Biomonitoring and exposure predictors of 29 dioxin, furan, and dl-PCB congeners in newborn meconium from Spain.

IF 3.5 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology Pub Date : 2025-11-01 Epub Date: 2025-08-06 DOI:10.1016/j.fct.2025.115681

Iñaki Lacomba, Antonio López, Raquel Hervàs-Ayala, Clara Coscollà

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引用次数: 0

Abstract

Prenatal exposure to persistent organic pollutants (POPs) is a matter of great concern due to the vulnerability of the foetus. Seventeen polychlorinated dibenzo-p-dioxins and dibenzofurans (PCCD/Fs) and 12 dioxin-like polychlorinated biphenyls (dl-PCBs) were measured in meconium samples from 50 Spanish newborns using gas chromatography coupled to high-resolution mass spectrometry (GC-HRMS). Median concentrations (wet weight) of PCDD/Fs and dl-PCBs were 0.017 pg toxic equivalents (TEQ)/g and 0.0017 pg TEQ/g, respectively. Highly significant correlations were observed between some congeners of dl-PCBs and octachlorodibenzo-p-dioxin (OCDD), suggesting their similar sources and kinetic behaviour. Neonatal weight and gestational age were demographic parameters that influenced dl-PCB levels in meconium. Multiple regression analysis showed that consumption of ultra-processed foods contributed to the levels of several dl-PCBs in meconium. Our study concludes that meconium may be employed as a human matrix for assessing prenatal exposure to POPs and provides, for the first time, information about predictors of exposure and biomonitoring of dioxins and furans in biological meconium samples.

查看原文本刊更多论文

西班牙新生儿胎中29种二恶英、呋喃和多氯联苯同系物的生物监测和暴露预测。

由于胎儿的脆弱性，产前暴露于持久性有机污染物（POPs）是一个非常令人关注的问题。采用气相色谱-高分辨率质谱联用技术（GC-HRMS）测定了50例西班牙新生儿胎粪样品中的17种多氯二苯并对二恶英和二苯并呋喃（PCCD/Fs）和12种二恶英样多氯联苯（dl-PCBs）。PCDD/Fs和dl-PCBs的中位浓度（湿重）分别为0.017 pg毒性当量(TEQ)/g和0.0017 pg TEQ/g。多氯联苯和八氯二苯并-对二恶英（OCDD）的一些同系物之间存在高度显著的相关性，表明它们的来源和动力学行为相似。新生儿体重和胎龄是影响胎便中多氯联苯水平的人口学参数。多元回归分析表明，食用超加工食品对胎便中几种多氯联苯的含量有影响。本研究的结论是，胎粪可作为评估产前持久性有机污染物暴露的人体基质，并首次提供了有关生物胎粪样本中二恶英和呋喃暴露预测和生物监测的信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Food and Chemical Toxicology 工程技术-毒理学

CiteScore

10.90

自引率

4.70%

发文量

651

审稿时长

31 days

期刊介绍： Food and Chemical Toxicology (FCT), an internationally renowned journal, that publishes original research articles and reviews on toxic effects, in animals and humans, of natural or synthetic chemicals occurring in the human environment with particular emphasis on food, drugs, and chemicals, including agricultural and industrial safety, and consumer product safety. Areas such as safety evaluation of novel foods and ingredients, biotechnologically-derived products, and nanomaterials are included in the scope of the journal. FCT also encourages submission of papers on inter-relationships between nutrition and toxicology and on in vitro techniques, particularly those fostering the 3 Rs. The principal aim of the journal is to publish high impact, scholarly work and to serve as a multidisciplinary forum for research in toxicology. Papers submitted will be judged on the basis of scientific originality and contribution to the field, quality and subject matter. Studies should address at least one of the following: -Adverse physiological/biochemical, or pathological changes induced by specific defined substances -New techniques for assessing potential toxicity, including molecular biology -Mechanisms underlying toxic phenomena -Toxicological examinations of specific chemicals or consumer products, both those showing adverse effects and those demonstrating safety, that meet current standards of scientific acceptability. Authors must clearly and briefly identify what novel toxic effect (s) or toxic mechanism (s) of the chemical are being reported and what their significance is in the abstract. Furthermore, sufficient doses should be included in order to provide information on NOAEL/LOAEL values.