Applied Biological Chemistry最新文献

{"title":"Comparative analysis of anti-obesity effects of green, fermented, and γ-aminobutyric acid teas in a high-fat diet-induced mouse model","authors":"Seung-Jun Lee,&nbsp;Kyoung Hwan Cho,&nbsp;Jong Cheol Kim,&nbsp;Ho Jin Choo,&nbsp;Jeong-Yun Hwang,&nbsp;Hyun Chin Cho,&nbsp;Young-Sool Hah","doi":"10.1186/s13765-024-00888-5","DOIUrl":"10.1186/s13765-024-00888-5","url":null,"abstract":"<div><p>Obesity, a prevalent disease associated with numerous chronic conditions, including hyperlipidemia, hyperglycemia, diabetes, and metabolic syndrome, remains a major global health challenge. This study investigated the potential of green tea (GT), fermented tea (FT), and γ-aminobutyric acid (GABA) tea (GBT), which are rich in phytonutrients and polyphenols, for the management of obesity. Using a high-fat diet-induced obese mouse model (C57BL/6N), we explored the effect of these teas on various obesity-related parameters. The mice were categorized into five groups: normal diet with water, high-fat diet with water, and high-fat diet supplemented with GT, FT, or GBT. Over 13 weeks, we monitored body weight, perirenal and liver fat, adipocyte lipid accumulation, and key metabolic indicators, such as serum cholesterol, leptin, insulin, and fasting blood glucose. These teas contain beneficial phytochemicals such as GABA, theanine, and caffeine, and have demonstrated an enhanced antioxidant capacity, which increases the scavenging of free radicals and may reduce oxidative stress. The animal study indicated a decrease in feeding efficiency and significant reductions in body weight liver fat, epididymal fat, and perirenal fat, as well as in adipocyte lipid accumulation. Additionally, notable improvements were observed in metabolic health indicators, including reductions in serum cholesterol, leptin, insulin, and fasting blood glucose levels. Our findings revealed that GT, FT, or GBT significantly counteracted the negative effects of a high-fat diet, suggesting their potential in combating obesity and related metabolic disorders.</p></div>","PeriodicalId":467,"journal":{"name":"Applied Biological Chemistry","volume":"67 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://applbiolchem.springeropen.com/counter/pdf/10.1186/s13765-024-00888-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140297156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Murraya koenigii (L.) Sprengel seeds and pericarps in relation to their chemical profiles: new approach for multidrug resistant Acinetobacter baumannii ventilator-associated pneumonia","authors":"Riham A. El-Shiekh,&nbsp;Rana Elshimy,&nbsp;Asmaa A. Mandour,&nbsp;Hanaa A. H. Kassem,&nbsp;Amal E. Khaleel,&nbsp;Saleh Alseekh,&nbsp;Alisdair R. Fernie,&nbsp;Mohamed A. Salem","doi":"10.1186/s13765-024-00886-7","DOIUrl":"10.1186/s13765-024-00886-7","url":null,"abstract":"<div><p><i>Acinetobacter</i> <i>baumannii</i> is without a doubt one of the most problematic bacteria causing hospital-acquired nosocomial infections in today's healthcare system. To solve the high prevalence of multi-drug resistant (MDR) in <i>A.</i> <i>baumannii</i>, we investigated one of the medicinal plants traditionally used as antibacterial agent; namely <i>Murraya</i> <i>koenigii</i> (L.) Sprengel. The total methanolic extracts of seeds and pericarps were prepared and their anti-bacterial activity was assessed using the agar diffusion method and minimum inhibitory concentration (MIC) was then calculated as compared to tigecycline. Then, an in-vivo murine model was established which confirmed the promising activity of <i>M.</i> <i>koenigii</i> seeds in demonstrating anti-bacterial and anti-inflammatory actions. The histopathological study of lungs, scoring of pulmonary lesions, counting of bacterial loads after infection by multi-drug resistant <i>A.</i> <i>baumannii</i> all provided evidence to support these findings. LC–MS/MS profiling coupled to molecular networking and chemometrics detected the presence of carbazole alkaloids, and coumarins as dominate metabolites of the active seed extracts. Positively correlated metabolites to antibacterial potential were 6-(2ʹ,3ʹ-dihydroxy-3-methylbutyl)-8-prenylumbelliferone, scopoline, and 5-methoxymurrayatin. An in-silico study was also performed on the crystal structure of MurF from <i>A.</i> <i>baumannii</i> (PDB ID: 4QF5), the studied structures of the mentioned extracts revealed good docking interaction at the active site suggestive of competition with the ATP ligand. These collective findings suggest that extracts of <i>Murraya</i> <i>koenigii</i> (L.) Sprengel seed is a novel prospective for the discovery of drug candidates against infections caused by MDR <i>A.</i> <i>baumannii</i>.</p></div>","PeriodicalId":467,"journal":{"name":"Applied Biological Chemistry","volume":"67 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://applbiolchem.springeropen.com/counter/pdf/10.1186/s13765-024-00886-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140291351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and application of a high-performance liquid chromatography diode-array detection (HPLC–DAD) method for the simultaneous quantification of phenolic compounds in the aerial part of Glehnia littoralis","authors":"Yun Ji Park,&nbsp;Yeong Bin Choi,&nbsp;Sang-Bin Oh,&nbsp;Jinyoung Moon,&nbsp;To Quyen Truong,&nbsp;Phuong Kim Huynh,&nbsp;Sang Min Kim","doi":"10.1186/s13765-024-00884-9","DOIUrl":"10.1186/s13765-024-00884-9","url":null,"abstract":"<div><p><i>Glehnia littoralis</i>, a medicinal herb employed in traditional practices for alleviating fatigue, cough, and a dry throat, is recognized for its beneficial properties due to a diverse array of active compounds found in its extracts. For example, the <i>G. littoralis</i> roots (Radix Glehniae) mainly contain coumarins and phenolic acids, serving as the primary focus of this study. Despite the widespread use of the tools in various industries and the development of multiple analytical methods for their examination, the edible aerial parts have industrial potential, and there is currently no analytical method available to identify their key components. In this study, a high-performance liquid chromatography method combined with diode array detection (HPLC–DAD) was developed to simultaneously detect 16 phenolic compounds previously reported to be present in the edible aerial parts of <i>G. littoralis</i>. The proposed approach included using gradient elution to change the solvent system from water/acetonitrile to water/methanol. Furthermore, the method validation was conducted, assessing its linearity, limit of detection, limit of quantification, precision, accuracy, and recovery, all of which demonstrated satisfactory results. Subsequently, the developed method was applied to quantify the phenolic compounds in various <i>G. littoralis</i> samples obtained from different organs, solvent extraction processes, and processing methods. Moreover, the online HPLC-ABTS (2,2ʹ-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) assay was used to evaluate the antioxidant capacities of individual constituents, identifying four important antioxidants and estimate the overall antioxidant capacity of the <i>G. littoralis</i> extract.</p></div>","PeriodicalId":467,"journal":{"name":"Applied Biological Chemistry","volume":"67 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://applbiolchem.springeropen.com/counter/pdf/10.1186/s13765-024-00884-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140188472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation analysis between artemisinin and its derivative contents and trichome characteristics from different Artemisia species","authors":"Yun Ji Park,&nbsp;To Quyen Truong,&nbsp;Yeong Bin Choi,&nbsp;Phuong Kim Huynh,&nbsp;Jinyoung Moon,&nbsp;Song Yi Koo,&nbsp;Hyoung Seok Kim,&nbsp;Sang Min Kim","doi":"10.1186/s13765-024-00883-w","DOIUrl":"10.1186/s13765-024-00883-w","url":null,"abstract":"<div><p><i>Artemisia</i> species have significant commercial, medical, and economic value and are widely used in the traditional medicine and pharmaceutical industries. Artemisinin, a powerful antimalarial agent, is an important pharmaceutical metabolite that primarily accumulates within the glandular trichomes (GTs) on the leaf surface of <i>Artemisia</i> plants. Trichomes arising from the elongation of epidermal cells can be classified into GTs and non-glandular trichomes (NGTs) based on their morphology. GTs and NGTs are present in <i>Artemisia</i> species, and the relationship between GTs and artemisinin has been extensively studied; however, the correlation between NGTs and artemisinin remains relatively unexplored. In this study, we inferred artemisinin derivatives and trichome characteristics based on the type of species, developmental stage, and leaf age and conducted correlation analyses to investigate the factors influencing artemisinin content across different <i>Artemisia</i> species. Artemisinin and its derivatives exhibited variations in distribution based on species and leaf age, with a decreasing trend observed across most species as the developmental stage progressed. Noticeable differences among <i>Artemisia</i> species were observed in leaf shape, morphology, and trichome distribution. Although the observed data did not evidently differentiate between species, developmental stage, and leaf age groups, principal component analysis revealed that artemisinin was positively associated with the NGTs density, indicating a correlation coefficient of 0.56 (<i>p</i> &lt; 0.0001). Therefore, the number of NGTs may affect the artemisinin content in different <i>Artemisia</i> species.</p></div>","PeriodicalId":467,"journal":{"name":"Applied Biological Chemistry","volume":"67 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://applbiolchem.springeropen.com/counter/pdf/10.1186/s13765-024-00883-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140188473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beneficial effects of cannabidiol from Cannabis","authors":"Sullim Lee,&nbsp;Yunjeong Lee,&nbsp;Yunseo Kim,&nbsp;Hyunji Kim,&nbsp;Haerim Rhyu,&nbsp;Kyoungmi Yoon,&nbsp;Chang-Dae Lee,&nbsp;Sanghyun Lee","doi":"10.1186/s13765-024-00867-w","DOIUrl":"10.1186/s13765-024-00867-w","url":null,"abstract":"<div><p>Cannabis, traditionally used for recreation due to psychoactive compounds in its leaves, flowers, and seeds, has not been thoroughly explored for potential therapeutic benefits. Δ9-<i>trans</i>-Tetrahydrocannabinol, a key cannabinoid in cannabis, causes hallucinogenic effects and delirium symptoms. In contrast, cannabidiol (CBD) does not induce hallucinations and has shown effectiveness in treating symptoms of various rare, incurable diseases. Cannabis exhibits neuroprotective, anti-inflammatory, anti-thrombotic, anti-bacterial, analgesic, and antiepileptic properties, recently attracting more attention. This review aims to summarize comprehensively the impact of cannabis on human health, focusing on endocannabinoids and their receptors. It also delves into recent CBD research advancements, highlighting the compound’s potential medical applications. Overall, this paper provides valuable insights into the prospective development of medical cannabis, with a particular emphasis on CBD.</p></div>","PeriodicalId":467,"journal":{"name":"Applied Biological Chemistry","volume":"67 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://applbiolchem.springeropen.com/counter/pdf/10.1186/s13765-024-00867-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140164222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acetyl genistin modulates myotube differentiation and attenuates dexamethasone-induced muscle atrophy through the FoxO1/3 signaling pathway in C2C12 myotubes","authors":"Won Min Jeong,&nbsp;Seung-Jin Kwag,&nbsp;Jun Young Ha,&nbsp;Seung-Jun Lee,&nbsp;Yeong-In Choe,&nbsp;Dong Yeol Lee,&nbsp;Dong Kyu Jeong,&nbsp;Hwan Hee Bae,&nbsp;Jin-Hee Seo,&nbsp;Young-Sool Hah,&nbsp;Sang Gon Kim","doi":"10.1186/s13765-024-00885-8","DOIUrl":"10.1186/s13765-024-00885-8","url":null,"abstract":"<div><p>Muscle atrophy, a debilitating condition characterized by loss of muscle mass and strength, is a major concern in various clinical settings. Acetyl genistin (AG), a bioactive compound, was evaluated for its role in muscle cell differentiation and its potential protective effects against dexamethasone (dexa)-induced muscle atrophy. Our study demonstrated that AG significantly promoted C2C12 myotube differentiation, as evidenced by enhanced myotube width and increased fusion index. Notably, AG treatment upregulated the expression of myogenic markers, including MHC, MyoD, and MyoG. Moreover, AG displayed protective properties by attenuating dexa-induced muscle atrophy, mainly by suppressing the expression of the atrophy-related genes MAFbx and MuRF1. AG's protective effects are mechanistically attributed to its regulation of the AMPK/FoxO-dependent signaling pathway. Our results highlighted the dual benefits of AG in fostering muscle differentiation and safeguarding against muscle atrophy, positioning it as a promising agent for muscle health and therapeutic applications.</p></div>","PeriodicalId":467,"journal":{"name":"Applied Biological Chemistry","volume":"67 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://applbiolchem.springeropen.com/counter/pdf/10.1186/s13765-024-00885-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140161317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classification of soybeans from different habitats based on metabolomic–transcriptomic integration","authors":"Jinghui Wang,&nbsp;Qiyou Zheng,&nbsp;Chenxu Wang,&nbsp;Ao Zhou","doi":"10.1186/s13765-024-00882-x","DOIUrl":"10.1186/s13765-024-00882-x","url":null,"abstract":"<div><p>Soybeans are a significant agricultural product in China, with certain geographical locations often yielding higher quality, and thus more expensive, soybean crops. In this study, metabolomics and transcriptomics analyses were conducted on soybean samples from nine regions in Heilongjiang and Liaoning Provinces using untargeted liquid chromatography–mass spectrometry (LC–MS) and Illumina sequencing technologies. The primary objective was to devise an effective and unbiased method for determining the geographical origin of each soybean variety to mitigate potential fraudulent practices. Through multidimensional and unidimensional analyses, successful identification of differentially expressed metabolites (DEMs) and differentially expressed genes (DEGs) was achieved, yielding statistically significant outcomes. Integration of the metabolomics and transcriptomics datasets facilitated the construction of a correlation network model capable of distinguishing soybeans originating from different geographical locations, leading to the identification of significant biomarkers exemplifying noteworthy distinctions. To validate the feasibility of this method in practical applications, partial least squares discriminant analysis was employed to differentiate soybean samples from the nine regions. The results convincingly showcased the applicability and reliability of this approach in accurately pinpointing the geographical origin of soybeans. Distinguishing itself from prior research in soybean traceability, this study incorporates an integrated analysis of metabolomics and transcriptomics data, thereby unveiling biomarkers that offer a more precise differentiation of soybean traits across distinct regions, thereby bridging a critical research gap within the soybean traceability domain. This innovative dual-data integration analysis methodology is poised to enhance the accuracy of soybean traceability tools and lay a new foundation for future agricultural product identification research.</p></div>","PeriodicalId":467,"journal":{"name":"Applied Biological Chemistry","volume":"67 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://applbiolchem.springeropen.com/counter/pdf/10.1186/s13765-024-00882-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140141342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive compounds from Withania somnifera dun and their toxicity against some piercing sucking pests","authors":"Amany Ragab,&nbsp;Mohamed A. Taher,&nbsp;Helmy H. El-Rafey,&nbsp;Ahmed Ramadan El-Rokh","doi":"10.1186/s13765-024-00880-z","DOIUrl":"10.1186/s13765-024-00880-z","url":null,"abstract":"<div><p>Piercing sucking pests are destructive to many strategic crops all over the world. Botanical pesticides can be used to control these pests. A new withanolide derivative <b>3</b> named sominone A ((20<i>R</i>,22<i>R</i>)-1<i>α</i>,3<i>β</i>,20,27-tetrahydroxywitha-5,24-dienolide) was isolated from the alkaloid fraction of the whole plant of <i>Withania somnifera</i>. In addition, there are three known compounds named withasomine <b>1</b>, methyl isoferulate <b>2</b>, and coagulin Q <b>4</b> were also isolated. The structures of isolated compounds were identified using different spectroscopic methods such as 1D, 2D NMR, and HRESIMS spectroscopy. The alkaloid fraction and the four isolated compounds were tested for their pesticidal activity against four piercing sucking pests (<i>Aphis craccivora</i> Koch, <i>Bemisia tabaci</i> Gennadius, <i>Nezara viridula</i> Linnaeus, and <i>Tetranychus urticae</i> Koch) that attack many strategic crops under laboratory conditions, along with azadirachtin (Okios 3.2% EC) as a positive control. The results showed that the alkaloid compound (withasomine <b>1</b>) was the most toxic to <i>A. craccivora</i>, <i>B. tabaci</i>, <i>N. viridula,</i> and <i>T. urticae,</i> with LC₅₀ values of 15.44, 36.61, 85.11, and 128.28 ppm, respectively, compared with the control. Withanolide compounds had moderate effects on all tested pests. Biochemical parameters of six enzymes; <i>α</i>-esterase,<i> β</i>-esterase, chitinase, acetylcholinesterase, glutathione-<i>S</i>-transferase, and peroxidase of <i>A. craccivora</i> were estimated at the LC₅₀ value of the most potent compound, withasomine <b>1</b> and the values were 38.83, 72.86, 31.45, 506.4, 2.62, and 251.0, respectively. The results demonstrated that all enzymes activity levels were increased compared with the control except a remarkable inhibition in AChE enzyme level was observed compared with control. Therefore, the alkaloid fraction of <i>W. somnifera</i> is a promising extract that contains many active compounds that can be used as a natural pesticide against many harmful pests in agriculture crops.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":467,"journal":{"name":"Applied Biological Chemistry","volume":"67 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://applbiolchem.springeropen.com/counter/pdf/10.1186/s13765-024-00880-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140123606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the binding interactions of NOP receptor with designed natural phytochemical-neuropeptide conjugates: an in silico and SPR study","authors":"Molly E. Murray,&nbsp;Beatriz G. Goncalves,&nbsp;Mary A. Biggs,&nbsp;Sophia A. Frantzeskos,&nbsp;Charlotta G. Lebedenko,&nbsp;Ipsita A. Banerjee","doi":"10.1186/s13765-024-00876-9","DOIUrl":"10.1186/s13765-024-00876-9","url":null,"abstract":"<div><p>The Nociceptin/orphanin FQ peptide (NOP) receptor is considered a member of the opioid receptor subfamily of G-protein coupled receptors (GPCRs) which has been shown to be present in many parts of the central nervous system (CNS). It plays biologically diverse roles in pain modulation, immune response and in neurodegenerative diseases. In this work, phytochemical conjugates of two known neuropeptides, melanocyte inhibition factor (MiF-1) and mammalian amidated neuropeptide NPFF with pain modulating ability were developed. The binding interactions of those conjugates with NOP receptor was examined as an approach to develop novel natural compounds that can modulate NOP receptor activity. The selected phytochemicals are well-known for their antioxidant abilities and are derived either from natural alkaloids (betanin), polyphenols (gallic acid and sinapic acid) or terpenes (pomolic acid). Each of the phytochemicals selected are antioxidants which may play a role in mitigating diseases. Three conjugates of betanin were designed with each peptide by conjugating each of the three carboxylic acid groups of betanin with the peptides, while all others were mono-conjugates. Our results indicated that the betanin conjugates with both peptides showed strong binding interactions while the pomolate-peptide conjugates showed moderate binding. In general, NPFF and its conjugates showed stronger binding with the receptor. Docking and molecular dynamics studies revealed that binding interactions occurred at the binding pocket encompassing the transmembrane helices TM1, TM3 and TM7 in most cases, with the ligands binding deep within the hydrophobic core. The binding interactions were further confirmed experimentally through SPR analysis, which also showed higher binding with the betanin conjugates. MMGBSA studies indicated that the binding energies of MiF-1 conjugates were higher compared to neat MiF-1. However, in the case of NPFF, while the betanin conjugates showed enhancement, in some cases the binding energies were found to be slightly reduced compared to neat NPFF. Overall our studies reveal that such natural phytochemical derivatives that can bind to the NOP receptor when conjugated to the mammalian amidated neuropeptide NPFF and the short sequence of melanocyte inhibiting factor MiF-1 may be potentially developed for further laboratory studies for potential pharmaceutical applications.</p></div>","PeriodicalId":467,"journal":{"name":"Applied Biological Chemistry","volume":"67 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://applbiolchem.springeropen.com/counter/pdf/10.1186/s13765-024-00876-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140077077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ginsenosides as dietary supplements with immunomodulatory effects: a review","authors":"Ping Tang,&nbsp;Sitong Liu,&nbsp;Junshun Zhang,&nbsp;Zhiyi Ai,&nbsp;Yue Hu,&nbsp;Linlin Cui,&nbsp;Hongyang Zou,&nbsp;Xia Li,&nbsp;Yu Wang,&nbsp;Bo Nan,&nbsp;Yuhua Wang","doi":"10.1186/s13765-024-00881-y","DOIUrl":"10.1186/s13765-024-00881-y","url":null,"abstract":"<div><p>Immune disorders have become one of the public health problems and imposes a serious economic and social burden worldwide. Ginsenosides, the main active constituents of ginseng, are regarded as a novel supplementary strategy for preventing and improving immune disorders and related diseases. This review summarized the recent research progress of ginsenosides in immunomodulation and proposed future directions to promote the development and application of ginsenosides. After critically reviewing the immunomodulatory potential of ginsenosides both in vitro and in vivo and even in clinical data of humans, we provided a perspective that ginsenosides regulated the immune system through activation of immune cells, cytokines, and signaling pathways such as MAPK, PI3K/Akt, STAT, and AMPK, as well as positively affected immune organs, gut flora structure, and systemic inflammatory responses. However, the evidence for the safety and efficacy of ginsenosides is insufficient, and the immune pathways of ginsenosides remain incompletely characterized. We believe that this review will provide a valuable reference for further research on ginsenosides as dietary supplements with immunomodulatory effects.</p></div>","PeriodicalId":467,"journal":{"name":"Applied Biological Chemistry","volume":"67 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://applbiolchem.springeropen.com/counter/pdf/10.1186/s13765-024-00881-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140045273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}