ACS Applied Bio Materials最新文献

{"title":"The Profiles of Laryngopharyngeal Reflux in Patients With Different Vocal Fold Lesions.","authors":"Jinhong Zhang, Xiaoyu Wang, Jiasen Wang, Jing Zhao, Chun Zhang, Zhi Liu, Jinrang Li","doi":"10.1016/j.jvoice.2022.08.002","DOIUrl":"10.1016/j.jvoice.2022.08.002","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the profiles of laryngopharyngeal reflux (LPR) and the relationship between hypopharyngeal-proximal reflux episodes (HREs) and the positive rate of salivary pepsin testing in patients with vocal fold lesions (VFLs).</p><p><strong>Methods: </strong>The enrolled patients were divided into vocal fold cancer group (VFCG), vocal fold leukoplakia group (VFLG), benign vocal fold lesion group (BVFLG) and control group (CG). Patients benefited from multichannel intraluminal impedance-pH monitoring (MII-pH) and multi-time point salivary pepsin testing (MTPSPT). The LPR profiles of patients with VFLs were studied by analyzing the MII-pH findings. The relationship between HREs and positive rate of MTPSPT was investigated through the nonparametric test.</p><p><strong>Results: </strong>177 patients were included. According to 24 h MII-pH, the occurrence of HREs tended to increase after meals. 55.75%, 63.98%, 66.82% and 55.77% of the HREs in the VFCG, VFLG, BVFLG and CG occurred within 3 h after meals, respectively. The overall positive rate of MTPSPT was higher in the VFCG than the remaining groups. In the VFCG, there was a significant correlation between overall positive results of MTPSPT and HREs occurring within 3 h after meals.</p><p><strong>Conclusion: </strong>In the Chinese population, the occurrence of HREs tend to more frequently after meals in patients with VFLs, and most HREs occur within 3 h after meals. By analyzing the 24h MII-pH findings, we can develop a more individualized anti-reflux therapeutic strategy for LPR patients.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"185-192"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40347202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are There Differences in the Cranial Base of Humans and Apes?","authors":"Michael S Benninger, Kaylin E Benninger, Timothy Haffey, Robert S Butler","doi":"10.1016/j.jvoice.2022.06.018","DOIUrl":"10.1016/j.jvoice.2022.06.018","url":null,"abstract":"<p><strong>Purpose: </strong>Differences in skull-base angles between humans, other hominid species and apes might account for the ability of humans to develop complex speech. This study compared midline skull base angles, and angles related to insertion of skull base musculature between these species.</p><p><strong>Methods: </strong>126 human adult, 29 adolescent, 19 children, and 13 fetus skulls were compared to 32 ape and a subset of non-human antiquity hominid casts of skulls (13). Cranial base measurements were taken using an eMicroscribe 3d G2 digitizer. Midline and muscle insertion measurements were obtained.</p><p><strong>Results: </strong>There were statistical differences in both the midline angles of the skull base (humans, 119^o; apes, 130^o) and in the Skull base angles related to points of muscle insertion (humans, 113^o; apes, 124^o), with humans exhibiting a more acute angle than the apes and other non-human hominids. There were no differences between human adults and children CONCLUSION: Acute angle differentiation of the midline skull base between humans and apes was confirmed with an alternate measurement method. Whether these angular differences are the primary reason for the lower position of the larynx in humans and the potential for more complex speech is still in debate.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"65-72"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40518030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of Acoustic Measures for the Discrimination Among Healthy, Rough, Breathy, and Strained Voices Using the Feedforward Neural Network.","authors":"Samuel Ribeiro de Abreu, Estevão Silvestre da Silva Sousa, Ronei Marcos de Moraes, Leonardo Wanderley Lopes","doi":"10.1016/j.jvoice.2022.07.002","DOIUrl":"10.1016/j.jvoice.2022.07.002","url":null,"abstract":"<p><strong>Objective: </strong>To identify and evaluate the best set of acoustic measures to discriminate among healthy, rough, breathy, and strained voices.</p><p><strong>Methods: </strong>This study used the vocal samples of the sustained /ε/ vowel from 251 patients with the vocal complaints, among which 51, 80, 63, and 57 patients exhibited healthy, rough, breathy, and strained voices, respectively. Twenty-two acoustic measures were extracted, and feature selection was applied to reduce the number of combinations of acoustic measures and obtain an optimal subset of measures according to the information gain attribute ranking algorithm. To classify signals as a function of predominant voice quality, a feedforward neural network was applied using a Levenberg-Marquardt supervised learning algorithm.</p><p><strong>Results: </strong>The best results were obtained from 11 combinations, with each combination presenting six acoustic measures. Kappa indices ranged from 0.7527 to 0.7743, the overall hit rates are 81.67%-83.27%, and the hit rates of healthy, rough, breathy, and strained voices are 74.51%-84.31%, 78.75%-90.00%, 85.71%-98.41%, and 68.42%-82.46%, respectively.</p><p><strong>Conclusions: </strong>We obtained the best results from 11 combinations, with each combination exhibiting six acoustic measures for discriminating among healthy, rough, breathy, and strained voices. These sets exhibited good Kappa performance and a good overall hit rate. The hit rate varied between acceptable and good for healthy voices, acceptable and excellent for rough voices, good and excellent for breathy voices, and poor and good for strained voices.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"1-9"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40446608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Between a Self-Voice Assessment and Objective-Voice Evaluation Outcomes in Speech Language Pathology Students.","authors":"Kyriaki Kyriakou, Elena Theodorou, Kakia Petinou, Ioannis Phinikettos","doi":"10.1016/j.jvoice.2022.06.032","DOIUrl":"10.1016/j.jvoice.2022.06.032","url":null,"abstract":"<p><strong>Aim: </strong>The aims of this study is to explore the correlation between the Voice Disorder Index (VDI) score and acoustic and phonatory respiratory voice parameters in speech language pathology (SLP) students with and without self-perceived voice disorders.</p><p><strong>Methods: </strong>The Voice Disorder Index (VDI) and the Lingwaves 3 \"Voice Protocol\" were administered to each participant in order to assess his/her self-perceived severity of his/her voice problem, as well as, acoustic and phonatory respiratory measurements. The correlation coefficients were used to evaluate and quantify the degree of a linear relationship between VDI scores and acoustic and phonatory respiratory voice measures in students with and without self-perceived voice disorders.</p><p><strong>Results: </strong>Relatively strong, strong and strong positive correlations were revealed when comparing the VDI physical subscale with the Dysphonia Severity Index (r(11) = 0.56, P = 0.048), mean loudness when reading in English (r(11) = 0.70, P = 0.008) and mean loudness when reading in Greek (r(11) =0.69, P = 0.009) respectively.</p><p><strong>Conclusions: </strong>SLP students may be more aware of the impact of their laryngeal discomfort and voice output characteristics on their daily activities that can predict certain acoustic parameters than the emotional and functional impact on their daily activities.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"281.e19-281.e25"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40576066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability and Validity of the Mandarin Version of Singing Voice Handicap Index - 10 (MSVHI-10).","authors":"Sherry Fu, Yi-Chen Chen, Chi-Te Wang","doi":"10.1016/j.jvoice.2022.06.022","DOIUrl":"10.1016/j.jvoice.2022.06.022","url":null,"abstract":"<p><strong>Objectives: </strong>The present study aims to evaluate the reliability and validity of the Mandarin version of the Singing Voice Handicap Index-10 (MSVHI-10).</p><p><strong>Methods: </strong>One hundred and fifteen singers, aged from 21 to 65, participated in this study. All the subjects completed the Mandarin version of the SVHI-10 and the Voice Handicap Index-10 (VHI-10). Other gathered information include sex, age, type of singing performance, and the accumulated years of singing. We also asked the participants to self-report the presence of singing voice complaint. Statistical analyses were performed to evaluate the validity, reliability, and the Receiver Operating Characteristic (ROC) curve of MSVHI-10.</p><p><strong>Results: </strong>The results showed high internal consistency (Cronbach's α =0.96), with the scores of each question ranged from 0.57 to 0.90. Forty-three singers re-filled the MSVHI-10 with an interval of 12.7 ± 9.3 days (mean ± standard deviation), and the results showed a high test-retest reliability (r = 0.98, P < 0.01). The SVHI-10 scores were significantly correlated with the VHI-10 (r = 0.54-0.72, P < 0.01). ROC analysis revealed a high differentiating accuracy for distinguishing between the subjects with or without singing voice complaints, with an area under the curve (AUC) of 0.97. At the cut-off score of 21.5, the sensitivity and specificity were 85.7% and 95.9%, respectively.</p><p><strong>Conclusions: </strong>The Mandarin version of the SVHI-10 has been shown to be a reliable and valid instrument for evaluating the self-perception of singing voice complaints.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"279.e1-279.e5"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40603524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of Reflux Characteristics in Outpatients of Otorhinolaryngology-Head and Neck Surgery by Age and Gender in the Chinese Population.","authors":"Xiaoyu Wang, Jinhong Zhang, Zhi Liu, Chun Zhang, Shizhen Zou, Jinrang Li","doi":"10.1016/j.jvoice.2022.07.024","DOIUrl":"10.1016/j.jvoice.2022.07.024","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the characteristics of patients with reflux diseases in the otorhinolaryngology-head and neck surgery clinics through the Reflux Symptom Scale-12 (RSS-12) and the Gastroesophageal Reflux Disease Questionnaire (GERD-Q).</p><p><strong>Methods: </strong>All included patients completed the RSS-12 and GERD-Q scales and were considered to have LPR with an RSS-12 score >11 and GERD with a GERD-Q score >7. Data were analyzed according to genders (male and female) and age (18-40, 41-60, and >60 years).</p><p><strong>Results: </strong>A total of 977 patients were included. the mean RSS-12 and GERD-Q score were 11.32±21.34 and 6.31±1.21, and the positive rate of LPR and GERD were 28.76% and 8.90%, respectively. Males had a higher positive rate of LPR and GERD than females, and there were more males with LPR who also had GERD. Among those with both LPR and GERD, males had significantly higher ear-nose-throat (ENT) symptom scores such as hoarseness and excess throat mucus than females. However, females had significantly higher scores of gastrointestinal (GI) symptoms, mainly indigestion and abdominal pain, and elder patients (>60 years) had higher scores of ENT, GI, respiratory symptoms, as well as the impact of symptoms on quality of life than the young patients (18-40, and 41-60 years).</p><p><strong>Conclusion: </strong>Patients in the otorhinolaryngology-head and neck surgery clinics have different reflux characteristics by gender and age in the Chinese population. Males had more severe ENT-related symptoms of distress, while females had more complaints of GI symptoms. Older patients had higher scores for ENT, GI and respiratory symptoms.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"193-199"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40625760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classification of Voice Quality Using Neck-Surface Acceleration: Comparison With Glottal Flow and Radiated Sound.","authors":"Marcin Włodarczak, Bogdan Ludusan, Johan Sundberg, Mattias Heldner","doi":"10.1016/j.jvoice.2022.06.034","DOIUrl":"10.1016/j.jvoice.2022.06.034","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of the present study is to investigate the usefulness of features extracted from miniature accelerometers attached to speaker's tracheal wall below the glottis for classification of phonation type. The performance of the accelerometer features is evaluated relative to features obtained from inverse filtered and radiated sound. While the former is a good proxy for the voice source, obtaining robust voice source features from the latter is considered difficult since it also contains information about the vocal tract filter. By contrast, the accelerometer signal is largely unaffected by the vocal tract and although it is shaped by subglottal resonances and the transfer properties of the neck tissue, these properties remain constant within a speaker. For this reason, we expect it to provide a better approximation of the voice source than the raw audio. We also investigate which aspects of the voice source are derivable from the accelerometer and microphone signals.</p><p><strong>Methods: </strong>Five trained singers (two females and three males) were recorded producing the syllable [pæ:] in three voice qualities (neutral, breathy and pressed) and at three pitch levels as determined by the participants' personal preference. Features extracted from the three signals were used for classification of phonation type using a random forest classifier. In addition, accelerometer and microphone features with highest correlation with the voice source features were identified.</p><p><strong>Results: </strong>The three signals showed comparable classification error rates, with considerable differences across speakers both with respect to the overall performance and the importance of individual features. The speaker-specific differences notwithstanding, variation of phonation type had consistent effects on the voice source, accelerometer and audio signals. With regard to the voice source, AQ, NAQ, L₁L₂ and CQ all showed a monotonic variation along the breathy - neutral - pressed continuum. Several features were also found to vary systematically in the accelerometer and audio signals: HRF, L₁L₂ and CPPS (both the accelerometer and the audio), as well as the sound level (for the audio). The random forest analysis revealed that all of these features were also among the most important for the classification of voice quality.</p><p><strong>Conclusion: </strong>Both the accelerometer and the audio signals were found to discriminate between phonation types with an accuracy approaching that of the voice source. Thus, the accelerometer signal, which is largely uncontaminated by vocal tract resonances, offered no advantage over the signal collected with a normal microphone.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"10-24"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40424274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Use of Vibrato in Belt and Legit Styles of Singing in Professional Female Musical-Theater Performers.","authors":"Alyssa S Becker, Peter J Watson","doi":"10.1016/j.jvoice.2022.07.018","DOIUrl":"10.1016/j.jvoice.2022.07.018","url":null,"abstract":"<p><strong>Objective: </strong>Musical theater (MT) performers are required to sing in several different styles, requiring different registration (quality) and different use of vibrato. Many measures of vibrato in MT performers are made in laboratory settings, studying a limited set of pitches, intensities, and vowels, using amateur and not well-defined professional singers. It is unclear if these observations are observed in well-known professional MT singers, during live instrumentally accompanied legit and belt performances.</p><p><strong>Study design: </strong>Descriptive from a convenience sample.</p><p><strong>Methods: </strong>Five well-known MT performers' recordings of one legit and one belt performance were downloaded for analysis of vocal vibrato. The vocal part was extracted from the recording and each note demarcated with and without vibrato. The pitch track of each note was analyzed for average pitch, duration, the proportion of a note sung with vibrato, if present, and written to file. The pitch track (f0 and time stamps) was written to a separate file for further analysis. This analysis consisted of vibrato rate (Hz), vibrato extent (semitones), and cycle-to-cycle perturbation (jitter-local and shimmer-local).</p><p><strong>Results: </strong>The most consistent finding was that the belt performances of the five singers had lesser proportion of notes sung with vibrato than their legit performances. The next consistent finding was that during belt performances, when vibrato was used, it was for a shorter duration within a note. There was a trend for the average rate of vibrato to be slower in the belt performances, but not to a substantial degree. There was no clear difference between legit and belt performances for vibrato extent or cycle-to-cycle perturbation.</p><p><strong>Conclusions: </strong>For these five performers, the strategy for the use of vibrato most often employed for differentiating the two singing styles was using less vibrato and when used to engage it for a shorter portion of a sung note. We believe this study offers reasonable ecological validity in how professional MT performers utilize vibrato to distinguish between belt and legit styles of singing. Vibrato rate and extent are subject to a number of factors which may not be in direct control of the singer. However, learning to sing with and without vibrato and the duration to which it is produced within a note may be a useful training strategy for students of MT.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"280.e7-280.e14"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40395068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Bilevel Positive Airway Pressure on Voice Quality.","authors":"Ayşe Karaoğullarından, Sanem Okşan Erkan","doi":"10.1016/j.jvoice.2022.06.027","DOIUrl":"10.1016/j.jvoice.2022.06.027","url":null,"abstract":"<p><strong>Objectives: </strong>Inflammation of the upper airways, thickening of the lateral pharyngeal walls, elongation of the soft palate and uvula, hypertrophy of the tonsils and base of the tongue can be seen in obstructive sleep apnea syndrome patients. Changes in these structures may affect articulation and phonation, negatively affecting the quality of the voice. Positive airway pressure (PAP) treatment reduces the volume of the root of the tongue, dissolves the edema in the upper respiratory tract, increases the posterior pharyngeal area, and positively changes the quality of the voice.</p><p><strong>Methods: </strong>A total of 151 people, 50 control group, and 101 patients, were included in the study between December 2020 and December 2021. The patient group was divided into two groups as continuous positive airway pressure (CPAP) and bilevel positive airway pressure (BPAP) users. All voice recordings were made in the control group and the patient group before and 3 months after CPAP and BPAP treatment, and were evaluated with the Praat (Paul, 2001) voice analysis program. The fundamental frequency of the sound (F0), frequency perturbation (jitter), amplitude perturbation (shimmer), noise-to-harmonic ratio (NHR) values were evaluated in the patient and control groups, and they were compared with each other before and after the treatment in the CPAP and BPAP groups.</p><p><strong>Results: </strong>Before and after PAP treatment; the changes in F0, Jitter, Shimmer, and NHR in the CPAP and BPAP group were statistically significant (P < 0.05). While the F0 change before and after PAP treatment was the most in the CPAP group, the jitter, shimmer and NHR changes were the most in the BPAP group.</p><p><strong>Conclusions: </strong>Regular 3-month PAP treatment positively affects F0, jitter, shimmer and NHR values. The greatest F0 change is in the use of CPAP, the improvement in jitter, shimmer and NHR is the most in the use of BPAP.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"288.e1-288.e7"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40614743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of Laryngopharyngeal Reflux in the Chinese Nurse Population.","authors":"Jing Wu, Leilei Yu, Junying Li, Xin Ma, Dan Zhang, Xue Shang","doi":"10.1016/j.jvoice.2022.06.031","DOIUrl":"10.1016/j.jvoice.2022.06.031","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the prevalence of laryngopharyngeal reflux (LPR) and knowledge of LPR in the Chinese nurse population.</p><p><strong>Method: </strong>From October 2021 through December 2021, participants were recruited from the PLA General Hospital's Sixth Medical Center. All included participants completed the Reflux Symptom Index (RSI), and LPR was defined as RSI > 13. In addition, each participant was asked to record whether they had any habits such as preferring to consume high-fat food and carbonated beverages, over-eating at dinner, sedentary after meals and lying down within 2 hour after meals, as well as whether they were aware of LPR. For the participants with RSI >13 points, they were treated using diet and lifestyle behavioral recommendations and were prescribed a twice daily pantoprazole (20 mg, 3 months).</p><p><strong>Results: </strong>A total of 828 participants were included. The positivity and awareness rates of LPR were 3.38% and 55.96%, respectively. RSI scores were significantly higher in LPR-positive subjects than in LPR-negative (16.79 ± 4.43 vs. 1.33 ± 2.33). Among the participants with LPR, there were significant positive association between RSI scores and preferring to consume high-fat food and carbonated beverages, over-eating at dinner, lying down within 2 hour after a meal, and sedentary after meals. RSI scores in 63% of participants with LPR significantly decreased from baseline to 1 month posttreatment. From 1 to 3 months posttreatment, 90% of participants had significantly lower RSI scores than pretreatment.</p><p><strong>Conclusions: </strong>There are a certain number of LPR patients in the Chinese nurse population, however, knowledge of LPR among nurses is unsatisfactory. Over-eating at dinner, lying down within 2 hour after a meal and sedentary after meals are risk factors for LPR. With combined regular dietary and lifestyle behavioral change and acid-suppressing treatment, most patients with LPR achieve effective remission.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"288.e15-288.e20"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40649059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}