Applied Biological Chemistry最新文献

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Biomarkers for biological quality control of Samsoeum: a scoping review 三叶草生物质量控制的生物标志物综述
IF 2.3 3区 农林科学
Applied Biological Chemistry Pub Date : 2025-05-26 DOI: 10.1186/s13765-025-01000-1
Mei Tong He, Ji Hwan Lee, Noriko Yamabe, Kiwon Jung, Ki Sung Kang
{"title":"Biomarkers for biological quality control of Samsoeum: a scoping review","authors":"Mei Tong He,&nbsp;Ji Hwan Lee,&nbsp;Noriko Yamabe,&nbsp;Kiwon Jung,&nbsp;Ki Sung Kang","doi":"10.1186/s13765-025-01000-1","DOIUrl":"10.1186/s13765-025-01000-1","url":null,"abstract":"<div><p>Samsoeum<b> (</b>SSE) is a traditional herbal prescription used to cure early signs of a cold such as headache, cough, runny nose, and fever. The safety and efficacy of SSE can be guaranteed with the use of its quality control biomarkers. Although chemical quality control is performed to ensure consistent efficacy of SSE, it has limitations in evaluating the efficacy of complex natural products. To find biological assays that could complement the biological quality control of SSE, we conducted a study of the literature. In this review, we collected and identified 17 articles that investigated the efficacy of SSE, including clinical, in vivo, and in vitro studies. As a result, most studies evaluated anti-inflammatory and anti-allergy efficacies. One clinical study has reported efficacy of SSE for chronic bronchitis. In basic studies, 7 in vivo studies and 4 in vitro studies were mainly related to chronic diseases, including inflammation, allergy, cancer, and obesity. Optimal in vitro and in vivo efficacy evaluation techniques that can assess consistent clinical effects should be chosen for future qualitative evaluation studies of herbal prescriptions (herbal medicines).</p></div>","PeriodicalId":467,"journal":{"name":"Applied Biological Chemistry","volume":"68 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://applbiolchem.springeropen.com/counter/pdf/10.1186/s13765-025-01000-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resveratrol protects against uremic serum-induced endothelial cell injury by activating the FUS/KLF2/FBXW7 signaling pathway 白藜芦醇通过激活FUS/KLF2/FBXW7信号通路来保护尿毒症血清诱导的内皮细胞损伤
IF 2.3 3区 农林科学
Applied Biological Chemistry Pub Date : 2025-05-24 DOI: 10.1186/s13765-025-00997-9
Danjun Wang, Jianlian Liu, Juan Wang, Yang Feng
{"title":"Resveratrol protects against uremic serum-induced endothelial cell injury by activating the FUS/KLF2/FBXW7 signaling pathway","authors":"Danjun Wang,&nbsp;Jianlian Liu,&nbsp;Juan Wang,&nbsp;Yang Feng","doi":"10.1186/s13765-025-00997-9","DOIUrl":"10.1186/s13765-025-00997-9","url":null,"abstract":"<div><h3>Background</h3><p>Chronic kidney disease causes endothelial cell dysfunction associated with uremia, which triggers a high risk of cardiovascular diseases. Furthermore, prolonged exposure of the vascular endothelium to uremic toxins could provoke endothelial damage in patients with end-stage renal disease. Resveratrol (RSV), a dietary polyphenol compound, has been reported to possess health benefits due to its anti-inflammatory and anti-oxidative properties. However, the role of RSV on uremic serum (US)-induced endothelial cell injury is still unclear.</p><h3>Methods</h3><p>HUVECs were stimulated by the US to mimic the inflammatory damage model in vitro. Cell viability and apoptosis were detected using CCK-8 and flow cytometry. IL-6, IL-1β, and TNF-α were evaluated using ELISA. ROS and SOD levels were detected using special assay kits. Kruppel-Like Factor 2 (KLF2), Fused-in-Sarcoma (FUS), and F-box and WD repeat domain-containing 7 protein (FBXW7) levels were determined using western blot. KLF2 mRNA level was examined using RT-qPCR. After ENCORI, HitPredict, and BioGRID software prediction, the interaction between KLF2 and FUS or FBXW7 was identified using RIP and Co-Immunoprecipitation (IP) assays.</p><h3>Results</h3><p>RSV could relieve US-triggered HUVEC viability inhibition, apoptosis, inflammatory response, and oxidative stress promotion. KLF2 knockdown partly attenuated the repression of RSV on US-induced HUVEC injury. Mechanistically, FUS bound with KLF2 to improve the stability of KLF2 mRNA. KLF2 interacted with FBXW7. RSV hindered US-caused HUVEC injury by regulating FUS/KLF2/FBXW7 pathway.</p><h3>Conclusion</h3><p>RSV exposure could mitigate US-evoked HUVEC dysfunction by activating the FUS/KLF2/FBXW7 pathway, providing a better understanding of the role of RSV in the anti-inflammatory therapeutics for uremia treatment.</p></div>","PeriodicalId":467,"journal":{"name":"Applied Biological Chemistry","volume":"68 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://applbiolchem.springeropen.com/counter/pdf/10.1186/s13765-025-00997-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144125525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of residue dissipation of hexaconazole in Chinese cabbage and spring scallion 六硝唑在大白菜和小葱中的残留耗散特性研究
IF 2.3 3区 农林科学
Applied Biological Chemistry Pub Date : 2025-05-23 DOI: 10.1186/s13765-025-00995-x
Ji Won Lee, Jin-Seong Kim, Ji Hyun Park, Hyun Ho Noh, Min Seok Oh, Jin-Hyo Kim, Kyeong-Ae Son
{"title":"Characterization of residue dissipation of hexaconazole in Chinese cabbage and spring scallion","authors":"Ji Won Lee,&nbsp;Jin-Seong Kim,&nbsp;Ji Hyun Park,&nbsp;Hyun Ho Noh,&nbsp;Min Seok Oh,&nbsp;Jin-Hyo Kim,&nbsp;Kyeong-Ae Son","doi":"10.1186/s13765-025-00995-x","DOIUrl":"10.1186/s13765-025-00995-x","url":null,"abstract":"<div><p>The characterization of hexaconazole residues was evaluated through both single and sequential applications in Chinese cabbage and spring scallion. Maximum residue levels following foliar application were determined to be 1.14 mg kg<sup>− 1</sup> in the cabbage and 0.04 mg kg<sup>− 1</sup> in the scallion, whereas the soil application contributed minimally. Notably, the initial residue in the cabbage was 28 times greater than that observed in the scallion. Fourteen days after the final foliar application, the cabbage exhibited a 3.6-fold increase in fresh weight, compared to a 1.4-fold increase in the scallion. The degradation rates of hexaconazole were calculated at 0.089 day<sup>− 1</sup> for the cabbage and 0.207 day<sup>− 1</sup> for the scallion, corresponding with degradation half-lives (T<sub>1/2</sub>) of 7.8 days for the cabbage, which was more than double the 3.4 days for the scallion. Biological T<sub>1/2</sub>s in vitro were 210 min for the scallion, while the degradation was not detected in the cabbage. Finally, the 50% dissipation times (DT<sub>50</sub>) were 3.6–3.8 days for the cabbage and 2.0-3.7 days for the scallion after foliar and sequential applications. In addition, hexaconazole exhibited persistence in soil under greenhouse conditions, resulting in the translocation of residues to rotational crops with detected concentrations reaching up to 0.013 mg kg<sup>− 1</sup>.</p></div>","PeriodicalId":467,"journal":{"name":"Applied Biological Chemistry","volume":"68 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://applbiolchem.springeropen.com/counter/pdf/10.1186/s13765-025-00995-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144117651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The antioxidant activity of diosgenin, a plant steroid sapogenin, in C2C12 myoblasts is achieved by blocking mitochondrial ROS production 薯蓣皂苷元(一种植物甾体皂苷元)在C2C12成肌细胞中的抗氧化活性是通过阻断线粒体ROS的产生来实现的
IF 2.3 3区 农林科学
Applied Biological Chemistry Pub Date : 2025-05-22 DOI: 10.1186/s13765-025-00996-w
Cheol Park, Gi-Young Kim, Yung Hyun Choi
{"title":"The antioxidant activity of diosgenin, a plant steroid sapogenin, in C2C12 myoblasts is achieved by blocking mitochondrial ROS production","authors":"Cheol Park,&nbsp;Gi-Young Kim,&nbsp;Yung Hyun Choi","doi":"10.1186/s13765-025-00996-w","DOIUrl":"10.1186/s13765-025-00996-w","url":null,"abstract":"<div><p>Diosgenin, a plant-derived steroid sapogenin, has been reported to have many health benefits, including antioxidant activity. Although oxidative stress is a major factor impeding the differentiation and homeostasis of skeletal muscles, its antioxidant activity in skeletal muscle cells has not been thoroughly studied. This study aimed to explore the protective mechanisms of diosgenin against oxidative damage in skeletal muscle cells. C2C12 murine myoblasts were pretreated with nontoxic concentrations of diosgenin and exposed to hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) to mimic oxidative stress. The results of this study showed that diosgenin significantly reduced H<sub>2</sub>O<sub>2</sub>-induced cytotoxicity, blocked the formation of comet tails, and increased the levels of 8-hydroxy-2’-deoxyguanosine, which are representative biomarkers of DNA damage. In addition, diosgenin counteracted H<sub>2</sub>O<sub>2</sub>-induced apoptosis by enhancing the Bax/Bcl-2 expression ratio and suppressing the activation of the caspase cascade, which is associated with the blockade of cytochrome <i>c</i> release into the cytoplasm by maintaining mitochondrial stability. Furthermore, diosgenin eliminated the production of intracellular and mitochondrial reactive oxygen species (ROS) by restoring glutathione (GSH) content and the activities of antioxidant enzymes such as GSH peroxidase 1 and manganese-dependent superoxide dismutase, which were inhibited by H<sub>2</sub>O<sub>2</sub>. Therefore, diosgenin protects C2C12 myoblasts from oxidative damage by attenuating mitochondrial ROS generation and regulating the mitochondrial apoptotic pathway.</p></div>","PeriodicalId":467,"journal":{"name":"Applied Biological Chemistry","volume":"68 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://applbiolchem.springeropen.com/counter/pdf/10.1186/s13765-025-00996-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144117788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
7,8-dihydroxyflavone and daphnetin have virucidal and neuraminidase inhibition activities against influenza A virus in vitro 7,8-二羟黄酮和瑞香素对甲型流感病毒具有体外杀病毒和神经氨酸酶抑制作用
IF 2.3 3区 农林科学
Applied Biological Chemistry Pub Date : 2025-05-21 DOI: 10.1186/s13765-025-00998-8
Sujeong Kim, Ju Won Kim, Sanghyun Lee, Yo Han Jang
{"title":"7,8-dihydroxyflavone and daphnetin have virucidal and neuraminidase inhibition activities against influenza A virus in vitro","authors":"Sujeong Kim,&nbsp;Ju Won Kim,&nbsp;Sanghyun Lee,&nbsp;Yo Han Jang","doi":"10.1186/s13765-025-00998-8","DOIUrl":"10.1186/s13765-025-00998-8","url":null,"abstract":"<div><p>Influenza A virus remains a major global health concern, underscoring the need for novel antiviral agents. This study investigated the antiviral potential of two natural compounds, 7,8-dihydroxyflavone (DHF) and daphnetin (DAP), against influenza A viruses in vitro. Following in vitro cytotoxicity and antioxidative activity assessments, the antiviral effects of DHF and DAP were evaluated, with a particular focus on their direct viral inhibition. DHF and DAP demonstrated complete virucidal activity influenza A virus at concentrations of 50 µM and 100 µM, respectively. However, neither compound inhibited influenza surface protein hemagglutination (HA), suggesting that their virucidal effects are independent of HA receptor binding. Both compounds exhibited neuraminidase (NA) inhibition, with DAP showing stronger activity compared to DHF. Furthermore, DHF and DAP suppressed influenza virus replication in cells, as evidenced by a reduction in green fluorescence protein (GFP) reporter expression in virus-infected cells. Growth kinetics analysis revealed that both compounds significantly reduced viral replication when applied to cells before or after viral infection. These findings demonstrate that DHF and DAP exhibit multifaceted antiviral activity, including direct virucidal action, NA inhibition, and suppression of viral replication. Our results suggest that DHF and DAP are promising candidates for the development of novel influenza therapeutics.</p></div>","PeriodicalId":467,"journal":{"name":"Applied Biological Chemistry","volume":"68 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://applbiolchem.springeropen.com/counter/pdf/10.1186/s13765-025-00998-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144100276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multifunctional properties of Phlomis aurea extracts: In-vitro antioxidant, antimicrobial, anticancer, potent repellency against two mosquito vectors and molecular docking studies 金莲提取物的多功能特性:体外抗氧化、抗菌、抗癌、对两种蚊媒的强驱避及分子对接研究
IF 2.3 3区 农林科学
Applied Biological Chemistry Pub Date : 2025-05-20 DOI: 10.1186/s13765-025-00982-2
Mohamed A. M. El-Tabakh, Ahmed Z. I. Shehata, Ahmed M. Sadek, Salem S. Salem, Ahmed A. Elmehdawy, Mahmoud Nazih, Gamal M. Omar, Ahmed A. Abo Elsoud, Ahmed N. G. Abdel-Aziz, Sozan Eid El-Abeid, Heba F. Abd-Elkhalek, Omnia M. Arief
{"title":"Multifunctional properties of Phlomis aurea extracts: In-vitro antioxidant, antimicrobial, anticancer, potent repellency against two mosquito vectors and molecular docking studies","authors":"Mohamed A. M. El-Tabakh,&nbsp;Ahmed Z. I. Shehata,&nbsp;Ahmed M. Sadek,&nbsp;Salem S. Salem,&nbsp;Ahmed A. Elmehdawy,&nbsp;Mahmoud Nazih,&nbsp;Gamal M. Omar,&nbsp;Ahmed A. Abo Elsoud,&nbsp;Ahmed N. G. Abdel-Aziz,&nbsp;Sozan Eid El-Abeid,&nbsp;Heba F. Abd-Elkhalek,&nbsp;Omnia M. Arief","doi":"10.1186/s13765-025-00982-2","DOIUrl":"10.1186/s13765-025-00982-2","url":null,"abstract":"<div><p>To develop economically viable and environmentally benign methodologies for organic reactions and reveal the practical utility of transitional natural compounds and their derivatives. In addition, a new research method to conduct docking studies against nuclear factors sheds light on the theoretical mechanism of action of <i>Phlomis aurea</i> extracts as antioxidant, antimicrobial, anticancer, and repellent. The pharmacological potential of <i>Phlomis aurea</i> is investigated in this research by analysing its aqueous and petroleum ether extracts. So, to evaluate antioxidant activity, the DPPH scavenging test was used and compared against ascorbic acid; aqueous extract showed noteworthy activity. Both extracts demonstrated noteworthy efficacy against various pathogens, such as <i>Enterococcus faecalis</i>,<i> Staphylococcus aureus</i>, and <i>Candida albicans</i>. The anti-cancer activity was also assessed using in-vitro assay on a standard cell line (Wi38) and two cancer cell lines (MDA and HepG2). The sensitivity of starving female <i>An. pharoensis</i> to the studied extracts was higher than that of <i>Cx. pipiens</i>, suggesting that these extracts may have potential applications in vector control. Docking study against nuclear factor erythroid 2–related factor 2 (Nrf2) (PDB ID: 3wn7), topoisomerase IV (PDB ID: 7lhz), COX protein (PDB ID: 6y3c), and Odorant Binding Protein 7 (OBP7) (PDB ID: 3r1o), to shed light on the theoretical mechanism expected as anti-oxidant, anti-microbial, anti-cancer and repellent effects against mosquitoes respectively, for galic acid as most significantly quantifying compounds on both extracts; highlighting the predicted mechanism of the proposed in-vitro assay, and confirming the present result.</p></div>","PeriodicalId":467,"journal":{"name":"Applied Biological Chemistry","volume":"68 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://applbiolchem.springeropen.com/counter/pdf/10.1186/s13765-025-00982-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144091095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kaempferol promotes apoptosis and inhibits proliferation and migration by suppressing HIF-1α/VEGF and Wnt/β-catenin activation under hypoxic condition in colon cancer 山奈酚通过抑制结肠癌缺氧条件下HIF-1α/VEGF和Wnt/β-catenin的激活,促进凋亡,抑制增殖和迁移
IF 2.3 3区 农林科学
Applied Biological Chemistry Pub Date : 2025-05-07 DOI: 10.1186/s13765-025-00992-0
Muhammad Haroon, Sun Chul Kang
{"title":"Kaempferol promotes apoptosis and inhibits proliferation and migration by suppressing HIF-1α/VEGF and Wnt/β-catenin activation under hypoxic condition in colon cancer","authors":"Muhammad Haroon,&nbsp;Sun Chul Kang","doi":"10.1186/s13765-025-00992-0","DOIUrl":"10.1186/s13765-025-00992-0","url":null,"abstract":"<div><p>A naturally occurring flavonoid compound found in several fruits and vegetables, kaempferol has garnered interest for its potential anticancer effects. The present investigation illustrates that kaempferol has multi-faceted anti-tumor effects in hypoxic colon cancer cells, HCT-15 (ATCC) and HCT-116 (KCLB) by inhibiting HIF-1α/VEGF angiogenesis, Wnt/β-catenin signaling, and epithelial-mesenchymal transition (EMT) progression. In conditions of hypoxia, kaempferol inhibited the stabilization of HIF-1α and its downstream targets (VEGF, ANG1, VEGFR2), while also obstructing Wnt/β-catenin activation by decreasing β-catenin and modifying the expression of pathway components (c-Myc, Cyclin-D1, LEF1, APC, and Axin-2). Kaempferol mitigated hypoxia-induced EMT by reinstating E-cadherin and inhibiting N-cadherin, Vimentin, and MMP-2/9, which corresponded with diminished migration in transwell and wound-healing assay. Mechanistic investigations demonstrated dual regulation of HIF-1α transcriptional activity (HRE luciferase) and MAPK signaling (p-ERK/p-38), in conjunction with ROS-induced DNA damage and intrinsic apoptosis (cleaved caspase-3/9 and Bcl-2 protein expression). The impact on angiogenesis, EMT, and survival pathways significantly diminished the proliferation, invasion, and metastatic capacity of hypoxic colon cancer cells which identifies kaempferol as an innovative multi-pathway inhibitor, thereby offering a strong justification for its advancement as a therapeutic agent for advanced colorectal cancer.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":467,"journal":{"name":"Applied Biological Chemistry","volume":"68 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://applbiolchem.springeropen.com/counter/pdf/10.1186/s13765-025-00992-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-cancer effects of wistin on malignant melanoma cells 维丝汀对恶性黑色素瘤细胞的抗癌作用
IF 2.3 3区 农林科学
Applied Biological Chemistry Pub Date : 2025-04-26 DOI: 10.1186/s13765-025-00991-1
Minjoo Han, Seong-Ah Shin, Huiji Kim, Mi-Jeong Ahn, Chang Sup Lee
{"title":"Anti-cancer effects of wistin on malignant melanoma cells","authors":"Minjoo Han,&nbsp;Seong-Ah Shin,&nbsp;Huiji Kim,&nbsp;Mi-Jeong Ahn,&nbsp;Chang Sup Lee","doi":"10.1186/s13765-025-00991-1","DOIUrl":"10.1186/s13765-025-00991-1","url":null,"abstract":"<div><p>Malignant melanoma (MM) is a severe skin cancer that arises from melanocytes, primarily caused by exposure to ultraviolet radiation. Although MM occurs less frequently than other skin cancers, its metastasis is easily activated, leading to a high mortality rate. MM incidence is gradually rising, necessitating the development of effective treatment strategies. Phytochemicals derived from plants are well recognized for their biological functions, including anticancer, anti-inflammatory, and antibacterial activities. However, the anticancer activity of wistin, an isoflavone, in MM remains unknown. This study aimed to investigate the anticancer effects of wistin on MM by elucidating its underlying molecular mechanisms. In this study, wistin significantly inhibited the cell viability and proliferation of B16 F10 melanoma cells. In addition, wistin induced apoptosis and cell cycle arrest and suppressed cell migration and invasion in B16 F10 cells. Moreover, our findings revealed that wistin downregulates phospho-ERK and p38. Overall, our results indicate that wistin exerts its anticancer effects by inhibiting the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways. Therefore, wistin could be a potential therapeutic candidate for the treatment of MM.</p></div>","PeriodicalId":467,"journal":{"name":"Applied Biological Chemistry","volume":"68 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://applbiolchem.springeropen.com/counter/pdf/10.1186/s13765-025-00991-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From nature to nutrition: exploring the synergistic benefits of functional foods and herbal medicines for holistic health 从自然到营养:探索功能性食品和草药对整体健康的协同效益
IF 2.3 3区 农林科学
Applied Biological Chemistry Pub Date : 2025-04-21 DOI: 10.1186/s13765-025-00985-z
Joyce Mudondo, Kenneth Happy, Roggers Gang, Yeongjun Ban, Youngmin Kang
{"title":"From nature to nutrition: exploring the synergistic benefits of functional foods and herbal medicines for holistic health","authors":"Joyce Mudondo,&nbsp;Kenneth Happy,&nbsp;Roggers Gang,&nbsp;Yeongjun Ban,&nbsp;Youngmin Kang","doi":"10.1186/s13765-025-00985-z","DOIUrl":"10.1186/s13765-025-00985-z","url":null,"abstract":"<div><p>Functional foods and herbal medicines have gained global demand due to their health benefits, which have led to increased consumer interest. Their contribution to health is associated to the existence of bioactive compounds with several pharmacological properties such as antidiabetic, antimicrobial, anticancer, and antiinflammatory activities etc. Several phytochemical compounds have been reported to prevent lifestyle disorders and diseases such as cardiovascular diseases, diabetes, obesity, and hypertension. Functional foods include dairy products, bakery products and cereals, nutraceuticals, fermented foods, probiotics and prebiotics, vegetables, and fruits, whereas herbal medicines include several herbal plants not limited to ginseng, <i>ginkgo biloba</i>, and <i>ephedra</i> etc. which are expressed in many several forms such as decoctions, capsules, powders, teas, and oils. The transformation of herbal medicines from general consumption has led to the infusion of herbal extracts into foods, leading to the development of herbal functional foods including porridges, soups, beverages, biscuits, candies, chocolates, and dietary supplements. Thus, this review aims to explore the synergistic pharmacological activities of functional foods and herbal medicines as well as the challenges shaping the industry. Following the growing demand of functional foods and herbal medicines, we found that similar bioactive compounds in functional foods and herbal medicines contribute to their health benefits. However, critical issues regarding the regulation of functional foods and herbal medicines to establish their safety and efficacy are still present. Therefore, research on functional foods and herbal medicines is necessary to confirm their safety and efficacy and thereby attract more consumers.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":467,"journal":{"name":"Applied Biological Chemistry","volume":"68 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://applbiolchem.springeropen.com/counter/pdf/10.1186/s13765-025-00985-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143856585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Design, synthesis, and biological evaluation of (E)-2-benzylidene-1-indanones derivatized by bioisosteric replacement of aurones 修正:设计、合成和生物等构取代aurones衍生的(E)-2-苄基-1-吲哚酮的生物学评价
IF 2.3 3区 农林科学
Applied Biological Chemistry Pub Date : 2025-04-18 DOI: 10.1186/s13765-025-00987-x
Youngshim Lee, Seunghyun Ahn, Euitaek Jung, Dongsoo Koh, Yoongho Lim, Young Han Lee, Soon Young Shin
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