ACS Applied Bio Materials最新文献

{"title":"","authors":"Ilavarasan Vickraman, Zhoveta Yhobu, Jan Grzegorz Małecki, Kavina Ganapathy, Ahipa Tantri Nagaraja and Srinivasa Budagumpi*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":"8 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsabm.5c00985","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Yang Wang, Dianpeng Li, Min He, Gang Wang* and Shulin Zhao*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":"8 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsabm.5c00634","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic Mesoporous Bioactive Glass Nanocomposite for Enhanced Osteogenesis and Angiogenesis in Bone Tissue Engineering.","authors":"Martina Vitázková, Fatih Kurtuldu, Saeed Sajjadi, Zuzana Neščáková, Lenka Buňová, Adriana Zeleňáková, Pavol Hrubovčák, Andrea Šoltýsová, Zulema Vargas-Osorio, Martin Michálek","doi":"10.1021/acsabm.5c00894","DOIUrl":"https://doi.org/10.1021/acsabm.5c00894","url":null,"abstract":"<p><p>Bone regeneration is a complex process involving multiple biological pathways that require the simultaneous stimulation of osteogenesis and angiogenesis. This study presents a three-step fabrication process for a magnetic mesoporous bioactive glass nanocomposite (CoBTSp) designed to enhance bone tissue regeneration. The platform includes the synthesis of mesoporous bioactive glass nanoparticles codoped with cobalt (Co²⁺) and boron (B³⁺), the creation of well-defined core-shell systems (MBGNs@SiO₂), and final decoration with superparamagnetic iron oxide nanoparticles (SPIONs). Its hierarchical structure enables the controlled and gradual release of bioactive ions, while the components improve biocompatibility and provide magnetic responsiveness for targeted bone therapy. Comprehensive physicochemical characterization confirmed the successful fabrication of CoBTSp, which exhibited superparamagnetic behavior for precise magnetic field localization. <i>In vitro,</i> assays demonstrated that CoBTSp enhanced angiogenic and osteogenic responses by upregulating <i>VEGFA</i>, <i>HIF1A</i>, <i>FGF2</i>, <i>RUNX2,</i> and <i>COL18A1</i> gene expression. The nanocomposite promoted osteoblast differentiation and stimulated mineral deposition, showing excellent biocompatibility without inducing cytotoxic or genotoxic effects. These findings establish CoBTSp as a promising and versatile platform for bone regeneration, combining remarkable biological functions and controlled ion release with magnetic targeting for improved clinical outcomes. Nonetheless, future research should focus on <i>in vivo</i> testing to optimize therapeutic ion levels and further develop magnetic mesoporous bioactive glass nanocomposites for regenerative medicine.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Superhydrophobic Fatty Acid-Based Spray Coatings with Dual-Mode Antifungal Activity.","authors":"Elena Prudnikov, Hanan Abu Hamad, Iryna Polishchuk, Alexander Katsman, Ester Segal, Boaz Pokroy","doi":"10.1021/acsabm.5c00596","DOIUrl":"10.1021/acsabm.5c00596","url":null,"abstract":"<p><p>Superhydrophobicity, a natural phenomenon commonly observed in plants and insects, imparts diverse functionalities, including self-cleaning capabilities and antibiofouling properties. Nature's design of a superhydrophobic surface relies on a combination of surface chemistry and hierarchical roughness at micro- and nanoscales, inspiring the design of artificial superhydrophobic coatings. These multifunctional coatings offer a promising approach for combating fungal infections that are becoming increasingly prevalent due to global warming and increased resistance to conventional fungicides. Notably, among emerging superhydrophobic surfaces, those made with natural, nontoxic, and environmentally friendly compounds via facile manufacturing methods offer key advantages and support sustainable engineering practices. In this study, we developed easy-to-apply, sprayable bimodal superhydrophobic coatings. The antifungal activity of these coatings, based on long-chain fatty acids, can be further enhanced by incorporating medium-chain fatty acids, as demonstrated against the model phytopathogen <i>Botrytis cinerea</i>. Specifically, we investigate the effect of incorporating sorbic or caprylic medium-chain fatty acids at various concentrations on the structure, physical properties, stability, and applicability of stearic acid-based coatings. Our results show that, depending on the composition, the antifungal activity of the coatings can be tuned, ranging from complete passive antibiofouling to dominant fungicidal action against <i>Botrytis cinerea</i>. Enabled by the synergistic effect of the hierarchical superhydrophobic structure and the incorporation of potent medium-chain fatty acids, these coatings offer a sustainable solution for surface protection against fungal infections and represent a promising alternative to conventional antifungal strategies.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"5970-5983"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12284891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144256619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Boron-Doped Mesoporous Bioactive Glass Nanoparticles (B-MBGNs) in Poly(ε-caprolactone)/Poly(propylene succinate-<i>co</i>-glycerol succinate) Nanofiber Mats for Tissue Engineering.","authors":"Clara Dourado Fernandes, Sena Harmanci, Alina Grünewald, Zoya Hadzhieva, Bruno F Oechsler, Claudia Sayer, Pedro H Hermes de Araújo, Aldo R Boccaccini","doi":"10.1021/acsabm.4c01871","DOIUrl":"10.1021/acsabm.4c01871","url":null,"abstract":"<p><p>Increased demand for advanced biomaterials in tissue engineering has driven research to develop innovative solutions based on smart material combinations. Mesoporous bioactive glass nanoparticles (MBGNs) have emerged as attractive materials because of their angiogenic and regenerative properties. This study explores the incorporation of boron-doped mesoporous bioactive glass nanoparticles (B-MBGNs) into poly(ε-caprolactone) (PCL) and poly(propylene succinate-<i>co</i>-glycerol succinate) (PPSG) fibers to enhance their biodegradation and bioactivity. B-MBGNs were synthesized via a microemulsion-assisted sol-gel method and characterized through morphology, pore size distribution, composition, and surface area. PCL/PPSG nanofibers were fabricated using an alternative combination of solvents, formic acid, and acetic acid. B-MBGNs were incorporated into PCL/PPSG solutions at concentrations of 5, 10, and 15 wt % and electrospun into nanofiber mats under a flow rate of 0.2 mL/h at 22 °C and 40% relative humidity, while the voltage applied at the needle tip was 18 kV and -2 kV at the rotating drum. The addition of 10 wt % of B-MBGNs resulted in nanofibers that exhibited a high degradation rate in PBS with a weight loss of 44% in 30 days, significant hydrophilicity with a contact angle of 33°, and improvements in cell viability tested with normal human dermal fibroblasts (NHDF). In addition, the study highlights the effect of the concentration of B-MBGNs on the morphology of the fibers, which can agglomerate and form undesired beads. Although the particles improved cellular activity, the changes in morphology caused tension points that reduced the elasticity of the fibers. Overall, this work contributes to the innovative use of green polyesters combined with boron ions in electrospun fibrous scaffolds, expanding the opportunities for applications in tissue regeneration, for example, to treat chronic wounds in diabetic patients.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"5557-5567"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12284861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bifunctional Metal Ion-Enhanced PDA-Coated Titanium for Superior Osteogenic and Antimicrobial Performance.","authors":"Chenhui Liu, Sikun Meng, Huachun Wang, Tianzhen Zhang, Cheng Qi, Mei Li, Jingyang Kang","doi":"10.1021/acsabm.4c01869","DOIUrl":"10.1021/acsabm.4c01869","url":null,"abstract":"<p><p>Titanium (Ti) implants serve as a popular solution for tooth replacement, because they combine excellent mechanical properties with high biocompatibility. However, the biologically inert nature of titanium surfaces restricts their osteogenic capacity and renders them prone to bacterial colonization, elevating the risk of biofilm formation and implant-associated infections. Surface modification of titanium implants is essential to overcoming these limitations. To optimize the titanium surface functionality, this study employed a polydopamine (PDA) coating strategy combined with subsequent incorporation of copper and manganese ions. We prepared Ti-PDA and then fabricated Ti-PDA-Cu and Ti-PDA-Cu/Mn samples. Material characterization revealed that Ti-PDA-Cu/Mn exhibits favorable surface wettability and biocompatibility, along with sustained and stable release of Cu²⁺ and Mn²⁺ ions. Experiments in vitro showed that Ti-PDA-Cu/Mn had good antimicrobial activity against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>, significantly promoted protein adsorption, osteoblast adhesion, proliferation, and mineralization, and upregulated the expression of osteogenic genes. A promising strategy has been established through this bifunctional modification to simultaneously enhance the osteogenic and antimicrobial properties of titanium implants.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"5568-5579"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12285667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Shanmugavel Chinnathambi*,&nbsp;Mahima Kumar,&nbsp;Basudeb Dutta*,&nbsp;Karthikeyan Subramani,&nbsp;Saravanan Kandasamy,&nbsp;Sebastian Kmiecik,&nbsp;Thangavel Vaijayanthi and Ganesh N. Pandian*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":"8 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsabm.5c00887","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Junjie Hu,&nbsp;Chi Zhang,&nbsp;Hao Xu,&nbsp;Yingda Wan,&nbsp;Xin Wang* and Rupei Tang*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":"8 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsabm.5c00578","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Siyi Lan,&nbsp;Ye Wang,&nbsp;Shengnan Zhang,&nbsp;Pei Sun,&nbsp;Yun Li,&nbsp;Yawen Zhang,&nbsp;Zhiyi Chen,&nbsp;Bin Liu and Zhen Yuan*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":"8 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsabm.5c00779","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Ryan Berthelot,&nbsp; and ,&nbsp;Fabio Variola*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":"8 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsabm.5c00697","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}