ACS Applied Bio Materials最新文献_第5页

Salmonella-Derived Fluorescent Carbon Dots for Reprogramming Tumor-Associated Macrophages and Enhancing Tumor Photodynamic Therapy. 沙门氏菌衍生的荧光碳点用于肿瘤相关巨噬细胞重编程和增强肿瘤光动力治疗。

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-05-24 DOI: 10.1021/acsabm.5c00624

Pei-Jie Zhang, Dong Zhou, Zi-Wei Yang, Yong-Guo Hu, Meng-Wen Ma, Jin-Xuan Fan, Yuan-Di Zhao, Jia-Hua Zou

{"title":"Salmonella-Derived Fluorescent Carbon Dots for Reprogramming Tumor-Associated Macrophages and Enhancing Tumor Photodynamic Therapy.","authors":"Pei-Jie Zhang, Dong Zhou, Zi-Wei Yang, Yong-Guo Hu, Meng-Wen Ma, Jin-Xuan Fan, Yuan-Di Zhao, Jia-Hua Zou","doi":"10.1021/acsabm.5c00624","DOIUrl":"https://doi.org/10.1021/acsabm.5c00624","url":null,"abstract":"Carbon dots (CDs) are used as photosensitizers for the photodynamic therapy of tumors while retaining the specific functional groups and biochemical properties of carbon precursors. However, the short-wavelength excitation of photosensitizers limits their application in the photodynamic therapy of tumors. Upconversion nanoparticles (UCNPs) effectively solve the problem of low penetration of photosensitizers due to short-wavelength excitation by converting low-energy near-infrared light into high-energy ultraviolet light or visible light. In this paper, carbon dots were prepared by a hydrothermal method using Salmonella and alendronic acid as raw materials, while the phosphate groups on the surface of carbon dots were coordinated with upconversion nanoparticles (UCNPs) to form UCNP@CD nanoprobes. Under the irradiation of an 808 nm laser, the emitted light from upconversion nanoparticles (UCNPs) can further catalyze carbon dots (CDs) to enhance the generation of reactive oxygen species for killing tumor cells. Meanwhile, carbon dots reprogrammed M2 macrophages into M1 macrophages to improve the tumor immunosuppressive microenvironment. The UCNP@CD nanoprobes were used for tumor-associated macrophage reprogramming and photodynamic therapy of tumors, which provides an effective strategy for multimodal synergistic tumor treatment.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144135882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reversal Drug Resistance of Tumor Cells by Manipulating its Membrane Heterogeneity through High Spatially Resolved Heating. 通过高空间分辨加热操纵肿瘤细胞的膜非均质性来逆转肿瘤细胞的耐药。

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-05-24 DOI: 10.1021/acsabm.5c00605

Yusai Zhao, Xiaoqing Chen, Hengwei Zhang, Yifan Ge, Di Li

{"title":"Reversal Drug Resistance of Tumor Cells by Manipulating its Membrane Heterogeneity through High Spatially Resolved Heating.","authors":"Yusai Zhao, Xiaoqing Chen, Hengwei Zhang, Yifan Ge, Di Li","doi":"10.1021/acsabm.5c00605","DOIUrl":"https://doi.org/10.1021/acsabm.5c00605","url":null,"abstract":"Multidrug resistance (MDR) presents a substantial challenge to the therapeutic efficacy of cancer chemotherapy. A common trait of drug-resistant cells is decreased cell membrane permeability, hindering the uptake of therapeutic agents. Additionally, these cells frequently overexpress drug efflux pumps that actively expel the drugs, leading to reduced intracellular accumulation. In this study, we introduce a high spatially resolved, domain-specific, mild heating strategy to counteract drug resistance using DNA nanodevices. This strategy aims to manipulate the membrane heterogeneity by increasing cell membrane permeability and decreasing the expression of drug efflux pumps. The DNA nanodevices (termed DNA nanoheaters) with specific domain affinity anchor distinct cell membrane domains (raft/nonraft) and elevate the local lipid environmental temperature upon near-infrared (NIR) laser exposure. This elevation in local lipid temperature modifies key biophysical membrane features of Doxorubicin-resistant tumor cells, resulting in a two-order magnitude decrease in IC50. Notably, our approach diverges from conventional methods that depend on the delivery of pharmacological reversal agents. Instead, we emphasize modulating the membrane properties of drug-resistant cells through mild physical stimuli, offering a potential reduction in systemic toxicity associated with chemotherapy.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144135884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulation of Doxorubicin-Induced ROS Accumulation in Cardiomyocytes Using Ibuprofen-Conjugated Synthetic Lipids as Carriers. 利用布洛芬共轭合成脂质作为载体调节阿霉素诱导的心肌细胞ROS积累。

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-05-23 DOI: 10.1021/acsabm.4c01932

Soumya Saroj, Akshaya Kana Veedu, Chandrasekhar Reddy U, Nalini Venkatesan, Abhishek K Verma, Muraleedharan Kannoth Manheri

{"title":"Modulation of Doxorubicin-Induced ROS Accumulation in Cardiomyocytes Using Ibuprofen-Conjugated Synthetic Lipids as Carriers.","authors":"Soumya Saroj, Akshaya Kana Veedu, Chandrasekhar Reddy U, Nalini Venkatesan, Abhishek K Verma, Muraleedharan Kannoth Manheri","doi":"10.1021/acsabm.4c01932","DOIUrl":"https://doi.org/10.1021/acsabm.4c01932","url":null,"abstract":"Conjugation of an NSAID such as ibuprofen to the head group of oxanorbornane-based lipids and the use of their aggregates as carriers for doxorubicin (Dox) are discussed here. These conjugates were characterized by various spectroscopic techniques, including 2D-NMR, and insights into their assembly were gathered through PXRD, AFM, SEM, DLS, and qNano techniques. Free lipids as well as their formulations (lipid:cholesterol:Dox in a 3:1.5:2 molar ratio) showed a high tendency to form solid lipid particles, which was verified by TEM analysis. The presence of the ibuprofen unit led to an increase in interlipid spacing and a characteristic change in their packing. Active loading through a pH gradient allowed us to achieve high drug entrapment and a controlled release profile. The formulation AT3.3, prepared by this method, showed a Dox entrapment of ∼90%, with a controlled release of ∼18% by the end of 24 h; only ∼66% of the entrapped Dox was released by the end of 5 days. Cytotoxicity studies in NIH3T3 cells and hemolytic assay results showed that these lipids and their formulations have a good safety profile. Results from flow cytometry experiments in A549 cells revealed that the formulation AT3.3 induces effects similar to free Dox, with cell cycle arrest predominantly at the S phase and G2/M phase. At the same time, the response from the blank formulation was comparable to that of the control. Confocal microscopy studies in NIH3T3 and A549 cells showed that free Dox gets localized mainly in the nucleus, while the use of the carrier (AT3.3) causes significant localization of the drug on the cytoplasmic side as well. ROS induction due to free Dox and its formulation (AT3.3) in cardiomyocytes and A549 cells was also compared, and the results showed a protective effect in cardiomyocytes when using this formulation.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrogel Foams Containing Superabsorbent Particles for Wound Care Applications. 水凝胶泡沫含有高吸水性颗粒的伤口护理应用。

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-05-23 DOI: 10.1021/acsabm.4c01719

Nora Bastida Agote, Alessandro Cianciosi, Andrea Ewald, Jürgen Groll, Toby A Jenkins, Markus J Kettel

{"title":"Hydrogel Foams Containing Superabsorbent Particles for Wound Care Applications.","authors":"Nora Bastida Agote, Alessandro Cianciosi, Andrea Ewald, Jürgen Groll, Toby A Jenkins, Markus J Kettel","doi":"10.1021/acsabm.4c01719","DOIUrl":"https://doi.org/10.1021/acsabm.4c01719","url":null,"abstract":"Herein, we report an innovative approach to design hydrogel foams by embedding superabsorbent polymer (SAP) particles with the aim of improving wound dressing applications. A cross-linking process was used to prepare hydrogel foams by just adding 3 components: an NCO-terminated three-arm prepolymer, SAP particles, and water. Variations in the chemical compositions allow creation of hydrogel foams with different material properties that can be applied to wounds with different characteristics. Hydrogel foams that are stable to electron beam sterilization are mechanically stable and have adjustable as well as very high absorption capacities. SAP-loaded foams have open pore structures and can be used to remove excess exudate from highly exudating wounds. Additionally, the SAP-loaded hydrogels have tunable high moisture donation properties and, hence, the potential to help keep contaminated wounds clean or to moisten a dry wound to enhance wound healing. Therefore, hydrogel foams with SAP particles have the potential to be used in advanced wound dressings for application on both dry and highly exudating, acute, and chronic wounds.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymer-Based Designer Particles as Drug Carriers: Strategies to Construct and Modify. 基于聚合物的设计粒子作为药物载体：构建和修饰策略。

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-05-23 DOI: 10.1021/acsabm.5c00041

Nidhi Gupta, Sampa Saha

{"title":"Polymer-Based Designer Particles as Drug Carriers: Strategies to Construct and Modify.","authors":"Nidhi Gupta, Sampa Saha","doi":"10.1021/acsabm.5c00041","DOIUrl":"https://doi.org/10.1021/acsabm.5c00041","url":null,"abstract":"Biological barriers present remarkable challenges for therapeutics delivery, requiring an advanced drug delivery system that can navigate through the complex physiological environment. Polymeric particles provide remarkable versatility due to their adaptable physiochemical properties, facilitating new designs that address complex delivery issues. This review focuses on recent advancements in the morphology of polymeric particles that emulate biological barriers to improve drug efficacy. It includes how structural engineering─such as designing rod-shaped particles for improved cellular uptake, red-blood-cell-shaped particles for prolonged circulation, worm-shaped carriers for improved tissue penetration, and multicompartmental systems for providing combination therapies─profoundly alters drug delivery capabilities. These designer particles exhibit enhanced target specificity, controlled release kinetics, and improved therapeutic outcomes relative to traditional spherical carriers. This particular review also emphasizes how a combination of polymer chemistry and fabrication methods facilitates achieving these advanced structures, while highlighting ongoing challenges in scale-up, reproducibility, and clinical translations. Through the analysis of structure-functional property correlations in various biomimetic designs, we have also attempted to provide insight into future advancements in polymeric delivery systems that have the potential to transform treatment strategies for complicated diseases via shape-directed biological interactions for better therapeutic outcomes.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phosphorus Phthalocyanine-Based NIR-II Nanoparticles for Photoacoustic Imaging and Photothermal Therapy of Thrombus. 基于酞菁磷的NIR-II纳米颗粒用于血栓的光声成像和光热治疗。

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-05-22 DOI: 10.1021/acsabm.5c00522

Zhaoyang Liu, Yufeng Zhu, Yilan Jin, Rong Wang, Junjie Xia, Yingqiao Wang, Hong Yang, Changxin Shen, Shiping Yang, Zhiguo Zhou

引用次数: 0

Correction to "In Situ Printing of Adhesive Hydrogel Scaffolds for the Treatment of Skeletal Muscle Injuries". 修正“原位打印黏附水凝胶支架治疗骨骼肌损伤”。

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-05-22 DOI: 10.1021/acsabm.5c00615

Carina S Russell, Azadeh Mostafavi, Jacob P Quint, Adriana C Panayi, Kodi Baldino, Tyrell J Williams, Jocelyn G Daubendiek, Victor Hugo Sánchez, Zack Bonick, Mairon Trujillo-Miranda, Su Ryon Shin, Olivier Pourquie, Sahar Salehi, Indranil Sinha, Ali Tamayol

引用次数: 0

Biocomposites-Coated Biodegradable Materials with Optimized Properties for Orthopedic Implant Biodegradability and Performance: A Comparative Study. 生物复合涂层生物可降解材料与骨科植入物生物降解性能的比较研究。

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-05-22 DOI: 10.1021/acsabm.5c00603

Hari Raj K, Gnanavel Sadasivam, Vamsi Krishna Dommeti

{"title":"Biocomposites-Coated Biodegradable Materials with Optimized Properties for Orthopedic Implant Biodegradability and Performance: A Comparative Study.","authors":"Hari Raj K, Gnanavel Sadasivam, Vamsi Krishna Dommeti","doi":"10.1021/acsabm.5c00603","DOIUrl":"https://doi.org/10.1021/acsabm.5c00603","url":null,"abstract":"Implant failure continues to be a critical concern in orthopedic interventions, frequently resulting in consequences such as fractures and necessitating revision procedures. Multiple causes, such as mechanical failure, inadequate osteointegration, and corrosion, lead to implant failure over time. This study seeks to resolve these challenges by surface-modifying biodegradable materials such as poly(lactic acid) (PLA) and AZ31 Mg alloy (Mg), integrating novel Biocomposites of titanium-hydroxyapatite (Ti-HA) to improve their efficacy. The altered materials aim to enhance mechanical strength, osteointegration, and regulated deterioration, thus minimizing the likelihood of implant failure. The characterization techniques validated the Biocomposites' adhesion on the implant's surface, mechanical analysis and corrosion resistance were also validated with the help of UTS and electrochemical studies, and in vitro analyses exhibited substantial improvements in material durability and biological compatibility. The result shows that the Biocomposite assistance improved the overall performance of the implant material. This work presents a pioneering strategy to mitigate implant failure by emphasizing these enhancements, facilitating more dependable and efficient solutions in orthopedic implantation, ultimately enhancing patient outcomes and decreasing the necessity for revision procedures. The earlier segment of the research study was confirmed with another Biocomposites (Ti-Zr), representing a continuation of that research work.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NIR-II Photoresponsive Magnetoliposomes for Remote-Controlled Release and Magnetic Resonance Imaging. 用于遥控释放和磁共振成像的NIR-II光响应磁脂质体。

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-05-22 DOI: 10.1021/acsabm.5c00233

Laura Fernández-Méndez, Yilian Fernández-Afonso, Pablo Martínez-Vicente, Ainhize Urkola-Arsuaga, Claudia Miranda-Pérez de Alejo, Irati L de la Pisa, Sandra Plaza-García, Jesús Ruíz-Cabello, Pedro Ramos-Cabrer, Lucía Gutiérrez, Susana Carregal-Romero

{"title":"NIR-II Photoresponsive Magnetoliposomes for Remote-Controlled Release and Magnetic Resonance Imaging.","authors":"Laura Fernández-Méndez, Yilian Fernández-Afonso, Pablo Martínez-Vicente, Ainhize Urkola-Arsuaga, Claudia Miranda-Pérez de Alejo, Irati L de la Pisa, Sandra Plaza-García, Jesús Ruíz-Cabello, Pedro Ramos-Cabrer, Lucía Gutiérrez, Susana Carregal-Romero","doi":"10.1021/acsabm.5c00233","DOIUrl":"https://doi.org/10.1021/acsabm.5c00233","url":null,"abstract":"Magnetic nanoparticles, especially iron oxide nanoparticles, have become versatile and widely used tools in nanomedicine due to their unique magnetic properties, biocompatibility, and tunable functionality. Liposomes have further enhanced the potential of iron oxide nanoparticles by serving as effective nanocarriers with advantages such as drug coencapsulation and enhanced molecular imaging properties. In this study, we present magnetoliposomes composed of ultrasmall free-floating iron oxide nanoparticles inside liposomes (LP-IONPs) and thermoresponsive phospholipids, which were designed as dual T2-T1 magnetic resonance imaging (MRI) contrast agents for image-guided liposome degradation and infrared light-responsive nanocarriers in the second biological window for remote-controlled drug delivery. We demonstrated a dynamic shift from T2 to T1 MRI contrast during intracellular degradation of LP-IONPs, along with successful light-activated drug release in cancer cells. Biodistribution studies using MRI and histological analysis confirmed their potential for in vivo applications. These results highlight the potential of LP-IONPs as image-guided and remote-controlled drug delivery systems.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combating Fuel Biocontamination: Tailored Antimicrobial Peptides and an Innovative Delivery Strategy. 对抗燃料生物污染：量身定制的抗菌肽和创新的交付策略。

IF 4.6

ACS Applied Bio Materials Pub Date : 2025-05-21 DOI: 10.1021/acsabm.5c00474

Swagata Das, Uttam Pal, Tanusri Saha-Dasgupta, Susanna Leong

{"title":"Combating Fuel Biocontamination: Tailored Antimicrobial Peptides and an Innovative Delivery Strategy.","authors":"Swagata Das, Uttam Pal, Tanusri Saha-Dasgupta, Susanna Leong","doi":"10.1021/acsabm.5c00474","DOIUrl":"https://doi.org/10.1021/acsabm.5c00474","url":null,"abstract":"Microbial invasion and subsequent fuel biocontamination have long posed significant challenges, leading to a significant infrastructural damage. The lack of systematic data on the correlation between environmental parameters and microbial growth has hampered the development of targeted solutions to date. To address this challenge, this study reports a targeted strategy to inactivate and control the proliferation of commonly identified fuel-contaminating microbial clusters through the development of synthetic peptides that can be delivered directly to fuel samples. From a library of short peptides which was designed based on the indolicidin template peptides, three unique sequences were found to have good broad-spectrum activity toward a range of microbes such as Bacillus, Sphingomonas, and Hormoconis, with P17, showing the highest killing potential. The structural analyses of the peptides based on circular dichroism spectroscopy revealed the helical propensity of the peptides in SDS micelles and a random flexible structure in solution. The peptides showed stability under biological conditions and minimal cytotoxicity against mammalian cells. This study presents an innovative method to effectively address fuel biocontamination using short peptides coupled with a potentially scalable protocol to administer the peptides to fuel samples.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0