{"title":"H<sub>2</sub>O<sub>2</sub>-Responsive Boronic Ester-Modified Mesoporous Silica Nanocarrier for TfR Mediated Tumor-Specific Drug Delivery Applications.","authors":"Hsiao-Yen Lee, Natesan Thirumalaivasan, Shu-Pao Wu","doi":"10.1021/acsabm.5c00645","DOIUrl":null,"url":null,"abstract":"<p><p>This study introduces a drug delivery system utilizing boronic ester-functionalized mesoporous silica nanoparticles (<b>MSNP-BA-Tf</b>) for targeted cancer therapy. By conjugating transferrin (Tf) to the MSNP surface, the system actively targets cancer cells via transferrin receptor (TfR)-mediated endocytosis. The incorporation of boronic ester linkages enables hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)-responsive drug release, enhancing therapeutic efficacy. In vitro experiments demonstrated that <b>MSNP-BA-Tf</b> effectively delivered doxorubicin (DOX) to cancer cells while sparing normal cells, as confirmed by fluorescence imaging and cytotoxicity assays. In vivo studies using a colon cancer xenograft model showed that <b>DOX@MSNP-BA-Tf</b> inhibited tumor growth more effectively than free DOX. These findings highlight <b>MSNP-BA-Tf</b> as a promising nanocarrier for cancer therapy, offering targeted and controlled drug delivery through active targeting and H<sub>2</sub>O<sub>2</sub> responsiveness.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6000,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1021/acsabm.5c00645","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
引用次数: 0
Abstract
This study introduces a drug delivery system utilizing boronic ester-functionalized mesoporous silica nanoparticles (MSNP-BA-Tf) for targeted cancer therapy. By conjugating transferrin (Tf) to the MSNP surface, the system actively targets cancer cells via transferrin receptor (TfR)-mediated endocytosis. The incorporation of boronic ester linkages enables hydrogen peroxide (H2O2)-responsive drug release, enhancing therapeutic efficacy. In vitro experiments demonstrated that MSNP-BA-Tf effectively delivered doxorubicin (DOX) to cancer cells while sparing normal cells, as confirmed by fluorescence imaging and cytotoxicity assays. In vivo studies using a colon cancer xenograft model showed that DOX@MSNP-BA-Tf inhibited tumor growth more effectively than free DOX. These findings highlight MSNP-BA-Tf as a promising nanocarrier for cancer therapy, offering targeted and controlled drug delivery through active targeting and H2O2 responsiveness.
期刊介绍：
ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications.
The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.
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