水溶性蓝色荧光香豆素取代唑衍生物在生物成像和生物偶联中的应用。

IF 4.7 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2025-07-21 Epub Date: 2025-07-09 DOI:10.1021/acsabm.5c00985

Ilavarasan Vickraman, Zhoveta Yhobu, Jan Grzegorz Małecki, Kavina Ganapathy, Ahipa Tantri Nagaraja, Srinivasa Budagumpi

{"title":"水溶性蓝色荧光香豆素取代唑衍生物在生物成像和生物偶联中的应用。","authors":"Ilavarasan Vickraman, Zhoveta Yhobu, Jan Grzegorz Małecki, Kavina Ganapathy, Ahipa Tantri Nagaraja, Srinivasa Budagumpi","doi":"10.1021/acsabm.5c00985","DOIUrl":null,"url":null,"abstract":"Blue fluorescent azolium salts with higher Stokes shift, increased water solubility, and bioorthogonal functionality were synthesized and explored. The promising molecules among the synthesized compounds exhibited a quantum yield of approximately 0.40 in biologically relevant buffer solutions. These derivatives were further examined for bioimaging and bioorthogonality under aqueous conditions.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"5552-5556"},"PeriodicalIF":4.7000,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Bioorthogonal Chemistry of Water-Soluble Blue Fluorescent Coumarin-Substituted Azole Derivatives for Bioimaging and Bioconjugation Applications.\",\"authors\":\"Ilavarasan Vickraman, Zhoveta Yhobu, Jan Grzegorz Małecki, Kavina Ganapathy, Ahipa Tantri Nagaraja, Srinivasa Budagumpi\",\"doi\":\"10.1021/acsabm.5c00985\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Blue fluorescent azolium salts with higher Stokes shift, increased water solubility, and bioorthogonal functionality were synthesized and explored. The promising molecules among the synthesized compounds exhibited a quantum yield of approximately 0.40 in biologically relevant buffer solutions. These derivatives were further examined for bioimaging and bioorthogonality under aqueous conditions.\",\"PeriodicalId\":2,\"journal\":{\"name\":\"ACS Applied Bio Materials\",\"volume\":\" \",\"pages\":\"5552-5556\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2025-07-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Bio Materials\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1021/acsabm.5c00985\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/9 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1021/acsabm.5c00985","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/9 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}

引用次数: 0

摘要

合成并探索了具有较高斯托克斯位移、较高水溶性和生物正交功能的蓝色荧光偶氮盐。合成的化合物中有前途的分子在生物相关缓冲溶液中表现出约0.40的量子产率。这些衍生物在水条件下进一步检查了生物成像和生物正交性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Bioorthogonal Chemistry of Water-Soluble Blue Fluorescent Coumarin-Substituted Azole Derivatives for Bioimaging and Bioconjugation Applications.

Blue fluorescent azolium salts with higher Stokes shift, increased water solubility, and bioorthogonal functionality were synthesized and explored. The promising molecules among the synthesized compounds exhibited a quantum yield of approximately 0.40 in biologically relevant buffer solutions. These derivatives were further examined for bioimaging and bioorthogonality under aqueous conditions.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.