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ACS Applied Bio Materials最新文献

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Improving Soft Tissue Integration of Acrylic Resin by Compositing with Bioactive Glass. 生物活性玻璃复合材料改善丙烯酸树脂的软组织整合。
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-07-21 Epub Date: 2025-07-02 DOI: 10.1021/acsabm.5c00655
Baokui Li, Jilin Wu, Yanmei Dong, Dong Qiu
{"title":"Improving Soft Tissue Integration of Acrylic Resin by Compositing with Bioactive Glass.","authors":"Baokui Li, Jilin Wu, Yanmei Dong, Dong Qiu","doi":"10.1021/acsabm.5c00655","DOIUrl":"10.1021/acsabm.5c00655","url":null,"abstract":"<p><p>With the extensive application of implants in tissue and organ repair, their integration with surrounding tissues is attracting increasing attention. Soft tissue is characterized by high dynamic strain and a complex immune microenvironment, imposing stringent requirements on the mechanical properties, biocompatibility, and surface characteristics of implanted materials. Therefore, compared to the success in implant/hard tissue integration, implant/soft tissue integration remains challenging, and failure to form a stable implant/soft tissue interface is often observed, leading to inflammation, tissue rejection, or even implant failure. To address this issue, we developed acrylic resin/bioactive glass composites. It was found that compositing bioactive glass significantly improved the soft tissue integration of the acrylic resin and effectively reduced its inflammatory response. A demonstration of the obtained composite in subgingival dentin defect restoration showed improved gingival covering and biological seal, highlighting its potential applications in cases where soft tissue integration is essential.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"6100-6108"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Digital Light Processing of Methacrylated Silk Fibroin Microneedles: Precision Engineering for Enhanced Transdermal Delivery and Skin Regeneration. 甲基丙烯酸丝素微针的数字光处理：增强透皮传递和皮肤再生的精密工程。
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-07-21 Epub Date: 2025-07-07 DOI: 10.1021/acsabm.5c00621
Fangzheng Tong, Xuyang Zhang, Xuanwen Wang, Siying Liu, Xiaoliang Cui, Yajie Zhou, Gang Li, Jun Zhang
{"title":"Digital Light Processing of Methacrylated Silk Fibroin Microneedles: Precision Engineering for Enhanced Transdermal Delivery and Skin Regeneration.","authors":"Fangzheng Tong, Xuyang Zhang, Xuanwen Wang, Siying Liu, Xiaoliang Cui, Yajie Zhou, Gang Li, Jun Zhang","doi":"10.1021/acsabm.5c00621","DOIUrl":"10.1021/acsabm.5c00621","url":null,"abstract":"<p><p>Despite the promising potential of digital light processing (DLP)─fabricated silk fibroin (SF) microneedles (MNs) in transdermal applications, their clinical translation faces two major challenges: insufficient manufacturing precision to achieve architectural resolution and inadequate mechanical strength to penetrate the epidermis effectively. To overcome these critical barriers, we developed a methacrylated silk fibroin (Sil-MA) bioink that combines high biocompatibility with enhanced printability. By systematically optimizing material formulation, printing parameters and MN geometry, we successfully fabricated DLP-printed Sil-MA MNs with precise architecture control and superior mechanical performance. These MNs demonstrated no cytotoxicity and enabled efficient transdermal delivery of three distinct dermatological therapeutics. Comprehensive in vitro and in vivo assessments indicated that the DLP-printed Sil-MA MNs also acted as mechanical stimulators, significantly promoting epidermal keratinocyte proliferation. This engineered platform offers a versatile strategy for developing multifunctional MN systems for therapeutic delivery and tissue engineering applications.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"6025-6039"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surface-Adaptive Gold-Based Nanoplatform for Low-Temperature Photothermal Treatment of Urinary Tract Infection. 表面自适应金基纳米平台低温光热治疗尿路感染。
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-07-21 Epub Date: 2025-07-10 DOI: 10.1021/acsabm.5c00369
Zhuang Liu, Jiahui Wu, Qing Li, Jinxia An
{"title":"Surface-Adaptive Gold-Based Nanoplatform for Low-Temperature Photothermal Treatment of Urinary Tract Infection.","authors":"Zhuang Liu, Jiahui Wu, Qing Li, Jinxia An","doi":"10.1021/acsabm.5c00369","DOIUrl":"10.1021/acsabm.5c00369","url":null,"abstract":"<p><p>Urinary tract infections (UTIs) caused by uropathogenic <i><i>Escherichia coli</i></i> (UPEC) have become a matter of concern because of the clinical use of multiple antibiotics, which results in antibiotic resistance in bacteria and causes the failure of treatments. Photothermal therapy (PTT) has been a high-potential method in antibacterial therapy on account of its noninvasion and avoiding bacterial resistance. However, high temperatures and nonselectivity related to PTT would cause serious damage to the surrounding healthy tissue. Herein, a surface-adaptive gold-based nanoplatform (AuNPs@GalNAc/DMMA-Cys) by conjugating N-acetylgalactosaminoside (GalNAc) and maleimidized cysteine (DMMA-Cys) on gold nanoparticles for low-temperature photothermal antibacterial therapy was proposed. The AuNPs@GalNAc/DMMA-Cys was characterized by the pH-activated photothermal effect on account of the translation from negative property to zwitterionic structure of DMMA-Cys and high adhesion toward UPEC originating from the recognition of GalNAc to FmlH protein. It can kill UPEC under low photothermal temperature but perform poorly against <i>S. aureus</i>. This approach may develop a promising tool for low-temperature photothermal antibacterial treatment.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"5680-5688"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144598871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-07-21
Anastasia Kryuchkova, Mariia Mikhailova, Pavel Zelenovskii, Igor Bdikin, Andrei Kholkin, Elena F. Krivoshapkina and Pavel V. Krivoshapkin*, 
{"title":"","authors":"Anastasia Kryuchkova,&nbsp;Mariia Mikhailova,&nbsp;Pavel Zelenovskii,&nbsp;Igor Bdikin,&nbsp;Andrei Kholkin,&nbsp;Elena F. Krivoshapkina and Pavel V. Krivoshapkin*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":"8 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsabm.5c00680","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-07-21
Ishana Kathuria, Subash Pandey, Ronald J. Schwandt, Peter Agyemang, Dilka Liyana Arachchige, Sushil K. Dwivedi, Henry Lanquaye, Haiying Liu* and Rudy L. Luck*, 
{"title":"","authors":"Ishana Kathuria,&nbsp;Subash Pandey,&nbsp;Ronald J. Schwandt,&nbsp;Peter Agyemang,&nbsp;Dilka Liyana Arachchige,&nbsp;Sushil K. Dwivedi,&nbsp;Henry Lanquaye,&nbsp;Haiying Liu* and Rudy L. Luck*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":"8 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsabm.5c00978","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-07-21
Lin Zhang, Yongsheng Du, Weixin Wang, Rui Gao, Yu Dong, Qiaoyun Wang and Fei Tong*, 
{"title":"","authors":"Lin Zhang,&nbsp;Yongsheng Du,&nbsp;Weixin Wang,&nbsp;Rui Gao,&nbsp;Yu Dong,&nbsp;Qiaoyun Wang and Fei Tong*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":"8 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsabm.5c00433","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-07-21
Prakash Kumar Sirvi, Paul Gajanan Balaji, Amit Kumar, Md Imtiyaz Alam, Ankita Sharma, Nabanita Das and Awesh Kumar Yadav*, 
{"title":"","authors":"Prakash Kumar Sirvi,&nbsp;Paul Gajanan Balaji,&nbsp;Amit Kumar,&nbsp;Md Imtiyaz Alam,&nbsp;Ankita Sharma,&nbsp;Nabanita Das and Awesh Kumar Yadav*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":"8 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsabm.5c00482","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-07-21
Chenhui Liu, Sikun Meng, Huachun Wang, Tianzhen Zhang, Cheng Qi, Mei Li and Jingyang Kang*, 
{"title":"","authors":"Chenhui Liu,&nbsp;Sikun Meng,&nbsp;Huachun Wang,&nbsp;Tianzhen Zhang,&nbsp;Cheng Qi,&nbsp;Mei Li and Jingyang Kang*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":"8 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsabm.4c01869","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-07-21
Ankita Dhiman, Piyush Thaper, Kailash Chandra Naga and Garima Agrawal*, 
{"title":"","authors":"Ankita Dhiman,&nbsp;Piyush Thaper,&nbsp;Kailash Chandra Naga and Garima Agrawal*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":"8 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsabm.5c00109","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-07-21
Peng Sun, Hao Cui, Changwei Ren, Chenzhen Xu, Chuanjie Yue, Jing’an Li* and Yongqiang Lai*, 
{"title":"","authors":"Peng Sun,&nbsp;Hao Cui,&nbsp;Changwei Ren,&nbsp;Chenzhen Xu,&nbsp;Chuanjie Yue,&nbsp;Jing’an Li* and Yongqiang Lai*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":"8 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsabm.5c00589","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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