Somporn Palasarn, Prattana Tanyapanyachon, Vanicha Vichai, Phongeun Sysouphanthong, Kevin D Hyde, Nattika Saengkrit, Masahiko Isaka
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引用次数: 0
摘要
从担子菌Panus similis TBRC-BCC 52578培养物中分离到四种铬二聚体，panussimilins A-D(1-4)（消旋混合物）和两种先前描述过的铬（5a/5b和6a/6b）。有趣的是，以前已经报道了与panusimilins a - c（1-3）密切相关的合成化合物，这些化合物是由Lewis酸促进植物来源的色素precoceni二聚化产生的。在本研究中，从真菌P. similis的培养液中分离出泛菌素。铬单体是对映体的非外消旋混合物，它们的绝对构型通过转化为Mosher酯衍生物得到了证实。对分离得到的化合物进行了细胞毒活性评价。其中2,2-二甲基-3,4,6-三羟基铬胺（6a/6b）对NCI-H187细胞具有选择性活性（IC50为9.1 μM）。另一方面，panusimilin B(2)在DPPH自由基清除实验中显示出抗氧化活性（IC50 66 μM）。
Chromene Dimers from Cultures of Basidiomycete Panus similis.
Four chromene dimers, panusimilins A-D (1-4) (racemic mixtures), and two previously undescribed chromanes (5a/5b and 6a/6b) were isolated from cultures of basidiomycete Panus similis TBRC-BCC 52578. Interestingly, synthetic compounds closely related to panusimilins A-C (1-3) were previously reported, which were produced by Lewis acid promoted dimerization of a plant-derived chromene, precocene II. In the present study, panusimilins were isolated from the culture broth extract of the fungus P. similis. The chromane monomers were shown to be a non-racemic mixture of enantiomers, and their absolute configurations were elucidated by conversion to Mosher ester derivatives. The isolated compounds were evaluated for their cytotoxic activities. Among them, 2,2-dimethyl-3,4,6-trihydroxychromane (6a/6b) showed selective activity to NCI-H187 cells (IC50 9.1 μM). On the other hand, panusimilin B (2) exhibited antioxidant activity in the DPPH radical scavenging assay (IC50 66 μM).
期刊介绍：
The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
When new compounds are reported, manuscripts describing their biological activity are much preferred.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
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