studies. The results reveal that the copper complexes show higher affinity for G4-DNA over duplex DNA, with 3 demonstrating the strongest binding among them. The complexes have also been tested for DNA nuclease activity against pUC19 plasmid DNA. Finally, the complexes showed significant cytotoxicity towards cancerous cell lines, namely HeLa and MCF-7 in comparison to the noncancerous cell line NIH-3T3. Annexin V/PI double staining assay demonstrated the apoptotic mode of cell death caused by the complexes. Overall, the results of G4-DNA interaction and anticancer activity are consistent, suggesting G4-DNA is the target for their biological activity.","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e202401628"},"PeriodicalIF":3.5,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0