ACS Applied Bio Materials最新文献_第8页

Enhanced Osteogenic Differentiation via Collagen and BMP-2 Mimetic Peptide Conjugation to β-TCP Scaffolds Using a Cold Atmospheric Plasma-Assisted Strategy.

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-03-17 Epub Date: 2025-03-03 DOI: 10.1021/acsabm.5c00029

Günnur Pulat, Eda Bilgiç, Utku Kürşat Ercan, Ozan Karaman

{"title":"Enhanced Osteogenic Differentiation via Collagen and BMP-2 Mimetic Peptide Conjugation to β-TCP Scaffolds Using a Cold Atmospheric Plasma-Assisted Strategy.","authors":"Günnur Pulat, Eda Bilgiç, Utku Kürşat Ercan, Ozan Karaman","doi":"10.1021/acsabm.5c00029","DOIUrl":"10.1021/acsabm.5c00029","url":null,"abstract":"Bone defects arising from trauma, disease, or surgical intervention represent significant challenges. Developing effective bone tissue engineering strategies to address these issues and promote repair is crucial. β-Tricalcium phosphate (β-TCP) has emerged as a promising synthetic graft due to its porous, degradable structure and excellent biocompatibility. However, the lack of biological cues in β-TCP limits its functionality, requiring different surface modification strategies. Bone morphogenetic protein-2 mimetic peptide (BMP; NSVNSKIPKACCVPTELSAI) and collagen mimetic peptide (CMP; GTPGPQGIAGQRGVV) have a known significant therapeutic potential due to their ability to enhance cell attachment and osteogenic differentiation. Herein, a peptide functionalization strategy for β-TCP scaffolds was introduced. Briefly, β-TCP was treated with cold atmospheric plasma (CAP) to create functional hydroxyl groups on the surface of the β-TCP. Subsequently, peptides were conjugated by using a three-step method: (1) silanization with APTES, (2) EDC activation, and (3) peptide conjugation. The successful surface modification with CAP and peptide conjugation was confirmed via XRD, FTIR, and Raman analysis. Furthermore, the effects of BMP and CMP peptides on osteogenic differentiation after CAP treatment were investigated in human mesenchymal stem cells (hMSCs). Both β-TCP/BMP and β-TCP/CMP scaffolds demonstrated excellent biocompatibility with hMSCs, enhancing cell proliferation and promoting osteogenic differentiation. Remarkably, β-TCP/CMP showed better results in terms of proliferation and differentiation compared with β-TCP/BMP. These findings highlight the clinical potential of peptide-functionalized β-TCP scaffolds for bone tissue engineering while also providing a promising methodology for β-TCP functionalization.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"2569-2579"},"PeriodicalIF":4.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-Assembled of Multifunctional Fluorescent Copper-DNA Nanoflowers for Cell-Specific-Target MicroRNA Imaging.

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-03-17 Epub Date: 2025-03-05 DOI: 10.1021/acsabm.5c00087

Wenhao Dai, Tongtong Zhang, Fan Zhang, Meiqin Zhang

{"title":"Self-Assembled of Multifunctional Fluorescent Copper-DNA Nanoflowers for Cell-Specific-Target MicroRNA Imaging.","authors":"Wenhao Dai, Tongtong Zhang, Fan Zhang, Meiqin Zhang","doi":"10.1021/acsabm.5c00087","DOIUrl":"10.1021/acsabm.5c00087","url":null,"abstract":"The development of simple and versatile approaches for the fabrication of DNA-based composite nanomaterials, endowed with defined morphologies and specific functionalities, is of paramount importance for various applications. Herein, we report a simple approach for the synthesis of multifunctional copper-DNA nanoflowers (Cu-DNF) that exclusively consist of rolling circle polymerized nanoflowers (DNF) and in situ synthesized concatemeric fluorescence copper nanoparticles. Through meticulous regulation of the assembly process, it is possible to generate Cu-DNF with precise sizes and stable fluorescence properties. The obtained Cu-DNF possesses robust biostability to resist degradation by nuclease, presumably resulting from the dense structure of the Cu-DNF. The Cu-DNF were also encoded with polyvalent tandem CD63 aptamer sequences, which enhanced their binding affinity and internalization efficiency into tumor cells. We demonstrate that the multifunctional Cu-DNF can efficiently internalize tumor cells for tracking and imaging analysis of intracellular microRNA. This approach may be beneficial for creating multifunctional DNA-based composite nanomaterials for various technological applications.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"2592-2600"},"PeriodicalIF":4.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tyrosine Kinase Inhibitor Lenvatinib Based Nano Formulations and Cutting-Edge Scale-Up Technologies in revolutionizing Cancer Therapy.

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-03-17 Epub Date: 2025-02-18 DOI: 10.1021/acsabm.4c01527

Samia Shaikh, Padakanti Sandeep Chary, Neelesh Kumar Mehra

{"title":"Tyrosine Kinase Inhibitor Lenvatinib Based Nano Formulations and Cutting-Edge Scale-Up Technologies in revolutionizing Cancer Therapy.","authors":"Samia Shaikh, Padakanti Sandeep Chary, Neelesh Kumar Mehra","doi":"10.1021/acsabm.4c01527","DOIUrl":"10.1021/acsabm.4c01527","url":null,"abstract":"Lenvatinib (LEN), a tyrosine kinase inhibitor, has emerged as a promising therapeutic agent for various solid tumors. Nevertheless, a number of constraints, including diminished bioavailability, incapacity to elicit localized inflammation, and inability to selectively accumulate at the tumor site, may impede the comprehensive exploitation of its versatile tyrosine kinase inhibitory capabilities. In order to achieve targeted delivery of LEN while also reducing its high dose used in conventional therapeutics, nanoformulation approaches can be adopted. The integration of LEN into various nanoformulations, such as nanoparticles, nanocrystals, high density lipoproteins (HDLs), liposomes, and micelles, is discussed, highlighting the advantages of these innovative approaches in a comparative manner; however, given that the current methods of nanoformulation synthesis employ toxic organic solvents and chemicals, there is an imperative need for exploring alternative, environmentally friendly approaches. The multifaceted effects of nanocarriers have rendered them profoundly applicable within the biomedical domain, serving as instrumental entities in various capacities such as vehicles for drug delivery and genetic material, diagnostic agents, facilitators of photothermal therapy, and radiotherapy. However, the scalability of these nanotechnological methodologies must be rigorously investigated and addressed to refine drug delivery mechanisms. This endeavor offers promising prospects for revolutionizing strategies in cancer therapeutics, thereby laying the foundation for future research in scale-up techniques in the pursuit of more effective and less toxic therapies for cancer.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":"8 3","pages":"1749-1784"},"PeriodicalIF":4.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the Impact of Thionine Functionalization on Magnetoelastic Sensor Performance.

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-03-17 Epub Date: 2025-01-29 DOI: 10.1021/acsabm.4c01488

Wenderson R F da Silva, Gilberto Rodrigues-Junior, Eduardo N D de Araújo, Everton Pereira-Andrade, Ângelo Malachias, Joaquim B S Mendes

引用次数: 0

Natural Product-Inspired Vanadium Pentoxide Nanoparticles Unlock Diabetic Therapeutic Potential: In Vitro and In Silico Evaluation. 受天然产物启发的五氧化二钒纳米粒子释放出糖尿病治疗潜力：体外和硅学评估。

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-03-17 Epub Date: 2025-02-13 DOI: 10.1021/acsabm.4c01534

Smriti Bansal, Archana Tomer, Purnima Jain

{"title":"Natural Product-Inspired Vanadium Pentoxide Nanoparticles Unlock Diabetic Therapeutic Potential: In Vitro and In Silico Evaluation.","authors":"Smriti Bansal, Archana Tomer, Purnima Jain","doi":"10.1021/acsabm.4c01534","DOIUrl":"10.1021/acsabm.4c01534","url":null,"abstract":"Mimicking the action of insulin and inhibition of specific enzymes involved in glucose metabolism by vanadium pentoxide (V2O5) make it a candidate for diabetes control, but its low absorption, unpredictable change of oxidation state in body passage, and inadequate ability to bond with the intended site limit its activity. Here, okra extract-capped V2O5 nanoparticles (ONPs) are fabricated, which exhibit significant absorptivity, mucoadhesion, and control release by producing vanadate ions as an intermediate. Further, they have been exploited for the antioxidant, anti-inflammatory, and antidiabetic studies. Characterization results demonstrated the presence of okra extract over the surface of nanoparticles. A capped V2O5 nanodrug exhibited enhanced electroactive rough surface area with groove-shaped pores. Fabricated ONPs were exploited for their antioxidant, anti-inflammatory, and antidiabetic properties. Results achieved from in vitro studies and molecular docking indicate its inhibition properties with 80.00 ± 1.73% and 69.93 ± 1.86% efficiency against α-amylase and α-glucosidase, respectively, without affecting the growth of probiotic Bifidobacterium adolescentis and Bifidobacterium bifidum present in the human gut. The cytotoxicity on the HacaT cell line and the glucose uptake assay on the HepG2 cell line make it a promising candidate as an antidiabetic drug.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"2027-2051"},"PeriodicalIF":4.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Impact of Exosome Chemistry in Cancer.

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-03-17 Epub Date: 2025-02-12 DOI: 10.1021/acsabm.4c01920

Shrishti Madhan, Rajib Dhar, Arikketh Devi

{"title":"Clinical Impact of Exosome Chemistry in Cancer.","authors":"Shrishti Madhan, Rajib Dhar, Arikketh Devi","doi":"10.1021/acsabm.4c01920","DOIUrl":"10.1021/acsabm.4c01920","url":null,"abstract":"As we progress into the 21st century, cancer stands as one of the most dreaded diseases. With approximately one in every four individuals facing a lifetime risk of developing cancer, cancer remains one of the most serious health challenges worldwide. Its multifaceted nature makes it an arduous and tricky problem to diagnose and treat. Over the years, researchers have explored plenty of approaches and avenues to improve cancer management. One notable strategy includes the study of extracellular vesicles (EVs) as potential biomarkers and therapeutics. Among these EVs, exosomes have emerged as particularly promising candidates due to their unique characteristic properties and functions. They are small membrane-bound vesicles secreted by cells carrying a cargo of biomolecules such as proteins, nucleic acids, and lipids. These vesicles play crucial roles in intercellular communication, facilitating the transfer of biological information between cell-to-cell communication. Exosomes transport cargoes such as DNA, RNA, proteins, and lipids involved in cellular reprogramming and promoting cancer. In this review, we explore the molecular composition of exosomes, significance of exosomes chemistry in cancer development, and its theranostic application as well as exosomes research complications and solutions.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"1862-1876"},"PeriodicalIF":4.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143397486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conductive Hybrid Hydrogel of Carbon Nanotubes-Protein-Cellulose: In Vivo Treatment of Diabetic Wound via Photothermal Therapy and Tracking Real-Time Wound Assessment via Photoacoustic Imaging.

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-03-17 Epub Date: 2025-02-19 DOI: 10.1021/acsabm.4c01755

Kaustubh Naik, Shikha Tripathi, Rahul Ranjan, Somesh Agrawal, Shweta Singh, Prodyut Dhar, Kanhaiya Singh, Vinod Tiwari, Avanish Singh Parmar

{"title":"Conductive Hybrid Hydrogel of Carbon Nanotubes-Protein-Cellulose: In Vivo Treatment of Diabetic Wound via Photothermal Therapy and Tracking Real-Time Wound Assessment via Photoacoustic Imaging.","authors":"Kaustubh Naik, Shikha Tripathi, Rahul Ranjan, Somesh Agrawal, Shweta Singh, Prodyut Dhar, Kanhaiya Singh, Vinod Tiwari, Avanish Singh Parmar","doi":"10.1021/acsabm.4c01755","DOIUrl":"10.1021/acsabm.4c01755","url":null,"abstract":"Diabetic wounds pose significant challenges in healthcare due to their slow healing rates and susceptibility to infections, leading to severe complications. In this study, we developed a carbon nanotube-based conductive protein-cellulose hydrogel designed to enhance wound healing through photothermal therapy. The hydrogel's unique properties, including high electrical conductivity and biocompatibility, were assessed in vitro for cell viability, hemolysis, and histological evaluations. In vivo studies on diabetic rats revealed that the hydrogel significantly improved wound healing, with faster wound closure rates. These results were supported by noticeable reductions in inflammatory markers and enhanced blood vessel formation, as observed through immunohistochemical analysis. Additionally, photoacoustic imaging offered real-time data on blood flow and tissue oxygen levels, showing positive trends in the healing process. Overall, these findings point to the potential of this conductive hydrogel, especially when paired with photothermal therapy, to serve as an effective treatment for diabetic wounds, offering promising possibilities in wound care strategies.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"2229-2241"},"PeriodicalIF":4.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Collagen Hybridizing Peptides Promote Collagen Fibril Growth In Vitro.

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-03-17 Epub Date: 2025-02-26 DOI: 10.1021/acsabm.4c01509

Sophia Huang, Nicole Ng, Mina Vaez, Boris Hinz, Iona Leong, Laurent Bozec

{"title":"Collagen Hybridizing Peptides Promote Collagen Fibril Growth In Vitro.","authors":"Sophia Huang, Nicole Ng, Mina Vaez, Boris Hinz, Iona Leong, Laurent Bozec","doi":"10.1021/acsabm.4c01509","DOIUrl":"10.1021/acsabm.4c01509","url":null,"abstract":"Recreating the structural and mechanical properties of native tissues in vitro presents significant challenges, particularly in mimicking the dense fibrillar network of extracellular matrixes such as skin and tendons. This study develops a reversible collagen film through cycling collagen self-assembly and disassembly, offering an innovative approach to address these challenges. We first generated an engineered collagen scaffold by applying plastic compression to the collagen hydrogel. The reversibility of the collagen assembly was explored by treating the scaffold with lactic acid, leading to its breakdown into an amorphous gel─a process termed defibrillogenesis. Subsequent immersion of this gel in phosphate buffer facilitated the reassembly of collagen into fibrils larger than those in the original scaffold yet with the D-banding pattern characteristic of collagen fibrils. Transfer learning of the mobileNetV2 convolutional neural network trained on atomic force microscope images of collagen nanoscale D-banding patterns was created with 99% training and testing accuracy. In addition, extensive external validation was performed, and the model achieved high robustness and generalization with unseen data sets. Further innovation was introduced by applying collagen hybridizing peptides, which significantly accelerated and directed the assembly of collagen fibrils, promoting a more organized and aligned fibrillar structure. This study not only demonstrates the feasibility of creating a reversible collagen film that closely mimics the density and structural properties of the native matrix but also highlights the potential of using collagen hybridizing peptides to control and enhance collagen fibrillogenesis. Our findings offer promising tissue engineering and regenerative medicine strategies by enabling precise manipulation of collagen structures in vitro.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"2003-2014"},"PeriodicalIF":4.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11921027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced Differentiation of Human Neural Stem Cells into Cortical Neurons Using 3D Chitosan Scaffolds.

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-03-17 Epub Date: 2025-02-26 DOI: 10.1021/acsabm.4c01927

Matthew Michael James, Yang Zhou, Miqin Zhang

{"title":"Enhanced Differentiation of Human Neural Stem Cells into Cortical Neurons Using 3D Chitosan Scaffolds.","authors":"Matthew Michael James, Yang Zhou, Miqin Zhang","doi":"10.1021/acsabm.4c01927","DOIUrl":"10.1021/acsabm.4c01927","url":null,"abstract":"Human neural stem cells (hNSCs) have the potential to differentiate into various neural cell types, including cortical neurons, which are of particular interest for understanding and treating neurodegenerative diseases. However, traditional 2D culture methods are limited in their ability to accurately mimic the physiologically relevant microenvironment, leading to slow differentiation rates and low yields of mature neurons. In this study, we developed and optimized 3D chitosan scaffolds to promote the more efficient differentiation of hNSCs into cortical neurons. These scaffolds provide a tunable, biocompatible, and mechanically favorable environment, supporting enhanced cell-to-cell interactions and mimicking the extracellular matrix more effectively than 2D systems. The differentiation process was further accelerated by preseeding scaffolds with hNSCs, leading to increased expression of key cortical neuron markers, such as MAP2 and TUBB3, within a 14-day period. Compared to Geltrex-coated controls, the preseeded scaffolds demonstrated superior cell adhesion, viability, and differentiation efficiency, with significant upregulation of mature cortical neuron markers. Our findings suggest that chitosan-based 3D culture systems represent a promising platform for improving the differentiation of hNSCs, offering a faster and more reliable method to generate cortical neurons for neurodegenerative disease research and potential therapeutic applications.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"2469-2481"},"PeriodicalIF":4.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation of Metal-Polyphenol Modified Zeolitic Imidazolate Framework-8 Nanoparticles for Cancer Drug Delivery. 制备用于癌症药物传输的金属-多酚修饰唑基咪唑啉框架-8 纳米粒子

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-03-17 Epub Date: 2025-02-14 DOI: 10.1021/acsabm.4c01608

Giao Thuy-Quynh Vu, Luan Minh Nguyen, Kim Ngan Nguyen Do, Dieu Linh Tran, Toi Van Vo, Dai Hai Nguyen, Long Binh Vong

{"title":"Preparation of Metal-Polyphenol Modified Zeolitic Imidazolate Framework-8 Nanoparticles for Cancer Drug Delivery.","authors":"Giao Thuy-Quynh Vu, Luan Minh Nguyen, Kim Ngan Nguyen Do, Dieu Linh Tran, Toi Van Vo, Dai Hai Nguyen, Long Binh Vong","doi":"10.1021/acsabm.4c01608","DOIUrl":"10.1021/acsabm.4c01608","url":null,"abstract":"With the rising incidence of cancer, chemotherapy has become a widely used treatment approach. However, the use of anticancer drugs such as doxorubicin (DOX) poses significant long-term risks due to its nonspecific distribution and severe side effects. Therefore, developing a nanoparticle-based drug delivery system (DDS) that enhances the bioavailability of DOX specifically to cancer cells is crucial while minimizing its side effects on normal cells. This study employed zeolitic imidazolate framework-8 (ZIF-8) as a DDS to encapsulate DOX using a one-pot method. The surface of this system was subsequently modified with a copper-gallic acid (Cu-GA) complex to form the Cu-GA/DOX@ZIF-8 (CGDZ) system. The CGDZ system effectively encapsulates DOX and demonstrates pH-responsive drug release, facilitating controlled drug release in the acidic environment of cancer cells. Furthermore, the Cu-GA coating enhances the biocompatibility of the material, reduces drug toxicity in normal endothelial cells (BAECs) due to the antioxidant feature of modified GA, and maintains the efficacy and intracellular trafficking of DOX in colon cancer cells (C-26). Interestingly, CGDZ nanoparticles showed significantly higher toxicity against cancer cells as compared to unmodified systems and free DOX. Overall, CGDZ exhibited significant in vitro efficacy in targeting cancer cell lines while reducing the toxicity of DOX, offering a novel and effective nanoparticle system for targeted cancer treatment.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"2052-2064"},"PeriodicalIF":4.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0