Food and Chemical Toxicology最新文献

Update to RIFM fragrance ingredient safety assessment, methoxy dicyclopentadiene carboxaldehyde, CAS Registry Number 86803-90-9.

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-29 DOI: 10.1016/j.fct.2025.115414

A M Api, A Bartlett, D Belsito, D Botelho, M Bruze, A Bryant-Friedrich, G A Burton, M A Cancellieri, H Chon, M Cronin, S Crotty, M L Dagli, W Dekant, C Deodhar, K Farrell, A D Fryer, L Jones, K Joshi, A Lapczynski, D L Laskin, M Lavelle, I Lee, H Moustakas, J Muldoon, T M Penning, A H Piersma, G Ritacco, N Sadekar, I Schember, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar

引用次数: 0

RIFM fragrance ingredient safety assessment, octahydro-4,7-methano-1H-indenecarbaldehyde, CAS Registry Number 30772-79-3.

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-28 DOI: 10.1016/j.fct.2025.115412

A M Api, A Bartlett, D Belsito, D Botelho, M Bruze, A Bryant-Friedrich, G A Burton, M A Cancellieri, H Chon, M Cronin, S Crotty, M L Dagli, W Dekant, C Deodhar, K Farrell, A D Fryer, L Jones, K Joshi, A Lapczynski, D L Laskin, M Lavelle, I Lee, H Moustakas, J Muldoon, T M Penning, A H Piersma, G Ritacco, N Sadekar, I Schember, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar

引用次数: 0

Update to RIFM fragrance ingredient safety assessment, acetophenone, CAS Registry Number 98-86-2.

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-27 DOI: 10.1016/j.fct.2025.115416

A M Api, A Bartlett, D Belsito, D Botelho, M Bruze, A Bryant-Friedrich, G A Burton, M A Cancellieri, H Chon, M Cronin, S Crotty, M L Dagli, W Dekant, C Deodhar, K Farrell, A D Fryer, L Jones, K Joshi, A Lapczynski, D L Laskin, M Lavelle, I Lee, H Moustakas, J Muldoon, T M Penning, A H Piersma, G Ritacco, N Sadekar, I Schember, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar

引用次数: 0

RIFM Natural Complex Substance (NCS) fragrance ingredient safety assessment, Sage oil, Spanish, CAS Registry Number 8022-56-8, RIFM ID 1042440.

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-27 DOI: 10.1016/j.fct.2025.115411

A M Api, A Bartlett, D Belsito, D Botelho, M Bruze, A Bryant-Friedrich, G A Burton, M A Cancellieri, H Chon, M L Dagli, W Dekant, C Deodhar, K Farrell, A D Fryer, L Jones, K Joshi, A Lapczynski, M Lavelle, I Lee, H Moustakas, J Muldoon, T M Penning, G Ritacco, N Sadekar, I Schember, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura

引用次数: 0

Update to RIFM fragrance ingredient safety assessment, α-amylcinnamaldehyde, CAS Registry Number 122-40-7.

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-27 DOI: 10.1016/j.fct.2025.115409

A M Api, A Bartlett, D Belsito, D Botelho, M Bruze, A Bryant-Friedrich, G A Burton, M A Cancellieri, H Chon, M Cronin, S Crotty, M L Dagli, W Dekant, C Deodhar, K Farrell, A D Fryer, L Jones, K Joshi, A Lapczynski, D L Laskin, M Lavelle, I Lee, H Moustakas, J Muldoon, T M Penning, A H Piersma, G Ritacco, N Sadekar, I Schember, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar

引用次数: 0

A 7-year feed study on the long-term effects of genetically modified maize containing cry1Ab/cry2Aj and EPSPS genes on gut microbiota and metabolite profiles across two generations of cynomolgus macaques

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-27 DOI: 10.1016/j.fct.2025.115419

Chenyun Wang , Shengtao Fan , Minghao Li , Yousong Ye, Zheli Li, Weihu Long, Yongjie Li, Zhangqiong Huang, Qinfang Jiang, Wanjing Yang, Rujia Yang, Donghong Tang

{"title":"A 7-year feed study on the long-term effects of genetically modified maize containing cry1Ab/cry2Aj and EPSPS genes on gut microbiota and metabolite profiles across two generations of cynomolgus macaques","authors":"Chenyun Wang , Shengtao Fan , Minghao Li , Yousong Ye, Zheli Li, Weihu Long, Yongjie Li, Zhangqiong Huang, Qinfang Jiang, Wanjing Yang, Rujia Yang, Donghong Tang","doi":"10.1016/j.fct.2025.115419","DOIUrl":"10.1016/j.fct.2025.115419","url":null,"abstract":"<div><div>The health implications of genetically modified (GM) crops remain controversial relative to their non-GM counterparts, particularly regarding long-term dietary exposure. Although the gut microbiome is a key health indicator, studies investigating the impact of GM crop consumption on intestinal microbiota remain limited. This study presents a comprehensive 7-year evaluation of GM maize expressing cry1Ab/cry2Aj and G10evo-EPSPS proteins through metagenomic and metabolomic analyses. We assessed the effects of GM maize consumption on gut microbiota diversity and metabolite profiles in cynomolgus macaques (<em>Macaca fascicularis</em>) compared with non-GM maize. Three diet regimens were implemented: a conventional compound feed (CK group), diet formulation containing 70 % non-GM maize (Corn group), and diet formulation containing 70 % GM maize (Tg group). The results demonstrated that feeding GM maize to the first (F0) and second (F1) generations of monkeys did not substantially affect the composition, community structure, or function of the intestinal microbiome, as indicated by species composition and diversity analyses. Minor differences in intestinal metabolites were observed but were not directly linked to transgenic maize consumption. Collectively, long-term intake of maize with <em>cry1Ab/cry2Aj</em> and <em>g10evo-epsps</em> genes had no adverse effects on macaques or their offspring.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115419"},"PeriodicalIF":3.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repurposing levomilnacipran to attenuate premature ovarian insufficiency induced by cyclophosphamide in female Wistar albino rats through modulation of TLR4/p38-MAPK/NF-κB p65, caspase-3-driven apoptosis, and Klotho protein expression

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-26 DOI: 10.1016/j.fct.2025.115406

Remon Roshdy Rofaeil , Ehab E. Sharata , Mina Ezzat Attya , Amira M. Abo-Youssef , Ramadan AM. Hemeida , Marwa M. Khalaf

{"title":"Repurposing levomilnacipran to attenuate premature ovarian insufficiency induced by cyclophosphamide in female Wistar albino rats through modulation of TLR4/p38-MAPK/NF-κB p65, caspase-3-driven apoptosis, and Klotho protein expression","authors":"Remon Roshdy Rofaeil , Ehab E. Sharata , Mina Ezzat Attya , Amira M. Abo-Youssef , Ramadan AM. Hemeida , Marwa M. Khalaf","doi":"10.1016/j.fct.2025.115406","DOIUrl":"10.1016/j.fct.2025.115406","url":null,"abstract":"<div><h3>Aim</h3><div>This study aims to explore the mitigative impact of levomilnacipran (LVM) against cyclophosphamide (CPA)-induced premature ovarian insufficiency by targeting TLR4/p38 MAPK/NF-κB p65, and klotho expression.</div></div><div><h3>Methods</h3><div>Rats were allocated into five groups as follows: control, LVM, CPA, CPA + LVM, and CPA + TRI. Serum hormones and histopathological examination were performed. To assess oxidative stress, ovarian MDA, GSH, and SOD were evaluated. The ovarian contents of caspase-3 and inflammatory markers were assessed using the ELISA method. The expression of ovarian NF-κB p65 was examined using an immunohistochemical technique. RT-qPCR was used to measure Bax and Bcl-2 mRNA expression. Utilizing a Western blot, the TLR4, p38 MAPK, α-Klotho, and cleaved caspase-3 levels were estimated. The estrous cycle was also monitored.</div></div><div><h3>Findings</h3><div>LVM attenuated CPA-induced ovarian toxicity by regulating hormones and alleviating histopathological aberrations. It also raised SOD and GSH levels and lowered MDA's ovarian content. Moreover, Bcl-2 levels were raised, Bax and caspase-3 expression levels were reduced, and IL-18, IL-1β, and TNF-α levels were all reduced. LVM-induced ovarian protection by diminishing TLR4/p38 MAPK/NF-κB p65 expression and boosting the protein levels of α-Klotho.</div></div><div><h3>Significance</h3><div>LVM mitigated POI caused by CPA by downregulating TLR4/p38 MAPK/NF-κB p65, enhancing the α-Klotho level and attenuating caspase-3 derived apoptosis.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115406"},"PeriodicalIF":3.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multivariate analysis of potentially toxic metal contents in soil and vegetables: Enrichment, bioconcentration, translocation from soil to vegetables, and assessment of human health toxicity 土壤和蔬菜中潜在有毒金属含量的多元分析：富集、生物浓缩、从土壤到蔬菜的迁移以及人类健康毒性评估

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-26 DOI: 10.1016/j.fct.2025.115413

Iftikhar-Ul-Haq , Mahmood Ahmed , Ali Abbas Aslam , Fatima Aftab , Mudassar Sanaullah , Riaz Hussain , Eisha Eiman , Awais Ali Aslam , Tanveer A. Wani , Seema Zargar

{"title":"Multivariate analysis of potentially toxic metal contents in soil and vegetables: Enrichment, bioconcentration, translocation from soil to vegetables, and assessment of human health toxicity","authors":"Iftikhar-Ul-Haq , Mahmood Ahmed , Ali Abbas Aslam , Fatima Aftab , Mudassar Sanaullah , Riaz Hussain , Eisha Eiman , Awais Ali Aslam , Tanveer A. Wani , Seema Zargar","doi":"10.1016/j.fct.2025.115413","DOIUrl":"10.1016/j.fct.2025.115413","url":null,"abstract":"<div><div>The excessive accumulation of metals in agricultural soils can profoundly impact the quality of vegetables grown in contaminated soil. Understanding the bioaccumulation of these metals in vegetables is essential for assessing human exposure risks. The present study aimed to investigate the concentration of potentially toxic metals (PTMs: Fe, Mn, Cu, Zn, Al, As, Cr, Cd, and Pb) in agricultural soil and some commonly consumed vegetables (carrot, reddish, cauliflower, pumpkin, and spinach). The samples were collected from agrarian farmlands near the industrial area of Multan Road, Kasur-Pakistan. The mean contents of all metals in soil, root, and shoot samples were within the limits set by the EU, WHO, FAO, and US EPA, except for Cr in soil and Cr, Cd, and Pb in root samples. Across all analyzed vegetables, the bioconcentration factors (BCF<sub>root</sub> and BCF<sub>shoot</sub> < 1, except As) and translocation factor (TF < 1) for all metals suggested that while these vegetables absorb metals, they generally do not accumulate or translocate them. Multivariate analysis indicated that both natural and anthropogenic activities contribute to metal contamination. The calculated hazard index (HI > 1) and cumulative cancer risk (CCR >1 × 10<sup>−3</sup>) values indicated the probability of non-carcinogenic and carcinogenic health risks for adults and children associated with the consumption of these vegetables. The findings provide critical insights for policymakers, agricultural regulators, and public health authorities to mitigate metal contamination risks and promote food safety.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115413"},"PeriodicalIF":3.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Attenuation of Paclitaxel-induced toxicities by polyphenolic natural compound rutin through inhibition of apoptosis and activation of NRF2/ARE signaling pathways.

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-26 DOI: 10.1016/j.fct.2025.115408

Souradeep Biswas, Mrinmoyee Mondal, Shampa Pakhira, Rituparna Ghosh, Priya Samanta, Jhinuk Basu, Arijit Bhowmik, Subhadip Hajra, Prosenjit Saha

{"title":"Attenuation of Paclitaxel-induced toxicities by polyphenolic natural compound rutin through inhibition of apoptosis and activation of NRF2/ARE signaling pathways.","authors":"Souradeep Biswas, Mrinmoyee Mondal, Shampa Pakhira, Rituparna Ghosh, Priya Samanta, Jhinuk Basu, Arijit Bhowmik, Subhadip Hajra, Prosenjit Saha","doi":"10.1016/j.fct.2025.115408","DOIUrl":"https://doi.org/10.1016/j.fct.2025.115408","url":null,"abstract":"<p><p>Paclitaxel is the first microtubule-stabilizing drug widely used as an antineoplastic agent. Hepatotoxicity, nephrotoxicity and myeloid suppression may lead to secondary malignancy which is an important adverse effect of paclitaxel-therapy. In this study, we have evaluated the potential protective role of natural flavonoid rutin against paclitaxel-induced toxicities in BALB/cmice. Paclitaxel was administered intraperitoneally (in alternate days at a dose of 8.5 mg/kg b.w.) and rutin was given every day by oral gavages (20 mg/kg b.w.) in BALB/c mice. Results showed that administration of paclitaxel significantly (P<0.05) increased the generation of ROS and NO in bone marrow, liver and kidney tissues. In contrast, co-administration of rutin and paclitaxel significantly (p<0.05) reduced the intracellular ROS and NO levels, reversed the toxic effects of paclitaxel through NRF2-mediated activation of antioxidant response element (ARE) pathway and upregulated activity of several phase-II antioxidant enzymes. Furthermore, rutin treatment inhibited apoptosis by downregulated expression of Bax, caspase-3 and cPARP in bone marrow, liver and kidney tissues. Additionally, the chemoprotective potential of rutin was confirmed by histopathological analysis. Thus, our results suggest that co-administration of rutin may serve as a promising preventive strategy against paclitaxel induced toxicities and indicate its future use as an adjuvant in chemotherapy.</p>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":" ","pages":"115408"},"PeriodicalIF":3.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endocrine-disrupting effects of 24 colorants used in food contact materials: In vitro and in silico studies

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-25 DOI: 10.1016/j.fct.2025.115410

Guowei Ma , Yiling Cui , Qian Li , Yuting Chen , Peixue Guo , Di Feng , Tingting Zhao

{"title":"Endocrine-disrupting effects of 24 colorants used in food contact materials: In vitro and in silico studies","authors":"Guowei Ma , Yiling Cui , Qian Li , Yuting Chen , Peixue Guo , Di Feng , Tingting Zhao","doi":"10.1016/j.fct.2025.115410","DOIUrl":"10.1016/j.fct.2025.115410","url":null,"abstract":"<div><div>Current research on endocrine-disrupting effects of colorants utilized in food contact materials (FCMs) ramains limited. This study investigated these effects through <em>in vitro</em> cell models and <em>in silico</em> toxicological models. A total of 24 synthetic colorants were collected from the Chinese market, including azo, anthraquinone, heterocyclic and fused-ring ketones, and phthalocyanines. Their endocrine-disrupting effects mediated by estrogen and androgen receptors were evaluated using an <em>in vitro</em> dual-luciferase reporter gene assay. Results showed no estrogenic or anti-estrogenic effects or androgenic activity in the colorants. However, three colorants, C.I. Pigment Red 177, C.I. Pigment Orange 71, and C.I. Pigment Blue 15, elicited anti-androgenic effects with 20 % relative inhibitory concentrations (RIC<sub>20</sub>) of 13.08, 40.52, and 33.27 μg/mL, respectively. In addition, <em>in silico</em> toxicological models predicted the endocrine-disrupting activity of the 24 colorants, showing predictive accuracy ranging from 35 % to 100 % consistency with <em>in vitro</em> experimental outcomes. Molecular docking revealed strong binding affinity and mechanisms of interaction between three colorants and the human androgen receptor. In summary, this study combined <em>in vitro</em> experiments and <em>in silico</em> toxicological models to investigate the endocrine-disrupting effects of organic colorants with different structural types, providing new insights perspective on health risks associated with their use in FCMs.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115410"},"PeriodicalIF":3.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0