Food and Chemical Toxicology最新文献

Corrigendum to “A 13-week repeated oral dose toxicity evaluation and a 4-week recovery evaluation of rosemary concentrate containing 50 % ursolic acid in male and female rats” [Food Chem. Toxicol. 197, February (2025) 115308] 《含有50%熊果酸的迷迭香浓缩物对雄性和雌性大鼠的13周重复口服剂量毒性评估和4周恢复评估》的勘误表[食品化学]。毒物。197,february (2025) 115308]

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-05-16 DOI: 10.1016/j.fct.2025.115548

Yanghoon Peter Jung , Suyoung Lim , Seulgi An , Hyunji Kim , Jae-Ho Shin

引用次数: 0

Cyclophosphamide-Induced Pulmonary Toxicity Involves Oxidative Stress, Inflammation, Apoptosis, and Fibrosis with Impaired Nrf2/HO-1 Signaling: Protective Role of Rosmarinic Acid. 环磷酰胺诱导的肺毒性涉及氧化应激、炎症、细胞凋亡和纤维化，并伴有Nrf2/HO-1信号通路受损：迷迭香酸的保护作用

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-05-14 DOI: 10.1016/j.fct.2025.115552

Mohammad H Abukhalil, Osama Y Althunibat, Norah A Althobaiti, Fatima S Alaryani, Aishah E Albalawi, Reem H Alhasani, Shatha G Felemban, Alaa J Al-Zayadneh, Baker Al-Shara, Sofian Alwardat

{"title":"Cyclophosphamide-Induced Pulmonary Toxicity Involves Oxidative Stress, Inflammation, Apoptosis, and Fibrosis with Impaired Nrf2/HO-1 Signaling: Protective Role of Rosmarinic Acid.","authors":"Mohammad H Abukhalil, Osama Y Althunibat, Norah A Althobaiti, Fatima S Alaryani, Aishah E Albalawi, Reem H Alhasani, Shatha G Felemban, Alaa J Al-Zayadneh, Baker Al-Shara, Sofian Alwardat","doi":"10.1016/j.fct.2025.115552","DOIUrl":"https://doi.org/10.1016/j.fct.2025.115552","url":null,"abstract":"<p><p>Cyclophosphamide (CYP) is a widely used immunosuppressive and antineoplastic agent; nevertheless, its use is linked to significant pulmonary toxicity. Rosmarinic acid (RA), a natural polyphenolic compound found in various medicinal plants, is well-known for its powerful anti-inflammatory and antioxidant properties. This study aimed to explore the protective effects of RA against CYP-induced lung damage in mice. The mice received co-treatment of RA (25 and 50 mg/kg, orally) and CYP (30 mg/kg, i.p.) for 10 consecutive days, with sacrifice occurring 24 hours after the final dose. Administration of CYP resulted in notable lung injury characterized by several histopathological changes and fibrosis, along with increased markers of oxidative stress, including malondialdehyde and protein carbonyl levels, and decreased antioxidant defenses such as reduced glutathione levels and superoxide dismutase and catalase activities. Furthermore, CYP treatment induced intense inflammatory reactions (enhanced NF-κB p65 expression and pro-inflammatory cytokines TNF-α and IL-6 levels) and apoptosis (reduced Bcl-2 and increased Bax and caspase-3) in lung tissues. Notably, treatment with RA alleviated CYP-induced lung injury by balancing redox state, reducing inflammation, and inhibiting apoptosis. Moreover, RA restored Nrf2/HO-1 signaling pathway in lung tissues. Our results suggest RA may represent a promising protective tool against CYP-induced lung injury via its ability to mitigate oxidative tissue injury, inflammation, and apoptosis and to restore Nrf2/HO-1 signaling pathway.</p>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":" ","pages":"115552"},"PeriodicalIF":3.9,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of potential natural compounds to relieve deoxynivalenol-induced intestinal damage based on bioinformatics and reverse network pharmacology 基于生物信息学和反向网络药理学的脱氧雪腐镰梨醇肠道损伤潜在天然化合物的鉴定

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-05-14 DOI: 10.1016/j.fct.2025.115551

Rui Li, Kang Feng, Yu Du, Xuebin Fan, Yaqin Zhang, Chenli Wang, Jingdi Zhang, Sheraz Ahmad, Rafique Amna, Ci Liu, Ruiyan Niu, Zilong Sun

{"title":"Identification of potential natural compounds to relieve deoxynivalenol-induced intestinal damage based on bioinformatics and reverse network pharmacology","authors":"Rui Li, Kang Feng, Yu Du, Xuebin Fan, Yaqin Zhang, Chenli Wang, Jingdi Zhang, Sheraz Ahmad, Rafique Amna, Ci Liu, Ruiyan Niu, Zilong Sun","doi":"10.1016/j.fct.2025.115551","DOIUrl":"10.1016/j.fct.2025.115551","url":null,"abstract":"<div><div>Deoxynivalenol (DON) is one of the most prevalent mycotoxins globally, causing a variety of toxic effects in both humans and animals. Numerous studies have demonstrated the considerable efficacy of natural medicines in treating and preventing DON-induced damage. Therefore, it is crucial to predict and screen highly efficient natural medicines and further investigate their mechanisms. In this study, we employed bioinformatics approaches to explore DON's pathogenic mechanism and targets. Utilizing drug prediction and screening databases, we conducted reverse prediction and screening of differentially expressed genes (DEGs) and key targets to obtain optimal natural medicines, ultimately identifying quercetin as the most promising candidate. Subsequently, network pharmacology analyses revealed that quercetin alleviated DON-induced intestinal damage by modulating inflammatory targets and the TNF/NF-κB pathways. Our experiments demonstrated that quercetin treatment improved DON-induced growth inhibition and intestinal damage in mice, while successfully reversing the abnormal expression of key target genes. Furthermore, quercetin restored the intestinal microbial imbalance induced by DON. Overall, these findings suggest that quercetin is a promising natural medicine capable of alleviating DON-induced intestinal dysfunction by regulating inflammation-related factor levels and gut microbiota, thereby providing new insights for the future prevention and treatment of mycotoxins.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"202 ","pages":"Article 115551"},"PeriodicalIF":3.9,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fatty acid oxidation contributed to NLRP3 inflammasome activation caused by N-nitrosamines co-exposure 脂肪酸氧化有助于n -亚硝胺共暴露引起的NLRP3炎性体活化。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-05-13 DOI: 10.1016/j.fct.2025.115549

Hu Zhang , Chao Zhao , Guo Hong , Wen Xiong , Junpeng Xia , Ruijun Dong , Qianqian Wang , Kaiyue Zhang , Bing Wang

{"title":"Fatty acid oxidation contributed to NLRP3 inflammasome activation caused by N-nitrosamines co-exposure","authors":"Hu Zhang , Chao Zhao , Guo Hong , Wen Xiong , Junpeng Xia , Ruijun Dong , Qianqian Wang , Kaiyue Zhang , Bing Wang","doi":"10.1016/j.fct.2025.115549","DOIUrl":"10.1016/j.fct.2025.115549","url":null,"abstract":"<div><div>Nitrosamines, as common environmental carcinogens, are closely related to the development of esophageal inflammation (EI). Studies have revealed that NLRP3 inflammasome activation was a key event in nitrosamine-induced EI. However, the involvement of fatty acid metabolism in nitrosamine-induced NLRP3 inflammasome activation has not been reported. In this study, we used human esophageal epithelial (Het-1A) cells to investigate the underlying mechanisms of fatty acid oxidation (FAO) dysregulation caused by nitrosamines mixture commonly found in drinking water. The results showed that the activity of CPT1A, the key rate-limiting enzyme for FAO, upregulated with the increase of nitrosamine concentrations, while the level of acetyl-CoA revealed decreasing trends. The cells in nitrosamine-stained groups underwent fatty acid metabolism disorders, in which the concentrations of key fatty acids showed accelerated decomposition trends. Furthermore, our results revealed that nitrosamines promoted FAO via the AMPK/ACC/CPT1A pathway. Nitrosamines triggered the activation of NLRP3 inflammatory vesicles in a dose-dependent manner, with concomitant elevation in the expression of NLRP3 activation-associated ASC oligomer, caspase-1 and acetyl-α-tubulin. In brief, FAO involved in the activation of NLRP3 inflammatory vesicles in Het-1A cells due to nitrosamines exposure. This study revealed the new perspective on the mechanism of fatty acid metabolism disruption triggered by nitrosamines co-exposure.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"202 ","pages":"Article 115549"},"PeriodicalIF":3.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Food and Chemical Toxicology. 食品与化学毒理学。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-05-13 DOI: 10.1016/j.fct.2025.115547

Chandrabose Uthra, Sumathy Shunmugam, Karuppiah Nagaraj, Gangatharan Muralitharan, Mohammed F Albeshr, Gunasekaran Velmurugan

引用次数: 0

Polystyrene bead ingestion promotes atherosclerosis plaque progression via BMP signaling in mice. 小鼠摄入聚苯乙烯珠可通过BMP信号促进动脉粥样硬化斑块进展。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-05-13 DOI: 10.1016/j.fct.2025.115455

Na Yang, Bo Wu, Xiaoxue He, Junhu Ma, Longhao Dai, RuiTing Ma, Tingting Yang, Xiaoxi Ning, Xiaoyan Li, Shaobin Jia

{"title":"Polystyrene bead ingestion promotes atherosclerosis plaque progression via BMP signaling in mice.","authors":"Na Yang, Bo Wu, Xiaoxue He, Junhu Ma, Longhao Dai, RuiTing Ma, Tingting Yang, Xiaoxi Ning, Xiaoyan Li, Shaobin Jia","doi":"10.1016/j.fct.2025.115455","DOIUrl":"https://doi.org/10.1016/j.fct.2025.115455","url":null,"abstract":"<p><p>Microplastics have emerged as persistent organic pollutants, generating significant concerns regarding their potential toxicity. Nevertheless, the impact of microplastics (MPs) on atherosclerosis in mammals remains uncertain. The present study investigated the deleterious effects of polystyrene microplastics (PS-MPs) on the cardiovascular system of mice. A total of thirty-six male ApoE<sup>-/-</sup> mice were divided into three groups: a control group and two experimental groups. The experimental groups were subjected to the exposure of 5 μm PS-MPs at concentrations of 1 μg/ml and 10 μg/ml, respectively, for twelve weeks. In parallel, HUVECs were treated with the same concentrations of PS-MPs to assess cellular responses. Our results indicate that PS-MPs exposure increased mouse body weight, disrupted lipid metabolism, and exacerbated atherosclerosis. Additionally, both in vivo and in vitro studies indicate that PS-MPs can induce oxidative stress and promote EndMT through the BMP signaling pathway. These findings suggest that PS-MPs may trigcger atherosclerosis and cardiovascular toxicity by activating the BMP pathway and driving EndMT via oxidative stress. In summary, this study elucidates the cardiovascular deleterious effects induced by PS-MPs in mice, providing new insights into the toxicity of PS-MPs in mammalian organisms.</p>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":" ","pages":"115455"},"PeriodicalIF":3.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paeoniflorin attenuates cisplatin induced ototoxicity by inhibiting ferroptosis mediated by HMGB1/NRF2/GPX4 pathway. 芍药苷通过抑制HMGB1/NRF2/GPX4通路介导的铁凋亡，减轻顺铂所致耳毒性。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-05-13 DOI: 10.1016/j.fct.2025.115550

Shaoli Chen, Wei Zheng, Yichao Wang, Xinyu Zhao, Wenhao Deng, Ni Chai

{"title":"Paeoniflorin attenuates cisplatin induced ototoxicity by inhibiting ferroptosis mediated by HMGB1/NRF2/GPX4 pathway.","authors":"Shaoli Chen, Wei Zheng, Yichao Wang, Xinyu Zhao, Wenhao Deng, Ni Chai","doi":"10.1016/j.fct.2025.115550","DOIUrl":"https://doi.org/10.1016/j.fct.2025.115550","url":null,"abstract":"<p><p>Cisplatin-induced ototoxicity is a major dose-limiting complication in cancer therapy, profoundly diminishing quality of life. Paeoniflorin (PAE), a bioactive compound from Paeonia lactiflora, exhibits diverse pharmacological activities. This study aimed to evaluate the efficacy of PAE in countering cisplatin-induced ototoxicity and explore its molecular mechanisms. Cochlear hair cell injury models were established both in vitro and in vivo using cisplatin. Ferroptosis was induced in HEI-OC1 cells with RSL3, and HMGB1-overexpressing models were constructed to investigate its role. The findings indicated that PAE effectively alleviated cisplatin-induced hearing loss and cochlear cell damage in both in vitro and in vivo models. Moreover, PAE significantly mitigated the inflammatory response triggered by cisplatin exposure. Mechanistically, PAE reduced oxidative stress and ferroptosis by upregulating nuclear factor erythroid 2-related factor 2 (NRF2), solute carrier family 7 member 11 (SLC7A11), and glutathione peroxidase 4 (GPX4). Notably, PAE directly interacted with HMGB1 and suppressed its expression, thereby inhibiting HMGB1-mediated ferroptosis in cochlear cells. This study highlights PAE as a promising therapeutic candidate for preventing cisplatin-induced ototoxicity. By elucidating the role of PAE in modulating ferroptosis through HMGB1 and the NRF2/SLC7A11/GPX4 pathway, our findings provide new insights into potential strategies for mitigating cisplatin-induced hearing loss.</p>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":" ","pages":"115550"},"PeriodicalIF":3.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of exposure factors for toxic metals in the hair of traffic police officers in Tehran, Iran 伊朗德黑兰交通警察头发中有毒金属暴露因素的调查。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-05-11 DOI: 10.1016/j.fct.2025.115511

Maedeh Roydel , Fatemeh Rajaei , Reza Dahmardeh Behrooz , Paromita Chakraborty

{"title":"Investigation of exposure factors for toxic metals in the hair of traffic police officers in Tehran, Iran","authors":"Maedeh Roydel , Fatemeh Rajaei , Reza Dahmardeh Behrooz , Paromita Chakraborty","doi":"10.1016/j.fct.2025.115511","DOIUrl":"10.1016/j.fct.2025.115511","url":null,"abstract":"<div><div>Scalp hair samples of traffic police officers were analyzed for 11 selected metals. The concentration of Pb and Co in the hair of traffic police officers in the city center had significant differences with other areas (<em>p</em> < 0.05). Also, the concentration of Al, Zn, and Cu in the hair of police officers in the south of Tehran was mainly different from other regions (<em>p</em> < 0.05). In this study, the concentrations of all studied elements were lower in traffic police officers who used masks and a considerable difference was observed between the concentrations of Co, Cu, Pb and Cd between the two groups (<em>p</em> < 0.05). In this study, a significant positive relationship was found between fish consumption and Cd concentration (r = 0.310; <em>p</em> < 0.01). A negative correlation was found between the intake of fruits and the levels of heavy metals Co, Zn, and As in hair. This study also found a negative correlation between BMI and hair concentrations of Cu, Zn, Cr, and Fe (r = −0.78, <em>p</em> > 0.02; r = −0.70, <em>p</em> > 0.05; r = −0.64, <em>p</em> > 0.05; r = −0.63, <em>p</em> > 0.05 respectively) in individuals classified as underweight (BMI ≤18.49 kg/m<sup>2</sup>, n = 8).</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"202 ","pages":"Article 115511"},"PeriodicalIF":3.9,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mineral profile of infant formula in the Las Vegas market: Compliance with label and regulations, contribution to dietary reference intakes and method comparison 拉斯维加斯市场婴儿配方奶粉的矿物质概况：符合标签和法规，对饮食参考摄入量的贡献和方法比较。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-05-11 DOI: 10.1016/j.fct.2025.115544

Desta Woldetsadik , Douglas B. Sims , Emmanuel Herrera Huerta , Timothy Nelson , Abigael Walker , Joshua Monk , Mark C. Garner , Christopher Adcock , Amanda C. Hudson , David E.B. Fleming

{"title":"Mineral profile of infant formula in the Las Vegas market: Compliance with label and regulations, contribution to dietary reference intakes and method comparison","authors":"Desta Woldetsadik , Douglas B. Sims , Emmanuel Herrera Huerta , Timothy Nelson , Abigael Walker , Joshua Monk , Mark C. Garner , Christopher Adcock , Amanda C. Hudson , David E.B. Fleming","doi":"10.1016/j.fct.2025.115544","DOIUrl":"10.1016/j.fct.2025.115544","url":null,"abstract":"<div><div>To date, there are few studies concerning determination of minerals in infant formulae intended to survey compliance of manufacturer claims and compliance with regulations. In this study, we collected infant formulae from the Las Vegas market to investigate the levels of Na, Mg, K, Mn, Fe, and Zn using inductively coupled plasma mass spectrometry (ICP-MS) following hot block-assisted digestion. Within analytical uncertainty, infant formula samples met label claims for Na, Mg, K, Fe, and Zn and were within the United States Food and Drug Administration (FDA) regulations. Estimated daily intakes (EDIs) of analyzed minerals from consumption of different types of infant formulae were: (158–316) mg d<sup>−1</sup> for Na, (42.5–63.8) mg d<sup>−1</sup> for Mg, (618–1025) mg d<sup>−1</sup> for K, (0.006–0.345) mg d<sup>−1</sup> for Mn, (4.79–16.6) mg d<sup>−1</sup> for Fe and (4.11–8.88) mg d<sup>−1</sup> for Zn. Except for Zn, the levels of other elements conform to currently recommended dietary reference values. In this study we also evaluated the accuracy of portable X-Ray Fluorescence (pXRF) for measuring Zn and Fe in infant formula. Bland-Altman analysis indicates that pXRF can be applied as a reliable technique for determination of Zn and Fe in infant formula.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"202 ","pages":"Article 115544"},"PeriodicalIF":3.9,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MLIF inhibits inflammation and maintains intestinal flora homeostasis in a dextran sulfate sodium (DSS)-induced colitis mouse model 在葡聚糖硫酸钠（DSS）诱导的结肠炎小鼠模型中，MLIF抑制炎症并维持肠道菌群稳态。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-05-10 DOI: 10.1016/j.fct.2025.115545

Yulin Ma , Jing Jing , Yuan Gao , Yongsheng Yu , Junqin Mao , Yuefan Zhang , Tiejun Li

{"title":"MLIF inhibits inflammation and maintains intestinal flora homeostasis in a dextran sulfate sodium (DSS)-induced colitis mouse model","authors":"Yulin Ma , Jing Jing , Yuan Gao , Yongsheng Yu , Junqin Mao , Yuefan Zhang , Tiejun Li","doi":"10.1016/j.fct.2025.115545","DOIUrl":"10.1016/j.fct.2025.115545","url":null,"abstract":"<div><div>Ulcerative colitis (UC) is a chronic inflammatory disease primarily affecting the colon, characterized by mucosal inflammation and ulceration. Monocyte locomotion inhibitory factor (MLIF), a heat-stable pentapeptide derived from <em>Entamoeba histolytica</em>, has demonstrated the anti-inflammatory capacity. The aim of the current work was to test the protective effects of MLIF in a dextran sulfate sodium (DSS)-induced colitis mouse model. Our findings indicated that MLIF significantly inhibition of colitis development, including body weight, DAI score, colon length, and spleen index. MLIF slowing the progression of inflammation in the colon of mice exposed to DSS, evidenced by HE staining and mRNA expression levels of <em>Il1b</em>, <em>Il6</em>, <em>Il18</em> and <em>Il10</em>. MLIF significantly alleviated intestinal barrier dysfunction in mice exposed to DSS, evidenced by AB-PAS staining and mRNA expression levels of <em>Tjp1</em>, <em>Ocln</em> and <em>Muc2</em>. Importantly, the administration of MLIF in colitis mice exerted beneficial effects on the gut microbiota, enhancing microbial diversity and abundance, and promoting the restoration of gut microbiota homeostasis. Non-targeted metabolomics results suggest that the benefits of MLIF may arise from its modulation of tryptophan metabolism pathways. In conclusion, MLIF prevention inflammation induction and preserves intestinal homeostasis against colitis induced by DSS.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"202 ","pages":"Article 115545"},"PeriodicalIF":3.9,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0