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Factors Predicting Dysphonia in Professional Voice Users. 专业嗓音使用者发音障碍的预测因素
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-01-01 Epub Date: 2022-08-10 DOI: 10.1016/j.jvoice.2022.07.010
Priscila Oliveira, Maria Eduarda de Oliveira Barbosa Cavalcante, Cássia Abrantes do Nascimento, Vanessa Veis Ribeiro
{"title":"Factors Predicting Dysphonia in Professional Voice Users.","authors":"Priscila Oliveira, Maria Eduarda de Oliveira Barbosa Cavalcante, Cássia Abrantes do Nascimento, Vanessa Veis Ribeiro","doi":"10.1016/j.jvoice.2022.07.010","DOIUrl":"10.1016/j.jvoice.2022.07.010","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the contribution of organizational, environmental, and personal factors in predicting dysphonia in professional voice users.</p><p><strong>Study design: </strong>This was a cross-sectional documentary study.</p><p><strong>Methods: </strong>The study sample consisted of 128 professional voice users (104 female and 24 male), with a mean age of 39.3 years. Dysphonia (laryngeal disorder associated with vocal complaints) was defined as the dependent variable. Organizational, environmental, and personal factors were defined as independent variables. Logistic regression models were used as predictive methods for data analysis. Evaluation and interpretation of the final model were performed using the ROC curve, odds ratio, and probability estimation.</p><p><strong>Results: </strong>Professional voice users exposed to low humidity and who talked a lot on their phones were less likely to be dysphonic than individuals who were not exposed to these factors. Those exposed to excessive vocal demand and who reported talking with effort were more likely to be dysphonic than those who were not exposed to these factors. The accuracy of the prediction model was 80.8%.</p><p><strong>Conclusions: </strong>Exposure to low humidity and talking a lot on the phone were protective factors. However, excessive vocal demand and straining were risk factors for predicting the presence of dysphonia in professional voice users with high accuracy.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"178-184"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40625163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term Average Spectrum and Nasal Accelerometry in Sentences of Differing Nasality and Forward-Focused Vowel Productions Under Altered Auditory Feedback. 在改变的听觉反馈下,不同鼻音和前向元音发音句子中的长期平均频谱和鼻音加速度。
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-01-01 Epub Date: 2022-08-30 DOI: 10.1016/j.jvoice.2022.07.026
Shao-Hsuan Lee, Guo-She Lee
{"title":"Long-term Average Spectrum and Nasal Accelerometry in Sentences of Differing Nasality and Forward-Focused Vowel Productions Under Altered Auditory Feedback.","authors":"Shao-Hsuan Lee, Guo-She Lee","doi":"10.1016/j.jvoice.2022.07.026","DOIUrl":"10.1016/j.jvoice.2022.07.026","url":null,"abstract":"<p><strong>Objectives and background: </strong>To investigate whether voice focus adjustments can alter the audio-vocal feedback and consequently modulate speech/voice motor control. Speaking with a forward-focused voice was expected to enhance audio-vocal feedback and thus decrease the variability of vocal fundamental frequency (F0).</p><p><strong>Materials and method: </strong>Twenty-two healthy, untrained adults (10 males and 12 females) were requested to sustain vowel /a/ with their natural focus and a forward focus and to naturally read the nasal, oral, and mixed oral-nasal sentences in normal noise-masked auditory conditions. Meanwhile, a miniature accelerometer was externally attached on the noise to detect the nasal vibrations during vocalization. Audio recordings were made and analyzed using the long-term average spectrum (LTAS) and power spectral analysis of F0.</p><p><strong>Results: </strong>Compared with naturally-focused vowel production and oral sentences, forward-focused vowel productions and nasal sentences both showed significant increases in nasal accelerometric amplitude and the spectral power within the range of 200∼300 Hz, and significantly decreased the F0 variability below 3 Hz, which has been reported to be associated with enhanced auditory feedback in our previous research. The auditory masking not only significantly increased the low-frequency F0 variability, but also significantly decreased the ratio of the spectral power within 200∼300 Hz to the power within 300∼1000 Hz for the vowel and sentence productions. Gender differences were found in the correlations between the degree of nasal coupling and F0 stability as well as in the LTAS characteristics in response to noise.</p><p><strong>Conclusions: </strong>Variations in nasal-oral acoustic coupling not only change the formant features of speech signals, but involuntarily influence the auditory feedback control of vocal fold vibrations. Speakers tend to show improved F0 stability in response to a forward-focused voice adjustment.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"25-36"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40339757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inflammatory Reactions to Laryngeal Injection of Hyaluronic Acid Derivatives. 喉部注射透明质酸衍生物的炎症反应。
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-01-01 Epub Date: 2022-08-06 DOI: 10.1016/j.jvoice.2022.07.003
Alhasan N Elghouche, Obinna I Nwosu, Alexander J Jones, Timothy J Shin, Bruce H Matt, Benjamin P Anthony
{"title":"Inflammatory Reactions to Laryngeal Injection of Hyaluronic Acid Derivatives.","authors":"Alhasan N Elghouche, Obinna I Nwosu, Alexander J Jones, Timothy J Shin, Bruce H Matt, Benjamin P Anthony","doi":"10.1016/j.jvoice.2022.07.003","DOIUrl":"10.1016/j.jvoice.2022.07.003","url":null,"abstract":"<p><strong>Objectives/hypothesis: </strong>To report the rate and describe the characteristics and management of inflammatory reactions following injection laryngoplasty with hyaluronic acid derivatives.</p><p><strong>Study design: </strong>Single institution, retrospective review.</p><p><strong>Methods: </strong>Adult and pediatric patients who underwent injection laryngoplasty with hyaluronic acid derivatives from 2013 to 2020 were identified. Demographics, indication for injection, type and volume of injected material, and use of general anesthesia were obtained. When a postoperative inflammatory response occurred, information regarding clinical presentation, timing, and subsequent management was collected.</p><p><strong>Results: </strong>A total of 464 patients who underwent 536 laryngeal injections with hyaluronic acid derivatives were included. There were 365 adult patients (median age 62 years) who underwent 431 injections and 99 pediatric patients (median age 2 years) who underwent 105 injections. The most common indications for injection were abnormal vocal fold mobility (70.3%) and aspiration (83.8%) for adult and pediatric patients, respectively. Juvéderm® was used in 449 cases (79.8% adult, 100% pediatric), and Restylane® was used in the remaining adult cases (20.2%). Procedures were mostly performed under general anesthesia (67.7% adult, 100% pediatric) with median injection volumes of 0.6 mL for adult and 0.3 mL for pediatric patients. An inflammatory reaction occurred following 3 of 536 injections (0.6%), all utilizing Juvéderm®. All three patients presented with stridor, dyspnea, and laryngeal edema within two days of injection. Each patient was admitted for observation and successfully treated with intravenous steroids and inhaled racemic epinephrine. One patient with comorbid pneumonia was intubated and required concomitant treatment with broad-spectrum antibiotics.</p><p><strong>Conclusions: </strong>Inflammatory reactions to hyaluronic acid derivatives used in injection laryngoplasty are rare but represent significant patient morbidity and can be managed with anti-inflammatory and airway stabilizing measures. Patients should be counseled appropriately regarding the risks of injection laryngoplasty with hyaluronic acid derivatives.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"269-273"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40597609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of Voice Therapy With Acapella Choice ® Device in Subjects With Vocal Fatigue Delivered Via Telepractice. 使用 Acapella Choice ® 设备通过远程练习对嗓音疲劳患者进行嗓音治疗的效果。
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-01-01 Epub Date: 2022-09-22 DOI: 10.1016/j.jvoice.2022.07.027
Marco Guzman, Andrés Ortega, Camila Rocha, Lia Salgado, Camilo Quezada
{"title":"Efficacy of Voice Therapy With Acapella Choice ® Device in Subjects With Vocal Fatigue Delivered Via Telepractice.","authors":"Marco Guzman, Andrés Ortega, Camila Rocha, Lia Salgado, Camilo Quezada","doi":"10.1016/j.jvoice.2022.07.027","DOIUrl":"10.1016/j.jvoice.2022.07.027","url":null,"abstract":"<p><strong>Purpose: </strong>The present study aimed at assessing the effectiveness of remote voice therapy (telepractice) implemented with Acapella Choice device in subjects with vocal fatigue.</p><p><strong>Methods: </strong>Thirty participants with vocal fatigue were randomly assigned to one of two treatment groups: (1) voice treatment with acapella Choice device plus vocal hygiene program (n=15), and (2) voice treatment with Water resistance therapy plus vocal hygiene program (n=15). Laryngoscopic assessment was conducted in all subjects to confirm diagnosis. Before and after voice therapy, participants underwent self-assessment of voice. Vocal Fatigue Index (VFI), Voice Handicap Index (VHI), and Vocal tract discomfort scale (VTDS) were used. Treatment period included six voice therapy sessions within 3 weeks, with a frequency of two therapy sessions per week. Each session lasted 30 minutes. For both groups, exercises consisted of a sequence of nine phonatory tasks performed with Acapella Choice (experimental group) and WRT (control group). Comparison for all variables were performed between experimental group and control group.</p><p><strong>Results: </strong>Significant improvements were found when comparing Pre and Post measures for both groups. No significant differences were found when comparing Acapella Choice group and WRT group.</p><p><strong>Conclusion: </strong>Remote physiologic voice therapy with Acapella Choice device and water resistance therapy seem to be both effective to improve voice in subjects diagnosed with vocal fatigue. No differences should be expected between these therapeutic protocols when treating patients with vocal fatigue. Moreover, both are effective at reducing tiredness of voice, voice avoidance, physical discomfort associated with voicing, subjective perception of sensory discomfort in throat, and reduction of physical, emotional, and functional impact of voice problems.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"281.e11-281.e18"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33481659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Introducing a New Dosimeter for the Assessment and Monitoring of Vocal Risk Situations and Voice Disorders. 介绍一种用于评估和监测嗓音风险状况和嗓音疾病的新型剂量计。
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-01-01 Epub Date: 2022-10-07 DOI: 10.1016/j.jvoice.2022.08.007
Marcos Llorente-Ortega, Adam Podhorski, Secundino Fernandez
{"title":"Introducing a New Dosimeter for the Assessment and Monitoring of Vocal Risk Situations and Voice Disorders.","authors":"Marcos Llorente-Ortega, Adam Podhorski, Secundino Fernandez","doi":"10.1016/j.jvoice.2022.08.007","DOIUrl":"10.1016/j.jvoice.2022.08.007","url":null,"abstract":"<p><strong>Purpose: </strong>There are many physiological parameters recorded by devices that are becoming more affordable, precise and accurate. However, the lack of development in the recording of voice parameters from the physiological or medical point of view is striking, given that it is a fundamental tool for the work of many people and given the high incidence and prevalence of voice pathologies that affect people's communication. In this paper we perform a complete literature review on the dosimeters used in voice research and to present a prototype dosimeter with a pilot study to show its capabilities.</p><p><strong>Method: </strong>We conducted a literature review using the keywords [MONITORING], [PHONATION], [ACCUMULATOR], [PORTABLE], [DOSIMETRY], [VOICE] searching in PubMed, Trip Database, HONcode, and SciELO search engines. From our review of dosimeter designs, we created our own prototype consisting of two main components: a Knowles Electronics BU-7135-0000 accelerometer mounted on a neck brace; and the ultra-low power MSP430FR5994 microcontroller. The selected sampling frequency was 2048 Hz. The device calculates the F0 every 250 ms and the amplitude and phonation activity every 31.25 ms. A pilot study was conducted using 2 subjects: one male during 11 days and one female during 14 days.</p><p><strong>Results: </strong>This work includes devices that have been created during the last 45 years as tools for the diagnosis and monitoring of the treatment of cases of vocal pathology and for the detection of phonatory patterns or risk situations for developing voice disorders or vocal pathologies. We also present recordings with our new device on the pattern of daily talk time, the fundamental frequency and the relative intensity of two subjects on different days.</p><p><strong>Conclusions: </strong>Interesting work has been done in the development of voice dosimeters with different approaches. In our experience it is not possible to access them for research and they are not yet in clinical use. It is possible that a joint approach with voice and voice disorders professionals and engineers working closely together could take advantage of current technology to develop a fully portable, useful, and efficient system.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"220-229"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33494619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validity and Reliability of the Persian Version of Reflux Symptom Score-12 in Patients with Laryngopharyngeal Reflux Disease. 波斯语版《反流症状评分-12》在喉咽反流病患者中的有效性和可靠性。
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-01-01 Epub Date: 2022-08-25 DOI: 10.1016/j.jvoice.2022.07.022
Azin Kohansal, Seyyedeh Maryam Khoddami, Noureddin Nakhostin Ansari, Jerome R Lechien, Kayvan Aghazadeh
{"title":"Validity and Reliability of the Persian Version of Reflux Symptom Score-12 in Patients with Laryngopharyngeal Reflux Disease.","authors":"Azin Kohansal, Seyyedeh Maryam Khoddami, Noureddin Nakhostin Ansari, Jerome R Lechien, Kayvan Aghazadeh","doi":"10.1016/j.jvoice.2022.07.022","DOIUrl":"10.1016/j.jvoice.2022.07.022","url":null,"abstract":"<p><strong>Objective: </strong>Cross cultural adaptation of the reflux symptom score-12 (RSS-12) into Persian language and to evaluate its validity and reliability in the assessment of patients with laryngopharyngeal reflux disease (LPRD).</p><p><strong>Study design: </strong>A cross-sectional and prospective cohort design.</p><p><strong>Methods: </strong>A standard forward and backward translation was followed to cross-culturally adapt the RSS-12 into Persian language. To study discriminative validity, the RSS-12p was administrated to 63 patients with LPRD (40 men and 23 women; mean age: 39.26 ± 9.79 years) and 50 healthy volunteers (31 men and 19 women; mean age: 37.24 ± 10.28 years). The patients completed the reflux symptom index (RSI) to assess construct validity. The test-retest reliability was investigated in 31 patients (time interval = 7 days).</p><p><strong>Results: </strong>There were no missing responses and floor or ceiling effects. The assessing of discriminative validity showed that the questionnaire was able to discriminate between patients with LPRD and healthy participants (P<0.001). Construct validity was confirmed by the Pearson correlation between the RSS-12p and the RSI (r<sub>p</sub>= 0.87; P<0.00). The internal consistency was confirmed with Cronbach α 0.85 and 0.72 for the RSS-12p and quality of life (QoL), respectively. Test-retest reliability was excellent (ICC<sub>agreement</sub> = 0.98 for the RSS-12p and 0.94 for QoL).</p><p><strong>Conclusions: </strong>The Persian version of RSS-12 is a valid and reliable self-administered questionnaire for assessing LPRD in Persian-speaking patients.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"279.e21-279.e26"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40447570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of Breath-holding Pulling Exercise in Patients with Vocal Fold Atrophy. 憋气牵拉运动对声带萎缩患者的效果
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-01-01 Epub Date: 2022-08-18 DOI: 10.1016/j.jvoice.2022.06.036
Ray Motohashi, Ryoji Tokashiki, Ujimoto Konomi, Eriko Sakurai, Yu Saito, Yusuke Shoji, Ayaka Osanai, Kiyoaki Tsukahara
{"title":"Effectiveness of Breath-holding Pulling Exercise in Patients with Vocal Fold Atrophy.","authors":"Ray Motohashi, Ryoji Tokashiki, Ujimoto Konomi, Eriko Sakurai, Yu Saito, Yusuke Shoji, Ayaka Osanai, Kiyoaki Tsukahara","doi":"10.1016/j.jvoice.2022.06.036","DOIUrl":"10.1016/j.jvoice.2022.06.036","url":null,"abstract":"<p><strong>Objective: </strong>In recent years, the incidence of vocal fold atrophy has increased among the elderly. Vocal function exercises (VFE) are performed in patients with age-related vocal fold atrophy; however, treatment could be challenging if the patient is unable to go to the hospital or in hospitals that do not have a speech pathologist. Breath-holding pulling exercises are simple and can be performed anywhere for the management of such patients. This study aimed to examine the effectiveness of breath-holding pulling exercises in patients with vocal fold atrophy.</p><p><strong>Study design: </strong>Retrospective study METHODS: With the hands folded in front of the chest, the patients were instructed to take a deep breath, pull their hands to the left and right, and then hold their breath for 5 seconds. The physician instructed the patients to do this 10 times each morning, afternoon, and evening. Speech function, acoustic analysis, pitch range, and Voice Handicap Index-10 (VHI-10) were evaluated and compared before and 4-8 weeks after treatment.</p><p><strong>Results: </strong>Maximum phonation time (MPT), the primary endpoint, significantly improved after treatment from 14.2 ± 6.6 to 20.3 ± 9.3 seconds. Among the secondary endpoints, mean flow rate (207.5 ± 104.4 to 165.1 ± 66.5 mL/s), pitch range (22.9 ± 8.3 to 26.2 ± 8.1 semitones), VHI-10 (18.1 ± 7.2 to 12.5 ± 6.3 points) jitter (2.5±1.6 to 1.7±1.2%), and shimmer (5.9±3.5 to 4.8±3.3%) showed significant improvement.</p><p><strong>Conclusion: </strong>Breath-holding pulling exercises were found to be effective in patients with vocal fold atrophy. These can be performed in hospitals with no speech pathologists, in patients who are unable to go to the hospital, and in patients who are hospitalized or unable to speak loudly. Moreover, as with conventional VFE, the training method achieves a high level of patient satisfaction.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"282.e29-282.e35"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40626730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic Role of the Initial Grade of Dysplasia on Premalignant Vocal Fold Lesions. 声带增生初期等级对恶性声带病变的预后作用
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-01-01 Epub Date: 2022-09-06 DOI: 10.1016/j.jvoice.2022.07.015
João Viana Pinto, José João Ruas, João Aragão Rodrigues, Isabel Pinto, Manuel Leal, Fernando Vales, Carla Pinto Moura
{"title":"Prognostic Role of the Initial Grade of Dysplasia on Premalignant Vocal Fold Lesions.","authors":"João Viana Pinto, José João Ruas, João Aragão Rodrigues, Isabel Pinto, Manuel Leal, Fernando Vales, Carla Pinto Moura","doi":"10.1016/j.jvoice.2022.07.015","DOIUrl":"10.1016/j.jvoice.2022.07.015","url":null,"abstract":"<p><strong>Purpose: </strong>The main objective of this study was to analyze the prognostic role of the initial grade of dysplasia on the progression to SCC.</p><p><strong>Study design: </strong>Retrospective cohort.</p><p><strong>Methods: </strong>This study was performed in the Otorhinolaryngology Department of a tertiary hospital center from January 2010 to December 2020. Every patient submitted to a microlaryngoscopy during this period with a histology of dysplasia on the first biopsy was included.</p><p><strong>Results: </strong>A total of 112 patients were included and median follow-up was 24 months (range 1-120 months). Mean age at diagnosis was 59.71 (+/- 12.03) and 88 patients were male (78.6%). Initial grade of dysplasia was mild on 60 patients (53.6%), moderate on 24 (21.4%), severe on 18 (16.1%), and carcinoma in situ in 10 (8.9%). Overall, 25 patients (21.4%) developed invasive squamous cell carcinoma (SCC) and 15 (13.4%) died during follow-up. On an adjusted 5 year's progression free survival analysis, considering gender, age, dysplasia grade, tobacco and alcohol consumption, the initial grade of dysplasia was the only factor significantly associated with progression to carcinoma (P = .047). When compared to mild dysplasia, moderate dysplasia had a Hazard Ratio (HR) of 0.81 (95%CI 0.21-3.22); severe dysplasia had a HR of 1.76 (95%CI 0.59-5.30) and carcinoma in situ had a HR of 4.25 (95%CI 1.44-12.59).</p><p><strong>Conclusion: </strong>The initial dysplasia grade seems to be the most important prognostic factor regarding progression to SCC in patients with premalignant vocal fold disease.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"238-244"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33450245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnosis of Early Glottic Cancer Using Laryngeal Image and Voice Based on Ensemble Learning of Convolutional Neural Network Classifiers. 基于卷积神经网络分类器的集合学习,利用喉部图像和声音诊断早期声门癌
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-01-01 Epub Date: 2022-09-06 DOI: 10.1016/j.jvoice.2022.07.007
Ickhwan Kwon, Soo-Geun Wang, Sung-Chan Shin, Yong-Il Cheon, Byung-Joo Lee, Jin-Choon Lee, Dong-Won Lim, Cheolwoo Jo, Youngseuk Cho, Bum-Joo Shin
{"title":"Diagnosis of Early Glottic Cancer Using Laryngeal Image and Voice Based on Ensemble Learning of Convolutional Neural Network Classifiers.","authors":"Ickhwan Kwon, Soo-Geun Wang, Sung-Chan Shin, Yong-Il Cheon, Byung-Joo Lee, Jin-Choon Lee, Dong-Won Lim, Cheolwoo Jo, Youngseuk Cho, Bum-Joo Shin","doi":"10.1016/j.jvoice.2022.07.007","DOIUrl":"10.1016/j.jvoice.2022.07.007","url":null,"abstract":"<p><strong>Objectives: </strong>The purpose of study is to improve the classification accuracy by comparing the results obtained by applying decision tree ensemble learning, which is one of the methods to increase the classification accuracy for a relatively small dataset, with the results obtained by the convolutional neural network (CNN) algorithm for the diagnosis of glottal cancer.</p><p><strong>Methods: </strong>Pusan National University Hospital (PNUH) dataset were used to establish classifiers and Pusan National University Yangsan Hospital (PNUYH) dataset were used to verify the classifier's performance in the generated model. For the diagnosis of glottic cancer, deep learning-based CNN models were established and classified using laryngeal image and voice data. Classification accuracy was obtained by performing decision tree ensemble learning using probability through CNN classification algorithm. In this process, the classification and regression tree (CART) method was used. Then, we compared the classification accuracy of decision tree ensemble learning with CNN individual classifiers by fusing the laryngeal image with the voice decision tree classifier.</p><p><strong>Results: </strong>We obtained classification accuracy of 81.03 % and 99.18 % in the established laryngeal image and voice classification models using PNUH training dataset, respectively. However, the classification accuracy of CNN classifiers decreased to 73.88 % in voice and 68.92 % in laryngeal image when using an external dataset of PNUYH. To solve this problem, decision tree ensemble learning of laryngeal image and voice was used, and the classification accuracy was improved by integrating data of laryngeal image and voice of the same person. The classification accuracy was 87.88 % and 89.06 % for the individualized laryngeal image and voice decision tree model respectively, and the fusion of the laryngeal image and voice decision tree results represented a classification accuracy of 95.31 %.</p><p><strong>Conclusion: </strong>The results of our study suggest that decision tree ensemble learning aimed at training multiple classifiers is useful to obtain an increased classification accuracy despite a small dataset. Although a large data amount is essential for AI analysis, when an integrated approach is taken by combining various input data high diagnostic classification accuracy can be expected.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"245-257"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33450243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Virtual Instruction on Educators' Voices During the COVID-19 Pandemic. 虚拟教学对 COVID-19 大流行期间教育工作者声音的影响。
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-01-01 Epub Date: 2022-08-15 DOI: 10.1016/j.jvoice.2022.08.012
Serina Addona, Paul M Evitts
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