Food and Chemical Toxicology最新文献_第9页

Mitigating Bisphenol-Induced Neurotoxicity: Exploring the Therapeutic Potential of Diosmin in Zebrafish Larvae 减轻双酚诱导的神经毒性：探索地奥米明对斑马鱼幼虫的治疗潜力。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-21 DOI: 10.1016/j.fct.2025.115402

Deenathayalan Uvarajan , Manish Ravikumar , Brindha Durairaj

{"title":"Mitigating Bisphenol-Induced Neurotoxicity: Exploring the Therapeutic Potential of Diosmin in Zebrafish Larvae","authors":"Deenathayalan Uvarajan , Manish Ravikumar , Brindha Durairaj","doi":"10.1016/j.fct.2025.115402","DOIUrl":"10.1016/j.fct.2025.115402","url":null,"abstract":"<div><div>Neurological disorders are commonly accompanied by inflammation of the brain, which can be triggered by oxidative stress and cell damage caused by hazardous environmental substances. The ubiquitous harmful chemical bisphenol A (BPA) has been linked to several neuropsychiatric disorders and is thought to contribute to oxidative damage. This study explored the mechanisms underlying the effects of BPA on neurological health. Diosmin (DM) is a natural flavonoid (C<sub>28</sub>H<sub>32</sub>O<sub>15</sub>) found in various plants, including citrus fruits and it possess various pharmacological activities. This study investigated the neuroprotective effects of DM on BPA-induced neuroinflammation in zebrafish larvae, suggesting its potential therapeutic uses. Developmental toxicity, including mortality, hatching rate, and heart rate, was evaluated to determine DM toxicity. Oxidative stress biomarkers such as reactive oxygen species (ROS), superoxide anions (O<sup>−2</sup>), lipid peroxidation (LPO), and nitric oxide (NO) were quantified using colorimetric assays in the head region of the larvae. Antioxidant enzyme activities were measured to assess the impact of DM on antioxidant defences. Neuroinflammation was evaluated by analysing pro-inflammatory markers using RT-qPCR, and motor neuron function was assessed using acetylcholinesterase (AChE) activity and behavioural assays. The findings indicate that exposure to DM prevents neurotoxicity induced by BPA by increasing antioxidant defence enzymes and reducing the levels of ROS, O<sup>2−</sup>, LPO, and NO in the head region of zebrafish larvae. Furthermore, DM enhanced motor neuron function by increasing AChE activity and decreasing neuroinflammation by reducing the levels of pro-inflammatory markers influenced by BPA. This study suggests that DM offers neuroprotection against BPA-induced oxidative damage and neuroinflammation, thereby paving the way for the development of new treatment options for neurological disorders.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115402"},"PeriodicalIF":3.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RIFM fragrance ingredient safety assessment, 4-acetoxy-2,5-dimethyl-3(2H)furanone, CAS Registry Number 4166-20-5 香料成分安全性评价，4-乙酰氧基-2,5-二甲基-3（2H）呋喃酮，中国科学院登记号4166-20-5。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-19 DOI: 10.1016/j.fct.2025.115397

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

Vitamin C and D do not increase the chemopreventive effect of aspirin on colon carcinogenesis in a mouse model 在小鼠模型中，维生素C和D不会增加阿司匹林对结肠癌的化学预防作用。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-19 DOI: 10.1016/j.fct.2025.115400

Maiara Pereira , Rafael Alencastro Brandão Ostermann , Wanessa de Fáveri , Adriani Paganini Damiani , Marina Lumertz Magenis , Isadora de Oliveira Monteiro , Luiza Martins Longaretti , Rubya Pereira Zaccaron , Paulo Cesar Lock Silveira , Ana Paula Bazo , Fernando Tadeu Trevisan Frajacomo , Vanessa Moraes de Andrade

{"title":"Vitamin C and D do not increase the chemopreventive effect of aspirin on colon carcinogenesis in a mouse model","authors":"Maiara Pereira , Rafael Alencastro Brandão Ostermann , Wanessa de Fáveri , Adriani Paganini Damiani , Marina Lumertz Magenis , Isadora de Oliveira Monteiro , Luiza Martins Longaretti , Rubya Pereira Zaccaron , Paulo Cesar Lock Silveira , Ana Paula Bazo , Fernando Tadeu Trevisan Frajacomo , Vanessa Moraes de Andrade","doi":"10.1016/j.fct.2025.115400","DOIUrl":"10.1016/j.fct.2025.115400","url":null,"abstract":"<div><div>Aspirin has significant antineoplastic effects on the colon, whereas the outcomes of Vitamin C and D supplementation have been inconsistent. This study addressed the isolated and combined effects of vitamins C and D with aspirin on chemically induced colon carcinogenesis in mice, focusing on redox balance and DNA damage. Adult male and female mice were divided into seven groups: a control group; a group treated with 1,2-dimethylhydrazine (DMH, 40 mg/kg twice per week during weeks 4 and 5); and groups treated with DMH plus the following: aspirin (6 mg/kg in water); Vitamin C (500 mg/L in water); Vitamin D (1500 IU by oral gavage); a combination of Vitamin C and aspirin; and a combination of Vitamin D and aspirin. The treatments were administered continuously for 12 weeks. The treatments, isolated or combined, reduced aberrant crypt formations. Aspirin alone reduced the formation of aberrant crypt foci (ACF) by 65 %, accompanied by a systemic reduction in oxidative stress and DNA damage prevention. However, adding vitamins C and D to aspirin did not enhance these effects. Vitamin D alone suppressed ACF formation and DNA damage in the liver, whereas vitamin C had a limited effect on colon carcinogenesis, despite reducing oxidative stress in the liver and colon. In summary, we found no evidence that vitamins C and D supplementation enhanced the chemopreventive effects of aspirin on colon cancer.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115400"},"PeriodicalIF":3.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of 28-day inhalation toxicity mechanism of environmentally friendly insulating gas C5F10O based on pharmacology and molecular docking technology 基于药理学和分子对接技术的环保绝缘气体C5F10O 28天吸入毒性机理评价

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-19 DOI: 10.1016/j.fct.2025.115356

Shuangshuang Tian , Qianqian Wan , Yimeng Chen , Benli Liu , Weihao Liu , Fanchao Ye , Zhou Huang

{"title":"Evaluation of 28-day inhalation toxicity mechanism of environmentally friendly insulating gas C5F10O based on pharmacology and molecular docking technology","authors":"Shuangshuang Tian , Qianqian Wan , Yimeng Chen , Benli Liu , Weihao Liu , Fanchao Ye , Zhou Huang","doi":"10.1016/j.fct.2025.115356","DOIUrl":"10.1016/j.fct.2025.115356","url":null,"abstract":"<div><div>C<sub>5</sub>F<sub>10</sub>O is a new eco-friendly insulating gas with excellent insulating properties and environmental characteristics. However, the toxicity of C<sub>5</sub>F<sub>10</sub>O needs to be studied before application. In this paper, 28-day inhalation toxicity experiments are conducted on rats exposed to C<sub>5</sub>F<sub>10</sub>O/air at 0 ppm, 500 ppm, 2000 ppm and 8000 ppm, with satellite groups at 0 ppm and 8000 ppm. The 28-day inhalation toxicity of C<sub>5</sub>F<sub>10</sub>O is invested in the term of the change of weight and food intake, the analysis of hematology, biochemistry, urine and histopathology. Molecular docking technology is used for virtual screening to analyze potential toxicological mechanisms. The results show that C<sub>5</sub>F<sub>10</sub>O has no effect on the food intake of rats. Combined with clinic and histopathology results, 8000 ppm C<sub>5</sub>F<sub>10</sub>O is toxic to the lungs of both male and female rats, and the lungs have not improved in the 8000 ppm satellite group which indicates the lungs as the target organ, and high dose C<sub>5</sub>F<sub>10</sub>O induces aggregation of rat lung foam cells. In addition, a NOAEC of 2000 ppm and a LOAEC of 6000 ppm are observed for C<sub>5</sub>F<sub>10</sub>O. Molecular docking results show that C<sub>5</sub>F<sub>10</sub>O binds to multiple proteins, impacting the HIF-1 pathway and immune response regulation, which may explain the foam cell aggregation in the lungs.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115356"},"PeriodicalIF":3.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RIFM fragrance ingredient safety assessment, heptyl alcohol, CAS registry number 111-70-6 香料成分安全性评价，庚醇，中国科学院登记号111-70-6。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-19 DOI: 10.1016/j.fct.2025.115395

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

Deep learning-assisted cellular imaging for evaluating acrylamide toxicity through phenotypic changes 通过表型变化评估丙烯酰胺毒性的深度学习辅助细胞成像。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-19 DOI: 10.1016/j.fct.2025.115401

Zhiyuan Ning , Yingming Zhang , Shikun Zhang , Xianfeng Lin , Lixin Kang , Nuo Duan , Zhouping Wang , Shijia Wu

引用次数: 0

Microparticles introduced by the processing of traditional Chinese medicine Hirudo nipponica Whitman might pose threat to patients 中药水蛭加工过程中引入的微颗粒可能对患者构成威胁。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-17 DOI: 10.1016/j.fct.2025.115399

Muting Yan , Xilin Fang , Riying Zhong , Houxiang Zhang , Ziying Zhu , Han Gong , Muxian Yan

{"title":"Microparticles introduced by the processing of traditional Chinese medicine Hirudo nipponica Whitman might pose threat to patients","authors":"Muting Yan , Xilin Fang , Riying Zhong , Houxiang Zhang , Ziying Zhu , Han Gong , Muxian Yan","doi":"10.1016/j.fct.2025.115399","DOIUrl":"10.1016/j.fct.2025.115399","url":null,"abstract":"<div><div><em>Hirudo nipponica Whitman</em> (HNW) is a traditional Chinese medicine (TCM) processed from leeches, commonly used for treating blood stasis syndrome, particularly in promoting blood circulation and alleviating blood stasis. This study aimed to examine microparticles (MPs) contamination of leeches and whether the production of MPs was related to processing. The results showed that the abundance of MPs in the whole, sectioned and powdery of HNW was 12.39, 13.93, 35.11 items/g, respectively. Fiber-like particles accounted for 90 % total. Transparent particles were the most abundant, followed by blue and black. Particles <1 mm were the most frequent. Notebly, 100 % cotton was the most detected material in the HNW, while rayon, cellulose and polyester accounted for 46 % of the total. The abundance of particles in powdery HNW increased significantly, with a higher percentage of <1 mm, similar type and colour to whole and sectioned HNW. It suggests that the large MPs may have been cut into smaller MPs during processing and bring more risk of MPs. It alerts us to the fact that pharmaceuticals and even commonly touched food products may pose a greater risk of MPs due to processing.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115399"},"PeriodicalIF":3.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Update to RIFM fragrance ingredient safety assessment, isoamyl propionate, CAS Registry Number 105-68-0 更新RIFM香料成分安全性评估，丙酸异戊酯，CAS注册号105-68-0。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-17 DOI: 10.1016/j.fct.2025.115396

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

Food safety assessment of genetically modified soybean DBN9004×DBN8002×DBN8205 in a subchronic rodent feeding study 转基因大豆在啮齿动物亚慢性喂养研究中的食品安全评价DBN9004×DBN8002×DBN8205。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-17 DOI: 10.1016/j.fct.2025.115398

Qinghong Zhou, Yinghua Liu, Shujing Zhang, Shufei Li, Miao Zhao, Xiaoli Zhou, Dianming Zhou, Zhiyong Qian

{"title":"Food safety assessment of genetically modified soybean DBN9004×DBN8002×DBN8205 in a subchronic rodent feeding study","authors":"Qinghong Zhou, Yinghua Liu, Shujing Zhang, Shufei Li, Miao Zhao, Xiaoli Zhou, Dianming Zhou, Zhiyong Qian","doi":"10.1016/j.fct.2025.115398","DOIUrl":"10.1016/j.fct.2025.115398","url":null,"abstract":"<div><div>Soybeans provide a nutritionally complete plant-based protein, containing all nine essential amino acids and bioactive compounds. The food safety of a novel triple-stacked genetically modified (GM) soybean, DBN9004 × DBN8002 × DBN8205 was evaluated in a 90-day rat feeding study. The GM soybean, developed through conventional hybridization of three GM lines (DBN9004, DBN8002 and DBN8205), incorporates genes conferring resistance to glyphosate (<em>epsps</em>), glufosinate (<em>pat</em>), and lepidopteran pests (<em>cry1Ac</em>, <em>cry2Ab2</em>, and <em>mVip3Aa</em>). One hundred Wistar Han RCC rats were divided into five groups (n = 10/sex/group) and fed diets containing 15 % or 30 % GM soybean, non-GM soybean (Jack), or a basal diet for 90 days. No treatment-related effects on body weight/gain, food consumption/utilization, clinical signs, mortality, ophthalmology, clinical pathology (hematology, prothrombin time, urinalysis, serum chemistry), organ weights, and gross and microscopic pathology were observed in rats fed with the GM soybean compared to the non-GM Jack and the basal-diet group. In rats, the results of this 90-day feeding study suggest that there were no significant differences in safety between GM soybean DBN9004 × DBN8002 × DBN8205 compared to the non-GM Jack.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115398"},"PeriodicalIF":3.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143661883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Reno- and hepato-protective effect of allopurinol after renal ischemia/reperfusion injury: Crosstalk between xanthine oxidase and peroxisome proliferator-activated receptor gamma signaling” [Food Chem. Toxicol. 178 (2023) 113868] 别嘌呤醇在肾缺血/再灌注损伤后的肝保护作用：黄嘌呤氧化酶和过氧化物酶体增殖物激活受体信号之间的串音[食品化学]。中国生物医学工程学报，2004 (5):349 - 349 [j]

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-15 DOI: 10.1016/j.fct.2025.115374

Eman Soliman , Shimaa Mustafa Elshazly , Samar M. Shewaikh , Fatma El-shaarawy

引用次数: 0