Food and Chemical Toxicology最新文献_第8页

Chronic exposure to polystyrene micro/nanoplastics triggers testicular dysfunction through PI3K/AKT/mTOR signaling-mediated spermatocyte senescence in mice 长期暴露于聚苯乙烯微/纳米塑料会通过PI3K/AKT/mTOR信号介导的小鼠精细胞衰老引发睾丸功能障碍。

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2025-08-14 DOI: 10.1016/j.fct.2025.115703

Huilian Zhang , Yi Li , Nan Zhu , Qiurui Liu , Jing Cai , Yixian Wen , Taihang Liu , Fei Han

{"title":"Chronic exposure to polystyrene micro/nanoplastics triggers testicular dysfunction through PI3K/AKT/mTOR signaling-mediated spermatocyte senescence in mice","authors":"Huilian Zhang , Yi Li , Nan Zhu , Qiurui Liu , Jing Cai , Yixian Wen , Taihang Liu , Fei Han","doi":"10.1016/j.fct.2025.115703","DOIUrl":"10.1016/j.fct.2025.115703","url":null,"abstract":"<div><div>While the potential microplastic toxicity has attracted considerable research attention, studies on its chronic reproductive effects in male mammals remain limited. Here, we investigated the chronic reproductive toxicity of polystyrene microplastics (PS-MPs, 5 μm) and polystyrene nanoplastics (PS-NPs, 20 nm) both in vitro, using GC2 cells, and in vivo, employing male C57 mice. Histopathological analysis revealed dilated seminiferous tubules, disorganized spermatocytes, and reduced spermatocyte counts in treated groups. Consistently, sperm count and motility were significantly decreased following PS-MPs and PS-NPs exposure. These effects were closely associated with spermatocyte senescence, as indicated by β-galactosidase activity and the markers of telomerase inhibition, DNA damage, and cell cycle arrest. Mechanistically, PS-MPs and PS-NPs trigger spermatocyte senescence through activation of the PI3K/AKT/mTOR signaling pathway. Our findings demonstrate that PS-MPs and PS-NPs cause structural damage and spermatogenic dysfunction in mouse testes, potentially mediated by spermatocyte senescence through the PI3K/AKT/mTOR pathway.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"205 ","pages":"Article 115703"},"PeriodicalIF":3.5,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144861970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zebrafish in neurotoxin research: Insights into botulinum toxicity, mechanisms, and therapy 斑马鱼在神经毒素研究：洞察肉毒杆菌毒性，机制和治疗。

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2025-08-14 DOI: 10.1016/j.fct.2025.115704

Khadija A. Mohammed , Stanley U. Nwawuba , Julia Canzian , Barbara D. Fontana , Denis B. Rosemberg , Isaac A. Adedara

{"title":"Zebrafish in neurotoxin research: Insights into botulinum toxicity, mechanisms, and therapy","authors":"Khadija A. Mohammed , Stanley U. Nwawuba , Julia Canzian , Barbara D. Fontana , Denis B. Rosemberg , Isaac A. Adedara","doi":"10.1016/j.fct.2025.115704","DOIUrl":"10.1016/j.fct.2025.115704","url":null,"abstract":"<div><div>Botulinum neurotoxins (BoNTs) are highly potent biological toxins produced by <em>Clostridium botulinum</em> and related species. They act by inhibiting the release of acetylcholine at the neuromuscular junction, leading to paralysis. Due to their ability to modulate synaptic activity, BoNTs have been widely studied for their toxicological properties, as well as their medical and cosmetic applications, including the treatment of neuromuscular disorders, chronic pain, and aesthetic concerns. The zebrafish (<em>Danio rerio</em>) has gained prominence in BoNT research, particularly due to its genetic tractability and suitability for high-throughput screening, making it an effective model for studying BoNT effects at molecular, cellular, and behavioral levels. This review explores the role of zebrafish in neurotoxin research, highlighting its utility in studying BoNT toxicity, synaptic mechanisms, gene silencing applications, and therapeutic interventions. We discuss zebrafish-based studies that provide insights into BoNT-induced behavioral and cognitive effects. Additionally, we examine how zebrafish facilitate high-throughput screening for BoNT-related compounds and antitoxins. Despite the contributions of zebrafish-based models in neurotoxicology, further research is needed to fully elucidate BoNT mechanisms and optimize a putative therapeutic potential.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"205 ","pages":"Article 115704"},"PeriodicalIF":3.5,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144861971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect and mechanism of NCOA4-mediated ferritinophagy in aluminum-induced ferroptosis of PC12 cells ncoa4介导的铁蛋白自噬在铝诱导的PC12细胞铁凋亡中的作用及机制

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2025-08-13 DOI: 10.1016/j.fct.2025.115699

Ruifeng Liang , Jiafen Zhang , Yan Luo , Yizhe Yang , Ting Zhou , Siyi Li , Jiawei Liu , Bingbing Zhang , Qiao Niu , Hongmei Zhang , Xiaojiang Qin , Junhong Gao

{"title":"The effect and mechanism of NCOA4-mediated ferritinophagy in aluminum-induced ferroptosis of PC12 cells","authors":"Ruifeng Liang , Jiafen Zhang , Yan Luo , Yizhe Yang , Ting Zhou , Siyi Li , Jiawei Liu , Bingbing Zhang , Qiao Niu , Hongmei Zhang , Xiaojiang Qin , Junhong Gao","doi":"10.1016/j.fct.2025.115699","DOIUrl":"10.1016/j.fct.2025.115699","url":null,"abstract":"<div><div>Aluminum (Al) can accumulate in the brain and cause significant neurotoxicity, with neuronal death being a major contributor to aluminum-induced cognitive decline. Recent studies highlight the involvement of Nuclear Receptor Coactivator 4 (NCOA4)-mediated ferritinophagy and ferroptosis in this process, but their specific roles remain unclear. In this study, PC12 cells were treated with aluminum maltolate [Al(mal)<sub>3</sub>], with or without deferoxamine (DFO), a ferroptosis inhibitor, to explore the role of ferroptosis in aluminum-induced toxicity. Ferritinophagy was further examined using 3-Methyladenine (3-MA) and small interfering RNA (siRNA) targeting NCOA4. Al(mal)<sub>3</sub> treatment increased intracellular iron, reactive oxygen species (ROS), and malondialdehyde (MDA) levels, while reducing glutathione (GSH), mitochondrial membrane potential (MMP), and glutathione peroxidase 4 (GPX4) expression—hallmarks of ferroptosis. DFO and inhibition of ferritinophagy reversed these effects. Moreover, suppression of NCOA4 restored ferritin levels and improved iron homeostasis. These findings suggest that aluminum may activate NCOA4-mediated ferritinophagy, leading to disrupted iron metabolism, oxidative stress, and ferroptosis in neuronal cells, thereby contributing to its neurotoxic effects.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"205 ","pages":"Article 115699"},"PeriodicalIF":3.5,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144858752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Update to RIFM fragrance ingredient safety assessment, benzaldehyde, CAS Registry Number 100-52-7 更新中国科学院登记号100-52-7的RIFM香料成分安全性评估，苯甲醛。

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2025-08-12 DOI: 10.1016/j.fct.2025.115682

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

Subacute exposure to thallium disrupts renal energy metabolism by impairing the function of subcellular organelles in aged mice of both sexes 亚急性暴露于铊破坏肾脏能量代谢的亚细胞细胞器的功能在老年小鼠的两性

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2025-08-11 DOI: 10.1016/j.fct.2025.115700

Huan Yao , Lincai Li , Qian Dai , Dong Li

{"title":"Subacute exposure to thallium disrupts renal energy metabolism by impairing the function of subcellular organelles in aged mice of both sexes","authors":"Huan Yao , Lincai Li , Qian Dai , Dong Li","doi":"10.1016/j.fct.2025.115700","DOIUrl":"10.1016/j.fct.2025.115700","url":null,"abstract":"<div><div>Thallium, a highly poisonous heavy metal, accumulates in the kidneys, causing damage that impairs its renal elimination. However, the adverse cellular effects of thallium in the kidneys of older individuals, particularly the alterations in energy metabolism, remain unclear. In this study, we demonstrated that thallium exposure (10 ppm) for 4 weeks affected water intake and kidney weight (<em>P</em> < 0.05) in aged female mice, whereas it affected food intake and body weight (<em>P</em> < 0.05) in aged male mice. Transcriptome analysis revealed that thallium exposure induced a renal inflammatory response and metabolic changes in aged male and female mice. In aged male mice, fatty acid analysis of the kidneys revealed that thallium exposure significantly increased the relative abundances of C18:0 (<em>P</em> < 0.01), C15:1 (<em>P</em> < 0.05), and C20:4n6 (<em>P</em> < 0.01) and significantly decreased those of C16:1 (<em>P</em> < 0.001) and total monounsaturated fatty acids (<em>P</em> < 0.05). In aged female mice, thallium exposure significantly (<em>P</em> < 0.05) increased the relative abundances of C20:0, C24:0, and C18:3n3. Protein analyses revealed that thallium exposure inhibited glutamate metabolism, the TCA cycle, and fatty acid degradation in mitochondria and peroxisomes in aged female mice. Thallium inhibited the TCA cycle and fatty acid degradation in peroxisomes in aged male mice. These findings establish that thallium exposure disrupts renal energy metabolism by impairing the function of subcellular organelles in aged female and male mice.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"205 ","pages":"Article 115700"},"PeriodicalIF":3.5,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144841766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RIFM fragrance ingredient safety assessment, benzeneacetonitrile, a-butylidene-, (Z), CAS Registry Number 130786-09-3 RIFM香料成分安全性评价，苯乙腈，a-丁基-，(Z)，中国科学院登记号130786-09-3

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2025-08-11 DOI: 10.1016/j.fct.2025.115689

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

Hexavalent chromium exposure induces immune dysregulation and lung tissue neutrophil extracellular traps formation 六价铬暴露诱导免疫失调和肺组织中性粒细胞胞外陷阱形成。

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2025-08-08 DOI: 10.1016/j.fct.2025.115692

Zhiqiang Ji , Zekang Su , Changmao Long , Shiyi Hong , Yali Zhang , Xiaoli Wang , Guiping Hu , Guang Jia

{"title":"Hexavalent chromium exposure induces immune dysregulation and lung tissue neutrophil extracellular traps formation","authors":"Zhiqiang Ji , Zekang Su , Changmao Long , Shiyi Hong , Yali Zhang , Xiaoli Wang , Guiping Hu , Guang Jia","doi":"10.1016/j.fct.2025.115692","DOIUrl":"10.1016/j.fct.2025.115692","url":null,"abstract":"<div><div>Hexavalent chromium [Cr(VI)] is a known human carcinogen that is associated with environmental pollution and health risks. However, the relationship between its immunotoxicity and inflammation is still poorly understood. In this study, researchers used a mouse dynamic inhalation exposure system to simulate Cr(VI) occupational environments and conducted multi-organ immunological assessment along with lung tissue inflammatory profiling. It was observed that Cr(VI) inhalation exposure induced selective, time-dependent variations in lymphocyte subsets across specific organs, accompanied by significant upregulation of immune-related cytokines. The exposure triggered neutrophil extracellular traps (NETs) formation in lung tissue with concurrent elevation in NETs-associated gene expression and inflammasome-related gene activation. Immune dysregulation demonstrated close correlation with inflammation characterized by NETs formation and inflammasome activation. Furthermore, a two-week recovery period resulted in significant amelioration of these Cr(VI)-induced immunological disturbances and inflammatory manifestations. These findings provide critical insights into the crosstalk between immune dysfunction and inflammatory activation in occupational Cr(VI) exposure.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"205 ","pages":"Article 115692"},"PeriodicalIF":3.5,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Triclosan inhibits human trophoblast cell migration via TCF12-mediated RASSF8 regulation 三氯生通过tcf12介导的RASSF8调控抑制人滋养细胞迁移。

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2025-08-07 DOI: 10.1016/j.fct.2025.115691

Guangzhu Dong , Wenbo Huang , Jiahe Qin , Jinzhao Ma , Yufeng Qin , Guizhen Du

{"title":"Triclosan inhibits human trophoblast cell migration via TCF12-mediated RASSF8 regulation","authors":"Guangzhu Dong , Wenbo Huang , Jiahe Qin , Jinzhao Ma , Yufeng Qin , Guizhen Du","doi":"10.1016/j.fct.2025.115691","DOIUrl":"10.1016/j.fct.2025.115691","url":null,"abstract":"<div><div>Triclosan (TCS), a fat-soluble broad-spectrum antimicrobial agent widely used in personal care products and medical disinfectants, has been linked to adverse reproductive outcomes including disrupted embryo implantation. The aim of the present study was to investigate the functional consequences and molecular mechanisms of TCS exposure on trophoblast cells, using the HTR-8/SVneo cell line as an established <em>in vitro</em> model of human extravillous trophoblasts. Exposure to environmentally relevant TCS concentrations (0–100 μM) revealed dose-dependent toxicity. Cell viability significantly decreased at more than 10 μM TCS, while migration was impaired at concentrations as low as 1 μM. RNA-sequencing (RNA-seq) and Chromatin immunoprecipitation sequencing (ChIP-seq) analyses of cells exposed to 10 μM TCS showed substantial redistribution of enhancer regions (marked by H3K27ac). Motif enrichment analysis identified TCF12 as the most significantly affected transcription factor among five differentially enriched factors. Further investigation demonstrated that TCS exposure upregulated both TCF12 and its target gene RASSF8. The functional relationship between these factors was confirmed through TCF12 knockdown experiments, which decreased RASSF8 expression and partially reversed TCS-induced migration inhibition. Luciferase reporter assays verified direct binding of TCF12 to the RASSF8 promoter region. This study reveals a novel TCF12-RASSF8 signaling pathway mediating TCS-induced trophoblast migration impairment, providing molecular insights into the reproductive toxicity of this common antimicrobial agent and identifying potential intervention targets for TCS-induced reproductive complications.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"205 ","pages":"Article 115691"},"PeriodicalIF":3.5,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144811505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pomegranates, pesticides and our heart 石榴、农药和我们的心脏。

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2025-08-06 DOI: 10.1016/j.fct.2025.115690

Fulvio Alexandre Scorza , Raphael Wuo-Silva , Josef Finsterer , Feres Chaddad-Neto

引用次数: 0

Health risk associated with exposure to atrazine residue in drinking water, soil and cassava (Manihot esculenta) from seven hard-to-reach farm settlements in Ago-Iwoye, Southwest Nigeria 与接触来自尼日利亚西南部阿戈-伊沃伊七个难以到达的农场居民点的饮用水、土壤和木薯（Manihot esculenta）中的阿特拉津残留有关的健康风险。

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2025-08-05 DOI: 10.1016/j.fct.2025.115684

Folarin Owagboriaye , Olusolape Ilusanya , Abdulwahab Osibogun , Ebenezer Dada , Marvelous Ariyibi , Opeyemi Ogunbiyi , Titilayo Adesetan , Gabriel Dedeke

{"title":"Health risk associated with exposure to atrazine residue in drinking water, soil and cassava (Manihot esculenta) from seven hard-to-reach farm settlements in Ago-Iwoye, Southwest Nigeria","authors":"Folarin Owagboriaye , Olusolape Ilusanya , Abdulwahab Osibogun , Ebenezer Dada , Marvelous Ariyibi , Opeyemi Ogunbiyi , Titilayo Adesetan , Gabriel Dedeke","doi":"10.1016/j.fct.2025.115684","DOIUrl":"10.1016/j.fct.2025.115684","url":null,"abstract":"<div><div>Studies on health risks associated with exposure to atrazine have largely focused on a single exposure pathway, less attention has been given to its potential integral risks resulting from multiple exposures. This study evaluated health risks associated with exposure to atrazine residues in drinking water, soil and cassava from seven hard-to-reach farm settlements in Ago-Iwoye, Nigeria. Drinking water, soils and cassava tuber collected from each farm settlement were analysed for atrazine residues using standard technique. The mean values obtained were used to evaluate exposure-related carcinogenic and non-carcinogenic health risks. Atrazine in soil ranged from 0.19 to 0.380 mg/kg. While a range of 0.01–0.04 mg/L was detected in stream water, cassava recorded a range of 0.004–0.008 mg/kg. Hazard Index associated with water and soil exposure was below the risk limit. Although the incremental lifetime cancer risk (ILCR) associated with soil was below the threshold risk limit, the ILCR associated with water exposure was slightly above the limit. The EDI and HRI associated with cassava consumption were below the threshold values for adults, but not for children. Exposure to water or cassava, but not soil, from the farm settlements may pose high risks, especially to children.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"205 ","pages":"Article 115684"},"PeriodicalIF":3.5,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0