Food and Chemical Toxicology最新文献_第10页

Atractylenolide III ameliorates DSS-induced colitis by improving intestinal epithelial barrier via suppressing the NF-κB-Mediated MLCK-pMLC signaling pathway 苍术内酯III通过抑制NF-κ b介导的MLCK-pMLC信号通路改善肠上皮屏障，改善dss诱导的结肠炎。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-02-01 DOI: 10.1016/j.fct.2024.115158

Ting-ting Dai , Wei Fang , Wen-tao Zhu , Zhi-li Han , Nian-xia Sun , Gang Yin , Dian-lei Wang

{"title":"Atractylenolide III ameliorates DSS-induced colitis by improving intestinal epithelial barrier via suppressing the NF-κB-Mediated MLCK-pMLC signaling pathway","authors":"Ting-ting Dai , Wei Fang , Wen-tao Zhu , Zhi-li Han , Nian-xia Sun , Gang Yin , Dian-lei Wang","doi":"10.1016/j.fct.2024.115158","DOIUrl":"10.1016/j.fct.2024.115158","url":null,"abstract":"<div><div>This study is to demonstrate the protection of atractylenolide III (AT III) on intestinal barrier dysfunction in ulcerative colitis (UC). UC model was established by 3% dextran sulfate sodium (DSS), and TNF-α was used to induce dysfunction in the intestinal epithelial barrier. TEER, FD-4 transmembrane flux and DAI were measured. Histopathological changes was identified by H&E staining, TJ structure changes were observed by TEM, IL-1β and TNF-α contents were measured by ELISA, bacterial translocation was investigated by FISH. The expressions of ZO-1, occludin, and the proteins in the MLCK/p-MLC and NF-κB pathways were analyzed by Western blotting or immunofluorescence. The results indicated that AT III alleviate the symptoms of DSS-induced colitis, reduce the disruption of intestinal epithelial barrier, and decrease FD4. Moreover, AT III inhibited the destruction of intestinal epithelial TJ structure and bacterial translocation in UC mice. AT III reversed the high levels of IL-1β and TNF-α, the decrease of occludin, ZO-1 expressions. Furthermore, AT III showed similar effects to PDTC (pyrrolidinedithiocarbamate) in ameliorating the disruption of the TNF-α-induced TEER and FD-4 disruption, MLCK protein expression, and MLC2 phosphorylation. In conclusion, AT III mitigates the dysfunction of intestinal epithelial barrier in UC through the NF-κB-mediated MLCK/p-MLC signaling pathway.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"196 ","pages":"Article 115158"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142754409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular insights of T-2 toxin exposure-induced neurotoxicity and the neuroprotective effect of dimethyl fumarate T-2毒素暴露诱导的神经毒性和富马酸二甲酯的神经保护作用的分子机制。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-02-01 DOI: 10.1016/j.fct.2024.115166

Xingyao Pei , Shuhui Ma , Liang Hong , Zonghui Zuo , Gang Xu , Chun Chen , Yao Shen , Dingkuo Liu , Cun Li , Daowen Li

{"title":"Molecular insights of T-2 toxin exposure-induced neurotoxicity and the neuroprotective effect of dimethyl fumarate","authors":"Xingyao Pei , Shuhui Ma , Liang Hong , Zonghui Zuo , Gang Xu , Chun Chen , Yao Shen , Dingkuo Liu , Cun Li , Daowen Li","doi":"10.1016/j.fct.2024.115166","DOIUrl":"10.1016/j.fct.2024.115166","url":null,"abstract":"<div><div>T-2 toxin, a potent environmental pollutant, has been proved to stimulate neuroinflammation, while the connection between T-2 toxin and pyroptosis remain elusive. Dimethyl fumarate (DMF), recently identified as a neuroprotectant and pyroptosis inhibitor, has potential therapeutic applications that are underexplored. Based on present study in vitro and vivo, we demonstrated that T-2 toxin induced the activation of NLRP3-Caspase-1 inflammasome in hippocampal neurons. In addition to proinflammatory mediator overexpression, gasdermin D (GSDMD)-dependently pyroptosis in the mouse hippocampal neuron cell line (HT22) treated by T-2 toxin was determined in our study. Moreover, the palliative effect of knockdown sequence of high mobility group B1 protein (HMGB1) provided more details for T-2 toxin-initiated pyroptosis. Importantly, we confirmed that DMF, as a novel inhibitor of GSDMD, could alleviate pyroptosis induced by T-2 toxin in an GSDMD targeting manner. In summary, our studies exposed the evidence that T-2 toxin could induce NLRP3 inflammasome activation and hippocampal neuronal pyroptosis. More notably, DMF was turn out to be a critical executioner for attenuating GSDMD-mediated pyroptosis. Our data found a new function of DMF and suggested a novel therapy strategy against mycotoxin-triggered neuronal inflammation, which leads to varieties of neurological diseases.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"196 ","pages":"Article 115166"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142764899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heavy metal contamination in cow and buffalo milk from industrial and residential areas of raipur, India: A health risk assessment 印度赖布尔工业区和居民区牛奶和水牛奶中的重金属污染：健康风险评估。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-02-01 DOI: 10.1016/j.fct.2024.115178

Anuradha Sharma , Shashi Gupta , Kamlesh Shrivas , Suryakant Chakradhari , Shamsh Pervez , Manas Kanti Deb

{"title":"Heavy metal contamination in cow and buffalo milk from industrial and residential areas of raipur, India: A health risk assessment","authors":"Anuradha Sharma , Shashi Gupta , Kamlesh Shrivas , Suryakant Chakradhari , Shamsh Pervez , Manas Kanti Deb","doi":"10.1016/j.fct.2024.115178","DOIUrl":"10.1016/j.fct.2024.115178","url":null,"abstract":"<div><div>This study investigated heavy metal contamination in cow and buffalo milk from industrial and residential areas of Raipur, India, assessing health risks and identifying contamination sources. Milk samples were collected from seven sites and analyzed for Zn, Ni, Fe, Mn, Cu, Cr, Cd, Pb, and As using inductively coupled plasma-optical emission spectroscopy (ICP-OES) and atomic absorption spectroscopy (AAS). Results revealed higher contamination in industrial areas, with fodder being a primary source for Zn, Ni, Fe, and Cu, while water contributed to Mn, Cr, and As. Estimated daily intake (EDI), target hazard quotient (THQ), and carcinogenic risk (CR) determination highlighted non-carcinogenic risks for Ni, Fe, and Pb, and significant carcinogenic risks for Pb and As. The concentrations of Zn, Ni, Fe, Mn, Cu, Cr, Cd, Pb, and As in milk samples were ranged from 1.708 to 3.243, 0.078–0.295, 1.480–4.450, 0.119–0.472, 0.032–0.461, 0.007–0.040, 0.006–0.032, 0.040–0.204, and 0.006–0.023 mg/kg, respectively. The principal component analysis (PCA) identified fodder as a source of Zn, Ni, Fe, Cu, and Cd, while water contributed to Mn, Cr, and As. This study needed monitoring and regulation to mitigate health risks from contaminated milk in Raipur.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"196 ","pages":"Article 115178"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142790706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Renoprotective effect of berberine in cisplatin-induced acute kidney injury: Role of Klotho and the AMPK/mtor/ULK1/Beclin-1 pathway 小檗碱在顺铂诱导的急性肾损伤中的肾保护作用：Klotho和AMPK/mTOR/ULK1/Beclin-1通路的作用

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-02-01 DOI: 10.1016/j.fct.2024.115179

Tasneem M. Salah, Mostafa A. Rabie, Nesrine S. El Sayed

{"title":"Renoprotective effect of berberine in cisplatin-induced acute kidney injury: Role of Klotho and the AMPK/mtor/ULK1/Beclin-1 pathway","authors":"Tasneem M. Salah, Mostafa A. Rabie, Nesrine S. El Sayed","doi":"10.1016/j.fct.2024.115179","DOIUrl":"10.1016/j.fct.2024.115179","url":null,"abstract":"<div><div>Cisplatin (Cisp) is a potent cancer drug, but its use is limited by acute kidney injury (AKI). Autophagy, a process that removes damaged proteins and maintains cellular homeostasis, has been shown to alleviate Cisp-induced AKI. The balance between autophagy and apoptosis is crucial to kidney protection. Treatment with Berberine, known for its antioxidant and anti-inflammatory effects in nephrotoxicity models, was studied for its potential to enhance autophagy in Cisp-induced AKI.</div><div>Treatment with Berberine (Berb) upregulated Klotho gene expression, enhancing autophagy as indicated by elevated protein levels of pS486-AMPK, pS638-ULK1, and Beclin-1, accompanied by a decrease in pS248-mTOR protein expression. Also, Berb mitigated oxidative stress by reducing elevated MDA levels and boosting SOD activity, which in turn suppressed inflammation by down-regulating HMGB1 and RAGE gene expression, as well as reducing pS536-NF-κB and IL-6 protein contents. Additionally, Berb reduced apoptosis by increasing Bcl-2 and decreasing Bax. This coordinated action preserved kidney function, evidenced by reductions in early injury markers (cystatin C, KIM-1, NGAL) and late markers (creatinine, BUN), along with attenuation of histopathological alterations. The use 3-MA, autophagy inhibitor, nullified these protective effects, highlighting Berb's role in promoting autophagy, reducing oxidative stress, inflammation, and apoptosis, and preserving renal health in Cisp-induced AKI.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"196 ","pages":"Article 115179"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142790707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

18β-glycyrrhetinic acid Mitigates bisphenol A-induced liver and renal damage: Inhibition of TNF-α/NF-κB/p38-MAPK, JAK1/STAT1 pathways, oxidative stress and apoptosis 18β-甘草次酸减轻双酚a诱导的肝脏和肾脏损害：抑制TNF-α/NF-κB/p38-MAPK， JAK1/STAT1通路，氧化应激和细胞凋亡。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-02-01 DOI: 10.1016/j.fct.2024.115218

Ekrem Darendelioglu , Cuneyt Caglayan , Sefa Küçükler , İbrahim Bayav , Fatih Mehmet Kandemir , Adnan Ayna , Sevda Sağ

{"title":"18β-glycyrrhetinic acid Mitigates bisphenol A-induced liver and renal damage: Inhibition of TNF-α/NF-κB/p38-MAPK, JAK1/STAT1 pathways, oxidative stress and apoptosis","authors":"Ekrem Darendelioglu , Cuneyt Caglayan , Sefa Küçükler , İbrahim Bayav , Fatih Mehmet Kandemir , Adnan Ayna , Sevda Sağ","doi":"10.1016/j.fct.2024.115218","DOIUrl":"10.1016/j.fct.2024.115218","url":null,"abstract":"<div><div>Bisphenol A (BPA) has been commonly used in various consumer products, including water bottles, food containers, and canned food linings. However, there are concerns about its potential toxicity to human health, particularly its impact on the liver and kidneys. The objective of this research was to investigate the potential ameliorative effects of 18β-glycyrrhetinic acid (GA) against BPA-induced hepatotoxicity and nephrotoxicity in rats. The animals were supplemented with BPA (250 mg/kg b.w.) alone or with GA (50 and 100 mg/kg b.w.) for 14 days. GA treatment alleviated the BPA-induced hepato-renal tissue injuries through reducing the serum ALT, AST and ALP levels, and urea and creatinine levels. GA co-treatment also increased activities of SOD, CAT and GPx enzymes and levels of GSH, and suppressed MDA levels in BPA induced tissues. BPA also induced inflammation by increasing the levels of TNF-α, NF-κB, JAK1, STAT1, P38 MAPK and JNK in liver and kidney tissues and GA treatment ameliorated these effects. BPA triggered apoptosis by increasing caspase-3, Bax, and cytochrome <em>c</em> at protein levels and also by decreasing the antiapoptotic Bcl-2 level. However, treatment with GA (50 and 100 mg/kg) decreased apoptosis. Overall, our results have revealed the potential ameliorative mechanisms of GA, as a possible agent for BPA-induced hepatotoxicity and nephrotoxicity.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"196 ","pages":"Article 115218"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142890905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemopreventive effect of Pistacia vera leaf extract against mammary carcinoma induced by dimethyl-benz(a)anthracene in vivo and in vitro: Potential role of antioxidant, antiinflammatory and immune mechanisms 黄连木叶提取物对二甲苯(a)蒽致乳腺癌的体内外化学预防作用：抗氧化、抗炎和免疫机制的潜在作用

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-02-01 DOI: 10.1016/j.fct.2024.115229

Ali G. Alkhathami , Esmail M. El-Fakharany , Mohamed H. El-Sayed , Ahmed Atwa , Fatma Khairallah Ali , Nashwa Hamad , Hussam Askar , Mahmoud Ashry

{"title":"Chemopreventive effect of Pistacia vera leaf extract against mammary carcinoma induced by dimethyl-benz(a)anthracene in vivo and in vitro: Potential role of antioxidant, antiinflammatory and immune mechanisms","authors":"Ali G. Alkhathami , Esmail M. El-Fakharany , Mohamed H. El-Sayed , Ahmed Atwa , Fatma Khairallah Ali , Nashwa Hamad , Hussam Askar , Mahmoud Ashry","doi":"10.1016/j.fct.2024.115229","DOIUrl":"10.1016/j.fct.2024.115229","url":null,"abstract":"<div><div>This study aimed to define the antitumor effect of ethanolic extract of <em>Pistacia vera</em> leaves (PEE) toward breast cancer both in vitro and in vivo using dimethyl-benz(<em>a</em>)anthracene (DMBA)-induced breast tumor in adult female rats. PEE showed a potent antioxidant effect toward both DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS (2,2′-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) radicals with IC<sub>50</sub> values of 72.6 and 107.4 μg/mL, respectively. PEE exerted its cytotoxicity in dose-dependent manners with favorable selectivity toward MCF-7 and MDA cancer cells, sparing normal WI-38 cells. Through considerable decreases in blood CA15.3, CEA, CA19.9, TNF-α, IL1β, IL-4, IL-6, and IL-10 levels, as well as mammary MDA and NO levels, PEE administration effectively improved the damage caused by breast cancer. Additionally, PEE exhibited remarkable increasing in mammary GSH content, GPx, SOD and CAT activities. The histopathological findings demonstrated the therapeutic potential of PEE that successfully improved the mammary gland alterations induced by DMBA and aborted cancer development. PEE has shown intriguing potential as an anti-inflammatory and antioxidant drug by targeting the expression of pro-inflammatory cytokines and oxidative stress indicators, which has helped to successfully treat malignancies in clinical settings. Collectively, our findings support chemo-preventive potential of PEE against DMBA-induced breast tumor in rats via enhancing apoptosis and immune response.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"196 ","pages":"Article 115229"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142926030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of 9,10-anthraquinone contamination in tea products from Indonesian manufacturers and its carcinogenic risk to consumer health 印尼茶叶产品中9,10-蒽醌污染评价及其对消费者健康的致癌风险。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-02-01 DOI: 10.1016/j.fct.2025.115239

Harmoko Harmoko , Rahmana Emran Kartasasmita , Hasim Munawar , Dadan Rohdiana , Fransiska Kurniawan , Daryono Hadi Tjahjono , Amadeo R. Fernández-Alba

{"title":"Evaluation of 9,10-anthraquinone contamination in tea products from Indonesian manufacturers and its carcinogenic risk to consumer health","authors":"Harmoko Harmoko , Rahmana Emran Kartasasmita , Hasim Munawar , Dadan Rohdiana , Fransiska Kurniawan , Daryono Hadi Tjahjono , Amadeo R. Fernández-Alba","doi":"10.1016/j.fct.2025.115239","DOIUrl":"10.1016/j.fct.2025.115239","url":null,"abstract":"<div><div>This study aimed to determine 9,10-anthraquinone (AQ) levels in Indonesian tea products from different manufacturers and assess the AQ's associated health risks. AQ levels increased significantly during withering and drying stages, using pinewood as a heat source. Generally, black tea was highly contaminated by AQ followed by green tea, oolong tea, and white tea. Out of a total of 116 samples from manufacturers using wood pellets as a heat source, 13% (15/116) of samples were contaminated with AQ exceeding the EU maximum residue level (MRL), and after accounting for measurement uncertainty, this value decreased to only 2% (2/116) that were deemed non-compliant. In contrast, 88% (57/65) and 50% (7/14) of tea samples were contaminated with AQ exceeding the EU MRL when manufacturers used pinewood and palm kernel shells as heat sources, respectively. However, based on our estimation, the risk level due to AQ exposure from Indonesian tea is still manageable, as indicated by calculating incremental lifetime cancer risk, <10⁻⁶ across all conditions studied (age group, type of tea, and heat source).</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"196 ","pages":"Article 115239"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polysorbate 80 and carboxymethylcellulose: A different impact on epithelial integrity when interacting with the microbiome 聚山梨酯80和羧甲基纤维素：与微生物群相互作用时对上皮完整性的不同影响。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-02-01 DOI: 10.1016/j.fct.2025.115236

Alicia Bellanco, Teresa Requena, M. Carmen Martínez-Cuesta

{"title":"Polysorbate 80 and carboxymethylcellulose: A different impact on epithelial integrity when interacting with the microbiome","authors":"Alicia Bellanco, Teresa Requena, M. Carmen Martínez-Cuesta","doi":"10.1016/j.fct.2025.115236","DOIUrl":"10.1016/j.fct.2025.115236","url":null,"abstract":"<div><div>The consumption of dietary emulsifiers, including polysorbate 80 (P80) and sodium carboxymethylcellulose (CMC), has raised safety concerns due to its interaction with the intestinal microbiome. This study demonstrated that increasing concentrations of P80 and CMC added to a dynamic four-stage gut microbiota model (BFBL gut simulator) altered the microbiome composition and impacted epithelial integrity in a dose-dependent manner. 16S rDNA amplicon-based metagenomics analysis revealed that these emulsifiers increased microbial groups with proinflammatory capacities while decreasing microbial taxa known to enhance barrier function. Increasing doses of P80 significantly decreased <em>Bacteroides dorei</em> and <em>Akkermansia</em>, taxa associated with anti-inflammatory potential, while increasing doses of CMC were linked to a higher abundance of <em>Ruminococcus torques</em> and <em>Hungatella</em>, which negatively impact barrier function. Both emulsifiers displayed a different impact on epithelial integrity when interacting with the microbiome. On one hand, supernatants from the BFBL simulator fed with P80 disrupted epithelial integrity to a lesser extent than the additive alone. On the other hand, both the microbiota and the supernatants from the BFBL simulator fed with CMC diminished the epithelial integrity, though the additive itself did not. These findings highlight the need to incorporate the gut microbiome in the risk assessment of these additives.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"196 ","pages":"Article 115236"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coconut oil reduces steroidogenic enzymes and imbalances estrogen receptors in the adrenal cortex of Mongolian gerbils 椰子油减少类固醇酶和失衡雌激素受体在蒙古沙鼠肾上腺皮质。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-02-01 DOI: 10.1016/j.fct.2025.115248

Vitor Grigio , Luiz Henrique Alves Guerra , Thalles Fernando Rocha Ruiz , Sebastião Roberto Taboga , Patrícia Simone Leite Vilamaior

{"title":"Coconut oil reduces steroidogenic enzymes and imbalances estrogen receptors in the adrenal cortex of Mongolian gerbils","authors":"Vitor Grigio , Luiz Henrique Alves Guerra , Thalles Fernando Rocha Ruiz , Sebastião Roberto Taboga , Patrícia Simone Leite Vilamaior","doi":"10.1016/j.fct.2025.115248","DOIUrl":"10.1016/j.fct.2025.115248","url":null,"abstract":"<div><div>This study aims to verify the effects of prolonged ingestion of coconut oil on the adrenal glands of Mongolian gerbils. Mongolian gerbils were used as an experimental model due to the morphological similarity of the adrenal glands to those of primates. Male Mongolian gerbils, 3 months of age, were divided into three experimental groups (n = 12): an intact control group, which received no treatment, a gavage control group, which received 0.1 ml of water daily by gavage, and a coconut oil-treated group, which received 0.1 ml of coconut oil daily for 12 months. The results showed that prolonged consumption of coconut oil caused an increase in cell area and thickness of the zona reticularis and the accumulation of lipid droplets, as well as reducing the amount of steroidogenic enzymes, such as CYP17, 3BHSD, and 17BHSD. It was also observed that the oil increased the expression of estrogen receptor alpha and their isoforms. These alterations allow us to conclude that changes in the lipid diet can cause alterations in the morphophysiology of the adrenal gland and, consequently, impact its functionality.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"196 ","pages":"Article 115248"},"PeriodicalIF":3.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RIFM fragrance ingredient safety assessment, 9-undecenal, CAS Registry Number 143-14-6

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-02-01 DOI: 10.1016/j.fct.2025.115286

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0