Food and Chemical Toxicology最新文献

RIFM fragrance ingredient safety assessment, maltol, CAS registry number 118-71-8 香料成分安全性评价，麦芽糖醇，中国科学院登记号118-71-8

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-28 DOI: 10.1016/j.fct.2025.115479

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

Update to RIFM fragrance ingredient safety assessment, 6-methyl-2-(4-methyl-3-cyclohexen-1-yl)-5-hepten-2-ol, CAS Registry Number 515-69-5 更新RIFM香料成分安全性评估，6-甲基-2-（4-甲基-3-环己烯-1-基）-5-庚-2-醇，CAS注册号515-69-5

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-28 DOI: 10.1016/j.fct.2025.115482

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

Exploring the relationship between daily intake and urinary excretion of the mycotoxins T-2 and HT-2 toxin in humans 探索人类每日摄入真菌毒素T-2和HT-2毒素与尿排泄的关系

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-28 DOI: 10.1016/j.fct.2025.115491

Hannah P. McKeon , Rudolf Hoogenveen , Marta M. Sopel , Marloes A.A. Schepens , Marcel J.B. Mengelers , Annick D. van den Brand , Judith A. de Heer , Anne Lise Brantsæter , Maria Kalyva , Trine Husøy

{"title":"Exploring the relationship between daily intake and urinary excretion of the mycotoxins T-2 and HT-2 toxin in humans","authors":"Hannah P. McKeon , Rudolf Hoogenveen , Marta M. Sopel , Marloes A.A. Schepens , Marcel J.B. Mengelers , Annick D. van den Brand , Judith A. de Heer , Anne Lise Brantsæter , Maria Kalyva , Trine Husøy","doi":"10.1016/j.fct.2025.115491","DOIUrl":"10.1016/j.fct.2025.115491","url":null,"abstract":"<div><div>T-2 toxin (T-2) and HT-2 toxin (HT-2) are mycotoxins that can contaminate food, especially cereals. Exposure to T-2 and HT-2 has mainly been estimated using dietary exposure assessment, however, human biomonitoring presents another valuable approach.</div><div>The relationship between daily intake and urinary excretion of T-2 and HT-2 over time in 40 Norwegian adults was modelled. T-2, HT-2 and T-2 triol were analysed in 24-h urine samples using LC-MS/MS. Dietary exposure of T-2 and HT-2 was calculated using 24-h weighed dietary records and concentration data in food derived from measured concentrations in raw food commodities. A statistical model was developed and fit to estimate the excreted fraction (f<sub>abs_excr</sub>) and residence time parameters.</div><div>Without deconjugation prior to analysis, T-2, HT-2 or T-2 triol were not detected in the urine of the 40 adults. Applying a deconjugation step, total HT-2 (HT-2 and its glucuronides) was detected in almost all samples. Using the statistical model, the mean f<sub>abs_excr</sub> was estimated to be 0.184, equivalent to 18.4 %. The estimated time in which 97.5 % of the ingested T-2 and HT-2 was excreted as total HT-2 was 14.3 h, and the elimination half-life was 4.0 h.</div><div>This study highlights the challenges involved in modelling the relationship between daily intake and urinary excretion of T-2 and HT-2 over time in humans. The findings indicate that approximately 20 % of the external exposure can be traced back in the urine within 24 h. However, additional research is required to support and strengthen these findings.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"201 ","pages":"Article 115491"},"PeriodicalIF":3.9,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Update to RIFM fragrance ingredient safety assessment, benzyl valerate, CAS Registry Number 10361-39-4 更新RIFM香料成分安全性评估，戊酸苄，CAS注册号10361-39-4

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-27 DOI: 10.1016/j.fct.2025.115480

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

Update to RIFM fragrance ingredient safety assessment, isocyclocitral, CAS Registry Number 1335-66-6 更新RIFM香料成分安全评估，异环戊二醛，CAS注册号1335-66-6

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-26 DOI: 10.1016/j.fct.2025.115477

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

Selenium content in milk and dairy products: Estimation of the daily intake and assessment of the potential risk to public health 牛奶和奶制品中的硒含量：每日摄入量的估计和对公众健康潜在风险的评估

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-25 DOI: 10.1016/j.fct.2025.115486

Burhan Basaran , Parisa Sadighara

{"title":"Selenium content in milk and dairy products: Estimation of the daily intake and assessment of the potential risk to public health","authors":"Burhan Basaran , Parisa Sadighara","doi":"10.1016/j.fct.2025.115486","DOIUrl":"10.1016/j.fct.2025.115486","url":null,"abstract":"<div><div>In this study, selenium levels in milk (n = 19), cheese (n = 49), yogurt (n = 13) and ayran (n = 8) of different brands sold in Türkiye were first determined by inductively coupled plasma mass spectrometry. The daily selenium intake resulting from the consumption of these foods was then calculated and evaluated with non-carcinogenic health risk. Selenium levels ranged from 9 <span><math><mrow><mo>−</mo></mrow></math></span> 32 and 1<span><math><mrow><mo>−</mo></mrow></math></span> 83 μg/L for milk and ayran, respectively, and from 0 <span><math><mrow><mo>−</mo></mrow></math></span> 224 and 12<span><math><mrow><mo>−</mo></mrow></math></span> 172 μg/kg for cheese and yogurt, respectively. The total daily selenium intake of persons aged 15> (general population) was determined to be 20.4 μg/day (0.292 μg/kg bw/day). The foods contributing most to the total daily selenium intake for all individuals in the same age group were yogurt (51.4 %), ayran (25.7 %), cheese (20.2 %) and milk (2.7 %). For individuals aged 15> (general population), the Target Hazard Quotient values resulting from the consumption of each food (milk, cheese, yogurt and ayran) and the Hazard Index value calculated by consuming all foods together (0.058) were less than 1. This study was detected any health risks related to selenium intake. This study was the first to evaluate health risks of selenium intake from consumption of some milk and dairy products in adult individuals.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"201 ","pages":"Article 115486"},"PeriodicalIF":3.9,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms of LPS-induced toxicity in endothelial cells and the protective role of geniposidic acid 脂多糖诱导内皮细胞毒性的机制及geniposidic酸的保护作用

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-25 DOI: 10.1016/j.fct.2025.115488

Yan Fang , He Meng , Jun Wang

{"title":"Mechanisms of LPS-induced toxicity in endothelial cells and the protective role of geniposidic acid","authors":"Yan Fang , He Meng , Jun Wang","doi":"10.1016/j.fct.2025.115488","DOIUrl":"10.1016/j.fct.2025.115488","url":null,"abstract":"<div><div>Vascular inflammation and oxidative stress are critical pathogenic factors in cardiovascular diseases. Lipopolysaccharide (LPS)-induced endothelial cytotoxicity, driven by oxidative stress and inflammation, remains incompletely understood. This study highlights the molecular mechanisms underlying LPS toxicity, focusing on the ROS/JNK/NLRP3 signaling axis. LPS disrupts mitochondrial function, increases ROS accumulation, activates JNK phosphorylation, and induces NLRP3 inflammasome activation, culminating in pyroptosis through caspase-1-mediated GSDMD cleavage. Mechanistic studies with the JNK inhibitor SP600125 confirmed the critical role of the ROS/JNK/NLRP3 pathway in LPS-induced endothelial damage. Additionally, PGC-1α, a key regulator of mitochondrial homeostasis, was identified as a protective factor suppressed by LPS, exacerbating ROS overproduction and inflammasome activation. To validate these findings, geniposidic acid (GPA), a natural antioxidant and anti-inflammatory compound, was employed. GPA effectively reduced ROS levels, inhibited JNK activation, and suppressed pyroptosis, supporting its utility as a chemical tool to confirm the pivotal role of ROS/JNK/NLRP3 signaling. This study elucidates the intricate interplay between oxidative stress, mitochondrial dysfunction, and pyroptosis, providing a comprehensive framework for addressing inflammation-driven vascular damage.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"201 ","pages":"Article 115488"},"PeriodicalIF":3.9,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143887023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioactive molecules in wheat “Senatore Cappelli" food chain: Extraction, analysis, processing, and beneficial properties 小麦“Senatore Cappelli”食物链中的生物活性分子：提取、分析、加工和有益特性

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-25 DOI: 10.1016/j.fct.2025.115475

Federica Armeli , Marzia Beccaccioli , Sabrina Antonia Prencipe , Emily Schifano , Daniela Tufi , Elisa Brasili , Alessia Cottarelli , Ottavia Giampaoli , Beatrice Mengoni , Alfredo Miccheli , Alessandro Pinto , Fabio Sciubba , Daniela Uccelletti , Rita Businaro , Giuliana Vinci , Massimo Reverberi , Maria De Giusti

{"title":"Bioactive molecules in wheat “Senatore Cappelli\" food chain: Extraction, analysis, processing, and beneficial properties","authors":"Federica Armeli , Marzia Beccaccioli , Sabrina Antonia Prencipe , Emily Schifano , Daniela Tufi , Elisa Brasili , Alessia Cottarelli , Ottavia Giampaoli , Beatrice Mengoni , Alfredo Miccheli , Alessandro Pinto , Fabio Sciubba , Daniela Uccelletti , Rita Businaro , Giuliana Vinci , Massimo Reverberi , Maria De Giusti","doi":"10.1016/j.fct.2025.115475","DOIUrl":"10.1016/j.fct.2025.115475","url":null,"abstract":"<div><div>Ancient grains, once forgotten due to the dominance of high-yield modern crops, are making a comeback due to concerns over biodiversity loss and global food challenges. This study examines the nutritional composition, safety, and health benefits of <em>Senatore Cappelli</em>, an ancient Italian durum wheat variety (SCW), highlighting its potential as a functional food. Using a multi-method approach, SCW was analyzed across four food chain stages (seeds, flour, pasta, and chaff) for compositional changes, phytochemical content, and safety. The safety of raw material was assessed by determination of biogenic amines, pesticides, mycotoxins and pathogenic microorganisms. The chemical profile detected by NMR spectroscopy revealed the presence of bioactive molecules such as phenolic acids and carotenoids in the case of chaff. The toxicity of ethanolic extracts was evaluated using <em>in vitro</em> assays on murine BV-2 microglial cells and <em>in vivo</em> assays on <em>Caenorhabditis elegans</em> animal model. No cytotoxic effects were detected at concentrations up to 250 ng/mL for chaff extract and 1000 ng/mL for seed, flour, and pasta extracts. Additionally, SCW extracts extended the lifespan of <em>C. elegans</em>, indicating potential anti-aging and health-promoting properties.</div><div>These results position SCW as a valuable resource for enhancing bioactive compounds, supporting its reintroduction into modern diets and its use in functional food development.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"201 ","pages":"Article 115475"},"PeriodicalIF":3.9,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143887022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Update to RIFM fragrance ingredient safety assessment, benzyl formate, CAS Registry Number 104-57-4 更新RIFM香料成分安全性评估，甲酸苄酯，CAS注册号104-57-4

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-24 DOI: 10.1016/j.fct.2025.115481

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

Update to RIFM fragrance ingredient safety assessment, 1,1-diethoxyheptane, CAS Registry Number 688-82-4 更新RIFM香料成分安全性评估，1,1-二氧基庚烷，CAS注册号688-82-4

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-23 DOI: 10.1016/j.fct.2025.115470

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

{"title":"Update to RIFM fragrance ingredient safety assessment, 1,1-diethoxyheptane, CAS Registry Number 688-82-4","authors":"A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar","doi":"10.1016/j.fct.2025.115470","DOIUrl":"10.1016/j.fct.2025.115470","url":null,"abstract":"<div><div>1,1-Diethoxyheptane was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog octanal dimethyl acetal (CAS # 10022-28-3) show that 1,1-diethoxyheptane is not expected to be genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class I material, and the exposure to 1,1-diethoxyheptane is below the TTC (0.03 mg/kg/day, 0.03 mg/kg/day, and 1.4 mg/day, respectively). The skin sensitization endpoint was completed using the Dermal Sensitization Threshold (DST) for non-reactive materials (900 μg/cm<sup>2</sup>); exposure is below the DST. The photoirritation/photoallergenicity endpoints were evaluated based on ultraviolet/visible (UV/Vis) spectra; 1,1-diethoxyheptane is not expected to be photoirritating/photoallergenic. The environmental endpoints were evaluated; 1,1-diethoxyheptane was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use (VoU) in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"201 ","pages":"Article 115470"},"PeriodicalIF":3.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0