Food and Chemical Toxicology最新文献

PAK1 mediates ivermectin-induced DNA damage in porcine oocytes during meiotic maturation PAK1介导猪卵母细胞减数分裂成熟过程中伊维菌素诱导的DNA损伤

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2025-07-25 DOI: 10.1016/j.fct.2025.115653

Tianhang Yu, Yijing He, Heran Li, Qinfeng Sun, Miaoyu Chen, Weihan Wang, Qiao Li, Shiqiang Ju

{"title":"PAK1 mediates ivermectin-induced DNA damage in porcine oocytes during meiotic maturation","authors":"Tianhang Yu, Yijing He, Heran Li, Qinfeng Sun, Miaoyu Chen, Weihan Wang, Qiao Li, Shiqiang Ju","doi":"10.1016/j.fct.2025.115653","DOIUrl":"10.1016/j.fct.2025.115653","url":null,"abstract":"<div><div>Ivermectin (IVM), a broad-spectrum antiparasitic agent, is widely utilized in agriculture and animal husbandry. However, the presence of its residues in the environment and food sources may pose potential risks to animal health. Although various cytotoxic effects of IVM have been reported, there is limited information available regarding whether IVM exposure can exert toxic effects on mammalian oocytes. In this study, porcine oocytes were exposed to varying concentrations of IVM for 44 h during <em>in vitro</em> maturation. The results showed that 10 μM IVM significantly inhibited oocyte maturation, as evidenced by the inhibition of first polar body (PB1) extrusion, cytoskeletal disorganization, and meiotic progression arrest. Furthermore, IVM treatment increased expression of γ-H<sub>2</sub>AX but decreased P21-activated kinase 1 (PAK1) in oocytes, while inhibiting DNA homologous recombination (HR) repair process. Interestingly, these negative effects of IVM were significantly alleviated by the increased expression of PAK1. However, co-treatment with Mirin, an inhibitor of HR repair, reversed the alleviating effect of PAK1 overexpression on oocyte meiotic maturation and DNA damage.</div><div>In conclusion, IVM exposure adversely affects the maturation of porcine oocytes and induced DNA damage. Additionally, PAK1 is involved in IVM-induced DNA damage in oocytes, and its mediating role is closely related to the regulation of HR repair.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"204 ","pages":"Article 115653"},"PeriodicalIF":3.5,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144722385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CDDO-Me triggers ROS-dependent ferroptosis and apoptosis in cervical cancer via targeting PI3K/Nrf2 pathway CDDO-Me通过靶向PI3K/Nrf2通路触发ros依赖性宫颈癌铁下垂和凋亡

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-07-24 DOI: 10.1016/j.fct.2025.115664

Wenxuan Li , Mengying Wang , Pan Du , Anna Han , Xinyue Feng , Liyan Chen

{"title":"CDDO-Me triggers ROS-dependent ferroptosis and apoptosis in cervical cancer via targeting PI3K/Nrf2 pathway","authors":"Wenxuan Li , Mengying Wang , Pan Du , Anna Han , Xinyue Feng , Liyan Chen","doi":"10.1016/j.fct.2025.115664","DOIUrl":"10.1016/j.fct.2025.115664","url":null,"abstract":"<div><h3>Context</h3><div>Cervical cancer (CC) ranks as one of the most common types of malignant tumors affecting women. CDDO-Me is derived from oleanolic acid, a pentacyclic triterpenoid obtained by chemical structural modification, which has been shown anti-tumor effects.</div></div><div><h3>Results</h3><div>CC cell proliferation was decreased by CDDO-Me both in vitro and in vivo. Mechanistically, CDDO-Me led to a reduction of intracellular mitochondrial volume and crista, or an increase of membrane density. The levels of ROS, Fe<sup>2+</sup>, MDA were increased while GSH was decreased. Meanwhile, the levels of protein expression of GPX4, Nrf2, NQO1 and FTH1 were observably inhibited by CDDO-Me. Specifically, ferroptosis triggered by CDDO-Me was reverted by DFO. It has been demonstrated that CDDO-Me-induced apoptosis and ferroptosis in CC cells is contingent upon the PI3K/AKT-mediated Nrf2/NQO1 pathway.</div></div><div><h3>Conclusions</h3><div>CDDO-Me induces CC cell lines apoptosis and ferroptosis through the PI3K/Nrf2 signaling pathway, for exerting anti-proliferation effects.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"204 ","pages":"Article 115664"},"PeriodicalIF":3.9,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144704817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intestinal metabolomic profiling provides insights into the molecular mechanisms for hyperuricemia-induced intestinal barrier dysfunctions in a hyperuricemia mouse model 肠道代谢组学分析为高尿酸血症小鼠模型中高尿酸血症诱导的肠屏障功能障碍的分子机制提供了见解。

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2025-07-24 DOI: 10.1016/j.fct.2025.115666

Hailong Li, Qingli Zhang, Tingting Tang, Lei Zhu, Qu Chen, Haili Zhang, Yan Zhang, Zichu Zhao, Di Xiao, Xinlei Sha, Jingrong Mu, Jingjing Kong

{"title":"Intestinal metabolomic profiling provides insights into the molecular mechanisms for hyperuricemia-induced intestinal barrier dysfunctions in a hyperuricemia mouse model","authors":"Hailong Li, Qingli Zhang, Tingting Tang, Lei Zhu, Qu Chen, Haili Zhang, Yan Zhang, Zichu Zhao, Di Xiao, Xinlei Sha, Jingrong Mu, Jingjing Kong","doi":"10.1016/j.fct.2025.115666","DOIUrl":"10.1016/j.fct.2025.115666","url":null,"abstract":"<div><div>Cadmium exposure could damage the liver, which is suggested to be associated with the hyperuricemia (HUA)-induced intestinal barrier injury. To reveal the mechanism for HUA-induced intestinal barrier injury, the HUA mice constructed by knockout (Ko) of the urate oxidase (<em>Uox</em>) gene and their corresponding controls were used for the metabolomics analysis. Clinical biochemistry from the plasma was assessed, and the histopathological changes of the intestines were evaluated. Metabolomics was performed to explore the intestinal metabolomic profiles from the Uox-Ko mice, and the potential metabolic biomarkers were identified. Compared with controls, Uox-Ko mice showed dramatically increased uric acid, creatinine, and urea nitrogen levels, along with sparse intestinal villi, mucosal and submucosal edema. Metabolomics found the five metabolites were significantly dysregulated in intestines from the Uox-Ko mice, which includes N-acetylornithine, palmitoleic acid, 4-pyridoxic acid, phenylacetylglycine and 3-indoxyl sulphate. These altered pathways were involved fatty acid biosynthesis, biosynthesis of amino acids, arginine biosynthesis, vitamin B6 metabolism and 2-oxocarboxylic acid metabolism. 4-pyridoxic acid was identified as the most promising metabolic biomarker for predicting HUA-induced intestinal barrier damage. Our findings suggest the metabolic disturbances may contribute to the development of HUA-induced intestinal barrier injury, which may shed light on the mechanisms of cadmium-induced liver damage.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"204 ","pages":"Article 115666"},"PeriodicalIF":3.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual Mechanisms of Vitisin A in Managing Alcoholic Liver Disease: Inhibition of Lipogenesis and Complement Activation. 维生素A治疗酒精性肝病的双重机制：抑制脂肪生成和补体激活。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-07-23 DOI: 10.1016/j.fct.2025.115639

Yuanqin Zhu, Huilin Deng, Jia Liu, Xusheng Li, Xin Huang, Zhaodi Che, Weibin Bai, Rui Jiao

{"title":"Dual Mechanisms of Vitisin A in Managing Alcoholic Liver Disease: Inhibition of Lipogenesis and Complement Activation.","authors":"Yuanqin Zhu, Huilin Deng, Jia Liu, Xusheng Li, Xin Huang, Zhaodi Che, Weibin Bai, Rui Jiao","doi":"10.1016/j.fct.2025.115639","DOIUrl":"https://doi.org/10.1016/j.fct.2025.115639","url":null,"abstract":"<p><p>Pyranoanthocyanins in aged red wine show superior stability, pigmentation, antioxidative, anti-inflammatory, and hypocholesterolemic properties compared to unmodified anthocyanin precursors in vitro. However, evidence supporting their health benefits in vivo remains limited. This study evaluated the hepatoprotective effects of Vitisin A compared to Cyanidin-3-O-glucoside using Lieber-DeCarli mouse and AML12 cell models. Additionally, mulberry wine anthocyanins and their aged counterparts were evaluated in vivo. All anthocyanin treatments significantly alleviated ethanol-induced hepatic steatosis and improved alcohol metabolism. Notably, Vitisin A markedly reduced plasma AST and ALT levels (p < 0.05), a result not observed with C3G. RNA-seq analysis showed Vitisin A induced significant gene expression changes, especially in complement system and lipid metabolism pathways. It inhibited fatty acid synthesis by upregulating p-AMPK/AMPK and p-ACC/ACC ratios, suppressing FASN expression, and reduced complement activation by downregulating C3 and decreasing C3ar1 and Tnf-α expression, mitigating Kupffer cell-mediated inflammation. In contrast, C3G and ACNS had limited effects on these pathways, particularly in complement modulation. These findings highlight the dual actions of vitisin A in inhibiting de novo lipogenesis and complement activation, demonstrating its superior efficacy over C3G. This study underscores the therapeutic potential of vitisin A as a functional food component for managing alcoholic liver disease.</p>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":" ","pages":"115639"},"PeriodicalIF":3.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lithium suppresses the Ras-Raf-MEK-ERK signaling in CD4 T cells and impairs the humoral immune system 锂抑制CD4 T细胞中的Ras-Raf-MEK-ERK信号，损害体液免疫系统

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-07-23 DOI: 10.1016/j.fct.2025.115661

Jiaojiao Wu , Yifan Zhao , Jie Zhang , Lihong Tu , Yalin Liu , Chuanxuan Wang , Ting Liu , Wei Wang , Yijia Luo , Yingzi Ju , Peng Xue , Yanyi Xu , Minghua Gu , Weidong Qu , Yubin Zhang

{"title":"Lithium suppresses the Ras-Raf-MEK-ERK signaling in CD4 T cells and impairs the humoral immune system","authors":"Jiaojiao Wu , Yifan Zhao , Jie Zhang , Lihong Tu , Yalin Liu , Chuanxuan Wang , Ting Liu , Wei Wang , Yijia Luo , Yingzi Ju , Peng Xue , Yanyi Xu , Minghua Gu , Weidong Qu , Yubin Zhang","doi":"10.1016/j.fct.2025.115661","DOIUrl":"10.1016/j.fct.2025.115661","url":null,"abstract":"<div><div>Lithium (Li) is a metal that broadly exists in human bodies. To date, the impact of Li on the humoral immune system remains to be defined. In this study, C57BL/6 mice treated with 50 or 200 ppm Li for 3 months and human peripheral blood mononuclear cells (PBMC) treated with Li in vitro were used. Treatment with 200 ppm Li suppressed the production of serum IgG, but not serum IgM in mice; treatment with 200 ppm Li impaired the activation of CD4 T cells and B cells, and the production of germinal center in mice. Mechanistically, treatment with 200 ppm Li impaired the Ras-Raf-MEK-ERK signaling in CD4 T cells and thereby suppressed the humoral immune system in mice. In line with this, in vitro treatment with Li on human PBMC decreased the production of IgG, but not IgM in the supernatants; in vitro treatment with Li on human PBMC suppressed the activation of CD4 T cells and impaired the Ras-Raf-MEK-ERK signaling in CD4 T cells. Collectively, the present study indicated that Li impaired the humoral immune system via repressing the Ras-Raf-MEK-ERK signaling in CD4 T cells, which was a previously unrecognized immunotoxicity of Li.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"204 ","pages":"Article 115661"},"PeriodicalIF":3.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144704815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Occurrence, sources and human health risk assessment of polybrominated diphenyl ethers in herbal medicinal preparations in Nigeria. 尼日利亚草药制剂中多溴联苯醚的出现、来源和人类健康风险评估。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-07-23 DOI: 10.1016/j.fct.2025.115659

Chukwujindu M A Iwegbue, Jane Oghenevwogaga, Grace E Obi-Iyeke, Peace Adigwe, Eseoghene R Avbunudiogaba, Alex O Ilenikhena, Grace Obi, Chinedu J Ossai, Eze W Odali, Bice S Martincigh

引用次数: 0

The cytotoxicity of synthetic cathinones on dopaminergic-differentiated SH-SY5Y neuroblastoma cell line: Exploring the role of β-keto metabolic reduction 合成卡西酮对多巴胺能分化的SH-SY5Y神经母细胞瘤细胞株的细胞毒性：探讨β-酮代谢减少的作用

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2025-07-23 DOI: 10.1016/j.fct.2025.115658

Rita P. Lopes , Cláudia C. Miranda , Tiago G. Fernandes , Helena Gaspar , Alexandra M.M. Antunes

{"title":"The cytotoxicity of synthetic cathinones on dopaminergic-differentiated SH-SY5Y neuroblastoma cell line: Exploring the role of β-keto metabolic reduction","authors":"Rita P. Lopes , Cláudia C. Miranda , Tiago G. Fernandes , Helena Gaspar , Alexandra M.M. Antunes","doi":"10.1016/j.fct.2025.115658","DOIUrl":"10.1016/j.fct.2025.115658","url":null,"abstract":"<div><div>Synthetic cathinones, a major class of new psychoactive substances (NPS), pose a growing public health threat due to their widespread recreational use, particularly among young people. While metabolism significantly influences xenobiotic toxicity, its role in synthetic cathinone neurotoxicity remains underexplored. Similarly to the other cathinones included in this study, 4-CBC and 3-CBC were rapidly metabolized <em>in vitro</em> (t<sub>1</sub>/<sub>2</sub> < 20 min), producing dihydro-metabolites as major products. To evaluate the toxicological relevance of this transformation, we synthesized ten dihydro-metabolites and assessed their cytotoxicity in differentiated SH-SY5Y cells. Most dihydro-derivatives were more neurotoxic than their parent cathinones, with dihydro-3-CBC, dihydro-3-CIC, dihydro-4-CIC, and dihydro-4-CBC displaying the lowest LC<sub>50</sub> values (0.24–0.28 mM). All dihydro-metabolites exhibited higher Hill slopes, indicating that small increases in their formation might result in significant toxicological consequences. Dihydro-α-PHP showed the steepest slope, raising concern given the high use and seizure rates of α-PHP in the Portuguese Azores and Madeira islands. These findings highlight the importance of β-ketone reduction in synthetic cathinone toxicity and suggest that similar metabolic transformations may contribute to the toxicity of other chemical agents.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"204 ","pages":"Article 115658"},"PeriodicalIF":3.5,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Potassium Bromate as a Positive Control in the In Vivo Fpg-Modified Comet Assay for the Detection of Oxidized Bases. 溴酸钾作为阳性对照物在体内fpg修饰Comet试验中检测氧化碱基的评价。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-07-22 DOI: 10.1016/j.fct.2025.115663

E Saenz-Martinez, M Collia, A Rodriguez-Garraus, A G Gil, A López de Cerain, A Azqueta

{"title":"Evaluation of Potassium Bromate as a Positive Control in the In Vivo Fpg-Modified Comet Assay for the Detection of Oxidized Bases.","authors":"E Saenz-Martinez, M Collia, A Rodriguez-Garraus, A G Gil, A López de Cerain, A Azqueta","doi":"10.1016/j.fct.2025.115663","DOIUrl":"https://doi.org/10.1016/j.fct.2025.115663","url":null,"abstract":"<p><p>The in vivo comet assay is validated for genotoxicity testing and included in ICH, ECHA, and EFSA strategies. However, OECD test guideline (TG) 489 In vivo Mammalian Alkaline Comet Assay covers only the standard version, detecting DNA strand breaks (SB) and alkali-labile sites (ALS), limiting mechanistic insights. Inclusion of the enzyme formamidopyrimidine DNA glycosylase (Fpg) allows detection of oxidised bases; 52 studies using enzymes to reveal DNA lesions undetectable with the standard comet assay were identified (Collins et al. 2020). Despite its frequent use, fewer than one-third of studies employing enzymes include positive controls, which would aid standardization and OECD TG 489 integration. The present study evaluates potassium bromate (KBrO<sub>3</sub>) as a potential positive control for the Fpg-modified comet assay. Wistar rats were dosed twice by oral gavage with different doses of KBrO<sub>3</sub> following OECD TG 489 principles, with DNA damage assessed in liver, duodenum, kidney, brain, and whole blood. Ethyl methanesulfonate (EMS) was used as a positive control for the standard version. The inclusion of Fpg digestion enhances assay sensitivity and specificity, and DNA oxidation damage induced by KBrO<sub>3</sub> is detected in kidney, liver, and duodenum within 3 hours indicating that it may be a good positive control.</p>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":" ","pages":"115663"},"PeriodicalIF":3.9,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perfluorohexane sulfonate (PFHxS) induces liver cytotoxicity by activating autophagy and endoplasmic reticulum stress-regulated mitochondrial pathway apoptosis 全氟己烷磺酸（PFHxS）通过激活自噬和内质网应激调节的线粒体通路凋亡诱导肝细胞毒性

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-07-22 DOI: 10.1016/j.fct.2025.115657

Wenying Chen , Shuangchao Liu , Yao Zhou , Bin Liu , Wei Wang , Cheng Chen , Zaixiang Lou , Xiao Li Shen

{"title":"Perfluorohexane sulfonate (PFHxS) induces liver cytotoxicity by activating autophagy and endoplasmic reticulum stress-regulated mitochondrial pathway apoptosis","authors":"Wenying Chen , Shuangchao Liu , Yao Zhou , Bin Liu , Wei Wang , Cheng Chen , Zaixiang Lou , Xiao Li Shen","doi":"10.1016/j.fct.2025.115657","DOIUrl":"10.1016/j.fct.2025.115657","url":null,"abstract":"<div><div>Perfluorohexane sulfonate (PFHxS), a common alternative to perfluorootane sulfonate, is extensively used in various industrial products. As PFHxS contamination becomes more prevalent, it has been detected in human umbilical cord blood, serum, and breast milk, among other samples. In humans, the elimination half-life of PFHxS is at least 8.5 years. Although PFHxS shows the highest tissue-plasma partition coefficients in the liver and is known to cause liver hypertrophy, the mechanisms underlying PFHxS-induced hepatotoxicity remain unclear. In present study, the impacts of PFHxS on human liver L02 cells were evaluated by examining cell viability, apoptotic rates, reactive oxygen species (ROS) levels, Ca<sup>2+</sup> levels, and protein expressions. Results revealed that a 24-h exposure to PFHxS at concentrations of 80–320 μM, particularly at 320 μM, triggered autophagy and endoplasmic reticulum stress (ERS)-regulated mitochondrial pathway apoptosis. This was characterized by increased ROS and Ca<sup>2+</sup> levels and upregulation of proteins such as LC3B-II, ATG3, ATG5, ATG7, <em>p</em>-Beclin-1, p62, ATF6, GRP78, CHOP, Bax, CYPD, and Cyt-C. Conversely, the protein expressions of Sigma-1 receptor (Sig-1R), <em>p</em>-mTOR, and Bcl-2 were inhibited. In conclusion, PFHxS induces liver cytotoxicity by activating autophagy and ERS-regulated mitochondrial pathway apoptosis. This study is the first to elucidate the mechanisms underlying PFHxS-induced liver cytotoxicity.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"204 ","pages":"Article 115657"},"PeriodicalIF":3.9,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144704816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantification and risk assessment of pesticide residues in Sultani seedless grapes: Implications for consumer safety Sultani无籽葡萄中农药残留的定量和风险评估：对消费者安全的影响

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-07-22 DOI: 10.1016/j.fct.2025.115655

Mehmet Keklik , Eylem Odabas , Ozgur Golge , Bulent Kabak

{"title":"Quantification and risk assessment of pesticide residues in Sultani seedless grapes: Implications for consumer safety","authors":"Mehmet Keklik , Eylem Odabas , Ozgur Golge , Bulent Kabak","doi":"10.1016/j.fct.2025.115655","DOIUrl":"10.1016/j.fct.2025.115655","url":null,"abstract":"<div><div>Pesticides are frequently used in viticulture to control various pests and diseases, but their residues can accumulate in grape products, raising concerns regarding consumer safety. This study aimed to evaluate the occurrence of 268 pesticide residues in Sultani seedless grapes produced in Turkey, with a particular focus on their potential implications for both acute and chronic health risks. Of the 473 grape samples analyzed by liquid chromatography-tandem mass spectrometry, only 11 samples (2.3 %) were free from detectable pesticide residues. Pesticide residues at quantifiable levels were identified in 462 samples (97.7 %), and 52 of these samples exceeded the European Union Maximum Residue Levels. The most frequently recorded pesticides in grapes, with occurrence rates exceeding 50 %, were ametoctradin, metalaxyl, cyprodinil, pyrimethanil, spirotetramat, and fluopyram. Chronic dietary exposure assessments revealed that pesticide residues in grapes do not pose substantial health risks to both adults and children in Turkey, as hazard quotients remained well below critical thresholds. However, acute exposure risks for acetamiprid, emamectin benzoate, and lambda-cyhalothrin exceeded acceptable limits in a fraction of the samples, especially for children. These findings underscore the importance of enhanced pesticide monitoring and regulatory compliance to ensure consumer safety and promote the adoption of integrated pest management practices.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"204 ","pages":"Article 115655"},"PeriodicalIF":3.9,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144694451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0