H₂O₂-Responsive Boronic Ester-Modified Mesoporous Silica Nanocarrier for TfR Mediated Tumor-Specific Drug Delivery Applications.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2025-07-21 Epub Date: 2025-06-23 DOI:10.1021/acsabm.5c00645

Hsiao-Yen Lee, Natesan Thirumalaivasan, Shu-Pao Wu

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引用次数: 0

Abstract

This study introduces a drug delivery system utilizing boronic ester-functionalized mesoporous silica nanoparticles (MSNP-BA-Tf) for targeted cancer therapy. By conjugating transferrin (Tf) to the MSNP surface, the system actively targets cancer cells via transferrin receptor (TfR)-mediated endocytosis. The incorporation of boronic ester linkages enables hydrogen peroxide (H₂O₂)-responsive drug release, enhancing therapeutic efficacy. In vitro experiments demonstrated that MSNP-BA-Tf effectively delivered doxorubicin (DOX) to cancer cells while sparing normal cells, as confirmed by fluorescence imaging and cytotoxicity assays. In vivo studies using a colon cancer xenograft model showed that DOX@MSNP-BA-Tf inhibited tumor growth more effectively than free DOX. These findings highlight MSNP-BA-Tf as a promising nanocarrier for cancer therapy, offering targeted and controlled drug delivery through active targeting and H₂O₂ responsiveness.

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用于TfR介导的肿瘤特异性药物递送的h2o2响应型硼酯修饰介孔二氧化硅纳米载体。

本研究介绍了一种利用硼酯功能化介孔二氧化硅纳米颗粒（MSNP-BA-Tf）靶向癌症治疗的药物传递系统。通过将转铁蛋白（Tf）偶联到MSNP表面，该系统通过转铁蛋白受体（TfR）介导的内吞作用积极靶向癌细胞。硼酯键的结合使过氧化氢（H2O2）反应性药物释放，提高治疗效果。荧光成像和细胞毒性实验证实，MSNP-BA-Tf能有效地将多柔比星（DOX）递送至癌细胞，同时保留正常细胞。使用结肠癌异种移植模型的体内研究表明，DOX@MSNP-BA-Tf比游离DOX更有效地抑制肿瘤生长。这些发现突出了MSNP-BA-Tf作为一种有前景的癌症治疗纳米载体，通过主动靶向和H2O2响应性提供靶向和受控的药物递送。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.