ACS Applied Bio Materials最新文献_第9页

Injectable, Self-Healing, Superadhesive PVA Hydrogels Promote Skin Wound Healing by Regulating the Inflammatory Microenvironment. 可注射的、自愈的、超粘的PVA水凝胶通过调节炎症微环境促进皮肤伤口愈合。

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-06-16 Epub Date: 2025-05-29 DOI: 10.1021/acsabm.5c00432

Ensi Liu, Shuai Cheng, Qiannan Zhao, Sen Lin, Xifan Mei

{"title":"Injectable, Self-Healing, Superadhesive PVA Hydrogels Promote Skin Wound Healing by Regulating the Inflammatory Microenvironment.","authors":"Ensi Liu, Shuai Cheng, Qiannan Zhao, Sen Lin, Xifan Mei","doi":"10.1021/acsabm.5c00432","DOIUrl":"10.1021/acsabm.5c00432","url":null,"abstract":"Macrophage cells are crucial in the inflammatory and proliferative phases of skin injury. The key to skin regeneration lies in controlling the immune response triggered by macrophages. The current treatment methods for skin defects include scar healing, skin grafting surgery, and skin flap repair surgery. The healing time is too long and cannot be cured for a long time, which seriously endangers the health and quality of life of patients. The hydrogel developed by predecessors has promoted the healing of skin defects by providing a moist environment for the wound surface. A hydrogel wound dressing with self-healing and adhesive qualities can offer enhanced protection to the wound and extend the material's lifespan. This study developed a high-adhesion, injectable, and self-healing hydrogel using PVA. The Northern Schisandrin B (NSB) were trapped within PVA hydrogels (PVA.gel). Due to the presence of PVA gel, which provides strong adhesion and anti-inflammatory properties to NSB, it addresses the issue of NSB solution not adhering to the wound surface, thus ensuring continuous action on the wound surface. During in vitro experiments on wound healing, the hydrogel has the ability to adhere to the wound's surface, thereby improving the healing process. The NSB.PVA.gel is capable of persistently suppressing inflammation to manage the inflammatory milieu in long-term wounds, ensuring a seamless shift from the inflammatory stage to the proliferation stage. The NSB.PVA.gel, known for its efficacy, safety, and ease of use, is capable of meeting a variety of clinical requirements.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"5120-5128"},"PeriodicalIF":4.6,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Bioelectronic Immunosensing Platform Comprising a Gold Dendritic 3D Architecture Sandwiched between Graphene Sheets for Oral Cancer Detection. 一种生物电子免疫传感平台，包括夹在石墨烯片之间的金树突状3D结构，用于口腔癌检测。

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-06-16 Epub Date: 2025-05-30 DOI: 10.1021/acsabm.5c00368

Buddhadev Purohit, Rohini Kumari, Ananya Srivastava, Pranjal Chandra

{"title":"A Bioelectronic Immunosensing Platform Comprising a Gold Dendritic 3D Architecture Sandwiched between Graphene Sheets for Oral Cancer Detection.","authors":"Buddhadev Purohit, Rohini Kumari, Ananya Srivastava, Pranjal Chandra","doi":"10.1021/acsabm.5c00368","DOIUrl":"10.1021/acsabm.5c00368","url":null,"abstract":"Epidemiological studies have shown that oral cancer is one of the most lethal forms of cancer, with a high risk of distant metastases and eventual death, largely due to late diagnosis. The noninvasive diagnosis of oral cancer can simplify sample collection, and when paired with single-step detection assays, it can facilitate and popularize early diagnosis, ultimately reducing the mortality rate. In light of this, we have designed a simple and noninvasive immunosensor for the facile and selective identification of the oral cancer biomarker cytokeratin 19 fragment-21-1 (CYFRA-21-1) in saliva samples, specifically in the clinically safe as well as diseased range. Prior to being utilized as a marker for oral carcinomas, CYFRA-21-1 was used as a biomarker for nonsmall cell lung cancer (NSCLC) as well as other cancers. Due to its high salivary secretion, it has become a powerful and reliable marker for the early detection of oral cancer in recent decades; however, there are very few studies pertaining to it. Moreover, the literature has reported the higher sensitivity and specificity of CYFRA-21-1 markers in saliva than in serum samples. Hence, in this study, the sensing surface was developed using a nanocomposite of gold nanodendrites (AuNDs) sandwiched between graphene oxide (GO) sheets for the sensitive detection of CYFRA-21-1 in saliva samples. Metallic dendrites based on nanohybrid systems possess astonishing conductive and catalytic properties. The first layer of GO is used as the substrate for enhanced growth of AuNDs, while the second layer of GO is utilized for covalent binding of the anti-CYFRA-21-1 antibody through bioconjugation reactions. The developed bioelectronic immunosensing platform is able to sense CYFRA-21-1 in a clinically safe as well as diseased range with a low limit of detection (LOD). It is easy to operate and can be integrated with a portable electrochemical analyzer for point-of-care (POC) oral cancer diagnosis in low-resource settings.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"5015-5023"},"PeriodicalIF":4.6,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chitosan-Supported Molecularly Imprinted Polypyrrole@MoSe₂ Nanosheet-Based Bioinspired Electrochemical Sensor for Improved Quantification of Gut Microbiota-Derived Hippuric Acid. 壳聚糖支持的分子印迹Polypyrrole@MoSe2纳米片仿生电化学传感器用于改进肠道微生物源性马尿酸的定量。

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-06-16 Epub Date: 2025-06-02 DOI: 10.1021/acsabm.5c00329

Archana, Anil Kumar, Pratima R Solanki

{"title":"Chitosan-Supported Molecularly Imprinted Polypyrrole@MoSe2 Nanosheet-Based Bioinspired Electrochemical Sensor for Improved Quantification of Gut Microbiota-Derived Hippuric Acid.","authors":"Archana, Anil Kumar, Pratima R Solanki","doi":"10.1021/acsabm.5c00329","DOIUrl":"10.1021/acsabm.5c00329","url":null,"abstract":"Hippuric acid (HA) is a well-known gut microbiota-derived metabolite involved in the development of various diseases such as chronic kidney disease, Chron's disease, and inflammatory bowel disease. HA being one of the most commonly found metabolites in gut microbiota is an important analyte considered for establishing an efficient, quick, sensitive, and reliable method for its detection in human samples. In this work, a molecularly imprinted polymer (MIP) technique has been focused on the electrochemical detection of HA using soft materials, as well as a bioinspired technique. Different characterization techniques have been used to validate the synthesis of MoSe2 NS, polypyrrole (PPY)@molybdenum diselenide (MoSe2)-MIP, such as X-ray diffraction, scanning electron microscopy, Fourier transform infrared spectroscopy, atomic force microscopy, contact angle, Brunauer-Emmett-Teller method, and transmission electron microscopy. Also, density functional theory computational study has been used to establish the theoretical interaction between the pyrrole (monomer) and HA (target analyte), as well as explore the highest occupied molecular orbital and lowest unoccupied molecular orbital interactions followed by molecular electrostatic potential and Mulliken charges. The chitosan-polypyrrole@MoSe2-MIP showed 14.92 μA log10(ng/mL)-1 cm-2 sensitivity and a low limit of detection of 0.76 ng/mL in the presence of the analyte using the differential pulse voltammetry technique. The fabricated sensor was also deployed to assess the level of HA in the spiked urine sample, further showing the recovery of 93-108%. Also, the green profile score for the PPY-MIP-based sensor is assessed using the Analytical GREEness MIP (AGREEMIP) metric tool.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"4961-4972"},"PeriodicalIF":4.6,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144197661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Macroheterogeneities Induced by Disulfide Bond Reduction in Native Mucus. 原生黏液中二硫键还原诱导的宏观异质性。

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-06-16 Epub Date: 2025-05-19 DOI: 10.1021/acsabm.4c01758

Giorgia Franzino, Fabiana Tescione, Domenico Larobina

{"title":"Macroheterogeneities Induced by Disulfide Bond Reduction in Native Mucus.","authors":"Giorgia Franzino, Fabiana Tescione, Domenico Larobina","doi":"10.1021/acsabm.4c01758","DOIUrl":"10.1021/acsabm.4c01758","url":null,"abstract":"Disulfide bond reducing agents have long been used as therapeutic drugs (mucolytics) for mucus hypersecretions. Breakage of disulfide bridges is known to cause a reduction in the degree of cross-linking, making the mucus more fluid. In addition to the drop in viscoelastic properties, the disulfide breakage is also known to affect the structure of the mucus on both micro- and mesoscale. Despite this knowledge, little is known about the reorganization of the mucus at the macroscopic scale. This contribution explores the effect of the reducing agent, tris(2-carboxyethyl)phosphine hydrochloride (TCEP), on the structure of native porcine gastric mucus. After exposing the mucus to increasing concentrations of TCEP, we measure the macroscopic rheological properties along with its microscopic dynamics. The results obtained show an increase in macroscopic heterogeneity with TCEP, which we attribute to the mucus tendency to phase separate. Furthermore, we examine the soluble fractions of the different reduced mucuses by measuring the size of the suspendable macromolecules. The results indicate that the size remains approximately constant with an increasing TCEP concentration. Our contribution may be important to describe the effects of a disulfide reducing agent on the mucus structure and, consequently, on mucociliary and cough clearance.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"4647-4656"},"PeriodicalIF":4.6,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12175130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anisotropic Growth of Filamentous Fungi in Wood Hydrogel Composites Increases Mechanical Properties. 丝状真菌在木材水凝胶复合材料中的各向异性生长提高了材料的力学性能。

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-06-16 Epub Date: 2025-06-06 DOI: 10.1021/acsabm.5c00374

Ciatta Wobill, Ziyu Zhang, Peter Fischer, Patrick A Rühs

{"title":"Anisotropic Growth of Filamentous Fungi in Wood Hydrogel Composites Increases Mechanical Properties.","authors":"Ciatta Wobill, Ziyu Zhang, Peter Fischer, Patrick A Rühs","doi":"10.1021/acsabm.5c00374","DOIUrl":"10.1021/acsabm.5c00374","url":null,"abstract":"There is a rising demand for sustainable, biodegradable, and robust materials in response to growing environmental concerns. Here, we propose using delignified wood as a scaffold for fungal proliferation to obtain wood-fungi composites. The delignification process preserves the fiber directionality inherent to natural wood, enabling fungi to grow along these fibers, enhancing the composites' mechanical properties, and promoting anisotropic fungal growth. The delignified wood was used as a scaffold for the growth of Aspergillus oryzae and Rhizopus oligosporus. Both wood-fungi composites exhibited a higher mechanical strength after fungal proliferation. We used balsa, poplar, and spruce as wood to demonstrate the effects of varying wood architectures. Even though the tensile strengths of all three wood scaffolds were not significantly different, wood scaffolds with lower densities promoted fungal growth. Increasing agar and glucose concentrations were found to significantly enhance tensile strength and Young's modulus. The tensile strength and Young's modulus of wood scaffolds increased from 101 kPa to nearly 103 kPa and 10-3 GPa to nearly 10-1 GPa, respectively. These results highlight the versatile nature of delignified wood as a platform for fungal growth. It offers tunable properties that can be optimized for various applications in composite manufacturing.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"5024-5031"},"PeriodicalIF":4.6,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12175164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144232614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-06-16

Elakkiya Krishnamoorthy, Gosala Radha and Balakumar Subramanian*,

引用次数: 0

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-06-16

Kunyao Xu, Hao Wang, Yongping Jiang* and Hanlu Wang*,

引用次数: 0

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-06-16

Anitha Jayapalan, Frank Tukur, Mahsa Azami, Mengxin Liu and Jianjun Wei*,