Food and Chemical Toxicology最新文献_第7页

RIFM fragrance ingredient safety assessment, ethyl safranate, CAS registry number 35044-57-6 香料成分安全性评价，马红花酸乙酯，中国科学院登记号35044-57-6。

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2026-04-01 Epub Date: 2026-01-16 DOI: 10.1016/j.fct.2026.115959

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

RIFM Natural Complex Substance (NCS) fragrance ingredient safety assessment, laurel leaf oil, CAS Registry Number 8007-48-5, RIFM ID 476-E2.12 天然复合物质（NCS）香料成分安全性评价，月桂叶油，CAS注册号8007-48-5，RIFM ID 476-E2.12。

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2026-04-01 Epub Date: 2026-01-21 DOI: 10.1016/j.fct.2026.115948

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

Update to RIFM fragrance ingredient safety assessment, dihydrocarvyl acetate, CAS Registry Number 20777-49-5 更新RIFM香料成分安全性评估，醋酸二氢乙烯酯，CAS注册号20777-49-5。

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2026-04-01 Epub Date: 2026-01-14 DOI: 10.1016/j.fct.2026.115941

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

Perfluorooctanoic acid affects in vitro adipogenesis in murine preadipocytes acting as an inducer of hypertrophic adipocytes 全氟辛酸作为肥厚型脂肪细胞的诱导剂，影响小鼠前脂肪细胞的体外脂肪形成。

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2026-04-01 Epub Date: 2026-01-23 DOI: 10.1016/j.fct.2026.115977

Maria Sofia Molonia , Santi Trischitta , Giovanni Toscano , Federica Lina Salamone , Antonella Saija , Antonio Speciale , Francesco Cimino

{"title":"Perfluorooctanoic acid affects in vitro adipogenesis in murine preadipocytes acting as an inducer of hypertrophic adipocytes","authors":"Maria Sofia Molonia , Santi Trischitta , Giovanni Toscano , Federica Lina Salamone , Antonella Saija , Antonio Speciale , Francesco Cimino","doi":"10.1016/j.fct.2026.115977","DOIUrl":"10.1016/j.fct.2026.115977","url":null,"abstract":"<div><div>Peroxisome proliferator-activated receptor gamma (PPAR-γ) is a key regulator of adipose tissue expansion, coordinating adipocyte physiological differentiation and maturation. In this study we evaluated the PPAR-γ effects of perfluorooctanoic acid (PFOA), a perfluorinated alkylated environmental obesogen, associated with an increased risk of diabetes, during adipogenic differentiation of 3T3-L1 murine cells. In particular, using <em>in vitro</em> monoculture (differentiating preadipocytes exposed to PFOA) or co-culture systems (differentiating preadipocytes in contact with PFOA-induced dysfunctional mature adipocytes) we examined adipocytes morphology and biological functions such as adipogenesis, insulin sensitivity and lipolytic response to adrenergic compounds. Exposure to PFOA (0.1–10 μM) promoted adipocyte hypertrophy inducing the formation of larger lipid vacuoles. These effects were also evident in the co-culture system, where paracrine factors released by PFOA-induced hypertrophic adipocytes influenced preadipocytes differentiation. Furthermore, both in the mono-culture and in the co-culture systems, PFOA exposure induced a metabolically unhealthy adipocyte phenotype affecting insulin sensitivity. Finally, findings obtained in mono-culture system evidence that these effects induced by PFOA may be related to its capability to affect lipid metabolism and pro/anti-inflammatory adipokine expression. This study, therefore, draws attention on PFOA as an obesogenic factor promoting adipocyte metabolic dysregulation and dysfunctional paracrine signaling.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"210 ","pages":"Article 115977"},"PeriodicalIF":3.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146043685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RIFM fragrance ingredient safety assessment, methyl cinnamate, CAS Registry Number 103-26-4 香料成分安全性评价，肉桂酸甲酯，CAS注册号103-26-4。

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2026-04-01 Epub Date: 2026-01-19 DOI: 10.1016/j.fct.2026.115965

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

Update to RIFM fragrance ingredient safety assessment, isopropylphenylbutanal, CAS Registry Number 125109-85-5 更新RIFM香料成分安全评估，异丙基苯丁醛，CAS登记号125109-85-5。

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2026-04-01 Epub Date: 2026-01-19 DOI: 10.1016/j.fct.2026.115963

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

{"title":"Update to RIFM fragrance ingredient safety assessment, isopropylphenylbutanal, CAS Registry Number 125109-85-5","authors":"A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar","doi":"10.1016/j.fct.2026.115963","DOIUrl":"10.1016/j.fct.2026.115963","url":null,"abstract":"<div><h3>Summary</h3><div>The existing information supports the use of this material as described in this safety assessment.</div><div>Isopropylphenylbutanal was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety. Target data show that isopropylphenylbutanal is not genotoxic and provide a calculated Margin of Exposure (MOE) > 100 for the repeated dose toxicity endpoint. Data on read-across analog 2-methyl-3-(<em>p</em>-isopropylphenyl)propionaldehyde (CAS # 103-95-7) provide a calculated MOE >100 for the reproductive toxicity endpoint and a No Expected Sensitization Induction Level (NESIL) of 5900 μg/cm<sup>2</sup> for the skin sensitization endpoint. The photoirritation/photoallergenicity endpoints were evaluated based on data and ultraviolet (UV) spectra; isopropylphenylbutanal is not photoirritating/photoallergenic. The local respiratory toxicity endpoint was evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class I material, and the exposure to isopropylphenylbutanal is below the TTC (1.4 mg/day). The environmental endpoints were evaluated; isopropylphenylbutanal was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use (VoU) in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"210 ","pages":"Article 115963"},"PeriodicalIF":3.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146016986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Probabilistic biokinetic lead modeling to quantify relative contribution of chocolate bar intake to blood lead levels 概率生物动力学铅模型量化巧克力棒摄入对血铅水平的相对贡献。

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2026-04-01 Epub Date: 2026-01-25 DOI: 10.1016/j.fct.2026.115979

Stephanie A. Thornton, Taylor M. Mincin, Oluwadamilare A. Adebambo, Marisa L. Kreider, Kenneth M. Unice

{"title":"Probabilistic biokinetic lead modeling to quantify relative contribution of chocolate bar intake to blood lead levels","authors":"Stephanie A. Thornton, Taylor M. Mincin, Oluwadamilare A. Adebambo, Marisa L. Kreider, Kenneth M. Unice","doi":"10.1016/j.fct.2026.115979","DOIUrl":"10.1016/j.fct.2026.115979","url":null,"abstract":"<div><div>Toxicokinetic models inform relative contribution assessments of constituents detected through biomonitoring. In this study, the U.S. EPA All-Ages Lead Model was used to evaluate whether chocolate bar consumption in the U.S. substantially contributes to the variance in blood lead levels (BLLs). Both deterministic estimates and probabilistic (Monte Carlo) sensitivity analyses were considered with age-specific exposure factors. Central tendency exposure scenarios revealed that chocolate contributed approximately 0.3–0.8 % of total Pb intake and 0.5–0.7 % of Pb in blood. In plausible high-end exposure scenarios (approximately 50–75 % of a full-size chocolate bar daily), chocolate contributed approximately 3.1–6.5 % of BLLs. Probabilistic analyses showed that BLL exceedances of the CDC blood-lead reference value were primarily associated with high-end soil and/or dust concentrations. Sensitivity analyses confirmed that soil and dust contributed 37 % and 51 % respectively to BLL variance in young children, while chocolate contributed approximately 0.1 %. BLL changes associated with chocolate consumption are most likely less than current analytical precision limits for commonly administered BLL tests. The findings indicate that chocolate consumption at typical U.S. levels represents a small fraction of overall Pb exposure. Risk management strategies should prioritize reducing residential soil and dust Pb exposures, the likely dominant pathways for elevated BLLs in the general population.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"210 ","pages":"Article 115979"},"PeriodicalIF":3.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146058254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Food-drug interaction: Anabolic steroids aggravate hepatic lipotoxicity and nonalcoholic fatty liver disease induced by trans fatty acids” [Food Chem. Toxicol. 116 Part B (June 2018) Pages 360–368] “食品-药物相互作用：合成代谢类固醇加重反式脂肪酸引起的肝脂毒性和非酒精性脂肪肝”[食品化学]的更正。毒物。116部分B（2018年6月）页360-368]

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2026-04-01 Epub Date: 2026-01-28 DOI: 10.1016/j.fct.2026.115971

Jamili D.B. Santos , Andréa A.S. Mendonça , Rafaela C. Sousa , Thaiany G.S. Silva , Solange M. Bigonha , Eliziária C. Santos , Reggiani V. Gonçalves , Rômulo D. Novaes

引用次数: 0

RIFM fragrance ingredient safety assessment, cedryl methyl ether, CAS Registry Number 67874-81-1 香精香料成分安全性评价，雪松甲基醚，中国科学院登记号67874-81-1。

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2026-04-01 Epub Date: 2026-01-31 DOI: 10.1016/j.fct.2026.115973

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

Dual potential of tetrandrine: Antiangiogenic efficacy and safety liabilities revealed through in silico, in vitro, and zebrafish models 粉防己碱的双重潜力：通过硅、体外和斑马鱼模型揭示的抗血管生成功效和安全性。

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2026-04-01 Epub Date: 2026-01-20 DOI: 10.1016/j.fct.2026.115967

Shaira Shane M. Orencio , Oliver B. Villaflores , Ferry Saputra , Gilbert Audira , Chung-Der Hsiao , Ross D. Vasquez

{"title":"Dual potential of tetrandrine: Antiangiogenic efficacy and safety liabilities revealed through in silico, in vitro, and zebrafish models","authors":"Shaira Shane M. Orencio , Oliver B. Villaflores , Ferry Saputra , Gilbert Audira , Chung-Der Hsiao , Ross D. Vasquez","doi":"10.1016/j.fct.2026.115967","DOIUrl":"10.1016/j.fct.2026.115967","url":null,"abstract":"<div><div>Tetrandrine, a <em>Stephania</em>-derived bisbenzylisoquinoline alkaloid, shows anticancer activity; however, its mechanisms, cardiotoxicity, and developmental effects are poorly understood. This study investigated tetrandrine's antiangiogenic efficacy and safety liabilities using in silico, in vitro, and in vivo methods. We hypothesized multi-target antiangiogenic activity, but dose-dependent toxicities limiting its therapeutic window.</div><div>Molecular docking predicted strong binding to angiogenesis targets: EGFR, MMP-13, and SRPK1. ADMET modeling indicated favorable pharmacokinetics yet moderate toxicity risks, with ProTox-III flagging immunotoxicity. In silico predictions indicated developmentally sensitive adverse effects, mirrored in zebrafish by greater embryonic sensitivity. In vitro assays confirmed MMP-13 inhibition (IC<sub>50</sub> = 4.376 ppm). In zebrafish embryos, tetrandrine significantly reduced intersegmental vessel formation, confirming antiangiogenic potential, but revealed higher embryonic sensitivity, indicating a narrow therapeutic window. Cardiac assays showed concentration-dependent increases in heart rate and decreases in stroke volume, revealing cardiotoxicity. Sub-toxic doses preserved locomotor and exploratory activity, suggesting functional safety at lower exposures.</div><div>These findings highlight tetrandrine's dual profile: a promising natural antiangiogenic agent with demonstrable efficacy, yet with significant cardiotoxic and developmental liabilities. This study provides crucial mechanistic insight into both its therapeutic and toxicological actions, establishing a translational foundation for its further development.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"210 ","pages":"Article 115967"},"PeriodicalIF":3.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146027888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0