Food and Chemical Toxicology最新文献_第8页

2nd Update to RIFM fragrance ingredient safety assessment, α-amylcinnamaldehyde, CAS Registry Number 122-40-7 更新RIFM香精成分安全性评估，α-氨基肉桂醛，CAS注册号122-40-7。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-27 DOI: 10.1016/j.fct.2025.115409

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

A 7-year feed study on the long-term effects of genetically modified maize containing cry1Ab/cry2Aj and EPSPS genes on gut microbiota and metabolite profiles across two generations of cynomolgus macaques 含cry1Ab/cry2Aj和EPSPS基因的转基因玉米对两代食蟹猕猴肠道微生物群和代谢物谱长期影响的7年饲料研究

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-27 DOI: 10.1016/j.fct.2025.115419

Chenyun Wang , Shengtao Fan , Minghao Li , Yousong Ye, Zheli Li, Weihu Long, Yongjie Li, Zhangqiong Huang, Qinfang Jiang, Wanjing Yang, Rujia Yang, Donghong Tang

{"title":"A 7-year feed study on the long-term effects of genetically modified maize containing cry1Ab/cry2Aj and EPSPS genes on gut microbiota and metabolite profiles across two generations of cynomolgus macaques","authors":"Chenyun Wang , Shengtao Fan , Minghao Li , Yousong Ye, Zheli Li, Weihu Long, Yongjie Li, Zhangqiong Huang, Qinfang Jiang, Wanjing Yang, Rujia Yang, Donghong Tang","doi":"10.1016/j.fct.2025.115419","DOIUrl":"10.1016/j.fct.2025.115419","url":null,"abstract":"<div><div>The health implications of genetically modified (GM) crops remain controversial relative to their non-GM counterparts, particularly regarding long-term dietary exposure. Although the gut microbiome is a key health indicator, studies investigating the impact of GM crop consumption on intestinal microbiota remain limited. This study presents a comprehensive 7-year evaluation of GM maize expressing cry1Ab/cry2Aj and G10evo-EPSPS proteins through metagenomic and metabolomic analyses. We assessed the effects of GM maize consumption on gut microbiota diversity and metabolite profiles in cynomolgus macaques (<em>Macaca fascicularis</em>) compared with non-GM maize. Three diet regimens were implemented: a conventional compound feed (CK group), diet formulation containing 70 % non-GM maize (Corn group), and diet formulation containing 70 % GM maize (Tg group). The results demonstrated that feeding GM maize to the first (F0) and second (F1) generations of monkeys did not substantially affect the composition, community structure, or function of the intestinal microbiome, as indicated by species composition and diversity analyses. Minor differences in intestinal metabolites were observed but were not directly linked to transgenic maize consumption. Collectively, long-term intake of maize with <em>cry1Ab/cry2Aj</em> and <em>g10evo-epsps</em> genes had no adverse effects on macaques or their offspring.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115419"},"PeriodicalIF":3.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repurposing levomilnacipran to attenuate premature ovarian insufficiency induced by cyclophosphamide in female Wistar albino rats through modulation of TLR4/p38-MAPK/NF-κB p65, caspase-3-driven apoptosis, and Klotho protein expression 左旋milnacpran通过调节TLR4/p38-MAPK/NF-κB p65、caspase-3驱动细胞凋亡和Klotho蛋白表达，减轻环磷酰胺诱导的雌性Wistar白化大鼠卵巢功能不全

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-26 DOI: 10.1016/j.fct.2025.115406

Remon Roshdy Rofaeil , Ehab E. Sharata , Mina Ezzat Attya , Amira M. Abo-Youssef , Ramadan AM. Hemeida , Marwa M. Khalaf

{"title":"Repurposing levomilnacipran to attenuate premature ovarian insufficiency induced by cyclophosphamide in female Wistar albino rats through modulation of TLR4/p38-MAPK/NF-κB p65, caspase-3-driven apoptosis, and Klotho protein expression","authors":"Remon Roshdy Rofaeil , Ehab E. Sharata , Mina Ezzat Attya , Amira M. Abo-Youssef , Ramadan AM. Hemeida , Marwa M. Khalaf","doi":"10.1016/j.fct.2025.115406","DOIUrl":"10.1016/j.fct.2025.115406","url":null,"abstract":"<div><h3>Aim</h3><div>This study aims to explore the mitigative impact of levomilnacipran (LVM) against cyclophosphamide (CPA)-induced premature ovarian insufficiency by targeting TLR4/p38 MAPK/NF-κB p65, and klotho expression.</div></div><div><h3>Methods</h3><div>Rats were allocated into five groups as follows: control, LVM, CPA, CPA + LVM, and CPA + TRI. Serum hormones and histopathological examination were performed. To assess oxidative stress, ovarian MDA, GSH, and SOD were evaluated. The ovarian contents of caspase-3 and inflammatory markers were assessed using the ELISA method. The expression of ovarian NF-κB p65 was examined using an immunohistochemical technique. RT-qPCR was used to measure Bax and Bcl-2 mRNA expression. Utilizing a Western blot, the TLR4, p38 MAPK, α-Klotho, and cleaved caspase-3 levels were estimated. The estrous cycle was also monitored.</div></div><div><h3>Findings</h3><div>LVM attenuated CPA-induced ovarian toxicity by regulating hormones and alleviating histopathological aberrations. It also raised SOD and GSH levels and lowered MDA's ovarian content. Moreover, Bcl-2 levels were raised, Bax and caspase-3 expression levels were reduced, and IL-18, IL-1β, and TNF-α levels were all reduced. LVM-induced ovarian protection by diminishing TLR4/p38 MAPK/NF-κB p65 expression and boosting the protein levels of α-Klotho.</div></div><div><h3>Significance</h3><div>LVM mitigated POI caused by CPA by downregulating TLR4/p38 MAPK/NF-κB p65, enhancing the α-Klotho level and attenuating caspase-3 derived apoptosis.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115406"},"PeriodicalIF":3.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multivariate analysis of potentially toxic metal contents in soil and vegetables: Enrichment, bioconcentration, translocation from soil to vegetables, and assessment of human health toxicity 土壤和蔬菜中潜在有毒金属含量的多元分析：富集、生物浓缩、从土壤到蔬菜的迁移以及人类健康毒性评估

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-26 DOI: 10.1016/j.fct.2025.115413

Iftikhar-Ul-Haq , Mahmood Ahmed , Ali Abbas Aslam , Fatima Aftab , Mudassar Sanaullah , Riaz Hussain , Eisha Eiman , Awais Ali Aslam , Tanveer A. Wani , Seema Zargar

{"title":"Multivariate analysis of potentially toxic metal contents in soil and vegetables: Enrichment, bioconcentration, translocation from soil to vegetables, and assessment of human health toxicity","authors":"Iftikhar-Ul-Haq , Mahmood Ahmed , Ali Abbas Aslam , Fatima Aftab , Mudassar Sanaullah , Riaz Hussain , Eisha Eiman , Awais Ali Aslam , Tanveer A. Wani , Seema Zargar","doi":"10.1016/j.fct.2025.115413","DOIUrl":"10.1016/j.fct.2025.115413","url":null,"abstract":"<div><div>The excessive accumulation of metals in agricultural soils can profoundly impact the quality of vegetables grown in contaminated soil. Understanding the bioaccumulation of these metals in vegetables is essential for assessing human exposure risks. The present study aimed to investigate the concentration of potentially toxic metals (PTMs: Fe, Mn, Cu, Zn, Al, As, Cr, Cd, and Pb) in agricultural soil and some commonly consumed vegetables (carrot, reddish, cauliflower, pumpkin, and spinach). The samples were collected from agrarian farmlands near the industrial area of Multan Road, Kasur-Pakistan. The mean contents of all metals in soil, root, and shoot samples were within the limits set by the EU, WHO, FAO, and US EPA, except for Cr in soil and Cr, Cd, and Pb in root samples. Across all analyzed vegetables, the bioconcentration factors (BCF<sub>root</sub> and BCF<sub>shoot</sub> < 1, except As) and translocation factor (TF < 1) for all metals suggested that while these vegetables absorb metals, they generally do not accumulate or translocate them. Multivariate analysis indicated that both natural and anthropogenic activities contribute to metal contamination. The calculated hazard index (HI > 1) and cumulative cancer risk (CCR >1 × 10<sup>−3</sup>) values indicated the probability of non-carcinogenic and carcinogenic health risks for adults and children associated with the consumption of these vegetables. The findings provide critical insights for policymakers, agricultural regulators, and public health authorities to mitigate metal contamination risks and promote food safety.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115413"},"PeriodicalIF":3.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Attenuation of Paclitaxel-induced toxicities by polyphenolic natural compound rutin through inhibition of apoptosis and activation of NRF2/ARE signaling pathways 多酚类天然化合物芦丁通过抑制细胞凋亡和激活NRF2/ARE信号通路来减弱紫杉醇诱导的毒性。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-26 DOI: 10.1016/j.fct.2025.115408

Souradeep Biswas , Mrinmoyee Mondal, Shampa Pakhira, Rituparna Ghosh, Priya Samanta, Jhinuk Basu, Arijit Bhowmik, Subhadip Hajra, Prosenjit Saha

{"title":"Attenuation of Paclitaxel-induced toxicities by polyphenolic natural compound rutin through inhibition of apoptosis and activation of NRF2/ARE signaling pathways","authors":"Souradeep Biswas , Mrinmoyee Mondal, Shampa Pakhira, Rituparna Ghosh, Priya Samanta, Jhinuk Basu, Arijit Bhowmik, Subhadip Hajra, Prosenjit Saha","doi":"10.1016/j.fct.2025.115408","DOIUrl":"10.1016/j.fct.2025.115408","url":null,"abstract":"<div><div>Paclitaxel is the first microtubule-stabilizing drug widely used as an antineoplastic agent. Hepatotoxicity, nephrotoxicity and myeloid suppression may lead to secondary malignancy which is an important adverse effect of paclitaxel-therapy. In this study, we have evaluated the potential protective role of natural flavonoid rutin against paclitaxel-induced toxicities in BALB/cmice. Paclitaxel was administered intraperitoneally (in alternate days at a dose of 8.5 mg/kg b.w.) and rutin was given every day by oral gavages (20 mg/kg b.w.) in BALB/c mice. Results showed that administration of paclitaxel significantly (P<0.05) increased the generation of ROS and NO in bone marrow, liver and kidney tissues. In contrast, co-administration of rutin and paclitaxel significantly (p<0.05) reduced the intracellular ROS and NO levels, reversed the toxic effects of paclitaxel through NRF2-mediated activation of antioxidant response element (ARE) pathway and upregulated activity of several phase-II antioxidant enzymes. Furthermore, rutin treatment inhibited apoptosis by downregulated expression of Bax, caspase-3 and cPARP in bone marrow, liver and kidney tissues. Additionally, the chemoprotective potential of rutin was confirmed by histopathological analysis. Thus, our results suggest that co-administration of rutin may serve as a promising preventive strategy against paclitaxel induced toxicities and indicate its future use as an adjuvant in chemotherapy.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115408"},"PeriodicalIF":3.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endocrine-disrupting effects of 24 colorants used in food contact materials: In vitro and in silico studies 食品接触材料中使用的24种着色剂对内分泌的干扰作用：体外和计算机研究。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-25 DOI: 10.1016/j.fct.2025.115410

Guowei Ma , Yiling Cui , Qian Li , Yuting Chen , Peixue Guo , Di Feng , Tingting Zhao

{"title":"Endocrine-disrupting effects of 24 colorants used in food contact materials: In vitro and in silico studies","authors":"Guowei Ma , Yiling Cui , Qian Li , Yuting Chen , Peixue Guo , Di Feng , Tingting Zhao","doi":"10.1016/j.fct.2025.115410","DOIUrl":"10.1016/j.fct.2025.115410","url":null,"abstract":"<div><div>Current research on endocrine-disrupting effects of colorants utilized in food contact materials (FCMs) ramains limited. This study investigated these effects through <em>in vitro</em> cell models and <em>in silico</em> toxicological models. A total of 24 synthetic colorants were collected from the Chinese market, including azo, anthraquinone, heterocyclic and fused-ring ketones, and phthalocyanines. Their endocrine-disrupting effects mediated by estrogen and androgen receptors were evaluated using an <em>in vitro</em> dual-luciferase reporter gene assay. Results showed no estrogenic or anti-estrogenic effects or androgenic activity in the colorants. However, three colorants, C.I. Pigment Red 177, C.I. Pigment Orange 71, and C.I. Pigment Blue 15, elicited anti-androgenic effects with 20 % relative inhibitory concentrations (RIC<sub>20</sub>) of 13.08, 40.52, and 33.27 μg/mL, respectively. In addition, <em>in silico</em> toxicological models predicted the endocrine-disrupting activity of the 24 colorants, showing predictive accuracy ranging from 35 % to 100 % consistency with <em>in vitro</em> experimental outcomes. Molecular docking revealed strong binding affinity and mechanisms of interaction between three colorants and the human androgen receptor. In summary, this study combined <em>in vitro</em> experiments and <em>in silico</em> toxicological models to investigate the endocrine-disrupting effects of organic colorants with different structural types, providing new insights perspective on health risks associated with their use in FCMs.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115410"},"PeriodicalIF":3.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “RIFM fragrance ingredient safety assessment, vanillin isobutyrate, CAS Registry Number 20665-85-4” [Food Chem. Toxicol. 197 Supplement 1 (2024) 115141 ISSN 0278–6915] 《中国科学院登记号20665-85-4：异丁酸香兰素香料成分安全评价》[食品化学]的勘误表。毒物。197增刊1 (2024)115141 ISSN 0278-6915]

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-23 DOI: 10.1016/j.fct.2025.115393

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , M. Lavelle , I. Lee , H. Moustakas , Y. Tokura

引用次数: 0

Validation of an estrogen receptor dimerization(α-α/α-β/β-β) BRET-based biosensors for screening estrogenic endocrine-disrupting chemicals 雌激素受体二聚化（α-α/α-β/β-β） bret生物传感器筛选雌激素内分泌干扰物的验证。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-22 DOI: 10.1016/j.fct.2025.115391

Yong-Kook Kwon , Na-yeon Kim , Soomin Yum , Haksoo Lee , BuHyun Youn , Gunyoung Lee , Yeong Min Shin , Hye Young Lee

{"title":"Validation of an estrogen receptor dimerization(α-α/α-β/β-β) BRET-based biosensors for screening estrogenic endocrine-disrupting chemicals","authors":"Yong-Kook Kwon , Na-yeon Kim , Soomin Yum , Haksoo Lee , BuHyun Youn , Gunyoung Lee , Yeong Min Shin , Hye Young Lee","doi":"10.1016/j.fct.2025.115391","DOIUrl":"10.1016/j.fct.2025.115391","url":null,"abstract":"<div><div>We validated the reproducibility and accuracy of a previously developed assay for screening endocrine-disrupting chemicals (EDCs) based on estrogen receptor (ER) dimerization (α-α/α-β/β-β), following OECD GD34 guidelines, to assess its applicability across various laboratories. The inter- and intra-laboratory accuracy was evaluated using 22 validation substances (ICCVAM-recommended substances for validating <em>in vitro</em> ER-binding assays) with confirmed estrogenic activity in four independent laboratories. Intra-laboratory reproducibility for 22 chemicals was at least 95.5 % for ER α-α and β-β and 100 % for ER α-β, with mean values of 98.9 % (ER α-α), 100 % (ER α-β), and 98.9 % (ER β-β), respectively. The inter-laboratory qualitative reproducibility for ER α-α, ER α-β, and ER β-β was 100 %, 100 %, and 95.5 %, respectively. The validated results for the ER dimerization (α-α/α-β/β-β) assays were compared with the results (17 test chemicals) from the National Toxicology Program Interagency Center for Evaluation of Alternative Toxicological Methods (NICEATM), confirming the validity of the assay. The accuracies for ER α-α, α-β, β-β dimerization in cell were 88.2 %, 94.1 %, 88.2 %, respectively. Thus, ER dimerization assays demonstrated high intra- and inter-laboratory reproducibility and accuracy through this validation study. This suggests that the assay is a robust method for detecting ER dimerization within cells.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115391"},"PeriodicalIF":3.9,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effects of crocin against gentamicin-induced damage in rat testicular tissue: Modulating the levels of NF-κB/TLR-4 and Bax/Bcl-2/caspase-3 signaling pathways 藏红花素对庆大霉素诱导的大鼠睾丸组织损伤的保护作用：调节NF-κB/TLR-4和Bax/Bcl-2/Caspase-3信号通路的水平

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-22 DOI: 10.1016/j.fct.2025.115407

Tuba Dogan , Betul Apaydın Yıldırım , Kubra Asena Terim Kapakin , Metin Kiliçliogli , Esra Aktas Senocak

{"title":"Protective effects of crocin against gentamicin-induced damage in rat testicular tissue: Modulating the levels of NF-κB/TLR-4 and Bax/Bcl-2/caspase-3 signaling pathways","authors":"Tuba Dogan , Betul Apaydın Yıldırım , Kubra Asena Terim Kapakin , Metin Kiliçliogli , Esra Aktas Senocak","doi":"10.1016/j.fct.2025.115407","DOIUrl":"10.1016/j.fct.2025.115407","url":null,"abstract":"<div><div>This study investigated the protective effects of crocin (CRO) on gentamicin (GM)-induced testicular toxicity in adult rats, focusing on oxidative stress, apoptosis, and inflammatory pathways such as Nuclear Factor Kappa B (NF-κB)/Toll-Like Receptor 4 (TLR-4) and Bcl-2-associated X protein (Bax)/B-cell lymphoma 2 (Bcl-2)/Caspase-3. Thirty-six male Sprague Dawley rats were divided into six groups: saline only, 25 mg/kg CRO, 50 mg/kg CRO, 80 mg/kg GM, 80 mg/kg GM + 25 mg/kg CRO, 80 mg/kg GM + 50 mg/kg CRO. Treatments were administered intraperitoneally for 8 days. GM increased malondialdehyde (MDA) levels, ischemia-modified albumin (IMA) levels and reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities in testicular tissue, indicating oxidative stress. Histopathology showed testicular degeneration. It also elevated Bax, Caspase-3, NF-κB, and TLR-4 expression while decreasing Bcl-2 levels, promoting apoptosis and inflammation. CRO treatment counteracted these effects by enhancing antioxidant enzyme activity, restoring GSH levels, and reducing MDA. Furthermore, CRO exhibited antiapoptotic and anti-inflammatory properties by modulating Bax/Bcl-2 and Caspase-3, and downregulating NF-κB/TLR-4 pathways. This study underscores crocin's protective effects against gentamicin-induced testicular toxicity through the modulation of key signaling pathways, suggesting its potential as a therapeutic strategy for aminoglycoside-induced reproductive damage.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115407"},"PeriodicalIF":3.9,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glyphosate-based herbicide as a potential risk factor for breast cancer 草甘膦除草剂是乳腺癌的潜在危险因素。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-21 DOI: 10.1016/j.fct.2025.115404

Lyvia Neves Rebello Alves , Luiza Poppe Merigueti , Matheus Correia Casotti , Bruno Cancian de Araújo , Raquel Silva dos Reis Trabach , Maria do Carmo Pimentel Batitucci , Débora Dummer Meira , Flávia de Paula , Eldamária de Vargas Wolfgramm dos Santos , Iúri Drumond Louro

{"title":"Glyphosate-based herbicide as a potential risk factor for breast cancer","authors":"Lyvia Neves Rebello Alves , Luiza Poppe Merigueti , Matheus Correia Casotti , Bruno Cancian de Araújo , Raquel Silva dos Reis Trabach , Maria do Carmo Pimentel Batitucci , Débora Dummer Meira , Flávia de Paula , Eldamária de Vargas Wolfgramm dos Santos , Iúri Drumond Louro","doi":"10.1016/j.fct.2025.115404","DOIUrl":"10.1016/j.fct.2025.115404","url":null,"abstract":"<div><div>Breast cancer is the most common neoplasm in women worldwide, with both genetic and environmental factors playing a role in its development. Glyphosate, the active ingredient in widely used agricultural herbicides, is recognized as a potential carcinogen and endocrine disruptor, making it a candidate for inducing epigenetic modifications linked to breast cancer. This study investigates the effects of the glyphosate-based herbicide Roundup® on non-tumorigenic (MCF10A) and tumorigenic (MCF7 and MDA-MB-231) breast cell lines, focusing on the expression of key breast cancer-related genes. Additionally, the study examines the association with epigenetic modifications and the use of epidrugs to reverse potential alterations, aiming to understand the risks and mechanisms of herbicide action. Results indicate that Roundup® affects cells through a non-estrogenic mechanism, impacting both hormone-dependent and -independent cells with varying toxic and proliferative effects depending on dose and exposure time. Moreover, it altered the expression of breast cancer-related genes such as <em>BRCA1</em> and <em>BRCA2</em> at low doses. The use of epigenetic modulators was able to reverse some Roundup®-induced changes, suggesting the herbicide's role in epigenetic modifications. Overall, these findings highlight the importance of understanding glyphosate-based herbicide mechanisms in humans, which could enable personalized prevention strategies to mitigate breast cancer risks.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115404"},"PeriodicalIF":3.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0