A Comprehensive Review Molecular Origami Classical DNA Folding Principle Empowering Modern Nanobiotechnology.

IF 4.7 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2025-09-29 DOI:10.1021/acsabm.5c01094

Sameera Shabnum Saleem, Siranjeevi Ravichandran, Susmitha Ravichandran, Krishna Raj Chinnadurai, Anbalagan Saravanan, Sundaram Vickram

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Abstract

DNA origami has become a transformative tool in nanotechnology, providing a robust and programmable method for fabricating highly ordered nanostructures with unparalleled accuracy. This article offers a thorough examination of the present state of DNA origami, first with an introduction to its origins and importance, and subsequently addressing the essential principles that dictate its design and folding processes. Multiple manufacturing methodologies and optimization tactics are examined, emphasizing innovations that improve structural complexity, stability, and functionalization. The study explores the many uses of DNA origami in biomedicine, sensing, drug delivery, and nanorobotics, highlighting its significant potential. Notwithstanding its potential, the analysis highlights significant problems like elevated manufacturing costs, restricted structural stability under physiological settings, scaling concerns, and integration difficulties with other nanomaterials. The future possibilities of DNA origami are examined, highlighting continuous advancements and multidisciplinary collaborations focused on addressing existing limits and converting this technology into useful, real-world applications.

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分子折纸的综合评价经典DNA折叠原理赋予现代纳米生物技术。

DNA折纸已经成为纳米技术的变革工具，提供了一种强大的、可编程的方法，以无与伦比的精度制造高度有序的纳米结构。这篇文章提供了DNA折纸的现状彻底检查，首先介绍了它的起源和重要性，随后解决的基本原则，规定其设计和折叠过程。考察了多种制造方法和优化策略，强调了提高结构复杂性、稳定性和功能化的创新。该研究探索了DNA折纸在生物医学、传感、药物输送和纳米机器人中的许多应用，突出了其巨大的潜力。尽管具有潜力，但该分析强调了一些重大问题，如制造成本升高、生理环境下结构稳定性受限、缩放问题以及与其他纳米材料的集成困难。研究了DNA折纸的未来可能性，强调了持续的进步和多学科合作，重点是解决现有的限制，并将这项技术转化为有用的，现实世界的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.