Molecular Networking-Driven Discovery of Antifungal Azaphilone Dimers from the Marine-Derived Fungus Humicola sp. HK1-8.

IF 3.3 2区生物学 Q2 CHEMISTRY, MEDICINAL

Journal of Natural Products Pub Date : 2025-06-16 DOI:10.1021/acs.jnatprod.5c00531

Min Chen, Zhong-Hui Li, Xia-Hao Zhu, Li Shen, Long Chen, Tian-Chi Wu, Li-Kui Zhang, Juan-Juan Wang, Chang-Yun Wang

引用次数: 0

Abstract

A novel azaphilone dimer, humilone A (1), along with its related monomer, humilone B (2), was isolated from cultures of the marine-derived fungus Humicola sp. HK1-8 using a molecular networking-guided discovery approach. Further investigation of the molecular family of azaphilone dimers led to the putative identification of four analogues, humilones C-F (3-6), based on systematic analysis of their characteristic MS/MS fragmentation patterns. Detailed fragmentation studies of the dimers revealed that the predominant cleavage fragments originated from C-C bond scission at the dimeric methylene bridge. Compound 1 displayed antifungal activity against Rhizoctonia solani.

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海洋源真菌Humicola sp. HK1-8抗真菌Azaphilone二聚体的分子网络发现。

利用分子网络引导的发现方法，从海洋来源真菌Humicola sp. HK1-8的培养物中分离出一种新的氮蚜酮二聚体humilone A(1)及其相关单体humilone B(2)。对氮唑啉二聚体分子家族的进一步研究，基于对其特征的MS/MS片段模式的系统分析，得出了四种类似物，即葎草酮C-F（3-6）。对二聚体的详细裂解研究表明，主要的裂解片段来自二聚体亚甲基桥上的C-C键断裂。化合物1对茄枯丝核菌有一定的抑制作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Natural Products 生物-药学

CiteScore

9.10

自引率

5.90%

发文量

294

审稿时长

2.3 months

期刊介绍： The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin. When new compounds are reported, manuscripts describing their biological activity are much preferred. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.