ACS Applied Bio Materials最新文献

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Emerging Trends in Designing the Dendrimer-Based Drug Delivery for Antineoplastic Therapies. 基于树突分子的抗肿瘤药物递送设计的新趋势。
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-06-23 DOI: 10.1021/acsabm.5c00498
Mohammad Adnan Raza, Anjila Firdous, Umesh Gupta, Umesh Patil, Ambika Singh, Ajazuddin
{"title":"Emerging Trends in Designing the Dendrimer-Based Drug Delivery for Antineoplastic Therapies.","authors":"Mohammad Adnan Raza, Anjila Firdous, Umesh Gupta, Umesh Patil, Ambika Singh, Ajazuddin","doi":"10.1021/acsabm.5c00498","DOIUrl":"https://doi.org/10.1021/acsabm.5c00498","url":null,"abstract":"<p><p>Dendrimers, a sophisticated nanoscale concept, are transforming cancer treatment by tackling the critical challenges plaguing conventional therapies: poor drug solubility, systemic toxicity, oral bioavailability, side effects, and drug resistance therapy. These branched molecular frameworks serve as attractive drug delivery nanocarriers, with their engineered structure enabling controlled release and targeted delivery of chemotherapeutic agents. This breakthrough promises to enhance the therapeutic index of anticancer drugs dramatically. We explore how these systems optimize crucial parameters, such as release kinetics, hydrophobic drug encapsulation, reduced toxicity, and mimic protein. Engineering these molecular carriers necessitates careful consideration of surface chemistry and the role of the functional group, with each feature being carefully tweaked to maximize therapeutic effectiveness. The field has observed amazing advances through the application of innovative polymeric studies, particularly poly(amidoamine), poly[lactic-<i>co</i>-glycolic acid], and PEGylated dendrimers. These sophisticated designs have proven exceptional promise in enhancing biocompatibility and achieving accurate drug targeting at the site of action. Our research expands on the phenomenal versatility of dendrimer-based delivery systems across a wide range of new delivery strategies, including targeted delivery, gene therapy, photodynamic therapy, and photothermal treatment as well as immune response enhancement and stimuli-responsiveness. Preclinical and clinical research has provided persuasive evidence that they can reduce off-target toxicity while increasing therapeutic outcomes. Considering these hopeful advancements, significant barriers remain on the way to widespread clinical acceptance. These include complex safety assessments for long-term usage and meeting regulatory standards for FDA approval. As we look ahead, the continued development of multifunctional dendrimers holds remarkable promise for altering cancer therapy; however, additional clinical validation will be required to realize their full potential in medical practice.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unveiling Exosome Potential: Transforming Treatments for Neurodegeneration. 揭示外泌体潜能:神经变性的转化治疗。
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-06-23 DOI: 10.1021/acsabm.5c00096
Ankit Tiwari, Brijesh Singh, Gireesh Kumar Singh, Jairam Meena, Ashish Kumar Agrawal, Saroj Kumar, Gyan Modi
{"title":"Unveiling Exosome Potential: Transforming Treatments for Neurodegeneration.","authors":"Ankit Tiwari, Brijesh Singh, Gireesh Kumar Singh, Jairam Meena, Ashish Kumar Agrawal, Saroj Kumar, Gyan Modi","doi":"10.1021/acsabm.5c00096","DOIUrl":"https://doi.org/10.1021/acsabm.5c00096","url":null,"abstract":"<p><p>Exosomes, tiny extracellular vesicles, hold significant potential as biological nanocarriers for diverse therapeutic agents due to their exceptional ability to navigate through the barriers of biological systems. This comprehensive review delves into the capability of exosomes in the therapy of neurodegenerative disorders, concentrating on their potential for targeted drug delivery. It examines the complex processes involved in exosome-mediated drug delivery, including targeting, cellular uptake, intracellular trafficking, and therapeutic release. Insights from preclinical studies and clinical trials are exploited, highlighting the impactful applications of exosomes, particularly in the treatment of Parkinson's, Alzheimer's, ALS, and Huntington's diseases. The review also addresses challenges such as immunogenicity, scalability, and regulatory obstacles while exploring emerging technologies like advanced exosome engineering, personalized medicine, and the integration of nanotechnology. Overall, this review accentuates the potential impact of exosome-based treatments in biomedicine alongside the critical need to overcome existing barriers.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gadolinium-Conjugated Lipoic Acid Hydrogels for Magnetic Resonance Imaging. 磁共振成像用钆共轭硫辛酸水凝胶。
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-06-23 DOI: 10.1021/acsabm.5c00584
Andrew R Brotherton, Bennett Phillips-Sorich, Naedum DomNwachukwu, Matthew D Bailey, Aarnav S Patel, Claudio Luchinat, Giacomo Parigi, Thomas J Meade
{"title":"Gadolinium-Conjugated Lipoic Acid Hydrogels for Magnetic Resonance Imaging.","authors":"Andrew R Brotherton, Bennett Phillips-Sorich, Naedum DomNwachukwu, Matthew D Bailey, Aarnav S Patel, Claudio Luchinat, Giacomo Parigi, Thomas J Meade","doi":"10.1021/acsabm.5c00584","DOIUrl":"https://doi.org/10.1021/acsabm.5c00584","url":null,"abstract":"<p><p>A gadolinium-based contrast agent (GBCA) disulfide homodimer (Gd<sup>3+</sup>SS) has been incorporated into a lipoic acid (LA)-based hydrogel (Gd<sup>3+</sup>Gel) for enhanced magnetic resonance imaging (MRI). This study evaluates the magnetic properties and <i>in vitro</i> behavior of Gd<sup>3+</sup>Gel for potential applications in tracking internal injuries. Results indicate a direct shortening in the relaxation rate with greater magnitude of LA polymerization and a 2.8-fold enhancement in relaxivity (<i>r</i><sub>1</sub>) at 1.4 T when Gd<sup>3+</sup>SS was conjugated into the hydrogel. This effect is attributed to a significant increase in the rotational correlation time (τ<sub>r</sub>) from 0.22 ± 0.05 ns (Gd<sup>3+</sup>SS) to 6 ± 1 ns (Gd<sup>3+</sup>Gel). Retention studies confirm that Gd<sup>3+</sup>SS remains covalently within the hydrogel, with retention of 64.7 ± 1.9% for Gd<sup>3+</sup>SS and 14.0 ± 1.4% for noncovalent binding gadoterate. The hydrogel relaxation rate (1/<i>T</i><sub>1</sub>) increases from 1.1 to 3.5 s<sup>-1</sup> at 7 T from blank gel to Gd<sup>3</sup><sup>+</sup>Gel (0.24 mM Gd<sup>3+</sup>). Cell studies show that PC3-PIP and RAW 264.7 cells maintain high viability with Gd<sup>3+</sup>SS but exhibit reduced viability with Gd<sup>3+</sup>Gel, consistent with known lipoic acid effects on immortalized cell lines. Cellular uptake studies using ICP-MS and confocal fluorescence microscopy confirm that monomeric Gd<sup>3+</sup>SS is readily internalized, whereas Gd<sup>3+</sup>Gel significantly limits diffusion and uptake. Rheology was conducted to determine the zero-shear viscosity of the LA hydrogel at various concentrations of LA. These findings suggest that the LA hydrogel scaffold enhances MRI contrast, minimizes leaching, and is easily injectable. Gd<sup>3+</sup>Gel is a promising tool for potential targeted imaging and controlled uptake during healing processes.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enzyme-Responsive Phosphate-Crosslinked Microgels with Enhanced Foliar Adhesion and Insecticide Stability: An Approach for Sustained Insecticide Delivery and Increased Plant Growth. 具有增强叶面粘附和杀虫剂稳定性的酶响应磷酸酯交联微凝胶:一种持续递送杀虫剂和促进植物生长的方法。
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-06-23 DOI: 10.1021/acsabm.5c00109
Ankita Dhiman, Piyush Thaper, Kailash Chandra Naga, Garima Agrawal
{"title":"Enzyme-Responsive Phosphate-Crosslinked Microgels with Enhanced Foliar Adhesion and Insecticide Stability: An Approach for Sustained Insecticide Delivery and Increased Plant Growth.","authors":"Ankita Dhiman, Piyush Thaper, Kailash Chandra Naga, Garima Agrawal","doi":"10.1021/acsabm.5c00109","DOIUrl":"10.1021/acsabm.5c00109","url":null,"abstract":"<p><p>Stimuli-responsive, biodegradable polymeric carriers have emerged as a promising platform for the effective utilization of agrochemicals to address the challenge of environmental pollution. In this work, we present the fabrication of 3,4-dihydroxyhydrocinnamic acid (DC)-functionalized cellulose-based microgels (DC-CelP MGs) crosslinked with phosphate moieties for the sustained release of the imidacloprid (Im) insecticide. These microgels are ∼220 nm in diameter and can degrade in the presence of cellulase enzyme available in soil and salivary glands of insects. Im@DC-CelP MGs exhibit 8.6% loading efficiency and 65% encapsulation efficiency for Im. Im@DC-CelP MGs display ∼76 and ∼94% Im release in the presence of 10 and 15 U cellulase enzyme over 160 h, respectively. Notably, the encapsulation of Im in Im@DC-CelP MGs significantly improves its photostability. The developed microgels show good foliar adhesion on Chinese cabbage leaves, which is beneficial to reduce the insecticide loss by rain. Furthermore, in contrast to bare Im_UV and Confidor_UV, Im@DC-CelP MGs_UV are able to retain the insecticidal activity of Im against the green peach aphid (<i>Myzus persicae</i>) even after UV treatment for 12 h. Additionally, the presence of phosphate-based crosslinking units render these microgels as potential sources of P. Experimental results reveal that the spraying of the Im@DC-CelP MG formulation improves seed germination and overall plant growth in Chinese cabbage, with no visible phytotoxic effects. Also, acid phosphatase activity in Chinese cabbage roots is reduced upon treatment with DC-CelP MGs and Im@DC-CelP MGs, suggesting the availability of P upon degradation of DC-CelP MGs by the cellulase enzyme in soil. Moreover, no phytotoxicity in the case of potato plants further indicates the wider applicability of the developed microgels. Overall, these results exhibit that the developed microgel carriers with enhanced foliar adhesion and insecticide stability along with the slow release feature for P can act as a promising platform for sustainable agriculture practices.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An MSC Chemotactic and Bone-Replaceable PLGA Material Involving Chemokine Loading OCP for Orthopedic Bone Defect Repair. 含趋化因子加载OCP的MSC趋化和骨可替代PLGA材料用于骨科骨缺损修复。
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-06-23 DOI: 10.1021/acsabm.5c00549
Yasuaki Kuriyama, Ryo Hamai, Yu Mori, Ryuichi Kanabuchi, Kazuyoshi Baba, Kaori Tsuchiya, Toshimi Aizawa, Osamu Suzuki
{"title":"An MSC Chemotactic and Bone-Replaceable PLGA Material Involving Chemokine Loading OCP for Orthopedic Bone Defect Repair.","authors":"Yasuaki Kuriyama, Ryo Hamai, Yu Mori, Ryuichi Kanabuchi, Kazuyoshi Baba, Kaori Tsuchiya, Toshimi Aizawa, Osamu Suzuki","doi":"10.1021/acsabm.5c00549","DOIUrl":"https://doi.org/10.1021/acsabm.5c00549","url":null,"abstract":"<p><p>This study investigated whether a composite consisting of octacalcium phosphate (OCP) and porous poly(lactide-<i>co</i>-glycolide) (PLGA) involving recombinant stromal-derived factor-1 (SDF-1) can be used to repair severe orthopedic bone defects. Four experiments were conducted: 1) analysis of loading and release of a model protein for SDF-1, cytochrome c for OCP/PLGA; 2) observation of the effect of SDF-1 on migration of mesenchymal stem cells (MSCs) in the presence of OCP/PLGA in vitro; 3) histomorphometry and immunohistochemistry of bone regeneration of OCP/PLGA/SDF-1 by its implantation into a 3 mm diameter rat femoral transcortical defect for 4 weeks; and 4) micro-CT analysis of the tissue and Fourier transform infrared (FTIR) spectroscopy using undecalcified specimens. The binding effects of cytochrome c and SDF-1 on 40 wt % OCP/PLGA were compared using OCP/PLGA with SDF-1 or cytochrome c prepared under saturated (S) and supersaturated (SS) conditions, containing low or high calcium and phosphate ion concentrations. The loading rates were higher in OCP/PLGA regardless of SS conditions than in PLGA, while the release rate was higher in OCP/PLGA loaded under SS conditions throughout the time, up to 168 h. MSC migration was most enhanced in the OCP/PLGA and loaded under SS conditions for up to 48 h. Bone regeneration was enhanced in OCP/PLGA loaded under SS conditions followed by S conditions and no SDF-1 loading of the OCP/PLGA for up to 4 weeks. Micro-CT and FTIR analyses suggested the material's biodegradation and new bone replacement, which was consistent with the histomorphometry. Osteocalcin-positive cells, tartrate-resistant acid phosphatase-positive cells, and C-X-C motif chemokine receptor type 4 positive cells were localized around the OCP/PLGA under SS conditions, corresponding to higher resorption of the OCP granules. The results suggest that OCP/PLGA involving SDF-1 may repair severe orthopedic bone defects.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent Trends in Hydrogel-Based Biosensor Technology for the Diagnosis of Neurodegenerative Diseases. 基于水凝胶的生物传感器技术在神经退行性疾病诊断中的最新进展。
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-06-22 DOI: 10.1021/acsabm.5c00420
Seda Ayçiçek, Şule Coşkun Cevher, Selim Acar
{"title":"Recent Trends in Hydrogel-Based Biosensor Technology for the Diagnosis of Neurodegenerative Diseases.","authors":"Seda Ayçiçek, Şule Coşkun Cevher, Selim Acar","doi":"10.1021/acsabm.5c00420","DOIUrl":"10.1021/acsabm.5c00420","url":null,"abstract":"<p><p>Early diagnosis of neurodegenerative diseases is essential for the development of appropriate treatment strategies. Current diagnostic methods have a number of limitations and challenges. Alternative biomaterials such as hydrogels are potential candidates that are attracting attention in the design process of biosensors for the diagnosis of neurodegenerative diseases. Three-dimensional networks of cross-linked hydrophilic polymers, known as hydrogels, have characteristics that are comparable to those of biological tissues. The integration of hydrogels into biosensor designs for the diagnosis of neurodegenerative diseases offers functionality and structural advantages. This review summarizes recent trends in hydrogel-based biosensors for the detection of neurodegenerative diseases, their design, applications, as well as a comprehensive overview of their advantages and disadvantages.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NIR-II Fluorescence Imaging-Guided Combinatorial Therapy of Breast Cancer Using ICG/Chelerythrine-Loaded Aptamer-Targeted Liposomes. NIR-II荧光成像引导下使用ICG/ chelerythrine负载适配体靶向脂质体联合治疗乳腺癌。
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-06-22 DOI: 10.1021/acsabm.5c00779
Siyi Lan, Ye Wang, Shengnan Zhang, Pei Sun, Yun Li, Yawen Zhang, Zhiyi Chen, Bin Liu, Zhen Yuan
{"title":"NIR-II Fluorescence Imaging-Guided Combinatorial Therapy of Breast Cancer Using ICG/Chelerythrine-Loaded Aptamer-Targeted Liposomes.","authors":"Siyi Lan, Ye Wang, Shengnan Zhang, Pei Sun, Yun Li, Yawen Zhang, Zhiyi Chen, Bin Liu, Zhen Yuan","doi":"10.1021/acsabm.5c00779","DOIUrl":"10.1021/acsabm.5c00779","url":null,"abstract":"<p><p>Breast cancer remains a major global health challenge. Great efforts have been made to develop advanced theranostic platforms for breast cancer. A critical limitation of the current approaches is insufficient tumor accumulation. To address this, we developed AS1411 aptamer-functionalized liposomes coloaded with indocyanine green (ICG) and chelerythrine (I/C@Lipo-A) for enhanced breast cancer theranostics. ICG serves as a dual-functional agent, enabling deep-tissue fluorescence (FL) imaging in the second near-infrared (NIR-II, 1000-1700 nm) window and photothermal therapy (PTT). Leveraging ICG's superior tissue penetration and reduced scattering in the NIR-II window, this system significantly improves tumor delineation and therapeutic precision. Meanwhile, chelerythrine (CHE), a natural benzophenanthridine alkaloid with potent anticancer activity, induces mitochondrial dysfunction, apoptosis, and reactive oxygen species (ROS) generation. However, their clinical application has been hindered by poor solubility and bioavailability. By coencapsulating ICG and CHE within tumor-targeting liposomes, we synergistically enhanced CHE's anticancer efficacy while enabling NIR-II FL imaging-guided PTT. This combinatorial strategy not only suppressed primary tumor growth but also inhibited distant metastases, significantly improving survival rates. Our work presents a robust, multifunctional platform for precision breast cancer theranostics, overcoming key barriers in drug delivery and imaging-guided therapy.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lactoferrin-Anchored Carboxymethyl Pullulan-MgO Nanocomposites for Targeted Delivery of Trans-Ferulic Acid: Physicochemical Characterization, In vitro and Ex vivo Studies. 乳铁蛋白锚定的羧甲基普鲁兰-氧化镁纳米复合材料靶向递送反式阿魏酸:物理化学表征,体外和离体研究。
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-06-21 DOI: 10.1021/acsabm.5c00482
Prakash Kumar Sirvi, Paul Gajanan Balaji, Amit Kumar, Md Imtiyaz Alam, Ankita Sharma, Nabanita Das, Awesh Kumar Yadav
{"title":"Lactoferrin-Anchored Carboxymethyl Pullulan-MgO Nanocomposites for Targeted Delivery of Trans-Ferulic Acid: Physicochemical Characterization, In vitro and Ex vivo Studies.","authors":"Prakash Kumar Sirvi, Paul Gajanan Balaji, Amit Kumar, Md Imtiyaz Alam, Ankita Sharma, Nabanita Das, Awesh Kumar Yadav","doi":"10.1021/acsabm.5c00482","DOIUrl":"10.1021/acsabm.5c00482","url":null,"abstract":"<p><p>The design of efficacious nanotherapeutics for neurodegenerative disorders necessitates the development of precisely targeted delivery systems capable of transversing the blood-brain barrier (BBB) while sustaining therapeutic efficacy. Here, we introduce a novel brain-targeted nanocomposite system comprising carboxymethylated pullulan-magnesium oxide (CMP-MgO) matrix encapsulating trans-ferulic acid (TFA) and last surface-functionalized with lactoferrin (Lf) to facilitate receptor-mediated transcytosis. Comprehensive physicochemical characterization, including dynamic light scattering (DLS), proton-nuclear magnetic resonance (<sup>1</sup>H NMR), fourier transform infrared (FT-IR), high resolution-transmission electron microscopy (HR-TEM), atomic force microscopy (AFM), powder X-ray diffraction (PXRD), thermogravimetric analysis (TGA), and circular dichroism (CD) spectroscopy, confirmed the structural integrity functionalization, and stability of the nanocomposites. DLS studies exhibited a hydrodynamic diameter of 386 ± 5.06 nm, a polydispersity index of 0.087 ± 0.008, and a zeta potential of -20.5 ± 0.19 mV of the Lf-TFA-CMP-MgO. Morphological analysis confirmed spherical particles with a smooth surface, and CD spectroscopy confirmed the perpetuation of the native structure of Lf after conjugation with the nanocomposite. The antioxidant assay highlighted significant free radical scavenging activity, reflecting the antioxidant potential of TFA and TFA-loaded nanocomposites. <i>In vitro</i> studies demonstrated excellent biocompatibility and enhanced cellular internalization due to Lf functionalization. Notably, the nanocomposite inhibited amyloid fibril formation by interacting with hen egg white lysozyme (HEWL). Furthermore, intranasal delivery achieved efficient nose-to-brain transport, with permeability of 415.45 μg/cm<sup>2</sup> at 6 h, highlighting its mucoadhesive properties and noninvasive therapeutic capability for Alzheimer's disease (AD).</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design and Synthesis of Ibuprofen-Based Self-Deliverable Hybrid Gel Systems: Stabilization of Silver Nanoparticles, Antibacterial and Self-Healing Properties. 基于布洛芬的自输送混合凝胶系统的设计与合成:银纳米颗粒的稳定、抗菌和自愈性能。
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-06-20 DOI: 10.1021/acsabm.5c00681
Ashish Bora, Ritika Munjal, Argha Chakraborty, Lata Meena, Shabin N Chathangad, Sushabhan Sadhukhan, Suman Mukhopadhyay
{"title":"Design and Synthesis of Ibuprofen-Based Self-Deliverable Hybrid Gel Systems: Stabilization of Silver Nanoparticles, Antibacterial and Self-Healing Properties.","authors":"Ashish Bora, Ritika Munjal, Argha Chakraborty, Lata Meena, Shabin N Chathangad, Sushabhan Sadhukhan, Suman Mukhopadhyay","doi":"10.1021/acsabm.5c00681","DOIUrl":"10.1021/acsabm.5c00681","url":null,"abstract":"<p><p>The reported molecule gel-forming component <i>N</i><sup>1</sup>,<i>N</i><sup>3</sup>,<i>N</i><sup>5</sup>-tris(4-aminophenyl)benzene-1,3,5-tricarboxamide (<b>TABTA</b>) has been synthesized and characterized using various spectroscopic tools and techniques. The hybrid gel systems were fabricated using <b>TABTA</b> with <b>ibuprofen</b> and <b>G8</b>, which act as silver nanoparticle synthesis and stabilization templates. All gels were fabricated using the minimum critical gelation (MGC) method, and the interactions among the gelator components forming hybrid gel matrices were examined by using FT-IR and PXRD spectroscopy. <b>G8-TABTA</b> forms metallogels with Ag<sup>+</sup>, Fe<sup>3+</sup>, Fe<sup>2+</sup>, Co<sup>2+</sup>, Cu<sup>2+</sup>, and Zn<sup>2+</sup> but not with the Ni<sup>2+</sup> perchlorate salt. In contrast, <b>TABTA-Ibp</b> exclusively forms a metallogel with silver perchlorate. The synthesized gels were characterized as viscoelastic materials, based on their rheological behavior. The storage modulus (<i>G</i>') and loss modulus (<i>G</i>″), along with their dependence on applied mechanical strain, were assessed through amplitude sweep measurements for all gels. Further rheological investigations, such as frequency sweep and thixotropic studies, confirmed their gel-like characteristics. The <b>TABTA-Ibp</b> gel matrix possesses significant features as it can deliver itself, has excellent injectability, and has self-healing capabilities. Drug release was monitored by using UV-visible spectroscopy at two different pH levels. The release of the <b>ibuprofen</b> drug from <b>TABTA-Ibp</b> organogel and <b>TABTA-Ibp-Ag</b> metallogel matrices was studied at room temperature by layering the gels with PBS buffer solution. At varying pH levels, 3 mL of PBS buffer was added to the gel matrices and left for 72 h. The UV-vis spectra of the supernatant solutions, collected at different time intervals, were recorded to determine the amount of drug released. Additionally, the antibacterial potential of the <b>G8-TABTA</b>, <b>G8-TABTA-Ag</b>, <b>G8-TABTA-Zn</b>, <b>TABTA-Ibp</b>, and <b>TABTA-Ibp-Ag</b> xerogels was evaluated against Gram-negative <i>Escherichia coli</i> and Gram-positive <i>Bacillus subtilis</i> bacteria.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural Impact of Anthracene-Appended Mn-MOF on Human Serum Albumin and Its Cellular Implications. 蒽附Mn-MOF对人血清白蛋白的结构影响及其细胞意义。
IF 4.6
ACS Applied Bio Materials Pub Date : 2025-06-20 DOI: 10.1021/acsabm.5c00887
Shanmugavel Chinnathambi, Mahima Kumar, Basudeb Dutta, Karthikeyan Subramani, Saravanan Kandasamy, Sebastian Kmiecik, Thangavel Vaijayanthi, Ganesh N Pandian
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