ACS Applied Bio Materials最新文献

{"title":"","authors":"Xiaojie Lin, Ruofan Liu, Zijun Gao, Yang Zhou, Jacob Beitzel, Aya Noguchi, Masayuki Kyomoto and Miqin Zhang*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":"8 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsabm.5c00576","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Zitong Yu,  and , Shuping Xu*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":"8 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsabm.5c00834","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Manik Shit, Manas Mahapatra, Satyajit Halder, Arnab Samanta, Mahammad Anas, Kuladip Jana* and Chittaranjan Sinha*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":"8 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsabm.5c00672","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Soumik Chatterjee, Souradeepa Ghosh, Manoranjan Bera, Maniklal Shee, Budhaditya Mukherjee* and N. D. Pradeep Singh*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":"8 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsabm.5c00569","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Manleen Kaur,  and , Neetu Singh*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":"8 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsabm.5c00545","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Fangzheng Tong, Xuyang Zhang, Xuanwen Wang, Siying Liu, Xiaoliang Cui, Yajie Zhou, Gang Li* and Jun Zhang*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":"8 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acsabm.5c00621","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"pH-Responsive Nanosuspension Based on an Orthoester for Synergistic Chemodynamic and Photothermal Therapy in Localized Cancer Treatment.","authors":"Junjie Hu, Chi Zhang, Hao Xu, Yingda Wan, Xin Wang, Rupei Tang","doi":"10.1021/acsabm.5c00578","DOIUrl":"10.1021/acsabm.5c00578","url":null,"abstract":"<p><p>This study aims to develop a pH-responsive nanosuspension for localized cancer therapy by integrating photothermal therapy (PTT) and chemodynamic therapy (CDT). Initially, we synthesized a compound containing two five-membered cyclic orthoester bonds (OE) as a liquid pharmaceutical excipient. This OE was subsequently coloaded with the photothermal agent indocyanine green (ICG) and iron oxide nanoparticles (Fe₃O₄), forming a stable nanosuspension (OE/ICG/Fe₃O₄). OE exhibits acid-sensitive degradation, enabling controlled drug release in the tumor microenvironment. The Fe₃O₄ nanoparticles can induce the generation of reactive oxygen species (ROS) through the Fenton reaction, which synergizes effectively with the photothermal effect of ICG. Additionally, the OE/ICG/Fe₃O₄ formulation prolongs drug retention in tumor tissues and enhances drug penetration. Furthermore, the formulation induces immune modulation via Fe₃O₄, thereby enhancing the overall therapeutic efficacy. Under 808 nm near-infrared laser irradiation, a tumor suppression rate of 84.6% was achieved through the combination of photothermal and chemodynamic therapies and immunotherapy. This study highlights the potential of OE-based nanosuspensions for localized cancer treatment, offering a multifunctional strategy to improve treatment outcomes while minimizing systemic toxicity.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"5854-5868"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144264747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indolo-[2,3-<i>b</i>]quinoxaline: A Core for the Stabilization of Room Temperature Liquid Crystalline Self-Assembly, Aggregation-Induced Emission, and Bioimaging Applications.","authors":"Rahul Ahmed, Vinay Sharma, Shweta Thakar, Paresh Kumar Behera, Praveen Kandpal, Doddamane Sreenivasamurthy Shankar Rao, Achalkumar Ammathnadu Sudhakar","doi":"10.1021/acsabm.5c00762","DOIUrl":"10.1021/acsabm.5c00762","url":null,"abstract":"<p><p>Aggregation-induced emission (AIE) is a significant property that enables the translation of the fluorescence emission of chromophores in solution to the solid state. In recent years, the development of AIE-active liquid crystals has garnered considerable interest. In this context, we introduce a class of indolo[2,3-<i>b</i>]quinoxaline (<b>IQ</b>) based luminescent liquid crystals, demonstrating excellent solubility and thermal stability. The efficient space-filling interactions in compounds with seven and ten peripheral <i>N</i>-alkoxy chains (<b>IQ3</b> and <b>IQ4</b>) stabilize a columnar liquid crystalline phase at room temperature. Interestingly, these compounds exhibit tunable luminescence and liquid crystalline self-assembly in addition to technologically important AIE properties, in contrast to the commonly observed aggregation-caused quenching (ACQ) in the case of discotic liquid crystals (DLC). Compound <b>IQ4</b> was selected for bioimaging studies due to its robust fluorescence behavior and AIE-active properties, facilitating uniform staining throughout the nematode cell body. Under aggregated conditions, visualization of the nematode body was significantly enhanced. Additionally, <b>IQ4</b> was explored as a fluorescent probe for staining MCF7 cancer cells, where cellular uptake and localization studies revealed its exceptional fluorescence intensity and remarkable ability to target and visualize cancer cells. Its ability to stain individual cancer cells enabled high-contrast imaging with striking fluorescence signals, while its precise localization illuminated distinct cellular structures, thereby enhancing the resolution of bioimaging.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"6278-6290"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highly Selective Electrochemical Detection of Vitamin K1 (Phylloquinone) in Simulated Blood Serum Using Bimetallic Cu/Ni-MOF Decorated CNT Composite on Nickel Foam.","authors":"Manaswini Ravipati, Simran Moorjani, Divyasri Ramasamy, Sushmee Badhulika","doi":"10.1021/acsabm.5c00325","DOIUrl":"10.1021/acsabm.5c00325","url":null,"abstract":"<p><p>Phylloquinone (Vitamin K) is a vital vitamin for humans since it plays a critical role in blood clotting by enabling the synthesis of proteins required for coagulation. The physiological and therapeutic significance of Vitamin K (VIT K) necessitates the development of precise techniques for its accurate quantification. In this study, we report the electrochemical detection of Vitamin K in simulated blood serum using a bimetallic CuNi-MOF/CNT (copper/nickel metal-organic framework decorated carbon nanotube) composite on nickel foam (NF) via differential pulse voltammetry (DPV). The CuNi-MOF/CNT composite is synthesized using a one-pot solvothermal method, embedding Cu/Ni-MOF with CNTs to form a porous structure with enhanced electrical properties. Scanning electron microscopy (SEM) reveals the presence of bimetallic MOFs with granular and cubical morphologies along with well-dispersed CNT structures; Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analyses confirm functional group interactions and crystallinity of the CuNi-MOF/CNT composite. The CuNi-MOF/CNT composite, drop-casted (0.5 wt %) on a Ni foam electrode, exhibits excellent electrochemical performance with a wide linear detection range from 30 nM to 10 μM, a high sensitivity of 1.97 mA μM^-1 cm^-2, and a low detection limit (LOD) of 0.03 nM. The sensor displays commendable selectivity, as it maintains its activity even when it is subjected to potentially interfering species like DA, AA, UA, and H₂O₂. The composite demonstrates excellent stability and reproducibility (tested using four electrodes). The superior performance of the sensor can be ascribed to the synergistic effect of the bimetallic Cu/Ni-MOF and CNTs, which enhances electron transfer, increases surface area, and improves conductivity. The unique structural and electronic properties of the composite contribute to the enhanced electrocatalytic activity, demonstrating its potential for advanced biosensing applications in clinical diagnostics and next-generation wearable health monitoring systems.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"5670-5679"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144292976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tunable Drug Release through Varying Drug Affinities for Ocular Chronic Disease.","authors":"Hyeonah Lee, Serim Byun, Moonyoung Kim, Hyeokjung Kim, Hyeran Noh","doi":"10.1021/acsabm.5c00425","DOIUrl":"10.1021/acsabm.5c00425","url":null,"abstract":"<p><p>Effective drug delivery is critical for the management of chronic diseases such as glaucoma, where sustained therapeutic levels can significantly enhance treatment outcomes. In this study, we present a Particles-on-a-Gel (PoG) system that leverages differential nanocarrier affinities to modulate drug release kinetics. By integrating poly(N-isopropylacrylamide) nanogels (pNIPAM) and silver nanoparticles (AgNPs), the PoG platform enables both controlled initial release and prolonged drug delivery. Isothermal titration calorimetry (ITC) was employed to quantitatively characterize the thermodynamic interactions between timolol maleate and the nanocarriers, revealing distinct binding modalities─hydrophobic interactions with pNIPAM and chemically driven binding with AgNPs. These findings underscore the role of thermodynamic tuning in optimizing drug-carrier interactions to enhance release profiles and retention. Furthermore, incorporation of the PoG system into a contact lens-based drug delivery platform demonstrated its translational potential, maintaining optical transparency while enabling sustained drug release. Overall, this work highlights the promise of thermodynamically guided nanocarrier design in developing patient-centric drug delivery systems for chronic disease management.</p>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":" ","pages":"5732-5742"},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144323799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}