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IF 4.6
ACS Applied Bio Materials Pub Date : 2025-07-21
Yasuaki Kuriyama, Ryo Hamai, Yu Mori, Ryuichi Kanabuchi, Kazuyoshi Baba, Kaori Tsuchiya, Toshimi Aizawa and Osamu Suzuki*, 
{"title":"","authors":"Yasuaki Kuriyama, Ryo Hamai, Yu Mori, Ryuichi Kanabuchi, Kazuyoshi Baba, Kaori Tsuchiya, Toshimi Aizawa and Osamu Suzuki*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":"8 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsabm.5c00549","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-07-21
Lucas F. de Lima*, André L. Ferreira, Letícia Ester dos Santos, Keyla Lívian P. Coelho, Keyla Teixeira Santos, Ariane Schmidt, Marcelo Bispo de Jesus, Thiago R.L.C. Paixão* and William R. de Araujo*, 
{"title":"","authors":"Lucas F. de Lima*, André L. Ferreira, Letícia Ester dos Santos, Keyla Lívian P. Coelho, Keyla Teixeira Santos, Ariane Schmidt, Marcelo Bispo de Jesus, Thiago R.L.C. Paixão* and William R. de Araujo*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":"8 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsabm.5c00825","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-07-21
Prabu Kumar Seetharaman, Bo Liu*, Ananth Sivapunniyam, Karthik Raja Ramalingam, Parthasarathy Ramalingam and Sathan Raj Natarajan, 
{"title":"","authors":"Prabu Kumar Seetharaman, Bo Liu*, Ananth Sivapunniyam, Karthik Raja Ramalingam, Parthasarathy Ramalingam and Sathan Raj Natarajan, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":"8 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsabm.5c00382","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-07-21
Andrew R. Brotherton, Bennett Phillips-Sorich, Naedum DomNwachukwu, Matthew D. Bailey, Aarnav S. Patel, Claudio Luchinat, Giacomo Parigi and Thomas J. Meade*, 
{"title":"","authors":"Andrew R. Brotherton, Bennett Phillips-Sorich, Naedum DomNwachukwu, Matthew D. Bailey, Aarnav S. Patel, Claudio Luchinat, Giacomo Parigi and Thomas J. Meade*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":"8 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsabm.5c00584","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-07-21
Shalini Dasgupta, Jaideep Adhikari, Priyanka Das, Shubhanshu Sarkar, Pallab Datta, Amit Roy Chowdhury and Ananya Barui*, 
{"title":"","authors":"Shalini Dasgupta, Jaideep Adhikari, Priyanka Das, Shubhanshu Sarkar, Pallab Datta, Amit Roy Chowdhury and Ananya Barui*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":"8 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsabm.5c00278","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-07-21
Rati Yadav, Padakanti Sandeep Chary, Harshada Bhalerao, Vaibhavi Srivastava, Ekta Pardhi, Avinash Pawar, Rajesh Sonti and Neelesh Kumar Mehra*, 
{"title":"","authors":"Rati Yadav, Padakanti Sandeep Chary, Harshada Bhalerao, Vaibhavi Srivastava, Ekta Pardhi, Avinash Pawar, Rajesh Sonti and Neelesh Kumar Mehra*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":"8 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsabm.5c00567","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PLGA-Loaded Monascin Intranasal Delivery System: Sustained-Release and Immunomodulatory Effect for Treatment of Allergic Rhinitis by Improving Regulatory T Cell Function. 负载plga的Monascin鼻内给药系统：通过改善调节性T细胞功能治疗变应性鼻炎的缓释和免疫调节作用。
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-07-21 Epub Date: 2025-06-15 DOI: 10.1021/acsabm.5c00387
Zhao Wang, Khawar Ali Shahzad, Ding Li, Boyu Cai, Zilin Huang, Maoxiang Xu, Jiaojiao Li, Dong Chen, Fei Tan
{"title":"PLGA-Loaded Monascin Intranasal Delivery System: Sustained-Release and Immunomodulatory Effect for Treatment of Allergic Rhinitis by Improving Regulatory T Cell Function.","authors":"Zhao Wang, Khawar Ali Shahzad, Ding Li, Boyu Cai, Zilin Huang, Maoxiang Xu, Jiaojiao Li, Dong Chen, Fei Tan","doi":"10.1021/acsabm.5c00387","DOIUrl":"10.1021/acsabm.5c00387","url":null,"abstract":"<p><p>Monascin, a natural and safe drug, exhibits potent anti-inflammatory, hypolipidemic, and antioxidative effects. However, their therapeutic potential and underlying mechanisms in allergic rhinitis (AR) remain unexplored. The intranasal delivery of monascin for treating AR faces the challenge of rapid clearance. Herein, to achieve sustained and prolonged release, we developed monascin-encapsulated poly(lactic <i>co</i> glycolic acid) nanoparticles (PLGA-MS) by the mechanical double emulsion technique, enabling effective local delivery of monascin for the treatment of AR. Histopathological staining, flow cytometry, ELISA, and network pharmacology were used to assess therapeutic effects and potential mechanisms of monascin in treating AR. In vitro and in vivo experiments revealed that PLGA-MS exhibited enhanced stability, excellent drug encapsulation capacity, and sustained drug release. PLGA-MS treatment showed a significant therapeutic effect in AR mice by decreasing inflammatory cells in nasal tissue and regulating IgE, histamine, and a variety of cytokines. PLGA-MS treatment decreased T helper 2 cells (Th2) and T helper 17 cells (Th17) while promoting and increasing Tregs (regulatory T cells). Further analysis showed elevated levels of IL-10 and TGF-β expression in Tregs post-treatment. Results of the CCK-8 assay, pathological analysis of vital organs, and serum analysis of liver and kidney functions demonstrated the biosafety of PLGA-MS. Additionally, network pharmacology identified immune response pathways that may support PLGA-MS's immunomodulatory effects in AR. Our study presented a biomaterial-facilitated intranasal delivery system for monascin, offering an effective therapeutic strategy for AR.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"5718-5731"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Situ Electrochemical Fabrication of Photoreactive Ag-Cu Bimetallic Nanocomposite Coating and Its Antibacterial-Osteogenic Synergy. 光反应性Ag-Cu双金属纳米复合涂层的原位电化学制备及其抗菌成骨协同作用。
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-07-21 Epub Date: 2025-06-17 DOI: 10.1021/acsabm.5c00802
Henigul Osman, Xiaohui Tang, Qin Wei, Bo Liu, Jie Gao, Yingbo Wang
{"title":"In Situ Electrochemical Fabrication of Photoreactive Ag-Cu Bimetallic Nanocomposite Coating and Its Antibacterial-Osteogenic Synergy.","authors":"Henigul Osman, Xiaohui Tang, Qin Wei, Bo Liu, Jie Gao, Yingbo Wang","doi":"10.1021/acsabm.5c00802","DOIUrl":"10.1021/acsabm.5c00802","url":null,"abstract":"<p><p>In response to the issues of infection and poor bone integration in orthopedic implants, this study successfully developed a multifunctional composite coating composed of poly(pyrrole) (PPy), hydroxyapatite (HA), and silver-copper (Ag-Cu) bimetallic nanoparticles (NPs) on titanium (Ti) substrates using an electrochemical in situ deposition technique. Upon near-infrared light (NIR, 808 nm) stimulation, this coating exhibits synergistic antibacterial and osteogenic effects through photothermal (PTT) and photodynamic (PDT) processes. Characterization results indicate that the Ag-Cu NPs are uniformly distributed within the coating (Ag: 1.7 wt %, Cu: 2.0 wt %), and the concentrations of Ag<sup>+</sup> and Cu<sup>2+</sup> released (2.9526 mg·L<sup>-1</sup> and 0.1932 mg·L<sup>-1</sup>, respectively) are significantly lower than the cytotoxic threshold (10 mg·L<sup>-1</sup>). PTT tests reveal that the coating achieves a PTT conversion efficiency of 33.8%, with the temperature rising to 49.9 °C within 10 min under 1.0 W·cm<sup>-2</sup> irradiation, generating high levels of singlet oxygen (<sup>1</sup>O<sub>2</sub>). This leads to a 100% bactericidal rate against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>. In vitro biocompatibility assays show that the gradient release of HA and the synergistic effect of Ag<sup>+</sup>/Cu<sup>2+</sup> significantly enhance the proliferation of bone marrow mesenchymal stem cells (BMSCs), with optical density reaching 1.49 after 7 days of culture. Additionally, osteogenic differentiation is promoted, as evidenced by a 2.9-fold increase in alkaline phosphatase (ALP) activity and a 2.1-fold increase in calcium nodule formation. Western blot analysis further confirmed that the coating induces the high expression of Runx2 via activation of the Wnt/β-catenin signaling pathway, thereby driving osteogenesis. This study presents a strategy for the development of smart implants with both efficient antibacterial and bone integration capabilities.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"6326-6338"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioorthogonal Chemistry of Water-Soluble Blue Fluorescent Coumarin-Substituted Azole Derivatives for Bioimaging and Bioconjugation Applications. 水溶性蓝色荧光香豆素取代唑衍生物在生物成像和生物偶联中的应用。
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-07-21 Epub Date: 2025-07-09 DOI: 10.1021/acsabm.5c00985
Ilavarasan Vickraman, Zhoveta Yhobu, Jan Grzegorz Małecki, Kavina Ganapathy, Ahipa Tantri Nagaraja, Srinivasa Budagumpi
{"title":"Bioorthogonal Chemistry of Water-Soluble Blue Fluorescent Coumarin-Substituted Azole Derivatives for Bioimaging and Bioconjugation Applications.","authors":"Ilavarasan Vickraman, Zhoveta Yhobu, Jan Grzegorz Małecki, Kavina Ganapathy, Ahipa Tantri Nagaraja, Srinivasa Budagumpi","doi":"10.1021/acsabm.5c00985","DOIUrl":"10.1021/acsabm.5c00985","url":null,"abstract":"<p><p>Blue fluorescent azolium salts with higher Stokes shift, increased water solubility, and bioorthogonal functionality were synthesized and explored. The promising molecules among the synthesized compounds exhibited a quantum yield of approximately 0.40 in biologically relevant buffer solutions. These derivatives were further examined for bioimaging and bioorthogonality under aqueous conditions.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"5552-5556"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144598870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
H2O2-Responsive Boronic Ester-Modified Mesoporous Silica Nanocarrier for TfR Mediated Tumor-Specific Drug Delivery Applications. 用于TfR介导的肿瘤特异性药物递送的h2o2响应型硼酯修饰介孔二氧化硅纳米载体。
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-07-21 Epub Date: 2025-06-23 DOI: 10.1021/acsabm.5c00645
Hsiao-Yen Lee, Natesan Thirumalaivasan, Shu-Pao Wu
{"title":"H<sub>2</sub>O<sub>2</sub>-Responsive Boronic Ester-Modified Mesoporous Silica Nanocarrier for TfR Mediated Tumor-Specific Drug Delivery Applications.","authors":"Hsiao-Yen Lee, Natesan Thirumalaivasan, Shu-Pao Wu","doi":"10.1021/acsabm.5c00645","DOIUrl":"10.1021/acsabm.5c00645","url":null,"abstract":"<p><p>This study introduces a drug delivery system utilizing boronic ester-functionalized mesoporous silica nanoparticles (<b>MSNP-BA-Tf</b>) for targeted cancer therapy. By conjugating transferrin (Tf) to the MSNP surface, the system actively targets cancer cells via transferrin receptor (TfR)-mediated endocytosis. The incorporation of boronic ester linkages enables hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)-responsive drug release, enhancing therapeutic efficacy. In vitro experiments demonstrated that <b>MSNP-BA-Tf</b> effectively delivered doxorubicin (DOX) to cancer cells while sparing normal cells, as confirmed by fluorescence imaging and cytotoxicity assays. In vivo studies using a colon cancer xenograft model showed that <b>DOX@MSNP-BA-Tf</b> inhibited tumor growth more effectively than free DOX. These findings highlight <b>MSNP-BA-Tf</b> as a promising nanocarrier for cancer therapy, offering targeted and controlled drug delivery through active targeting and H<sub>2</sub>O<sub>2</sub> responsiveness.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"6079-6087"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12284862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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