ACS Applied Bio Materials最新文献

{"title":"Hybrid Nanocarrier Delivers Immuno-Photothermal Therapy to Modulate Pancreatic Tumor Microenvironment.","authors":"Jordan Robert, Deepak S Chauhan, Katia Cherifi, Quoc Thang Phan, Veena Sangwan, Gregory De Crescenzo, Xavier Banquy","doi":"10.1021/acsabm.5c00562","DOIUrl":"https://doi.org/10.1021/acsabm.5c00562","url":null,"abstract":"<p><p>Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers due to its complex tumor microenvironment and limited treatment options. The present study explores a therapeutic strategy that combines immuno- and photothermal therapies (PTT) using hybrid polymer-metal nanoparticles (NPs) to modulate the pancreatic tumor microenvironment, leading to sustained therapeutic efficacy. Core-satellite particles constituted of gold nanorods grafted at the surface of polylactic polyethylene block copolymer particles were designed to encapsulate a potent PI3K-γ inhibitor. The release of the drug from the particles was controlled by near-infrared laser irradiation power and time, offering versatility in controlling dosage profile noninvasively over 96 h. In vitro, 2D cultures of pancreatic cancer cells (KPC) exhibited significantly higher uptake of the hybrid nanoparticles compared to proinflammatory (M1) and anti-inflammatory (M2) macrophages. Consequently, KPC cells were more sensitive to PTT and could be eradicated while maintaining macrophages' viability. Through the photostimulated release of the PI3K-γ inhibitor, the particles effectively repolarized M2 macrophages to the M1 phenotype, enhancing cancer cell eradication. These positive outcomes were further confirmed on 3D cocultures of KPC and macrophage spheroids. Additionally, we showed that macrophages exposed to the nanoparticles exhibited sustained antitumor activity when repeatedly put in contact with cancer cells, confirming the long-term efficacy of the treatment. This study highlights the potential of the present polymer-metal hybrid nanoparticles as a versatile platform for combined immuno- and photothermal therapy in PDAC.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144100957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional <i>Tradescantia pallida</i> Derived Copper-Nitrogen Codoped Green Carbon Dots as Nanozyme, Dual Sensor, and Fluorescent Ink for Anticounterfeiting and Smart Textiles.","authors":"Khushboo Warjurkar, Rajan Patyal, Vinay Sharma","doi":"10.1021/acsabm.5c00150","DOIUrl":"https://doi.org/10.1021/acsabm.5c00150","url":null,"abstract":"<p><p>The integration of optical, catalytic, and fluorescent properties in a green eco-friendly product opens avenues for multifunctionality in diverse applications ranging from biosensing and environmental monitoring to smart textiles. Green precursor derived carbon dots (CDs) offer opportunities to tailor their properties to achieve multifunctionality in a single material. Herein, multifunctional copper and nitrogen codoped CDs (Cu,N-GCDs) are reported, which show employability as a nanozyme, colorimetric hydrogen sensor, fluorometric iron sensor, anticounterfeiting agent, and ink for smart textiles. The reported Cu,N-GCDs show peroxidase (POD)-like activity induced by the Cu and N doping. This property is successfully employed in colorimetric H₂O₂ sensing in a wide concentration range of 2 to 1500 mM with a limit of detection (LOD) of 121 μM. The Cu,N-GCDs also exhibited the sensitive and selective fluorometric detection of Fe³⁺ ions with an LOD of 38.95 pM. Moreover, Cu,N-GCDs were employed in making invisible fluorescent ink to draw on paper and cotton cloth, exhibiting their applicability as easy-to-use security technology for information encryption and anticounterfeiting and contributing to aesthetic fashion designing in smart textiles.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated Bioelectrochemical Conversion of <i>Bacillus subtilis</i>-Pretreated Sugar Cane Bagasse: Metabolic Profile Optimization for Enhanced Microbial Fuel Cell Efficiency and Sustainable Biorefinery Applications.","authors":"Anjana Ratheesh, Bhuvanendran Revamma Sreelekshmy, Anil Kumar T R, Sarika Sasidharan, Rubina Basheer, Kanakangi Sukumaran Nair, Ananthakrishnan Jayakumaran Nair, Sheik Muhammadhu Aboobakar Shibli","doi":"10.1021/acsabm.5c00310","DOIUrl":"https://doi.org/10.1021/acsabm.5c00310","url":null,"abstract":"<p><p>Lignocellulose recalcitrance remains a significant economic challenge in modern biomass conversion processes. Microbial strategies offer considerable promise for ecofriendly bioenergy generation. This study presents an advanced integrated approach that combines bacterial treatment with a bioelectrochemical system (BES) to enhance the conversion efficiency of lignocellulosic biomass. Unlike integrated or sequential approaches, a comparative evaluation of two distinct pretreatment strategies, alkaline delignification and biological treatment, was conducted independently to assess their individual effectiveness in sugar cane bagasse (SCB) degradation and their performance in a microbial fuel cell (MFC). Biological treatment with <i>B. subtilis</i> alone yielded superior outcomes in terms of saccharification efficiency, microbial growth, and bioelectricity generation, as evidenced by higher open-circuit potentials in MFC half-cell studies in comparison with alkali delignified SCB. Notably, <i>B. subtilis</i> treatment increased cellulose content by 72% and reduced hemicellulose and lignin by approximately 0.84-fold, indicating effective enzymatic action. Metabolomic profiling identified 2846 metabolites that significantly diverged between the experimental groups. Notably, lignin-derived compounds such as ferulic acid, syringic acid, and p-coumaric acid were detected at elevated levels, confirming enhanced ligninase activity in pretreated SCB. Additionally, the presence of organic acids (e.g., acetic acid), amino acids, and their derivatives, resulting from the breakdown of cellulose, hemicellulose, and lignin, provided essential bioenergy substrates for exoelectrogenic organisms in BESs. This integration led to a maximum power density of 353 ± 5 mW/m² and a current density of 200 ± 3 mA/m², demonstrating significant enhancement in performance of MFC. Furthermore, the biotransformation of SCB facilitated the channeling of metabolites into value-added products, increasing the overall efficiency of the biomass valorization. Thus, the rational utilization of SCB underscores its potential for scalable biorefinery applications and its broader implications for sustainable bioenergy production.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SiO₂-Coated ZnO for Photothermal and Photodynamic Antibacterial Applications in Bone Repair.","authors":"Yanxia Zhang, Nazakaiti Imamaimaiti, Xiaohui Tang, Jua Kim, Tao Jiang, Huiting Fu, Haobo Pan, Yingbo Wang","doi":"10.1021/acsabm.5c00147","DOIUrl":"https://doi.org/10.1021/acsabm.5c00147","url":null,"abstract":"<p><p>Poly(L-lactic acid) (PLLA) is a promising material for bone substitutes due to its biodegradability and biocompatibility. However, its limited osteogenic activity and antibacterial properties restrict its applications. To address these challenges, this study develops PLLA/SiO₂@ZnO/PDA/PLL composite fibrous materials using an approach that integrates electrospinning with ultrasonic techniques. The composite exhibits photothermal antibacterial functionality and osteoinductive properties. The material demonstrates excellent hydrophilicity, sustained-release capability, and antibacterial activity. Upon near-infrared light exposure, Zn²⁺ ions are released, disrupting bacterial membranes via electrostatic interactions and lipid peroxidation induced by reactive oxygen species. This dual mechanism leads to bacterial membrane rupture and biofilm degradation. Zn²⁺ ions also interfere with bacterial respiratory enzymes, disrupting the electron transfer process and achieving efficient antibacterial effects. The composite further shows outstanding biocompatibility and osteoinductivity, promoting vascular endothelial cell and osteoblast adhesion and enhancing calcium-phosphate salt deposition. In vivo studies confirm its safety with no significant toxicity or adverse effects on tissues and organs. This PLLA/SiO₂@ZnO/PDA/PLL composite offers significant potential for repairing infected bone tissue and provides a strong foundation for future applications in bone tissue engineering.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intratumoral Delivery of High Boron-Containing Carbon Quantum Dots for Enhanced Boron Neutron Capture Therapy.","authors":"Xianwei Luo, Zhijie Wang, Mingxin Yang, Runhong Lei, Jingru Yang, Mengyao Li, Haoyang Hao, Zhicai Liu, Hongyu Tang, Bingbing Peng, Youjia Tian, Kui Chen, Ya-Nan Chang, Hui Yuan, Jianfei Tong, Linbo Zhu, Chengyu Lu, Gengmei Xing, Juan Li","doi":"10.1021/acsabm.5c00479","DOIUrl":"https://doi.org/10.1021/acsabm.5c00479","url":null,"abstract":"<p><p>The development of boron-containing carbon quantum dots for boron neutron capture therapy (BNCT) offers a promising strategy for treating refractory tumors. We synthesized carbon quantum dots with optimized parameters including feed ratio, reaction time, temperature, and pH, followed by a purification process to obtain stable, boric-acid-based boron-rich carbon quantum dots (BAQDs). The large-scale production of BAQDs was implemented by this dependable and simple synthesis method. With a boron content of 15.47 wt %, the BAQDs surpassed the clinical drug boronophenylalanine. It is also the highest recorded in BNCT-related carbon quantum dot materials research. Furthermore, BAQDs exhibited excellent water solubility, stability, and biocompatibility. The experimental results demonstrated that BAQDs exhibited an effective inhibition performance against 4T1 cells under neutron irradiation. Furthermore, BAQDs displayed successful tumor-targeting delivery capabilities. In vivo biodistribution analyses revealed efficient accumulation of BAQDs at the tumor site, with a boron content of 124.32 ± 27.64 ppm 0.5 h post-injection. With their effective boron delivery capability, BAQDs represent a promising boron delivery agent for tumor therapy via BNCT, with substantial potential for clinical application.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of uMUC-1 Targeted NEMO Particles with pH-Activatable MRI Signals for Enhanced Detection of Malignant Breast Cancer Cells.","authors":"Dhruvi M Panchal, Alexia R Gorman, Celia Martinez de la Torre, Barrick M Silverman, Anthony J Scalzo, Hunter T Snoderly, Benoit Driesschaert, Margaret F Bennewitz","doi":"10.1021/acsabm.5c00365","DOIUrl":"10.1021/acsabm.5c00365","url":null,"abstract":"<p><p>Magnetic resonance imaging (MRI) detects more breast cancers than mammography due to its superior soft tissue contrast; however, it still misdiagnoses 40% of benign tumors as malignant due to clinically used nonspecific contrast agents (e.g., gadolinium chelates). To overcome this limitation, we developed receptor-targeted, pH-sensitive Nano-Encapsulated Manganese Oxide (NEMO) particles as an alternative <i>T</i>₁-weighted MRI contrast agent. A breast cancer targeting peptide, EPPT, against underglycosylated mucin-1, promotes preferential endocytosis of NEMO particles by malignant cells and specific activation of the MRI signal inside low pH endosomes/lysosomes. In just 30 min, EPPT-NEMO particles produced rapid and robust <i>T</i>₁-weighted MRI contrast inside T47D breast cancer cells that reached ∼276% signal enhancement, which was significantly brighter than MCF10A benign control cells (∼57% enhancement). Mn cellular content further confirmed peptide targeting specificity, while confocal microscopy showed the colocalization of EPPT-NEMO particles with endosomes and lysosomes. EPPT-NEMO particles show promise as alternative <i>T</i>₁-weighted MRI contrast agents, producing significantly brighter signals in breast cancer cells compared to benign cells within clinically relevant timeframes. These advancements in targeted MRI contrast agents could lead to improved accuracy in breast cancer diagnosis and ultimately to better patient outcomes.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"4251-4261"},"PeriodicalIF":4.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tackling Microbial Contamination in Polydioxanone-Based Membranes for Regenerative Therapy: Bioengineering an Antibiotic-Loaded Platform.","authors":"Victoria L Abdo, Jamil A Shibli, Raphael C Costa, Maria H Rossy Borges, Ademar Wong, Maria D P T Sotomayor, Martinna Bertolini, Luciene C Figueiredo, Valentim A R Barão, Elidiane C Rangel, Joao Gabriel S Souza","doi":"10.1021/acsabm.5c00263","DOIUrl":"10.1021/acsabm.5c00263","url":null,"abstract":"<p><p>Barrier membranes are essential components of tissue regenerative therapies, acting as physical barriers to protect the healing site. Although collagen-based membranes are widely used, they degrade enzymatically, often triggering inflammation and cytotoxicity arising from residual cross-linking agents. Synthetic polymer-based membranes, such as polydioxanone (PDO), present customizable properties, predictable degradation rates, and induce bone formation more effectively. However, both materials are at risk of exposure to the microbial contamination. To address this, antibiotics have been loaded onto membranes as drug-delivery systems, a strategy that has not yet been explored for PDO membranes. In this study, the oral polymicrobial contamination of PDO-based membranes was evaluated and compared with collagen membranes and aimed to develop an amoxicillin-loaded PDO (AMX-PDO) membrane. For this purpose, PDO membranes with different pore sizes (0.25, 0.50, and 1.00 mm) and two commercially available collagen membranes were evaluated, using in vitro and in situ models, in terms of polymicrobial accumulation. Next, AMX-PDO membranes were developed by glow discharge plasma using Ar and O₂ gases and an amoxicillin compound. The findings revealed similar microbial levels for both PDO and collagen-based membranes, but PDO membranes modulated microbial composition with reduced (∼3-5 fold-decrease) levels of specific oral pathogens. The AMX-PDO membrane maintained similar physical and chemical properties to those of untreated membranes, but it significantly reduced polymicrobial accumulation and prevented microbial cells from passing through them. Thus, they acted as more than passive physical barriers only, but rather as biologically active barriers. Therefore, amoxicillin loading on PDO barrier membranes by means of plasma technology seems to be a promising strategy to prevent local infection during regenerative therapy.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"4119-4131"},"PeriodicalIF":4.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12093370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Porphyrin-Derived Carbon Dots for Red-Light Activated Photodynamic Therapy of Breast Cancer.","authors":"Abeer Ansary, Nicolás Montesdeoca, Samir F El-Mashtoly, Stephan A Hahn, Mohamed E El-Khouly, Johannes Karges","doi":"10.1021/acsabm.5c00332","DOIUrl":"10.1021/acsabm.5c00332","url":null,"abstract":"<p><p>In recent years, cancer has emerged as a major global health threat, ranking among the top causes of mortality. While treatments such as surgery, immunotherapy, radiation therapy, and chemotherapy remain widely used, photodynamic therapy has been gaining significant interest. Most of the photosensitizing agents employed in clinical settings are derived from tetrapyrrolic frameworks, including porphyrins, chlorins, and phthalocyanines. Although these compounds have demonstrated therapeutic effectiveness, they suffer from critical drawbacks, such as limited solubility in water and inadequate (photo)stability. To address these issues, herein, the formulation of the previously reported and promising photosensitizer tetrakis(4-carboxyphenyl) porphyrin into carbon dots is reported. The carbon dots were found with enhanced aqueous solubility, high (photo)stability, and greater singlet oxygen quantum yield overcoming the limitations of the molecular photosensitizer. While being nontoxic in the dark, the carbon dots induced a phototherapeutic effect in breast cancer cells and multicellular tumor spheroids.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"4230-4238"},"PeriodicalIF":4.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bifunctional Nanostarch against Neuronal Apoptosis via Mitochondria Protection for Ameliorating Ischemic Stroke Injury and Promoting Long-Term Neurological Recovery.","authors":"Ji Xia, Jin Huang, Yixiao Yan, Chenxin Jian, Jiansheng He, Nisha Wang, Lei Shi, Qiyang Ding, Hao Tian, Wei Gao","doi":"10.1021/acsabm.4c02005","DOIUrl":"10.1021/acsabm.4c02005","url":null,"abstract":"<p><p>Mitochondrial damage occurs as an initial event following ischemic onset, and the extent of mitochondrial dysfunction is highly correlated to the severity of ischemia-induced cell death. Once appropriate therapeutic interventions are provided, the ischemic tissue can be salvaged, which is of great significance in achieving better neurological outcomes. Herein, we developed a nanosized starch as a targeting nanoplatform, featuring effective blood-brain barrier (BBB) penetration through lactoferrin-mediated transcytosis. Notably, the nanostarch-based delivery of Mdivi-1 and Alda-1 enables controlled release in the acidic lysosome of neurons, effectively inhibiting the pathological mitochondrial fission and metabolizing toxic aldehydes, thereby creating protective effects on maintaining mitochondrial function. Moreover, we demonstrated that mitochondrial protection induces a transition from activated pro-death responses to a pro-survival state by reducing the release of pro-apoptotic proteins, significantly contributing to the long-term recovery of neurological function. Overall, our nanostarch provided an in-depth understanding of the delivery of mitochondrial protectants and underscored the potential and utility of mitochondrial protection for ischemic stroke via minimizing neuronal apoptosis.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"3833-3844"},"PeriodicalIF":4.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanotechnology Assisted Drug Delivery Strategies for Chemotherapy: Recent Advances and Future Prospects.","authors":"Pavan K Yadav, Divya Chauhan, Pooja Yadav, Amrendra K Tiwari, Nazneen Sultana, Deepak Gupta, Keerti Mishra, Jiaur R Gayen, Muhammad Wahajuddin, Manish K Chourasia","doi":"10.1021/acsabm.5c00046","DOIUrl":"10.1021/acsabm.5c00046","url":null,"abstract":"<p><p>In pursuit of the treatment of cancer, nanotechnology engineering has emerged as the simplest and most effective means, with the potential to deliver antitumor chemotherapeutics at the targeted site. Employing nanotechnology for drug delivery provides diverse nanosize particles ranging from one to a thousand nanometers. Reduced size improves drug bioavailability by increasing drug diffusion and decreasing the efflux rate. These nanocarriers offer an enormous scope for modification following the chemical and biological properties of both the drug and its disease. Moreover, these nanoformulations assist in targeting pharmaceutically active drug molecules to the desired site and have gained importance in recent years. Their modern use has revolutionized the antitumor action of many therapeutic agents. Higher drug loading efficiency, thermal stability, easy fabrication, low production cost, and large-scale industrial production draw attention to the application of nanotechnology as a better platform for the delivery of drug molecules. Furthermore, the interaction of nanocarrier technology-assisted agents lowers a drug's toxicity and therapeutic dosage, reduces drug tolerance, and enhances active drug concentration in neoplasm tissue, thus decreasing the concentration in healthy tissue. Nanotechnology-based medications are being widely explored and have depicted effective cancer management <i>in vivo</i> and <i>in vitro</i> systems, leading to many clinical trials with promising results. This review summarizes the innovative impact and application of different nanocarriers developed in recent years in cancer therapy. Subsequently, it also describes the essential findings and methodologies and their effects on cancer treatment. Compared with conventional therapy, nanomedicines can significantly improve the therapeutic effectiveness of antitumor drugs. Thus, the adverse effects associated with healthy tissues are decreased, and adverse effects are scaled back through enhanced permeability and retention effects. Lastly, future insights assisting nanotechnology in active therapeutics delivery and their scope in cancer chemotherapeutics have also been discussed.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"3601-3622"},"PeriodicalIF":4.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143950798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}