{"title":"Exploring Lipid Droplets for Enhancing Cytoskeletal Stability and Repair Capacity via Carbonized Polymer Dot-Assisted Fluorescence Imaging.","authors":"Zitong Yu, Shuping Xu","doi":"10.1021/acsabm.5c00834","DOIUrl":null,"url":null,"abstract":"<p><p>Lipid droplets (LDs), as dynamic organelles, are regarded as core carriers of energy storage and participate in cell signaling and metabolic process regulation. The interaction between LDs and cytoskeletons may profoundly affect cell growth and pathological processes; however, direct evidence is absent. Our study employed an LD-targeted carbonized polymer dot (CPD) that exhibits high photostability and superior imaging capabilities with confocal fluorescence imaging to visually observe the behaviors of LDs in reinforcing cytoskeletons and assisting cytoskeletal repair. Results demonstrate that LDs could enhance the stability of the cytoskeletons, helping cells resist damage from external factors. Once they were damaged, the LDs could quickly increase in content to facilitate cytoskeletal repair. These findings reveal the important role of LDs as \"regulatory hubs\" and offer fresh perspectives on the mechanism behind LD-cytoskeleton interactions.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"6360-6367"},"PeriodicalIF":4.6000,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1021/acsabm.5c00834","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/16 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
引用次数: 0
Abstract
Lipid droplets (LDs), as dynamic organelles, are regarded as core carriers of energy storage and participate in cell signaling and metabolic process regulation. The interaction between LDs and cytoskeletons may profoundly affect cell growth and pathological processes; however, direct evidence is absent. Our study employed an LD-targeted carbonized polymer dot (CPD) that exhibits high photostability and superior imaging capabilities with confocal fluorescence imaging to visually observe the behaviors of LDs in reinforcing cytoskeletons and assisting cytoskeletal repair. Results demonstrate that LDs could enhance the stability of the cytoskeletons, helping cells resist damage from external factors. Once they were damaged, the LDs could quickly increase in content to facilitate cytoskeletal repair. These findings reveal the important role of LDs as "regulatory hubs" and offer fresh perspectives on the mechanism behind LD-cytoskeleton interactions.
期刊介绍：
ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications.
The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.
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