α-Fe Nanoparticles and Multiwalled Carbon Nanotubes Composite with Improved Photothermal Conversion Efficiency for Tumor Therapy.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2025-07-21 Epub Date: 2025-06-12 DOI:10.1021/acsabm.5c00772

Ihtisham Ahmad Butt, Peinan Yin, Naihan Chen, Wei Zhang

{"title":"α-Fe Nanoparticles and Multiwalled Carbon Nanotubes Composite with Improved Photothermal Conversion Efficiency for Tumor Therapy.","authors":"Ihtisham Ahmad Butt, Peinan Yin, Naihan Chen, Wei Zhang","doi":"10.1021/acsabm.5c00772","DOIUrl":null,"url":null,"abstract":"The efficiency of photothermal therapy based on conventional Fe3O4 nanoparticles (NPs) is limited due to their low absorption in the near-infrared (NIR) region. To surmount this obstacle, α-Fe nanoparticles/multiwalled carbon nanotubes (MWCNTs) composite is synthesized by incipient wetness impregnation (IWI). Due to improved extinction and heat generation mechanism (plasmons/electrons thermalization) of metallic Fe NPs with in nanocomposite structure, the photothermal conversion efficiency of Fe/MWCNTs composite is 87.98% (content: 60 μg/mL, 808 nm at power density of 1 W/cm2), which is highest among the previously reported Fe3O4 and other carbon-based nanostructures. The HaCaT cell viability after 72 h of coculturing is more than 91%, indicating the good biocompatibility of nanocomposite. The viability of B16-F10 melanoma cells is only 9.78% (808 nm laser irradiation for 15 min at 0.33 W/cm2), demonstrating the potential for hands-on applications.","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"6291-6304"},"PeriodicalIF":4.6000,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1021/acsabm.5c00772","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/12 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}

引用次数: 0

Abstract

The efficiency of photothermal therapy based on conventional Fe₃O₄ nanoparticles (NPs) is limited due to their low absorption in the near-infrared (NIR) region. To surmount this obstacle, α-Fe nanoparticles/multiwalled carbon nanotubes (MWCNTs) composite is synthesized by incipient wetness impregnation (IWI). Due to improved extinction and heat generation mechanism (plasmons/electrons thermalization) of metallic Fe NPs with in nanocomposite structure, the photothermal conversion efficiency of Fe/MWCNTs composite is 87.98% (content: 60 μg/mL, 808 nm at power density of 1 W/cm²), which is highest among the previously reported Fe₃O₄ and other carbon-based nanostructures. The HaCaT cell viability after 72 h of coculturing is more than 91%, indicating the good biocompatibility of nanocomposite. The viability of B16-F10 melanoma cells is only 9.78% (808 nm laser irradiation for 15 min at 0.33 W/cm²), demonstrating the potential for hands-on applications.

查看原文本刊更多论文

α-铁纳米粒子与多壁碳纳米管复合材料光热转换效率提高的肿瘤治疗

传统的Fe3O4纳米颗粒在近红外（NIR）区吸收较低，限制了其光热治疗的效率。为了克服这一障碍，采用初湿浸渍法合成了α-Fe纳米颗粒/多壁碳纳米管（MWCNTs）复合材料。由于纳米复合结构金属铁NPs的消光和产热机制（等离子体激元/电子热化）得到改善，Fe/MWCNTs复合材料的光热转换效率为87.98%（含量：60 μg/mL， 808 nm，功率密度为1 W/cm2），是目前报道的Fe3O4和其他碳基纳米结构中最高的。共培养72 h后HaCaT细胞存活率大于91%，表明纳米复合材料具有良好的生物相容性。B16-F10黑色素瘤细胞的存活率仅为9.78% (808 nm激光照射15分钟，0.33 W/cm2)，显示了实际应用的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.