Food and Chemical Toxicology最新文献_第10页

Therapeutic potential of rosmarinic acid in tramadol-induced hepatorenal toxicity: Modulation of oxidative stress, inflammation, RAGE/NLRP3, ER stress, apoptosis, and tissue functions parameters

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-01-21 DOI: 10.1016/j.fct.2025.115275

Onur Karaca , Nurhan Akaras , Hasan Şimşek , Cihan Gür , Mustafa İleritürk , Sefa Küçükler , Selman Gencer , Fatih Mehmet Kandemir

{"title":"Therapeutic potential of rosmarinic acid in tramadol-induced hepatorenal toxicity: Modulation of oxidative stress, inflammation, RAGE/NLRP3, ER stress, apoptosis, and tissue functions parameters","authors":"Onur Karaca , Nurhan Akaras , Hasan Şimşek , Cihan Gür , Mustafa İleritürk , Sefa Küçükler , Selman Gencer , Fatih Mehmet Kandemir","doi":"10.1016/j.fct.2025.115275","DOIUrl":"10.1016/j.fct.2025.115275","url":null,"abstract":"<div><h3>Aim</h3><div>Tramadol (TRM), a widely used opioid analgesic for moderate to severe pain, is associated with liver and kidney toxicity at high doses or prolonged use. This study investigates the protective role of rosmarinic acid (RA), a natural phenolic compound known for its antioxidant, anti-inflammatory, and cell-protective properties, against TRM-induced hepatorenal toxicity.</div></div><div><h3>Methods</h3><div>Thirty-five male Wistar rats were divided into five groups: Control, TRM, RA, TRM + RA25, and TRM + RA50. Rats received TRM (50 mg/kg) and RA (25 or 50 mg/kg), with liver and kidney function tests, oxidative stress, inflammation, ER stress, apoptosis, and tissue damage indicators assessed through qRT-PCR, ELISA, Western blotting, H&E, and immunohistochemical analysis.</div></div><div><h3>Results</h3><div>TRM induced liver and kidney dysfunctions, evident from increased ALT, AST, ALP, urea, creatinine, nephrin, TIM-1 and 8-OHdG levels, along with activated oxidative stress, inflammation, ER stress, and apoptosis pathways. RA significantly reduced these effects, ameliorating histologic and immunohistochemical markers of tissue damage and inflammation.</div></div><div><h3>Conclusion</h3><div>RA demonstrates therapeutic potential by mitigating TRM-induced hepatorenal toxicity and preserving tissue integrity.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"197 ","pages":"Article 115275"},"PeriodicalIF":3.9,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143027478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of GSK3β signaling mediated lysosomal biosynthesis dysregulation in fluoride-induced neurological impairment

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-01-20 DOI: 10.1016/j.fct.2025.115267

Yi Cheng , Yuhui Du , Yue Hu , Xinying Wang , Qingyuan Li , Xi Yan , Ming Dou , Weihua Jia , Fangfang Yu , Yue Ba , Guoyu Zhou

{"title":"The role of GSK3β signaling mediated lysosomal biosynthesis dysregulation in fluoride-induced neurological impairment","authors":"Yi Cheng , Yuhui Du , Yue Hu , Xinying Wang , Qingyuan Li , Xi Yan , Ming Dou , Weihua Jia , Fangfang Yu , Yue Ba , Guoyu Zhou","doi":"10.1016/j.fct.2025.115267","DOIUrl":"10.1016/j.fct.2025.115267","url":null,"abstract":"<div><div>Neurological dysfunction induced by fluoride is still one of major concern worldwide, yet the underlying mechanisms remain elusive. To explore whether fluoride disrupts lysosomal biosynthesis via the GSK3β signaling, leading to neurological damage, both <em>in vivo</em> rat models and <em>in vitro</em> PC12 cell models were conducted. Subsequent findings revealed reduced spatial learning and memory abilities, decreased hippocampal neurons, and disrupted neuronal arrangement in NaF-treated rats. <em>In vitro</em>, PC12 cells exhibited decreased cell viability and increased apoptosis rates after NaF treatment for 24 h. Moreover, immunofluorescence assays demonstrated that there is a reduction in the number of mature lysosomes and an increase in immature lysosomes in NaF-treated PC12 cells, evident by decreased co-localization of LAMP1 with Arl8b, and increased co-localization of LAMP1 with Rab7. Furthermore, both <em>in vivo</em> and <em>in vitro</em>, the protein expression of cleaved caspase-3 was upregulated, whereas the protein expressions of TFEB and CTSB were downregulated. The GSK3β signaling activation was detected, and this was confirmed by silencing GSK3β with siRNA <em>in vitro</em>. Collectively, these results indicate that NaF can impair lysosomal biosynthesis via GSK3β signaling, promoting neuronal apoptosis, and consequently impairing neurological function in rats.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"197 ","pages":"Article 115267"},"PeriodicalIF":3.9,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143021531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aprepitant ameliorates vancomycin-induced kidney injury: Role of GPX4/system Xc− and oxidative damage 阿瑞吡坦改善万古霉素诱导的肾损伤：GPX4/系统Xc-和氧化损伤的作用

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-01-19 DOI: 10.1016/j.fct.2025.115264

Maha H. Sharawy , Ahmed M. Abdel-Rahman , Noha Abdel-Rahman

{"title":"Aprepitant ameliorates vancomycin-induced kidney injury: Role of GPX4/system Xc− and oxidative damage","authors":"Maha H. Sharawy , Ahmed M. Abdel-Rahman , Noha Abdel-Rahman","doi":"10.1016/j.fct.2025.115264","DOIUrl":"10.1016/j.fct.2025.115264","url":null,"abstract":"<div><div>Vancomycin, a glycopeptide antibiotic, is used in cases of drug-resistant bacterial infections, but unfortunately is associated with acute kidney injury (AKI). We here explore the protective potential of aprepitant against vancomycin-induced AKI. Vancomycin (500 mg/kg/i.p) was given to rats for seven days and aprepitant (20 mg/kg/p.o) was administered one day before and for seven days concomitant with vancomycin. At the end of the experiment, kidney function, oxidative stress, autophagy and ferroptosis markers were assessed. We show that aprepitant reduced kidney/body weight ratio, serum creatinine and blood urea nitrogen levels. It improved renal structure and enhanced the antioxidant machinery as indicated by elevated catalase activity and GSH levels and reduced renal MDA. Aprepitant managed to inhibit ferroptosis by decreasing system Xc<sup>−</sup> and GPX4 renal levels. As a result, levels of autophagic markers ATG3, LC3A and LC3B were attenuated. These results were confirmed by electron microscopy examination of cellular structures. In addition, aprepitant increased p62 protein expression. Moreover, aprepitant decreased the apoptotic marker cleaved caspase-3 levels. Our results suggest a new repurposed role for aprepitant in protecting against AKI. This protective effect relies on its antioxidant effect and the influence of inhibiting ferroptosis which resulted in downregulation of autophagy and apoptosis.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"197 ","pages":"Article 115264"},"PeriodicalIF":3.9,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142997324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Maternal ochratoxin A exposure impairs meiosis progression and primordial follicle formation of F1 offspring” [Food and Chemical Toxicology 168 (2022) 113386] “母体赭曲霉毒素A暴露损害F1后代减数分裂进程和原始卵泡形成”的更正[食品与化学毒理学168(2022)113386]。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-01-19 DOI: 10.1016/j.fct.2025.115257

Yue Song , Jinxin Zhao , Tian Qiao , Lan Li , Dachuan Shi , Yonghong Sun , Wei Shen , Xiaofeng Sun

引用次数: 0

Dexlansoprazole is an aryl hydrocarbon receptor agonist 右兰索拉唑是芳烃受体和ITE的干扰物。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-01-19 DOI: 10.1016/j.fct.2025.115262

Kuo-Liang Wei , Shan-Chun Chen , Chih-Yi Lin , Yu-Ting Chou , Wei-Tin Kuo , Teik-Wei Chuah , Jyan-Gwo Joseph Su

{"title":"Dexlansoprazole is an aryl hydrocarbon receptor agonist","authors":"Kuo-Liang Wei , Shan-Chun Chen , Chih-Yi Lin , Yu-Ting Chou , Wei-Tin Kuo , Teik-Wei Chuah , Jyan-Gwo Joseph Su","doi":"10.1016/j.fct.2025.115262","DOIUrl":"10.1016/j.fct.2025.115262","url":null,"abstract":"<div><div>Dexlansoprazole, a proton pump inhibitor, is commonly used to treat gastro-esophageal reflux disease and erosive esophagitis. The activated aryl hydrocarbon receptor (AhR) functions as a transcription factor by binding to the aryl hydrocarbon response element (AHRE) of its target genes, with cytochrome P450 (CYP) 1A1 being the most well-known target. In this study, we demonstrated that dexlansoprazole stimulates AhR activity, leading to increased CYP1A1 expression. Our findings indicate that treatment with 2 μM dexlansoprazole is sufficient to induce CYP1A1 mRNA and protein expression, as well as AHRE-mediated transcriptional activity, in both human and mouse cells. Using AhR signal-deficient mutant cells and specific AhR antagonists—SR1, GNF351, and CH-223191—we confirmed that AhR is required for dexlansoprazole-induced CYP1A1 expression. Additionally, we showed that dexlansoprazole promotes AhR nuclear translocation, acting as an AhR agonist. However, due to its lower potency compared to FICZ and ITE in activating AhR, dexlansoprazole suppresses FICZ- and ITE-induced CYP1A1 expression in human liver HepG2 and ovarian granulosa HO23 cell lines, suggesting that it functions as both an AhR agonist and a modulator. This study offers valuable insights into the potential clinical side effects of dexlansoprazole.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"197 ","pages":"Article 115262"},"PeriodicalIF":3.9,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142997333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ferulic acid protects rat offspring from maternal high-fat, high-fructose diet-induced toxicity and developmental retardation through a direct effect on pancreatic islets 阿魏酸通过对胰岛的直接作用，保护大鼠后代免受母体高脂肪、高果糖饮食引起的毒性和发育迟缓。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-01-18 DOI: 10.1016/j.fct.2025.115265

Hekmat L. El-Gammal, Fatma Omar, Ayman Hyder

{"title":"Ferulic acid protects rat offspring from maternal high-fat, high-fructose diet-induced toxicity and developmental retardation through a direct effect on pancreatic islets","authors":"Hekmat L. El-Gammal, Fatma Omar, Ayman Hyder","doi":"10.1016/j.fct.2025.115265","DOIUrl":"10.1016/j.fct.2025.115265","url":null,"abstract":"<div><div>Maternal obesity predisposes offspring to type 2 diabetes (T2D) through a direct chronic effect of lipids on pancreatic β-cell neogenesis. β-cells produce FABP3 to bind and metabolize fatty acids. Ferulic acid (FA) is a natural product that may inhibit fatty acids' binding to FABP3, preventing their toxicity. It is aimed to evaluate the consequences of maternal feeding on high-fat, high fructose diet (HFFD) and the role of FA on the offspring. Four-week-old female rats were fed HFFD for 9 weeks prior to and throughout gestation and lactation to develop T2D. A group of them received 50 mg/kg FA daily. Offspring were sampled on gestational day 18 (GD18), and postnatal days (PND) 3 and 30. HFFD increased offspring's blood glucose, insulin, Homa-IR, HbA1c, triglycerides, cholesterol, intrahepatic and intra-insular lipid droplets. The mechanism of islet inflammation and apoptosis, detected by Il-1b and cleaved caspase3, involved the nuclear translocation of NFκB p65. Maternal HFFD caused developmental retardations in offspring's ovaries, testes, kidney and liver. Coupling FA treatment with the maternal HFFD maintained normoglycemia, lipidemia, and healthy islets, and prevented developmental retardations. FA administration to T2D mothers revealed positive effects on the offspring that is related to its direct protective effect on pancreatic β-cells.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"197 ","pages":"Article 115265"},"PeriodicalIF":3.9,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142997336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Update to RIFM fragrance ingredient safety assessment, 4,8-dimethyl-7-nonen-2-ol, CAS Registry Number 40596-76-7 更新RIFM香料成分安全性评估，4,8-二甲基-7-壬烯-2-醇，CAS登记号40596-76-7。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-01-18 DOI: 10.1016/j.fct.2025.115259

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , M. Lavelle , I. Lee , H. Moustakas , Y. Tokura

引用次数: 0

Safety and antioxidant assessments of BLR-E50, 50% ethanolic extract from red beans co-fermented by Bacillus subtilis and Lactobacillus bulgaricus 枯草芽孢杆菌与保加利亚乳杆菌共发酵红豆50%乙醇提取物BLR-E50的安全性及抗氧化性评价

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-01-17 DOI: 10.1016/j.fct.2025.115261

Su-Tze Chou , Yi-Hua Chen , Yi-Hung Chen , Yu‐Chen Tsai , Yun-Chin Chung , Ju-Pi Li

{"title":"Safety and antioxidant assessments of BLR-E50, 50% ethanolic extract from red beans co-fermented by Bacillus subtilis and Lactobacillus bulgaricus","authors":"Su-Tze Chou , Yi-Hua Chen , Yi-Hung Chen , Yu‐Chen Tsai , Yun-Chin Chung , Ju-Pi Li","doi":"10.1016/j.fct.2025.115261","DOIUrl":"10.1016/j.fct.2025.115261","url":null,"abstract":"<div><div>Since red beans have poor textural properties, fermentation is commonly used to help produce better pulse products. To obtain BLR-E50, red beans are fermented using a co-culture of <em>Bacillus subtilis</em> and <em>Lactobacillus bulgaricus</em>, followed by extraction with 50% ethanol. The present data demonstrate that BLR-E50 did not exhibit mutagenicity, genotoxicity, or subacute oral toxicity. BLR-E50 showed antioxidant abilities <em>in vitro</em>. Under H<sub>2</sub>O<sub>2</sub>-challenged conditions, the dietary addition of BLR-E50 extended the survival time of female <em>Drosophila melanogaster (D. melanogaster)</em>. Meanwhile, BLR-E50 modulated the antioxidant system in H<sub>2</sub>O<sub>2</sub>-treated <em>D. melanogaster</em>. Oral administration of BLR-E50 also improved motor abilities and reduced tyrosine hydroxylase levels in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurodegeneration mouse model. Overall, this study presents that BLR-E50 is safe and possesses antioxidant, anti-aging, and neuroprotective capabilities, providing scientific evidence for the potential application of fermented red bean products as antioxidants in future dietary interventions.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"197 ","pages":"Article 115261"},"PeriodicalIF":3.9,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142997398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gold nanoparticles and induction of structural alteration and enhanced oxidative stress in rat lens 金纳米颗粒与诱导大鼠晶状体结构改变和氧化应激增强。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-01-17 DOI: 10.1016/j.fct.2025.115263

Samaa Samir Kamar , Lobna A. Elkhateb , Asmaa Mohammed ShamsEldeen , Randa Mohamed Abdel-Moneim El-Mofty , Mohamed Mahmoud Elsebaie , Nermin Nabil Fayed , Hala Hassan Mohamed

{"title":"Gold nanoparticles and induction of structural alteration and enhanced oxidative stress in rat lens","authors":"Samaa Samir Kamar , Lobna A. Elkhateb , Asmaa Mohammed ShamsEldeen , Randa Mohamed Abdel-Moneim El-Mofty , Mohamed Mahmoud Elsebaie , Nermin Nabil Fayed , Hala Hassan Mohamed","doi":"10.1016/j.fct.2025.115263","DOIUrl":"10.1016/j.fct.2025.115263","url":null,"abstract":"<div><div>There is an emerging wide use of nanotechnology in the medical fields. The information regarding distribution and clearance of gold nanoparticles (AuNPs) in the ocular tissue is insufficient. We investigated the cumulative effect of AuNPs on rat lens structure and their effect on the redox state and aquaporin-0 (AQP0) expression. Thirty-six male rats were distributed as follow: control, AuNPs-200 (200 μg/kg/rat for 4-weeks) and AuNPs-500 (500 μg/kg/rat for 4-weeks) groups. Rats were euthanized after 4-weeks, and the eye lenses were investigated for histological studies, transmission and scanning electron microscopic studies, immunohistochemistry for AQP0 and morphometric measures. Lens homogenates were investigated for tumour necrosis factor-alpha (TNF-α) and total reactive oxygen species levels by ELISA and for p-c-SRC by western-blot. AuNPs administration induced morphological and ultrastructural changes in rat lens. Degenerative changes in the lens epithelium, cytoplasmic vacuoles, distorted separated cortical lens fibers and loss of ball-and-socket junctions were observed. A significant reduction of AQP0-immune-staining with a significant elevation of TNF-α, total ROS and p-c-SRC content in rat lens homogenates were detected as compared to the control group. Repetitive spherical 20 nm-sized AuNPs administration, especially at 500 μg/kg/rat, induced structural changes in lens fibers of rats and increased oxidative stress level in the lens tissue.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"197 ","pages":"Article 115263"},"PeriodicalIF":3.9,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142997317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is the potential for bioaccumulation of cannabinoids underestimated? Insights from biomimetic chromatography in cannabinoid exposure evaluation 大麻素的生物积累潜力被低估了吗？大麻素暴露评价中仿生色谱的见解。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-01-17 DOI: 10.1016/j.fct.2025.115252

Krzesimir Ciura , Kamila Jarzyńska , Katarzyna Ewa Greber , Wiesław Sawicki , Karolina Jagiello , Bartosz Wielgomas , Magdalena Kierkowicz

{"title":"Is the potential for bioaccumulation of cannabinoids underestimated? Insights from biomimetic chromatography in cannabinoid exposure evaluation","authors":"Krzesimir Ciura , Kamila Jarzyńska , Katarzyna Ewa Greber , Wiesław Sawicki , Karolina Jagiello , Bartosz Wielgomas , Magdalena Kierkowicz","doi":"10.1016/j.fct.2025.115252","DOIUrl":"10.1016/j.fct.2025.115252","url":null,"abstract":"<div><div>The use of cannabis-related products is currently experiencing extraordinary growth in popularity in the European and US markets. A wide variety of cannabis-related products have emerged, including oils, tinctures, edibles, topicals, cosmetics, and even beverages and sweets, offering the purported medical benefits without the psychoactive effects associated with <em>Cannabis sativa</em>. However, there is a significant gap in our understanding of bioaccumulation processes and their long-term effects, particularly as cannabinoids are highly lipophilic molecules. In this study, we used a biochromatographic approach to experimentally determine the lipophilicity, binding to phospholipids and affinity to plasma protein of selected cannabinoids to comprehensively assess their bioaccumulation potential. The results obtained clearly indicated that cannabinoids, including the particularly popular cannabidiol, promote bioaccumulation. Importantly, a higher affinity for phospholipids indicated non-specific binding, which can lead to phospholipidosis. Cannabinoids exhibit a stronger binding affinity to human serum albumin (HSA) compared to diclofenac, which might affect the pharmacokinetics of regularly taken medications when co-administered.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"197 ","pages":"Article 115252"},"PeriodicalIF":3.9,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142997340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0