ACS Applied Bio Materials最新文献_第6页

Polymer-Based Designer Particles as Drug Carriers: Strategies to Construct and Modify. 基于聚合物的设计粒子作为药物载体：构建和修饰策略。

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-05-23 DOI: 10.1021/acsabm.5c00041

Nidhi Gupta, Sampa Saha

{"title":"Polymer-Based Designer Particles as Drug Carriers: Strategies to Construct and Modify.","authors":"Nidhi Gupta, Sampa Saha","doi":"10.1021/acsabm.5c00041","DOIUrl":"https://doi.org/10.1021/acsabm.5c00041","url":null,"abstract":"Biological barriers present remarkable challenges for therapeutics delivery, requiring an advanced drug delivery system that can navigate through the complex physiological environment. Polymeric particles provide remarkable versatility due to their adaptable physiochemical properties, facilitating new designs that address complex delivery issues. This review focuses on recent advancements in the morphology of polymeric particles that emulate biological barriers to improve drug efficacy. It includes how structural engineering─such as designing rod-shaped particles for improved cellular uptake, red-blood-cell-shaped particles for prolonged circulation, worm-shaped carriers for improved tissue penetration, and multicompartmental systems for providing combination therapies─profoundly alters drug delivery capabilities. These designer particles exhibit enhanced target specificity, controlled release kinetics, and improved therapeutic outcomes relative to traditional spherical carriers. This particular review also emphasizes how a combination of polymer chemistry and fabrication methods facilitates achieving these advanced structures, while highlighting ongoing challenges in scale-up, reproducibility, and clinical translations. Through the analysis of structure-functional property correlations in various biomimetic designs, we have also attempted to provide insight into future advancements in polymeric delivery systems that have the potential to transform treatment strategies for complicated diseases via shape-directed biological interactions for better therapeutic outcomes.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phosphorus Phthalocyanine-Based NIR-II Nanoparticles for Photoacoustic Imaging and Photothermal Therapy of Thrombus. 基于酞菁磷的NIR-II纳米颗粒用于血栓的光声成像和光热治疗。

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-05-22 DOI: 10.1021/acsabm.5c00522

Zhaoyang Liu, Yufeng Zhu, Yilan Jin, Rong Wang, Junjie Xia, Yingqiao Wang, Hong Yang, Changxin Shen, Shiping Yang, Zhiguo Zhou

引用次数: 0

Correction to "In Situ Printing of Adhesive Hydrogel Scaffolds for the Treatment of Skeletal Muscle Injuries". 修正“原位打印黏附水凝胶支架治疗骨骼肌损伤”。

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-05-22 DOI: 10.1021/acsabm.5c00615

Carina S Russell, Azadeh Mostafavi, Jacob P Quint, Adriana C Panayi, Kodi Baldino, Tyrell J Williams, Jocelyn G Daubendiek, Victor Hugo Sánchez, Zack Bonick, Mairon Trujillo-Miranda, Su Ryon Shin, Olivier Pourquie, Sahar Salehi, Indranil Sinha, Ali Tamayol

引用次数: 0

Biocomposites-Coated Biodegradable Materials with Optimized Properties for Orthopedic Implant Biodegradability and Performance: A Comparative Study. 生物复合涂层生物可降解材料与骨科植入物生物降解性能的比较研究。

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-05-22 DOI: 10.1021/acsabm.5c00603

Hari Raj K, Gnanavel Sadasivam, Vamsi Krishna Dommeti

{"title":"Biocomposites-Coated Biodegradable Materials with Optimized Properties for Orthopedic Implant Biodegradability and Performance: A Comparative Study.","authors":"Hari Raj K, Gnanavel Sadasivam, Vamsi Krishna Dommeti","doi":"10.1021/acsabm.5c00603","DOIUrl":"https://doi.org/10.1021/acsabm.5c00603","url":null,"abstract":"Implant failure continues to be a critical concern in orthopedic interventions, frequently resulting in consequences such as fractures and necessitating revision procedures. Multiple causes, such as mechanical failure, inadequate osteointegration, and corrosion, lead to implant failure over time. This study seeks to resolve these challenges by surface-modifying biodegradable materials such as poly(lactic acid) (PLA) and AZ31 Mg alloy (Mg), integrating novel Biocomposites of titanium-hydroxyapatite (Ti-HA) to improve their efficacy. The altered materials aim to enhance mechanical strength, osteointegration, and regulated deterioration, thus minimizing the likelihood of implant failure. The characterization techniques validated the Biocomposites' adhesion on the implant's surface, mechanical analysis and corrosion resistance were also validated with the help of UTS and electrochemical studies, and in vitro analyses exhibited substantial improvements in material durability and biological compatibility. The result shows that the Biocomposite assistance improved the overall performance of the implant material. This work presents a pioneering strategy to mitigate implant failure by emphasizing these enhancements, facilitating more dependable and efficient solutions in orthopedic implantation, ultimately enhancing patient outcomes and decreasing the necessity for revision procedures. The earlier segment of the research study was confirmed with another Biocomposites (Ti-Zr), representing a continuation of that research work.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NIR-II Photoresponsive Magnetoliposomes for Remote-Controlled Release and Magnetic Resonance Imaging. 用于遥控释放和磁共振成像的NIR-II光响应磁脂质体。

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-05-22 DOI: 10.1021/acsabm.5c00233

Laura Fernández-Méndez, Yilian Fernández-Afonso, Pablo Martínez-Vicente, Ainhize Urkola-Arsuaga, Claudia Miranda-Pérez de Alejo, Irati L de la Pisa, Sandra Plaza-García, Jesús Ruíz-Cabello, Pedro Ramos-Cabrer, Lucía Gutiérrez, Susana Carregal-Romero

{"title":"NIR-II Photoresponsive Magnetoliposomes for Remote-Controlled Release and Magnetic Resonance Imaging.","authors":"Laura Fernández-Méndez, Yilian Fernández-Afonso, Pablo Martínez-Vicente, Ainhize Urkola-Arsuaga, Claudia Miranda-Pérez de Alejo, Irati L de la Pisa, Sandra Plaza-García, Jesús Ruíz-Cabello, Pedro Ramos-Cabrer, Lucía Gutiérrez, Susana Carregal-Romero","doi":"10.1021/acsabm.5c00233","DOIUrl":"https://doi.org/10.1021/acsabm.5c00233","url":null,"abstract":"Magnetic nanoparticles, especially iron oxide nanoparticles, have become versatile and widely used tools in nanomedicine due to their unique magnetic properties, biocompatibility, and tunable functionality. Liposomes have further enhanced the potential of iron oxide nanoparticles by serving as effective nanocarriers with advantages such as drug coencapsulation and enhanced molecular imaging properties. In this study, we present magnetoliposomes composed of ultrasmall free-floating iron oxide nanoparticles inside liposomes (LP-IONPs) and thermoresponsive phospholipids, which were designed as dual T2-T1 magnetic resonance imaging (MRI) contrast agents for image-guided liposome degradation and infrared light-responsive nanocarriers in the second biological window for remote-controlled drug delivery. We demonstrated a dynamic shift from T2 to T1 MRI contrast during intracellular degradation of LP-IONPs, along with successful light-activated drug release in cancer cells. Biodistribution studies using MRI and histological analysis confirmed their potential for in vivo applications. These results highlight the potential of LP-IONPs as image-guided and remote-controlled drug delivery systems.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combating Fuel Biocontamination: Tailored Antimicrobial Peptides and an Innovative Delivery Strategy. 对抗燃料生物污染：量身定制的抗菌肽和创新的交付策略。

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-05-21 DOI: 10.1021/acsabm.5c00474

Swagata Das, Uttam Pal, Tanusri Saha-Dasgupta, Susanna Leong

{"title":"Combating Fuel Biocontamination: Tailored Antimicrobial Peptides and an Innovative Delivery Strategy.","authors":"Swagata Das, Uttam Pal, Tanusri Saha-Dasgupta, Susanna Leong","doi":"10.1021/acsabm.5c00474","DOIUrl":"https://doi.org/10.1021/acsabm.5c00474","url":null,"abstract":"Microbial invasion and subsequent fuel biocontamination have long posed significant challenges, leading to a significant infrastructural damage. The lack of systematic data on the correlation between environmental parameters and microbial growth has hampered the development of targeted solutions to date. To address this challenge, this study reports a targeted strategy to inactivate and control the proliferation of commonly identified fuel-contaminating microbial clusters through the development of synthetic peptides that can be delivered directly to fuel samples. From a library of short peptides which was designed based on the indolicidin template peptides, three unique sequences were found to have good broad-spectrum activity toward a range of microbes such as Bacillus, Sphingomonas, and Hormoconis, with P17, showing the highest killing potential. The structural analyses of the peptides based on circular dichroism spectroscopy revealed the helical propensity of the peptides in SDS micelles and a random flexible structure in solution. The peptides showed stability under biological conditions and minimal cytotoxicity against mammalian cells. This study presents an innovative method to effectively address fuel biocontamination using short peptides coupled with a potentially scalable protocol to administer the peptides to fuel samples.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Porous Silica Nanoparticle Entrapped Small Gd(III) and Mn(II) Complexes as MRI Contrast Agents. 多孔二氧化硅纳米颗粒包裹小Gd（III）和Mn（II）配合物作为MRI造影剂。

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-05-21 DOI: 10.1021/acsabm.5c00747

Geetanjali Deka, Riya Mallik, Ismile Sk, Chandan Mukherjee

{"title":"Porous Silica Nanoparticle Entrapped Small Gd(III) and Mn(II) Complexes as MRI Contrast Agents.","authors":"Geetanjali Deka, Riya Mallik, Ismile Sk, Chandan Mukherjee","doi":"10.1021/acsabm.5c00747","DOIUrl":"https://doi.org/10.1021/acsabm.5c00747","url":null,"abstract":"Among the in vivo imaging techniques, magnetic resonance imaging (MRI) provides soft-tissue images with high spatial resolution without using any harmful ionizing radiation. Prior to in vivo imaging, the administration of a bolus injection of paramagnetic species, coined as contrast agents (CAs), has become almost routine to facilitate conspicuous imaging in a relatively short measurement period. The contrast agents are mainly small Gd(III)-complexes of macrocyclic and acyclic organic ligands with polar pendant arms. Nonetheless, reports on some adverse effects due to the accumulation of bare Gd(III) ions in the human body from the used gadolinium-based contrast agents necessitate extensive investigations on Mn(II)-complexes to engender potential alternatives. While thermodynamically stable and kinetically inert Mn-complexes with inner-sphere water molecule(s) have been developed and tested as CAs, the enhancement in the relaxivity value beyond 3.5 mM-1 s-1 has been intriguing. This review discloses the recent strategies for incorporating paramagnetic small Gd(III) and Mn(II) complexes within the porous nanosystems, the physicochemical properties, and stability and contrast efficiency improvement after confinement. The generation of \"smart\" and environmentally responsive contrasting probes by incorporating appropriate functional groups onto the surface of the robust nanosystems is also presented herein.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hesperidin Derivatives Contained Hydrogel Dressing for Photothermal Treatment of Melanoma and Postoperative Tissue Regeneration. 含橙皮苷衍生物的水凝胶敷料用于黑色素瘤光热治疗和术后组织再生。

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-05-21 DOI: 10.1021/acsabm.5c00633

Jiaqian He, Zheng Zhou, Wenxiang Zhu, Xin Chen, Shuai Zhu, Jingjing Sun, You Zuo, Mengni Yang, Mengyi Yu, Lingxiu Yang, Jiajie Lei, Wenjia Shao, Xiaoli He, Hairong Liu

{"title":"Hesperidin Derivatives Contained Hydrogel Dressing for Photothermal Treatment of Melanoma and Postoperative Tissue Regeneration.","authors":"Jiaqian He, Zheng Zhou, Wenxiang Zhu, Xin Chen, Shuai Zhu, Jingjing Sun, You Zuo, Mengni Yang, Mengyi Yu, Lingxiu Yang, Jiajie Lei, Wenjia Shao, Xiaoli He, Hairong Liu","doi":"10.1021/acsabm.5c00633","DOIUrl":"https://doi.org/10.1021/acsabm.5c00633","url":null,"abstract":"Melanoma is a severe malignant skin tumor. It is crucial to effectively eliminate melanoma and promote rapid and healthy regeneration of postoperative tissue defects. Herein, hesperidin derivatives (HD) have been developed as the bioactive components of hydrogels that are capable of ablating melanoma via photothermal therapy (PTT) and promoting tissue regeneration. HD have been prepared by heating hesperidin alkaline solution followed by dialysis and lyophilization, and GelMA hydrogels encapsulating HD kill cancer cells and bacteria under near-infrared (NIR) irradiation. The in vitro test and in vivo transcriptomic analysis confirmed that the HD containing GelMA hydrogels induce the immunogenic cell death (ICD) effect of tumor cells by significantly upregulating chemokine-related, cytokine-related, and apoptosis-related genes, thereby enhancing therapeutic efficacy. In a mouse model of infected skin wounds, the HD containing hydrogels under 808 nm light irradiation effectively promoted wound repair. This was achieved through accelerated wound closure and enhanced skin regeneration, mediated by increased angiogenesis and collagen deposition. In conclusion, the HD containing hydrogels provide a new strategy for the clinical treatment of melanoma and postoperative tissue defect repair following operative resection of cancer.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface Charge Overrides Protein Corona Formation in Determining the Cytotoxicity, Cellular Uptake, and Biodistribution of Silver Nanoparticles. 在决定银纳米颗粒的细胞毒性、细胞摄取和生物分布时，表面电荷覆盖蛋白质电晕形成。

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-05-21 DOI: 10.1021/acsabm.5c00392

Marianna Barbalinardo, Francesca Chiarini, Gabriella Teti, Francesca Paganelli, Elisa Mercadelli, Andrea Bartoletti, Andrea Migliori, Manuela Piazzi, Jessika Bertacchini, Paola Sena, Alessandra Sanson, Mirella Falconi, Carla Palumbo, Massimiliano Cavallini, Denis Gentili

{"title":"Surface Charge Overrides Protein Corona Formation in Determining the Cytotoxicity, Cellular Uptake, and Biodistribution of Silver Nanoparticles.","authors":"Marianna Barbalinardo, Francesca Chiarini, Gabriella Teti, Francesca Paganelli, Elisa Mercadelli, Andrea Bartoletti, Andrea Migliori, Manuela Piazzi, Jessika Bertacchini, Paola Sena, Alessandra Sanson, Mirella Falconi, Carla Palumbo, Massimiliano Cavallini, Denis Gentili","doi":"10.1021/acsabm.5c00392","DOIUrl":"https://doi.org/10.1021/acsabm.5c00392","url":null,"abstract":"Silver nanoparticles (AgNPs) hold great promise in biomedical applications due to their unique properties and potential for specific tissue targeting. However, the clinical translation of nanoparticle-based therapeutics remains challenging, primarily due to an incomplete understanding of how nanoparticle properties influence interactions at the nano-bio interface, as well as the role of surface-adsorbed proteins (i.e., protein corona) in modulating nanoparticle-cell interactions. This study demonstrates that the surface charge has a greater influence than protein corona formation in determining the cytotoxicity, cellular uptake, and biodistribution of AgNPs. Using negatively and positively charged AgNPs, we show that while protein corona formation is essential for ensuring nanoparticle availability for cellular interactions, the adsorption of biomolecules is nonspecific and independent of surface charge. Conversely, the surface charge significantly influences the interactions of AgNPs with cells. Positively charged nanoparticles exhibit enhanced cellular uptake, preferential accumulation in lysosomes, and pronounced mitochondrial damage compared to their negatively charged counterparts, resulting in greater cytotoxic effects. This effect is particularly evident in human breast cancer cells, where negatively charged nanoparticles show minimal uptake and cytotoxicity. These findings demonstrate that surface charge is the primary factor governing nanoparticle-cell interactions rather than protein corona formation. Nonetheless, the protein corona plays a critical role in stabilizing nanoparticles in physiological environments.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hybrid Nanocarrier Delivers Immuno-Photothermal Therapy to Modulate Pancreatic Tumor Microenvironment. 混合纳米载体提供免疫光热疗法调节胰腺肿瘤微环境。

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-05-20 DOI: 10.1021/acsabm.5c00562

Jordan Robert, Deepak S Chauhan, Katia Cherifi, Quoc Thang Phan, Veena Sangwan, Gregory De Crescenzo, Xavier Banquy

{"title":"Hybrid Nanocarrier Delivers Immuno-Photothermal Therapy to Modulate Pancreatic Tumor Microenvironment.","authors":"Jordan Robert, Deepak S Chauhan, Katia Cherifi, Quoc Thang Phan, Veena Sangwan, Gregory De Crescenzo, Xavier Banquy","doi":"10.1021/acsabm.5c00562","DOIUrl":"https://doi.org/10.1021/acsabm.5c00562","url":null,"abstract":"Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers due to its complex tumor microenvironment and limited treatment options. The present study explores a therapeutic strategy that combines immuno- and photothermal therapies (PTT) using hybrid polymer-metal nanoparticles (NPs) to modulate the pancreatic tumor microenvironment, leading to sustained therapeutic efficacy. Core-satellite particles constituted of gold nanorods grafted at the surface of polylactic polyethylene block copolymer particles were designed to encapsulate a potent PI3K-γ inhibitor. The release of the drug from the particles was controlled by near-infrared laser irradiation power and time, offering versatility in controlling dosage profile noninvasively over 96 h. In vitro, 2D cultures of pancreatic cancer cells (KPC) exhibited significantly higher uptake of the hybrid nanoparticles compared to proinflammatory (M1) and anti-inflammatory (M2) macrophages. Consequently, KPC cells were more sensitive to PTT and could be eradicated while maintaining macrophages' viability. Through the photostimulated release of the PI3K-γ inhibitor, the particles effectively repolarized M2 macrophages to the M1 phenotype, enhancing cancer cell eradication. These positive outcomes were further confirmed on 3D cocultures of KPC and macrophage spheroids. Additionally, we showed that macrophages exposed to the nanoparticles exhibited sustained antitumor activity when repeatedly put in contact with cancer cells, confirming the long-term efficacy of the treatment. This study highlights the potential of the present polymer-metal hybrid nanoparticles as a versatile platform for combined immuno- and photothermal therapy in PDAC.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144100957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0