Food and Chemical Toxicology最新文献_第8页

Titanium dioxide nanoparticles disturb glucose homeostasis in association with impaired enteroendocrine cell differentiation 二氧化钛纳米颗粒扰乱葡萄糖稳态与肠内分泌细胞分化受损相关

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-05-01 DOI: 10.1016/j.fct.2025.115504

Kai Zou , Linna Du , Jing Qin , Jiacheng Zhou , Yanping Xiao , Xixi Song , Hongxia Liu , Xiu Wang

{"title":"Titanium dioxide nanoparticles disturb glucose homeostasis in association with impaired enteroendocrine cell differentiation","authors":"Kai Zou , Linna Du , Jing Qin , Jiacheng Zhou , Yanping Xiao , Xixi Song , Hongxia Liu , Xiu Wang","doi":"10.1016/j.fct.2025.115504","DOIUrl":"10.1016/j.fct.2025.115504","url":null,"abstract":"<div><div>Gut hormones secreted by enteroendocrine cells play a critical role in maintaining glucose homeostasis. However, the adverse endocrine effects related to glucose homeostasis caused by food additives are not well understood. This work aims to investigate the effects of titanium dioxide nanoparticles (TiO<sub>2</sub> NPs) in comparison to titanium dioxide microparticles (TiO<sub>2</sub> MPs) on glucose homeostasis, with a specific focus on the enteroendocrine cells and gut hormones. Our research found that exposure to 1 % (w/w) TiO<sub>2</sub> NPs, unlike TiO<sub>2</sub> MPs, resulted in elevated blood glucose levels and impaired glucose tolerance in mice. Notably, 1 % (w/w) TiO<sub>2</sub> NPs significantly influenced the differentiation of the intestinal epithelium while not causing any notable histological changes or affecting cell proliferation in the mouse ileum. Furthermore, the levels of gut hormones, including glucagon-like peptide-1 (GLP-1), peptide YY (PYY) and cholecystokinin (CCK), released from mouse ileum tissues were also significantly reduced following exposure to 1 % (w/w) TiO<sub>2</sub> NPs. Using the intestinal organoid model, we also discovered that 20 μg/mL TiO<sub>2</sub> NPs impaired enteroendocrine cell differentiation, reduced basal GLP-1 secretion levels, and disrupted the GLP-1 secretion response to nutrient stimuli. Our research highlights the detrimental effects of TiO<sub>2</sub> NPs as potential intestinal endocrine disruptor and underscores the need to optimize their particle size for safe use in the food industry.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"202 ","pages":"Article 115504"},"PeriodicalIF":3.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RIFM fragrance ingredient safety assessment, dimethylcyclohex-3-ene-1-carbaldehyde (isomer unspecified), CAS Registry Number 27939-60-2. 香料成分安全性评价，二甲基环己基-3-烯-1-乙醛（未指明异构体），中国科学院登记号27939-60-2。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-30 DOI: 10.1016/j.fct.2025.115493

A M Api, A Bartlett, D Belsito, D Botelho, M Bruze, A Bryant-Friedrich, G A Burton, M A Cancellieri, H Chon, M Cronin, S Crotty, M L Dagli, W Dekant, C Deodhar, K Farrell, A D Fryer, L Jones, K Joshi, A Lapczynski, D L Laskin, M Lavelle, I Lee, H Moustakas, J Muldoon, T M Penning, A H Piersma, G Ritacco, N Sadekar, I Schember, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar

引用次数: 0

RIFM natural complex substance (NCS) fragrance ingredient safety assessment, ho wood oil, CAS Registry Number 8022-91-1, RIFM ID 217-D2.12. 天然复合物质（NCS）香料成分安全性评价，何木油，CAS注册号8022-91-1，RIFM ID 217-D2.12。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-30 DOI: 10.1016/j.fct.2025.115494

A M Api, A Bartlett, D Belsito, D Botelho, M Bruze, A Bryant-Friedrich, G A Burton, M A Cancellieri, H Chon, M Cronin, S Crotty, M L Dagli, W Dekant, C Deodhar, K Farrell, A D Fryer, L Jones, K Joshi, A Lapczynski, D L Laskin, M Lavelle, I Lee, H Moustakas, J Muldoon, T M Penning, A H Piersma, G Ritacco, N Sadekar, I Schember, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar

{"title":"RIFM natural complex substance (NCS) fragrance ingredient safety assessment, ho wood oil, CAS Registry Number 8022-91-1, RIFM ID 217-D2.12.","authors":"A M Api, A Bartlett, D Belsito, D Botelho, M Bruze, A Bryant-Friedrich, G A Burton, M A Cancellieri, H Chon, M Cronin, S Crotty, M L Dagli, W Dekant, C Deodhar, K Farrell, A D Fryer, L Jones, K Joshi, A Lapczynski, D L Laskin, M Lavelle, I Lee, H Moustakas, J Muldoon, T M Penning, A H Piersma, G Ritacco, N Sadekar, I Schember, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar","doi":"10.1016/j.fct.2025.115494","DOIUrl":"10.1016/j.fct.2025.115494","url":null,"abstract":"<p><p>Ho wood oil was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety. Data for the components of the NCS do not show a concern for genotoxicity. Ho wood oil was evaluated for the repeated dose and reproductive toxicity endpoints on the basis of component analysis using a combination of target data, read-across data, and Threshold of Toxicological Concern (TTC); ho wood oil is safe for use under the conditions described in this safety assessment for the repeated dose and reproductive toxicity endpoints. Data for components of the NCS do not show a concern for skin sensitization under the current, declared levels of use. The photoirritation endpoint was evaluated based on the UV/Vis absorption spectra for the components of the NCS; ho wood oil is not expected to be photoirritating. The photoallergenicity endpoint was evaluated based on the UV/Vis absorption spectra for the components of the NCS; ho wood oil is not expected to be photoallergenic. The local respiratory toxicity endpoint for this NCS was evaluated using the inhalation TTC for a Cramer Class III material, and the inhalation exposure to ho wood oil is below the TTC (0.47 mg/day). Based on the component assessment, ho wood oil does not contain Persistent, Bioaccumulative, and Toxic (PBT) or (very) Persistent, (very) Bioaccumulative (vPvB) components as per the IFRA Environmental Standards and does not present a risk to the aquatic environment at the current reported VoUs.</p>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":" ","pages":"115494"},"PeriodicalIF":3.9,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

l-theanine alleviates ulcerative colitis by repairing the intestinal barrier through regulating the gut microbiota and associated short-chain fatty acids l -茶氨酸通过调节肠道菌群和相关短链脂肪酸修复肠道屏障，缓解溃疡性结肠炎。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-29 DOI: 10.1016/j.fct.2025.115497

Aoxiang Liu , Bin Wang , Minming Wang , Rui Tang , Wei Xu , Wenjun Xiao

{"title":"l-theanine alleviates ulcerative colitis by repairing the intestinal barrier through regulating the gut microbiota and associated short-chain fatty acids","authors":"Aoxiang Liu , Bin Wang , Minming Wang , Rui Tang , Wei Xu , Wenjun Xiao","doi":"10.1016/j.fct.2025.115497","DOIUrl":"10.1016/j.fct.2025.115497","url":null,"abstract":"<div><div>Ulcerative colitis (UC) is closely related to impaired intestinal barrier function and imbalanced gut microbial communities. <span>l</span>-theanine shows great potential in maintaining intestinal integrity and regulating the gut microbiota and associated short-chain fatty acids (SCFAs). However, whether <span>l</span>-theanine can alleviate UC by repairing the intestinal barrier through these regulatory processes remains unclear. In this study, <span>l</span>-theanine was used to optimize the gut microbiota, and the restorative effect and mechanism of <span>l</span>-theanine in UC by repairing the gut barrier through the gut microbiota and SCFAs were investigated via fecal microbiota transplantation. The findings revealed that <span>l</span>-theanine regulated the gut microbiota structure, increased SCFA contents, and promoted gut barrier repair in UC mice. Moreover, <span>l</span>-theanine upregulated the protein and mRNA expression of G-protein-coupled receptor 43 (GPR43), AKT, and phosphatidylinositide 3-kinase (PI3K). These results indicated that <span>l</span>-theanine alleviates UC by repairing the gut barrier via regulating the gut microbiota and SCFAs through the GPR43/PI3K/AKT signaling pathway activation. This study provides a method of preventing and treating UC via <span>l</span>-theanine as a safe food dietary supplement.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"202 ","pages":"Article 115497"},"PeriodicalIF":3.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights into the pharmacokinetics, biodistribution, and oral toxicity of a polymeric benzimidazole – Curcumin nanocomplex with a multitarget anticancer potential 具有多靶点抗癌潜力的聚合苯并咪唑-姜黄素纳米复合物的药代动力学、生物分布和口服毒性研究

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-29 DOI: 10.1016/j.fct.2025.115483

Noha E. Ibrahim , Heba Shawky , Amany S. Maghraby , Ebtehal K. Farrag

{"title":"Insights into the pharmacokinetics, biodistribution, and oral toxicity of a polymeric benzimidazole – Curcumin nanocomplex with a multitarget anticancer potential","authors":"Noha E. Ibrahim , Heba Shawky , Amany S. Maghraby , Ebtehal K. Farrag","doi":"10.1016/j.fct.2025.115483","DOIUrl":"10.1016/j.fct.2025.115483","url":null,"abstract":"<div><div>The current study investigates the oral toxicity of a PEGylated β-cyclodextrin-curcumin functionalized benzimidazole nanocomplex (BMPE-Cur) with multitarget anticancer potential in Swiss albino mice. Acute and chronic toxicities were evaluated after oral administration of BMPE-Cur in single doses ranging between 0.5 and 2.5 g/kg and repeated dosing of 5, 10, and 25 mg/kg for 28 consecutive days, respectively. Pharmacokinetic (PK) and biodistribution profiles of BMPE-Cur were analyzed by LC-MS. The toxicological assessments revealed that BMPE-Cur was tolerable up to 2.5 g/kg, with moderate organosomatic and biochemical alterations associated with doses >1.5 g/kg, whereas repeated dosing induced dose-dependent histopathological, hematological, and biochemical alterations. Doses within a range of 5–10 mg/kg were well tolerated, as indicated by the general normalization of the mentioned parameters. PK analysis revealed a similar value of maximum plasma concentration (C<sub>max</sub>) attained by the free BMPE and BMPE-Cur. However, the latter accelerated the time to reach C<sub>max</sub> (T<sub>max</sub>) by 50 %, concomitant with longer residence time and lower clearance rate. BMPE-Cur also presented excellent hemocompatibility with human blood, with 46.58 %–99.96 % lower hemolysis than free BMPE within the same concentration range. These findings underscore the favorable pharmacokinetics and biocompatibility of BMPE-Cur while identifying safe therapeutic doses for potential human translation.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"202 ","pages":"Article 115483"},"PeriodicalIF":3.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxicity of long term exposure to low dose polystyrene microplastics and nanoplastics in human iPSC-derived cardiomyocytes 长期暴露于低剂量聚苯乙烯微塑料和纳米塑料对人类ipsc来源的心肌细胞的毒性

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-29 DOI: 10.1016/j.fct.2025.115489

Jianyong Ma , Drew M. Ladd , Necati Kaval , Hong-Sheng Wang

{"title":"Toxicity of long term exposure to low dose polystyrene microplastics and nanoplastics in human iPSC-derived cardiomyocytes","authors":"Jianyong Ma , Drew M. Ladd , Necati Kaval , Hong-Sheng Wang","doi":"10.1016/j.fct.2025.115489","DOIUrl":"10.1016/j.fct.2025.115489","url":null,"abstract":"<div><div>Microplastics and nanoplastics (MNPs) are widespread environmental pollutants with potential risks to human health including cardiovascular effects. However, the impact of MNPs on the heart, particularly in human-relevant cardiac models, remains poorly understood. In this study, we investigated the long term effects of polystyrene (PS) MNPs-1 μm (PS-1) and 0.05 μm (PS-0.05) in human iPSC-derived cardiomyocytes (hiPSC-CMs). PS MNPs exposure reduced myocyte viability in a time- and dose-dependent manner. At a low dose of 0.1 μg/L, both PS-0.05 and PS-1 suppressed myocyte contractility, reduced Ca<sup>2+</sup> transient amplitude, and altered contraction and Ca<sup>2+</sup> transient dynamics. In hypertrophic hiPSC-CMs, PS-0.05 exposure exacerbated hypertrophy, increasing cell size and proBNP expression, a marker of myocyte hypertrophy. The mechanism of PS MNPs-induced cardiotoxicity likely involved mitochondrial dysfunction, as indicated by decreased mitochondrial membrane potential, increased mitochondrial ROS, and elevated intracellular ROS levels. This is the first study to assess the long term impact of low dose MNPs in human cardiomyocytes, providing crucial insight into the potential cardiac toxicity of MNPs and their implications for human heart health.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"202 ","pages":"Article 115489"},"PeriodicalIF":3.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the effects of Mangiferin on human lymphocytes of healthy individuals and the balance of Th1 and Th2 芒果苷对健康人淋巴细胞及Th1、Th2平衡的影响

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-29 DOI: 10.1016/j.fct.2025.115495

Vahid Reza Askari , Saeideh Saadat , Vafa Baradaran Rahimi , Elahe Kamelnia , Mohammad Hossein Boskabady

{"title":"Evaluation of the effects of Mangiferin on human lymphocytes of healthy individuals and the balance of Th1 and Th2","authors":"Vahid Reza Askari , Saeideh Saadat , Vafa Baradaran Rahimi , Elahe Kamelnia , Mohammad Hossein Boskabady","doi":"10.1016/j.fct.2025.115495","DOIUrl":"10.1016/j.fct.2025.115495","url":null,"abstract":"<div><div>Mangiferin is a xanthone glycoside that can be found abundantly in different parts of plants, with fruits like figs containing significant amounts. This study aimed to examine the immunomodulatory effects of Mangiferin on helper T lymphocytes. They were exposed to different concentrations of Mangiferin (10, 30, and 100 μM) and dexamethasone (0.1 mM) in the presence of phytohemagglutinin (PHA). The levels of cell proliferation, nitric oxide (NO), malondialdehyde (MDA), and glutathione (GSH) were determined using biochemical techniques. In addition, the levels of messenger RNA for interferon-γ (IFN-γ), interleukin-4 (IL-4), and IL-10 were measured through real-time PCR. The values for IFN-γ/IL-4 (Th1/Th2), IFN-γ/IL-10 (Th1/Treg), and IL-4/IL-10 (Th2/Treg) ratios were calculated by dividing their respective values. In the PHA-stimulated group, there was a notable decrease in IFN-γ/IL-4 and GSH levels, while other factors showed a significant increase compared to the control. Mangiferin significantly reduced cell proliferation, MDA/GSH ratio, MDA, and NO production. Additionally, Mangiferin demonstrated a concentration-dependent decrease in IFN-γ and IL-4 levels and an increase in IL-10 levels compared to the PHA group. The two higher concentrations of Mangiferin notably decreased the IFN-γ, IFN-γ/IL-10, and IL-4/IL-10 ratio values. Mangiferin exhibits more specific anti-oxidant, anti-inflammatory, and immunomodulatory activities compared to dexamethasone.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"202 ","pages":"Article 115495"},"PeriodicalIF":3.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RIFM fragrance ingredient safety assessment, maltol, CAS registry number 118-71-8 香料成分安全性评价，麦芽糖醇，中国科学院登记号118-71-8

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-28 DOI: 10.1016/j.fct.2025.115479

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

RIFM fragrance ingredient safety assessment, 3-(5,5,6-trimethylbicyclo[2.2.1]hept-2-yl)cyclohexan-1-ol, CAS registry number 3407-42-9 香料成分安全性评价，3-（5,5,6-三甲基双环[2.2.1]庚-2-基）环己烷-1-醇，CAS注册号3407-42-9

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-28 DOI: 10.1016/j.fct.2025.115478

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

Update to RIFM fragrance ingredient safety assessment, 6-methyl-2-(4-methyl-3-cyclohexen-1-yl)-5-hepten-2-ol, CAS Registry Number 515-69-5 更新RIFM香料成分安全性评估，6-甲基-2-（4-甲基-3-环己烯-1-基）-5-庚-2-醇，CAS注册号515-69-5

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-28 DOI: 10.1016/j.fct.2025.115482

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0