Chemistry - An Asian Journal最新文献_第2页

Self-Propelled MnO₂-Based Colloidal Motors for Active Treatment of Periodontal Inflammation.

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-04-09 DOI: 10.1002/asia.202500157

Miaomiao Huang, Changcheng Ke, Ling Yang, Narisu Hu, Yingjie Wu, Qiang He

{"title":"Self-Propelled MnO2-Based Colloidal Motors for Active Treatment of Periodontal Inflammation.","authors":"Miaomiao Huang, Changcheng Ke, Ling Yang, Narisu Hu, Yingjie Wu, Qiang He","doi":"10.1002/asia.202500157","DOIUrl":"https://doi.org/10.1002/asia.202500157","url":null,"abstract":"Chemically powered colloidal motors exhibit significant potential for applications in oral cleaning and antimicrobial treatment. The integration of MnO2-based colloidal motors with common mouth-rinsing H2O2 solutions for sterilization and disinfection via reactive oxygen species (ROS) represents an ideal approach. In this study, we fabricate uniform dumbbell-shaped (DS-MnO2-motor), spherical (S-MnO2-motor), and silver half-coated spherical Janus Ag-MnO2 colloidal motors (JS-MnO2-motor) using hydrothermal, co-precipitation, and sputtering methods, respectively. These motors are propelled by O2 bubble ejection generated from the catalytic decomposition of low-concentration H2O2 by peroxidase-like MnO2 components. Notably, the JS-MnO2-motors achieve a maximum speed of 146.4 µm s-1 in gargle containing 1.5% H2O2. In vitro and in vivo antimicrobial trials demonstrated that the JS-MnO2-motor gargle exhibits superior sterilization rates of 98.1% and 97.4% against both planktonic and biofilm-forming P. gingivalis and F. nucleatum. Consequently, it significantly enhances the therapeutic efficacy in treating periodontitis in Wistar rats, as evidenced by a marked reduction in inflammatory cells. The mechanical force exerted by these colloidal motors, along with cation adhesion to bacterial membranes and the antimicrobial effects of ROS, collectively contribute to this enhanced performance. Our findings introduce a novel strategy for the treatment of chronic inflammatory diseases.","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e202500157"},"PeriodicalIF":3.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ruthenium Catalyzed Mechanochemical Transformation of Sulfonamide Group to Fluoro, Trifluoromethyl, and Trifluoromethoxy Functionalities.

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-04-09 DOI: 10.1002/asia.202500221

Satenik Mkrtchyan, Vishal B Purohit, Vaibhav D Prajapati, Ronak V Prajapati, Oleksandr Shalimov, Sehrish Sarfaraz, Khurshid Ayub, Viktor O Iaroshenko

引用次数: 0

Insights into the Versatile and Efficient Characteristics, Classifications, and Rational Design of Surface-Grafted Smart Hydrogels.

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-04-09 DOI: 10.1002/asia.202500441

Nehal, Shikha Awasthi

{"title":"Insights into the Versatile and Efficient Characteristics, Classifications, and Rational Design of Surface-Grafted Smart Hydrogels.","authors":"Nehal, Shikha Awasthi","doi":"10.1002/asia.202500441","DOIUrl":"https://doi.org/10.1002/asia.202500441","url":null,"abstract":"Hydrogels have emerged as flexible biomaterials with enormous potential in biomedical applications due to their outstanding biocompatibility and ability to hold a high water concentration. Hydrogels have low toxicity and are biodegradable. This review begins with a look at the various riveting characteristics and classifications of hydrogel nanocomposites reinforced with various metallic and ceramic components. A distinct focus is offered on thoroughly deliberating surface modification techniques with special attention on fabrication, patterning, and their applications in biomedical fields. The review describes the value of novel cross-linking techniques including physical, chemical, and physical-chemical dual cross-linking in adapting hydrogel characteristics to specific applications. This review also explains the major bioapplication of functionalized hydrogels. It emphasizes the importance of nanocomposite hydrogels and multifunctional self-assembled monolayers in solving contemporary biological difficulties such as infection control, medication delivery, and tissue regeneration. It explains the need for interdisciplinary collaboration and ongoing research efforts to realize the full potential of hydrogels and nanomaterials in biomedical applications. Overall, this review gives useful insights into current advances and future possibilities for hydrogels grafted with metals and ceramic additives in biomedical applications, highlighting the need for multidisciplinary cooperation and ongoing research in nano(bio)technology.","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e202500441"},"PeriodicalIF":3.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143809982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MXene-Wood Composites: A Review of Fabrication, Properties, Applications, and Future Prospects.

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-04-09 DOI: 10.1002/asia.202500444

Jing Yang, Shipeng Li, Xin Zheng, Zhenwu Chen, Sai Wu, Yajun Pang, Zhehong Shen, Hao Chen

引用次数: 0

Efficient Synthesis of Arylhydrazone Capsule with Single Precursor for Encapsulation of C₆₀ and C₇₀.

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-04-08 DOI: 10.1002/asia.202500289

Qian Li, He Deng, Wei Zeng, Qi Zhao, Tianguang Zhan, Shigui Chen, Lu Wang

引用次数: 0

Switchable Mechanochromic Poly(methyl acrylate) Enabled by Dianthryl Disilane.

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-04-08 DOI: 10.1002/asia.202500317

Yuyan Liu, Tianjun Yu, Jinping Chen, Rui Hu, Guoqiang Yang, Yi Li, Yi Zeng

{"title":"Switchable Mechanochromic Poly(methyl acrylate) Enabled by Dianthryl Disilane.","authors":"Yuyan Liu, Tianjun Yu, Jinping Chen, Rui Hu, Guoqiang Yang, Yi Li, Yi Zeng","doi":"10.1002/asia.202500317","DOIUrl":"https://doi.org/10.1002/asia.202500317","url":null,"abstract":"Mechanochromic polymers have potential in visualization of microscopic damages in materials, and the integration of non-invasive switching into mechanochromic polymers can enable rich on-demand functionality of polymer materials. In this work, we report the development of a mechanoresponsive fluorescent polymer with photogated properties, comprising poly(methyl acrylate) (PMA) and the photoswitchable mechanophore S2A2, which features two anthracene groups linked by a disilane spacer. The mechanochromic polymer PMA-S2A2 exhibits ratiometric fluorescence response upon mechanical deformation, which arises from the monomer and excimer emission ratio of anthracene controlled by the polymer strain. The mechanochromic property of the polymer can be switched off by irradiation with 365 nm UV light which induces [4 + 4] cycloaddition of the anthracene groups between and within the polymer chains. Importantly, the anthracene dimers can be reversibly dissociated in situ within the polymer film by irradiation with 254 nm UV, restoring the mechanochromic function. Furthermore, intermolecular photodimerization of anthracene increases the molecular weight and forms an entanglement network, significantly enhancing the material toughness. This reversible photocontrolled switch design offers a novel strategy for developing mechanochromic materials with modulated responses and mechanical properties.","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e202500317"},"PeriodicalIF":3.5,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transferrin Tethered Fluorescent Organic Nanoparticles for Receptor-Mediated Targeted Delivery of Paclitaxel to Cancer Cells.

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-04-08 DOI: 10.1002/asia.202500135

Afreen Zaman, Prasanta Kumar Das

{"title":"Transferrin Tethered Fluorescent Organic Nanoparticles for Receptor-Mediated Targeted Delivery of Paclitaxel to Cancer Cells.","authors":"Afreen Zaman, Prasanta Kumar Das","doi":"10.1002/asia.202500135","DOIUrl":"https://doi.org/10.1002/asia.202500135","url":null,"abstract":"Cancer remains a critical global issue, marked by its high mortality rates. Despite achieving remarkable progress in cancer treatments, conventional chemotherapeutic drugs face numerous limitations. To this end, nanomaterial-based targeted drug delivery systems have emerged as a hope of promise. In this study, we report the design and development of transferrin (Tf) tethered naphthalene-diimide-based fluorescent organic nanoparticles (NDI-OH-Tf) for targeted delivery of paclitaxel to cancer cells with over expressed transferrin receptors (TfR). Spherical NDI-OH FONPs were fabricated through J-type of aggregation of NDI-OH amphiphiles in a 1:99 (v/v) DMSO-H2O mixture. These NDI-OH FONPs exhibited aggregation induced emission (AIE) at an emission wavelength of λem = 594 nm. The hydroxyl groups on the surface of the NDI-OH FONPs were conjugated with carboxyl groups of transferrin, forming NDI-OH-Tf FONPs. These NDI-OH-Tf FONPs were successfully used for targeted bioimaging and drug delivery to TfR+ cancer cells through ligand receptor interaction between transferrin and TfR. Notably, paclitaxel loaded NDI-OH-Tf exhibited ∼2.9-fold higher efficacy toward TfR+ cancer cells compared to normal cells and ∼3.3-fold higher cytotoxicity than free PTX due to transferrin mediated targeted accumulation of PTX in cancer cells.","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e202500135"},"PeriodicalIF":3.5,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

β1,6-Selective Enzymatic N-Acetylglucosamination Catalyzed by the Family GH84 N-Acetyl-β-D-glucosaminidase from Bacteroides thetaiotaomicron and its Glycosyl Acceptor Specificity.

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-04-08 DOI: 10.1002/asia.202500142

Rika Okuno, Shunsuke Nakada, Kisuke Tonomura, Yuji Aso, Daijiro Takeshita, Takayuki Ohnuma, Tomonari Tanaka

{"title":"β1,6-Selective Enzymatic N-Acetylglucosamination Catalyzed by the Family GH84 N-Acetyl-β-D-glucosaminidase from Bacteroides thetaiotaomicron and its Glycosyl Acceptor Specificity.","authors":"Rika Okuno, Shunsuke Nakada, Kisuke Tonomura, Yuji Aso, Daijiro Takeshita, Takayuki Ohnuma, Tomonari Tanaka","doi":"10.1002/asia.202500142","DOIUrl":"https://doi.org/10.1002/asia.202500142","url":null,"abstract":"The chemoenzymatic synthesis of oligosaccharides presents a highly attractive methodology with significant potential for diverse applications, particularly through using various glycosidases. In this study, the O-glycan core 6 disaccharide moiety, GlcNAcβ1-6GalNAc, was successfully synthesized via enzymatic glycosylation using an N-acetyl-β-D-glucosaminidase from Bacteroides thetaiotaomicron (BtOGA), a member of glycoside hydrolase family 84 (GH84), alongside an N-acetyl-D-glucosamine oxazoline derivative (GlcNAc-oxa) as the glycosyl donor. Furthermore, an investigation into glycosyl acceptor recognition in BtOGA-catalyzed enzymatic glycosylation indicated that the presence of an aromatic group at the anomeric position and an axial hydroxy group at the 4-position of the saccharide moiety is crucial for effective recognition of BtOGA as a glycosyl acceptor. The protecting-group-free chemoenzymatic synthesis of the core 6 disaccharide moiety was achieved by integrating the direct synthesis of GlcNAc-oxa thorough Shoda activation method using a water-soluble dehydration condensing agent in an aqueous medium, followed by BtOGA-catalyzed enzymatic glycosylation.","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e202500142"},"PeriodicalIF":3.5,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of Cyclic [n]Spirobifluorenylene Compounds and Electron Delocalization in Their Radical Cation Species.

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-04-08 DOI: 10.1002/asia.202500320

Tomoya Imai, Toru Amaya

{"title":"Characterization of Cyclic [n]Spirobifluorenylene Compounds and Electron Delocalization in Their Radical Cation Species.","authors":"Tomoya Imai, Toru Amaya","doi":"10.1002/asia.202500320","DOIUrl":"https://doi.org/10.1002/asia.202500320","url":null,"abstract":"Charge delocalization through spiro-conjugation provides insights for the rational design of next-generation charge transport materials. We have previously conducted studies using terminally alkyl-protected cyclic [3]spirobifluorenylene compound 1-[3], which features a cyclic structure composed of bifluorenyl units. ESR studies on this radical cation species have shown that its electron is delocalized over approximately three bifluorenyl units, meaning that it is delocalized across the entire molecule. In this study, we newly synthesized cyclic [n]spirobifluorenylene compounds 1-[4] and 1-[5] and investigated their spectroscopic and electrochemical properties, and chemical oxidation behavior. Additionally, DFT calculations were performed not only for the neutral species but also for the radical cation species. Furthermore, we examined the influence of the number of perpendicular π-conjugated units on electron delocalization in their radical cation species. As a result, ESR spectral analysis of the radical cation species 1-[4]·+ and 1-[5]·+ revealed that electrons were delocalized over 3.37 and 3.87 units, respectively, when considering bifluorenyl as the unit structure.","PeriodicalId":145,"journal":{"name":"Chemistry - An Asian Journal","volume":" ","pages":"e202500320"},"PeriodicalIF":3.5,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Room Temperature Operation of All-Solid-State Potassium-Ion Battery Enabled by Unconventional Ionic Solid Electrolyte K₆[Rh₄Zn₄(l-cys)₁₂O]·nH₂O.

IF 3.5 3区化学

Chemistry - An Asian Journal Pub Date : 2025-04-08 DOI: 10.1002/asia.202401781

Ryo Sakamoto, Kosuke Nakamoto, Atsushi Inoishi, Masato Ito, Nobuto Yoshinari, Takumi Konno, Yukihiro Hara, Takafumi Fujii, Shigeto Okada

引用次数: 0