Food and Chemical Toxicology最新文献_第9页

Exploring the relationship between daily intake and urinary excretion of the mycotoxins T-2 and HT-2 toxin in humans 探索人类每日摄入真菌毒素T-2和HT-2毒素与尿排泄的关系

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-28 DOI: 10.1016/j.fct.2025.115491

Hannah P. McKeon , Rudolf Hoogenveen , Marta M. Sopel , Marloes A.A. Schepens , Marcel J.B. Mengelers , Annick D. van den Brand , Judith A. de Heer , Anne Lise Brantsæter , Maria Kalyva , Trine Husøy

{"title":"Exploring the relationship between daily intake and urinary excretion of the mycotoxins T-2 and HT-2 toxin in humans","authors":"Hannah P. McKeon , Rudolf Hoogenveen , Marta M. Sopel , Marloes A.A. Schepens , Marcel J.B. Mengelers , Annick D. van den Brand , Judith A. de Heer , Anne Lise Brantsæter , Maria Kalyva , Trine Husøy","doi":"10.1016/j.fct.2025.115491","DOIUrl":"10.1016/j.fct.2025.115491","url":null,"abstract":"<div><div>T-2 toxin (T-2) and HT-2 toxin (HT-2) are mycotoxins that can contaminate food, especially cereals. Exposure to T-2 and HT-2 has mainly been estimated using dietary exposure assessment, however, human biomonitoring presents another valuable approach.</div><div>The relationship between daily intake and urinary excretion of T-2 and HT-2 over time in 40 Norwegian adults was modelled. T-2, HT-2 and T-2 triol were analysed in 24-h urine samples using LC-MS/MS. Dietary exposure of T-2 and HT-2 was calculated using 24-h weighed dietary records and concentration data in food derived from measured concentrations in raw food commodities. A statistical model was developed and fit to estimate the excreted fraction (f<sub>abs_excr</sub>) and residence time parameters.</div><div>Without deconjugation prior to analysis, T-2, HT-2 or T-2 triol were not detected in the urine of the 40 adults. Applying a deconjugation step, total HT-2 (HT-2 and its glucuronides) was detected in almost all samples. Using the statistical model, the mean f<sub>abs_excr</sub> was estimated to be 0.184, equivalent to 18.4 %. The estimated time in which 97.5 % of the ingested T-2 and HT-2 was excreted as total HT-2 was 14.3 h, and the elimination half-life was 4.0 h.</div><div>This study highlights the challenges involved in modelling the relationship between daily intake and urinary excretion of T-2 and HT-2 over time in humans. The findings indicate that approximately 20 % of the external exposure can be traced back in the urine within 24 h. However, additional research is required to support and strengthen these findings.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"201 ","pages":"Article 115491"},"PeriodicalIF":3.9,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Update to RIFM fragrance ingredient safety assessment, benzyl valerate, CAS Registry Number 10361-39-4 更新RIFM香料成分安全性评估，戊酸苄，CAS注册号10361-39-4

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-27 DOI: 10.1016/j.fct.2025.115480

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

Update to RIFM fragrance ingredient safety assessment, isocyclocitral, CAS Registry Number 1335-66-6 更新RIFM香料成分安全评估，异环戊二醛，CAS注册号1335-66-6

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-26 DOI: 10.1016/j.fct.2025.115477

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

TiO2 P25 nanoparticles induce mitochondrial damage and increased glutathione synthesis in SH-SY5Y neural cells TiO2 P25纳米颗粒诱导SH-SY5Y神经细胞线粒体损伤和谷胱甘肽合成增加

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-26 DOI: 10.1016/j.fct.2025.115496

Stepanka Jelinkova , Jana Bacova , Erika Rousarova , Pavlina Nyvltova , Petr Knotek , Jan Capek , Lenka Ticha , Tomas Rousar

{"title":"TiO2 P25 nanoparticles induce mitochondrial damage and increased glutathione synthesis in SH-SY5Y neural cells","authors":"Stepanka Jelinkova , Jana Bacova , Erika Rousarova , Pavlina Nyvltova , Petr Knotek , Jan Capek , Lenka Ticha , Tomas Rousar","doi":"10.1016/j.fct.2025.115496","DOIUrl":"10.1016/j.fct.2025.115496","url":null,"abstract":"<div><div>The increasing occurrence of TiO<sub>2</sub> nanoparticles in the environment leads to a higher risk of their entry into the human body. Because the nanomaterials can cross the blood-brain barrier, the knowledge of their effect in neural cells is also crucial. However, the exact mechanism of toxicity remains unclear. Therefore, our objective was to evaluate the biological effect of TiO<sub>2</sub> nanoparticles in neural cells. Therefore, we aimed to evaluate the biological effect of TiO<sub>2</sub> nanoparticles in neural cells. We used neuroblastoma SH-SY5Y cells treated with 25 nm TiO<sub>2</sub> nanoparticles (TiO<sub>2</sub> P25; 1–100 μg·mL<sup>−1</sup>; 24–72 h). We measured dehydrogenase activity, glutathione metabolism, DNA damage and mitochondrial respiration. After treatment of SH-SY5Y cells with TiO<sub>2</sub> P25, we found a dose- and time-dependent decrease in dehydrogenase activity together with nuclear changes. Interestingly, 100 μg·mL<sup>−1</sup> TiO<sub>2</sub> P25 caused a significant increase of glutathione levels <em>(p < 0.001)</em> linked with increased glutamate-cysteine ligase expression after both 24 and 48 h. Furthermore, as the first study at all, we observed the significant decreases of mitochondrial respiration in SH-SY5Y cells caused by treatments with 10 and 100 μg·mL<sup>−1</sup> TiO<sub>2</sub> P25 after 48 and 72 h. In conclusion, our study brings new finding of occurrence of decreased mitochondrial respiration without glutathione depletion in SH-SY5Y cells contributing to the understanding of TiO<sub>2</sub> P25 toxicity in neural cells.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"202 ","pages":"Article 115496"},"PeriodicalIF":3.9,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RIFM Natural Complex Substance (NCS) fragrance ingredient safety assessment, ho leaf oil, CAS Registry Number 8022-91-1, RIFM ID 217-E2.12 天然复合物质（NCS）香精成分安全性评价，何叶油，CAS注册号8022-91-1，RIFM ID 217-E2.12

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-25 DOI: 10.1016/j.fct.2025.115474

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

RIFM natural complex substance (NCS) fragrance ingredient safety assessment, ho bark oil, CAS registry number 8022-91-1, RIFM ID 217-C2.12 天然复合物质（NCS）香料成分安全性评价，何皮油，CAS注册号8022-91-1，RIFM ID 217-C2.12

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-25 DOI: 10.1016/j.fct.2025.115471

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

Safety evaluation of a food enzyme containing phospholipase activity produced by a strain of Fusarium commune 一株镰刀菌生产的含磷脂酶活性食品酶的安全性评价

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-25 DOI: 10.1016/j.fct.2025.115484

Myrthe W. van den Dungen, Mélina Galano, Peter J.I. van de Vondervoort, Irsan Kooi, Angela de Bruine, Noël N.M.E. van Peij, Hanna E. Abbas-Lindfors

{"title":"Safety evaluation of a food enzyme containing phospholipase activity produced by a strain of Fusarium commune","authors":"Myrthe W. van den Dungen, Mélina Galano, Peter J.I. van de Vondervoort, Irsan Kooi, Angela de Bruine, Noël N.M.E. van Peij, Hanna E. Abbas-Lindfors","doi":"10.1016/j.fct.2025.115484","DOIUrl":"10.1016/j.fct.2025.115484","url":null,"abstract":"<div><div>Phospholipases are commonly used food enzymes, e.g. to improve bread-making properties. For organic food certifications, enzymes need to be produced by non-genetically modified organisms, but no such ‘classical’ phospholipases are currently available. To this aim, a phospholipase product was developed with a <em>Fusarium commune</em> strain, a microorganism having no reported uses in the food industry. The safety of microbially-derived food enzymes depends largely on the safety of the production strain. Strain <em>F. commune</em> LFC was obtained by classical strain improvement. Whole-Genome Sequencing and literature search allowed to identify potential gene clusters for the mycotoxins beauvericin (BEA), moniliformin (MON), and fusaric acid (FA). Analysis of these mycotoxins revealed that no toxicologically relevant levels were produced during controlled submerged fermentation. The enzyme concentrate was assessed in a range of toxicity studies. The Ames test (OECD 471) was concluded to be equivocal, but the ToxTracker® AO assay suggested an indirect mode of action, induced by dose-dependent oxidative stress. The in vitro micronucleus test (OECD 487) and the in vivo follow-up Comet assay (OECD 489) confirmed that the food enzyme was not genotoxic. The repeated-dose oral toxicity study (OECD 408) showed no adverse effects in any of the treatment groups and allowed to derive a NOAEL of 1124 mg TOS/kg bw/day. The Margin of Exposure with estimated dietary intakes in human food applications was determined to be > 2500. It is therefore concluded that the use of the phospholipase enzyme LFC as processing aid in baking and other cereal-based applications is safe.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"201 ","pages":"Article 115484"},"PeriodicalIF":3.9,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selenium content in milk and dairy products: Estimation of the daily intake and assessment of the potential risk to public health 牛奶和奶制品中的硒含量：每日摄入量的估计和对公众健康潜在风险的评估

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-25 DOI: 10.1016/j.fct.2025.115486

Burhan Basaran , Parisa Sadighara

{"title":"Selenium content in milk and dairy products: Estimation of the daily intake and assessment of the potential risk to public health","authors":"Burhan Basaran , Parisa Sadighara","doi":"10.1016/j.fct.2025.115486","DOIUrl":"10.1016/j.fct.2025.115486","url":null,"abstract":"<div><div>In this study, selenium levels in milk (n = 19), cheese (n = 49), yogurt (n = 13) and ayran (n = 8) of different brands sold in Türkiye were first determined by inductively coupled plasma mass spectrometry. The daily selenium intake resulting from the consumption of these foods was then calculated and evaluated with non-carcinogenic health risk. Selenium levels ranged from 9 <span><math><mrow><mo>−</mo></mrow></math></span> 32 and 1<span><math><mrow><mo>−</mo></mrow></math></span> 83 μg/L for milk and ayran, respectively, and from 0 <span><math><mrow><mo>−</mo></mrow></math></span> 224 and 12<span><math><mrow><mo>−</mo></mrow></math></span> 172 μg/kg for cheese and yogurt, respectively. The total daily selenium intake of persons aged 15> (general population) was determined to be 20.4 μg/day (0.292 μg/kg bw/day). The foods contributing most to the total daily selenium intake for all individuals in the same age group were yogurt (51.4 %), ayran (25.7 %), cheese (20.2 %) and milk (2.7 %). For individuals aged 15> (general population), the Target Hazard Quotient values resulting from the consumption of each food (milk, cheese, yogurt and ayran) and the Hazard Index value calculated by consuming all foods together (0.058) were less than 1. This study was detected any health risks related to selenium intake. This study was the first to evaluate health risks of selenium intake from consumption of some milk and dairy products in adult individuals.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"201 ","pages":"Article 115486"},"PeriodicalIF":3.9,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mn2O3 NPs-induced liver injury is potentially associated with gut microbiota dysbiosis in broiler chicken Mn2O3 nps诱导的肉鸡肝损伤可能与肠道菌群失调有关

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-25 DOI: 10.1016/j.fct.2025.115487

Yuanliang Li , Jiangnan Yi , Kai Liu , Xiaoqing Liu , Chamba Yangzom , Jiaqiang Pan , Mujahid Iqbal , Lianmei Hu , Zhaoxin Tang , Ying Li , Hui Zhang

{"title":"Mn2O3 NPs-induced liver injury is potentially associated with gut microbiota dysbiosis in broiler chicken","authors":"Yuanliang Li , Jiangnan Yi , Kai Liu , Xiaoqing Liu , Chamba Yangzom , Jiaqiang Pan , Mujahid Iqbal , Lianmei Hu , Zhaoxin Tang , Ying Li , Hui Zhang","doi":"10.1016/j.fct.2025.115487","DOIUrl":"10.1016/j.fct.2025.115487","url":null,"abstract":"<div><div>Mn<sub>2</sub>O<sub>3</sub> nanometer particles(Mn<sub>2</sub>O<sub>3</sub> NPs), a new material, is widely used in medicine, electrochemical sensing and energy storage fields. The widespread use of Mn<sub>2</sub>O<sub>3</sub> NPs has caused health concerns, and it is necessary to clarify the toxic mechanism of Mn<sub>2</sub>O<sub>3</sub> NPs exposure. Our findings showed that Mn<sub>2</sub>O<sub>3</sub> NPs exposure could lead to liver histological abnormalities, mitochondrial dysfunction in liver, as well as mitochondrial-mediated apoptosis, autophagy and mitochondrial dynamics disorder, and eventually lead to liver injury. At the same time, the ileal epithelium suffered physiological damage and inflammation after Mn<sub>2</sub>O<sub>3</sub> NPs exposure, and the expression levels of genes and proteins related to intestinal barrier function (MUC1 ZO-1 Claudin1 and Occludin) were significantly down-regulated. Meanwhile, 16s sequencing analysis of intestinal bacteria showed that Mn<sub>2</sub>O<sub>3</sub> NPs exposure caused significant changes in intestinal flora abundance. The Firmicutes/Bacteroidetes ratio increased, and the abundance of probiotics (Bacteroides, Bifidobacterium, Faecalibacterium) decreased, while the abundance of harmful bacteria (Streptococcus, Enterococcus, Pseudomonas) increased. The changes in these microflorae may potentially impact the development of liver injury. Altogether, these results provide novel insights into the potential mechanism of Mn<sub>2</sub>O<sub>3</sub> NPs related hepatotoxicity induced by gut microbiota via the gut-liver axis, and contribute to a better interpretation of the health impact of Mn<sub>2</sub>O<sub>3</sub> NPs.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"202 ","pages":"Article 115487"},"PeriodicalIF":3.9,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms of LPS-induced toxicity in endothelial cells and the protective role of geniposidic acid 脂多糖诱导内皮细胞毒性的机制及geniposidic酸的保护作用

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-25 DOI: 10.1016/j.fct.2025.115488

Yan Fang , He Meng , Jun Wang

{"title":"Mechanisms of LPS-induced toxicity in endothelial cells and the protective role of geniposidic acid","authors":"Yan Fang , He Meng , Jun Wang","doi":"10.1016/j.fct.2025.115488","DOIUrl":"10.1016/j.fct.2025.115488","url":null,"abstract":"<div><div>Vascular inflammation and oxidative stress are critical pathogenic factors in cardiovascular diseases. Lipopolysaccharide (LPS)-induced endothelial cytotoxicity, driven by oxidative stress and inflammation, remains incompletely understood. This study highlights the molecular mechanisms underlying LPS toxicity, focusing on the ROS/JNK/NLRP3 signaling axis. LPS disrupts mitochondrial function, increases ROS accumulation, activates JNK phosphorylation, and induces NLRP3 inflammasome activation, culminating in pyroptosis through caspase-1-mediated GSDMD cleavage. Mechanistic studies with the JNK inhibitor SP600125 confirmed the critical role of the ROS/JNK/NLRP3 pathway in LPS-induced endothelial damage. Additionally, PGC-1α, a key regulator of mitochondrial homeostasis, was identified as a protective factor suppressed by LPS, exacerbating ROS overproduction and inflammasome activation. To validate these findings, geniposidic acid (GPA), a natural antioxidant and anti-inflammatory compound, was employed. GPA effectively reduced ROS levels, inhibited JNK activation, and suppressed pyroptosis, supporting its utility as a chemical tool to confirm the pivotal role of ROS/JNK/NLRP3 signaling. This study elucidates the intricate interplay between oxidative stress, mitochondrial dysfunction, and pyroptosis, providing a comprehensive framework for addressing inflammation-driven vascular damage.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"201 ","pages":"Article 115488"},"PeriodicalIF":3.9,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143887023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0