Applied Biological Chemistry最新文献

{"title":"Targeted delivery of isoliquiritigenin by ultrasonic microbubbles attenuate myocardial injury via suppressing inflammation and oxidative stress and activating AMPK/SIRT1/eNOS signaling pathway in rats","authors":"Shuang Liang,&nbsp;Lijing Zhang,&nbsp;Shanshan Liang","doi":"10.1186/s13765-023-00805-2","DOIUrl":"10.1186/s13765-023-00805-2","url":null,"abstract":"<div><p>To investigate the protective efficacy of ultrasound targeted microbubble destruction (UTMD) combined with Isoliquiritigenin on myocardial injury in rats. The GK rat model of cardiomyopathy was successfully established by the induction of adriamycin. Then these rats with cardiomyopathy were randomly assigned into the model group, isoliquiritigenin microbubbles and ultrasound alone or combination group, using healthy ones as normal control. After 8-week consecutive treatment, the relevance indexes of diabetes, echocardiography as well as the hyperlipidemia, oxidative stress of model animals were examined. In addition, the fibrosis, morphological changes and inflammation response of myocardial tissues were also assessed. After further 4-week intervention, the blood biochemical indexes and the cardiac functions of model rats received the combined treatment were improved (all <i>P</i> &lt; 0.05) compare to those received either monotherapy or saline. After chronic treatment, the heart/body weight ratio and serum cardiac index levels in model rats received combined treatment were significantly changed (all <i>P</i> &lt; 0.05) compared with others. Furthermore, combination therapy could ameliorate excessive oxidation stress and inflammation response as well as up-regulate the expression levels of AMPK/SIRT1/eNOS signaling pathway. Targeted delivery of isoliquiritigenin by ultrasonic microbubbles can ameliorate the myocardial injury via activating AMPK/SIRT1/eNOS signaling pathways.</p></div>","PeriodicalId":467,"journal":{"name":"Applied Biological Chemistry","volume":"66 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://applbiolchem.springeropen.com/counter/pdf/10.1186/s13765-023-00805-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44049343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural, functional, nutritional composition and analytical profiling of Triticum aestivum L.","authors":"Mai K. Ammar,&nbsp;Rasha S. Hanafi,&nbsp;Mouchira A. Choucry,&nbsp;Heba Handoussa","doi":"10.1186/s13765-023-00804-3","DOIUrl":"10.1186/s13765-023-00804-3","url":null,"abstract":"<div><p>Wheat is considered as the most important cereal grain globally. It has a vast economic importance as it is used in producing bread, pastries, and household flour and serving as food for livestock among other uses. Different biological activities of wheat were correlated with the presence of polyphenols due to their antioxidant activities and other preventative capabilities. Wheat can also be used as an antidiabetic, anti-inflammatory, anticancer, antimicrobial, and antiaging agent. Omics has established itself during the past 20 years as a crucial tool for comprehending the internal systems of various plant systems including wheat using LC–MS, GC–MS, and UV spectrophotometry as analytical techniques. The current review represents in depth search regarding wheat cultivation, botanical description, economic significance, quantitative phytochemical characterization, and biological importance. Additionally, a critical assessment of the cited omics research on wheat was conducted with an emphasis on the analytical instrument, methods of analysis and results interpretation.</p></div>","PeriodicalId":467,"journal":{"name":"Applied Biological Chemistry","volume":"66 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2023-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://applbiolchem.springeropen.com/counter/pdf/10.1186/s13765-023-00804-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44693799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing the extraction of essential oil from cinnamon leaf (Cinnamomum verum) for use as a potential preservative for minced beef","authors":"Reta Merid Yitbarek,&nbsp;Habtamu Admassu,&nbsp;Fekiya Mohammed Idris,&nbsp;Eskindir Getachew Fentie","doi":"10.1186/s13765-023-00798-y","DOIUrl":"10.1186/s13765-023-00798-y","url":null,"abstract":"<div><p>Cinnamon leaf essential oil extraction using steam distillation method is a time-consuming and energy-intensive process. Furthermore, a lower yield and a higher rate of product degradation are this method’s main drawbacks. Thus, the goal of this research is to optimize the extraction process parameters of cinnamon leaf essential oil in response to maximizing the yield while retaining quality by using response surface methodology (RSM). The application of extracted essential oil on minced beef to assess its preservative effect was also the other objective of this research. Extraction time (120–210 min), extraction temperature (105–115 ℃), and feed mass (300–600 g) were the chosen independent variables of the optimization experiment using central composite design (CCD). Furthermore, the extracted essential oil’s antibacterial and microbiological preservative activity on minced beef was evaluated. At extraction time of 175.43 min, extraction temperature of 105 °C, and a feed mass of 600 g, the optimum predicted value of cinnamon leaf essential oil yield and cinnamaldehyde concentration (% area) was 2.9% and 34.6%, respectively. Moreover, the second-order polynomial equation fits the experimental data for 20-run experimental data. The chemical composition of cinnamon leaf essential oil extracted at optimal conditions was dominated by eugenol (60.68%) and cinnamaldehyde (33.94%). Additionally, the optimally extracted cinnamon essential oil inhibited the growth of bacteria, particularly gram-positive bacteria. After twenty-one days of storage at 4 °C, total viable count of minced beef seasoned with cinnamon essential oil at concentration of 1.2% (v/v) was lower than 10⁶ CFU/g. To conclude, optimized cinnamon leaf essential oil extraction process provides better yield while retaining its functional properties.</p></div>","PeriodicalId":467,"journal":{"name":"Applied Biological Chemistry","volume":"66 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2023-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://applbiolchem.springeropen.com/counter/pdf/10.1186/s13765-023-00798-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45177563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Production of omega-5 gliadin monoclonal antibodies for allergenic evaluation of WDEIA-causing wheat varieties","authors":"Jae-Ryeong Sim,&nbsp;Jong-Yeol Lee,&nbsp;Sewon Kim","doi":"10.1186/s13765-023-00807-0","DOIUrl":"10.1186/s13765-023-00807-0","url":null,"abstract":"<div><p>In allergic individuals, ingestion of wheat can lead to wheat-dependent exercise-induced anaphylaxis (WDEIA). Many studies have been conducted to find WDEIA allergen–deficient wheat, including by generating omega-5 gliadin antibodies. However, the reported antibodies have not been specific enough to detect omega-5 gliadins encoded on the 1B chromosome. In this study, we generated monoclonal antibodies against the major allergens causing WDEIA, omega-5 gliadins. Using these antibodies (mono-O5B-1C10), we assessed accumulation of omega-5 gliadins in wild-type and nullisomic-tetrasomic (NT) lines of the wheat (<i>Triticum aestivum</i>) varieties Chinese Spring (CS) by one- and two-dimensional gel electrophoresis, followed by Coomassie blue staining or immunoblotting with mono-O5B-1C10. We also tested mono-O5B-1C10 for major omega-5 gliadins in various wheat germplasms. Our results thus demonstrate the specificity of mono-O5B-1C10 for major omega-5 gliadins and potentially useful for identifying of omega-5 gliadin–deficient wheat varieties that should not cause WDEIA.</p></div>","PeriodicalId":467,"journal":{"name":"Applied Biological Chemistry","volume":"66 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://applbiolchem.springeropen.com/counter/pdf/10.1186/s13765-023-00807-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48878861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic bactericidal effects of carvone and β-lactams against Xanthomonas campestris pv. vesicatoria","authors":"Jeong Yoon Kim,&nbsp;Ju Yeon Kim,&nbsp;Jae Yeon Park,&nbsp;Jin-Seong Kim,&nbsp;Min-Kyung Seo,&nbsp;Min-Kyoung Shin,&nbsp;Jin-Hyo Kim","doi":"10.1186/s13765-023-00803-4","DOIUrl":"10.1186/s13765-023-00803-4","url":null,"abstract":"<div><p><i>Xanthomonas campestris</i> pv. <i>vesicatoria</i> (Xcv) causes brown spots on the leaves, stems, and fruits of plants, called bacterial leaf scorch (BLS). For the control of pathogens, antibiotics have been used frequently, and they can develop the resistance. In this study, the bactericidal and synergistic effects of caraway oil and its main components against the pathogen (Xcv) were investigated. The tested caraway oil consisted of 58.4% of carvone and 31.1% of limonene. The minimum inhibitory concentration (MIC) of caraway oil and carvone was the same as 125 μg mL⁻¹, and the minimum bactericidal concentration (MBC) was 1000 μg mL⁻¹ for caraway oil and 500 μg mL⁻¹ for carvone, while limonene showed no inhibition below 1000 μg ml⁻¹. In the growth of Xcv, carvone treatment over 31.3 μg mL⁻¹ inhibited dose-dependently, and the bactericidal effect showed after 18 h more than 250 μg mL⁻¹; It was agreed with the release of intracellular components over 250 μg mL⁻¹, especially. Furthermore, carvone damaged the plasmid DNA of Xcv, and it would be the reason for the bactericidal activity. The synergistic effect of carvone was found with β-lactams selectively; the fractional inhibitory concentration (FIC) indexes of carvone with ampicillin or amoxicillin were below 0.5, and the mixture of carvone (125 μg mL⁻¹) and ampicillin (500 μg mL⁻¹) showed the bactericidal activity as well.</p></div>","PeriodicalId":467,"journal":{"name":"Applied Biological Chemistry","volume":"66 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://applbiolchem.springeropen.com/counter/pdf/10.1186/s13765-023-00803-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47429108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of iridoid profiles in the growth period of aerial parts of Pseudolysimachion rotundum var. subintegrum and their antioxidant and MUC5AC inhibitory potential","authors":"Soobin Song,&nbsp;Doo-Young Kim,&nbsp;Seon Min Oh,&nbsp;So-Yeun Woo,&nbsp;Il-joo Kim,&nbsp;Mun-Ock Kim,&nbsp;Ji-Yoon Park,&nbsp;Namho Kim,&nbsp;Hae-Young Kim,&nbsp;Juhee Lee,&nbsp;Sang Yoon Kim,&nbsp;Bang Yeon Hwang,&nbsp;Hyung Won Ryu,&nbsp;Sei-Ryang Oh","doi":"10.1186/s13765-023-00796-0","DOIUrl":"10.1186/s13765-023-00796-0","url":null,"abstract":"<div><p>YPL-001 is a drug substance of <i>Pseudolysimachion rotundum</i> var. <i>subintegrum</i> and has been reported to be a potent COPD inhibitor. For the first time, this study demonstrated a correlation among the iridoid constituents, antioxidants, and MUC5AC inhibition activities in <i>P. rotundum</i> during different growth stages (5 to 11 weeks). Single-factor extraction was used to optimize the plant extraction conditions to maximize the major iridoid constituents (70% ethanol, 40 °C, 1 h); isolated metabolites 1–6 were identified using nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry (MS). The contents of each metabolite and antioxidant/MUC5AC inhibition effects were markedly changed according to the growth stages, especially for catalposide (2, 5.97 → 10.99 mg/g, 1.8-fold) and isovanillyl catapol (5, 4.42 → 20.00 mg/g, 4.5-fold), which were the predominant substances in August. Our results indicated that YPL-001 could potentially contribute to enhancing the <i>P. rotundum</i> value in accumulated iridoids at the growth stage and the biological effect aspects to develop industrial medicinal crops.</p></div>","PeriodicalId":467,"journal":{"name":"Applied Biological Chemistry","volume":"66 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://applbiolchem.springeropen.com/counter/pdf/10.1186/s13765-023-00796-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43609865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beneficial effects of WON-21 on the symptoms of a hangover and identification of active compounds: experimental studies on antioxidant, anti-inflammation, and alcohol-metabolizing enzymes","authors":"Ji Hwan Lee,&nbsp;Wonsang Huh,&nbsp;Ji Yun Baek,&nbsp;Jun Yeon Park,&nbsp;So Hyeon Kim,&nbsp;Il-Ho Park,&nbsp;Jaesung Pyo,&nbsp;Chang-Seob Seo,&nbsp;Ki Sung Kang","doi":"10.1186/s13765-023-00800-7","DOIUrl":"10.1186/s13765-023-00800-7","url":null,"abstract":"<div><p>Many hangover cure products containing natural ingredients that are also effective against alcohol-related liver damage or improve liver function have recently become available. In addition to curing liver damage, antioxidants, anti-inflammatory agents, and blood ethanol reduction aids are emerging as relief targets that reduce hangover symptoms. We investigated the ameliorating effect of WON-21 herbal medicinal products by studying the mixing ratio of oriental medicine concept with respect to antioxidant potential, anti-inflammation, and aldehyde dehydrogenase (ALDH) and alcohol dehydrogenase (ADH) enzyme activities. WON-21 and its components exerted antioxidant and anti-inflammatory effects. Rutin, taxifolin, and quercetin showed superior antioxidant effects compared to the other components. WON-12 effectively reduced iNOS and COX-2 in LPS-stimulated macrophages. Quercetin and apigenin were 2 compounds effective for the inhibition of iNOS and COX-2. WON-21 and quercetin also significantly increased the activities of ALDH and ADH enzymes in a concentration-dependent manner.</p></div>","PeriodicalId":467,"journal":{"name":"Applied Biological Chemistry","volume":"66 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2023-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://applbiolchem.springeropen.com/counter/pdf/10.1186/s13765-023-00800-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41375881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of volatile compounds of Perilla crop (Perilla frutescens L.) in South Korea","authors":"Kyu Jin Sa,&nbsp;So Jung Jang,&nbsp;Sookyeong Lee,&nbsp;Hyun Park,&nbsp;Jungeun Cho,&nbsp;Jungsook Sung,&nbsp;Ju Kyong Lee","doi":"10.1186/s13765-023-00801-6","DOIUrl":"10.1186/s13765-023-00801-6","url":null,"abstract":"<div><p>This study was performed to identify and profile the volatile compounds present in three different types of <i>Perilla</i> leaves collected from South Korea. Volatile compounds were analyzed by gas-chromatograph-mass spectrometry. In total, 41 volatile compounds were identified belonging to nine chemical classes (six alcohols, seven aldehydes, two benzodioxoles, two esters, three ethers, four ketones, five monoterpenes, one phenylpropanoid, and eleven sesquiterpenes). In cultivated type of var. <i>frutescens</i> (CF), weedy type of var. <i>frutescens</i> (WF), and weedy type of var. <i>crispa</i> (WC), a total of 34, 39, and 41 volatile compounds, respectively, were identified. The predominant compound in CF and WF was perilla ketone (PK; 87.2% and 64.5%, respectively) and in WC was perilla aldehyde (PA; 26.4%). There were 29 and 27 volatile compounds that showed significant differences of content between WC and CF or WF, respectively. In terms of chemotype based on the volatile compounds, CF and WC were PK type and PA or phenylpropanoid (PP) types, respectively. WF accessions, which were PK and PP types in chemical composition, showed intermediate characteristics in the composition of volatile compounds compared with CF and WC. The results obtained in this study identified successfully the composition and content of volatile compounds in <i>Perilla</i> crop in South Korea. These results will provide useful information for industries and research related to <i>Perilla</i> crop.</p></div>","PeriodicalId":467,"journal":{"name":"Applied Biological Chemistry","volume":"66 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://applbiolchem.springeropen.com/counter/pdf/10.1186/s13765-023-00801-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4822522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occurrence and health risk assessment of antimony, arsenic, barium, cadmium, chromium, nickel, and lead in fresh fruits consumed in South Korea","authors":"Jian Lee,&nbsp;Insun Hwang,&nbsp;Ye-Seul Park,&nbsp;Do Yup Lee","doi":"10.1186/s13765-023-00799-x","DOIUrl":"10.1186/s13765-023-00799-x","url":null,"abstract":"<div><p>Although various fruits are consumed as fresh produce in South Korea, information on the concentrations of heavy metals in such fruits remains lacking despite the known toxic effects of the metals. Moreover, the health risks posed by seven potentially toxic metals (As, Ba, Cd, Cr, Ni, Pb, and Sb) ingested through fruit consumption have not been assessed using recent dietary data and occurrence data. Inductively coupled plasma-mass spectrometry was used to quantify these metals in 207 samples of fresh fruits mainly consumed in South Korea. The mean concentrations (mg kg⁻¹ fresh weight) of the metals in all fruit samples were as follows: As &lt; 0.0021, Ba 0.3675, Cd &lt; 0.0022, Cr 0.0307, Ni 0.0815, Pb 0.0236, and Sb &lt; 0.0021. Only Ba showed a significant negative correlation with Pb (ρ =  −0.5385) in the studied fruits at the 95% confidence level. The non-carcinogenic risk of the seven metals in terms of hazard quotients was Pb (0.0149) &gt; As (0.0086) &gt; Ni (0.0081) &gt; Sb (0.0080) &gt; Ba (0.0031) &gt; Cd (0.0027) &gt; Cr (0.0001), and the hazard index, which is the sum of the hazard quotients, was 0.0275 (less than 1). The carcinogenic risks of As and Pb were 4.62E − 07 and 5.05E − 07, respectively (below 1E − 04). The hazard index of seven metals and carcinogenic risks of As and Pb indicated that no health risks were associated with fruit consumption in the Korean population. However, the hazard quotient and carcinogenic risk of Pb in apples were the highest for children aged 1–2 years, indicating that continuous targeted risk monitoring in this age group is required.</p></div>","PeriodicalId":467,"journal":{"name":"Applied Biological Chemistry","volume":"66 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://applbiolchem.springeropen.com/counter/pdf/10.1186/s13765-023-00799-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4539461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethnomedicine and ethnopharmacology of medicinal plants used in the treatment of diabetes mellitus in Uganda","authors":"Roggers Gang,&nbsp;Motlalepula Matsabisa,&nbsp;Denis Okello,&nbsp;Youngmin Kang","doi":"10.1186/s13765-023-00797-z","DOIUrl":"10.1186/s13765-023-00797-z","url":null,"abstract":"<div><p>Diabetes mellitus (DM) is a global health problem owing to its high prevalence and increased morbidity and mortality. The prevalence of DM and impaired glucose tolerance in Uganda is approximately 4.1% and 6.6%, respectively. Medicinal plants are commonly used for the management of DM, especially in developing countries, such as Uganda<i>.</i> According to several ethnobotanical surveys conducted in Uganda, various medicinal plants are used in DM management. Meanwhile, ethnopharmacological studies have confirmed the anti-diabetic efficacy of various plants and plant-derived formulations from Uganda. However, these information remain highly fragmented without a single repository for plants used in the management and treatment of DM in Uganda, hindering further investigations. Therefore, this study aimed to comprehensively explore plants used for DM treatment in Uganda and retrieve relevant ethnopharmacological and ethnomedicinal information that can be used for DM therapy development. English peer-reviewed articles and books were searched in scientific databases, especially PubMed, Scopus, Google Scholar, Science Direct, SciFinder, and Medline, to retrieve information on medicinal plants used for DM treatment and management in Uganda. The databases were searched to obtain published literature on the anti-diabetic activities and safety of plants among the identified plants. The family name, plant parts used, anti-diabetic activities, dosage, and mechanisms of action of plant extracts were captured. In total, 46 species belonging to 26 families are used to treat DM in Uganda. Most species belonged to the Fabaceae (20%), Asteraceae (13%), and Solanaceae (7%) families. Anti-diabetic activities of 27 (59%) species have been scientifically investigated, whereas the rest have not been evaluated. This review indicated that various medicinal plants are used in the traditional treatment and management of DM across different regions in Uganda. Scientific investigations have revealed the anti-diabetic potential and safety of several of these plants. However, there is a need to validate the anti-diabetic potential of other unstudied plants. Additionally, isolating and characterizing active principles and elucidating the anti-diabetic mechanism of these plants and performing preclinical and clinical studies in the future could aid in the formulation of an effective and safe treatment for DM.</p></div>","PeriodicalId":467,"journal":{"name":"Applied Biological Chemistry","volume":"66 1","pages":""},"PeriodicalIF":3.2,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://applbiolchem.springeropen.com/counter/pdf/10.1186/s13765-023-00797-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"4255154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}