Chenhui Liu, Sikun Meng, Huachun Wang, Tianzhen Zhang, Cheng Qi, Mei Li, Jingyang Kang
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引用次数: 0
Abstract
Titanium (Ti) implants serve as a popular solution for tooth replacement, because they combine excellent mechanical properties with high biocompatibility. However, the biologically inert nature of titanium surfaces restricts their osteogenic capacity and renders them prone to bacterial colonization, elevating the risk of biofilm formation and implant-associated infections. Surface modification of titanium implants is essential to overcoming these limitations. To optimize the titanium surface functionality, this study employed a polydopamine (PDA) coating strategy combined with subsequent incorporation of copper and manganese ions. We prepared Ti-PDA and then fabricated Ti-PDA-Cu and Ti-PDA-Cu/Mn samples. Material characterization revealed that Ti-PDA-Cu/Mn exhibits favorable surface wettability and biocompatibility, along with sustained and stable release of Cu2+ and Mn2+ ions. Experiments in vitro showed that Ti-PDA-Cu/Mn had good antimicrobial activity against Escherichia coli and Staphylococcus aureus, significantly promoted protein adsorption, osteoblast adhesion, proliferation, and mineralization, and upregulated the expression of osteogenic genes. A promising strategy has been established through this bifunctional modification to simultaneously enhance the osteogenic and antimicrobial properties of titanium implants.
钛(Ti)种植体是一种流行的牙齿替代解决方案,因为它们结合了优异的机械性能和高生物相容性。然而,钛表面的生物惰性限制了其成骨能力,使其容易被细菌定植,增加了生物膜形成和植入物相关感染的风险。钛植入物的表面改性是克服这些限制的关键。为了优化钛的表面功能,本研究采用了聚多巴胺(PDA)涂层策略,并随后掺入铜和锰离子。首先制备了Ti-PDA,然后制备了Ti-PDA- cu和Ti-PDA- cu /Mn样品。材料表征表明,Ti-PDA-Cu/Mn具有良好的表面润湿性和生物相容性,并能持续稳定地释放Cu2+和Mn2+离子。体外实验表明,Ti-PDA-Cu/Mn对大肠杆菌和金黄色葡萄球菌具有良好的抑菌活性,显著促进蛋白吸附、成骨细胞粘附、增殖和矿化,上调成骨基因的表达。通过这种双功能修饰,同时提高钛种植体的成骨和抗菌性能,建立了一种有前途的策略。
期刊介绍:
ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications.
The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.