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Update to RIFM fragrance ingredient safety assessment, myristic acid, CAS Registry Number 544-63-8 更新RIFM香料成分安全性评估，肉豆蔻酸，CAS注册号544-63-8。
IF 3.5 3区 医学
Food and Chemical Toxicology Pub Date : 2026-04-01 Epub Date: 2025-12-04 DOI: 10.1016/j.fct.2025.115888
A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar
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引用次数: 0
RIFM fragrance ingredient safety assessment, dihydro-β-ionone, CAS registry number 17283-81-7 香料成分安全性评价，二氢β-离子酮，中国科学院登记号17283-81-7。
IF 3.5 3区 医学
Food and Chemical Toxicology Pub Date : 2026-04-01 Epub Date: 2026-01-17 DOI: 10.1016/j.fct.2026.115955
A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar
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引用次数: 0
Update to RIFM fragrance ingredient safety assessment, ethyl pyruvate, CAS registry number 617-35-6 更新RIFM香料成分安全性评估，丙酮酸乙酯，CAS注册号617-35-6。
IF 3.5 3区 医学
Food and Chemical Toxicology Pub Date : 2026-04-01 Epub Date: 2026-01-16 DOI: 10.1016/j.fct.2026.115954
A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar
{"title":"Update to RIFM fragrance ingredient safety assessment, ethyl pyruvate, CAS registry number 617-35-6","authors":"A.M. Api ,&nbsp;A. Bartlett ,&nbsp;D. Belsito ,&nbsp;D. Botelho ,&nbsp;M. Bruze ,&nbsp;A. Bryant-Friedrich ,&nbsp;G.A. Burton Jr. ,&nbsp;M.A. Cancellieri ,&nbsp;H. Chon ,&nbsp;M. Cronin ,&nbsp;S. Crotty ,&nbsp;M.L. Dagli ,&nbsp;W. Dekant ,&nbsp;C. Deodhar ,&nbsp;K. Farrell ,&nbsp;A.D. Fryer ,&nbsp;L. Jones ,&nbsp;K. Joshi ,&nbsp;A. Lapczynski ,&nbsp;D.L. Laskin ,&nbsp;Y. Thakkar","doi":"10.1016/j.fct.2026.115954","DOIUrl":"10.1016/j.fct.2026.115954","url":null,"abstract":"","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"210 ","pages":"Article 115954"},"PeriodicalIF":3.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145996702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RIFM Natural Complex Substance (NCS) fragrance ingredient safety assessment, thyme oil, red, CAS Registry Number 8007-46-3, RIFM ID 471.E2.12 天然复合物质（NCS）香料成分安全性评价，百里香油，红色，CAS注册号8007-46-3，RIFM ID 471.E2.12。
IF 3.5 3区 医学
Food and Chemical Toxicology Pub Date : 2026-04-01 Epub Date: 2026-01-16 DOI: 10.1016/j.fct.2026.115936
A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar
{"title":"RIFM Natural Complex Substance (NCS) fragrance ingredient safety assessment, thyme oil, red, CAS Registry Number 8007-46-3, RIFM ID 471.E2.12","authors":"A.M. Api ,&nbsp;A. Bartlett ,&nbsp;D. Belsito ,&nbsp;D. Botelho ,&nbsp;M. Bruze ,&nbsp;A. Bryant-Friedrich ,&nbsp;G.A. Burton Jr. ,&nbsp;M.A. Cancellieri ,&nbsp;H. Chon ,&nbsp;M. Cronin ,&nbsp;S. Crotty ,&nbsp;M.L. Dagli ,&nbsp;W. Dekant ,&nbsp;C. Deodhar ,&nbsp;K. Farrell ,&nbsp;A.D. Fryer ,&nbsp;L. Jones ,&nbsp;K. Joshi ,&nbsp;A. Lapczynski ,&nbsp;D.L. Laskin ,&nbsp;Y. Thakkar","doi":"10.1016/j.fct.2026.115936","DOIUrl":"10.1016/j.fct.2026.115936","url":null,"abstract":"","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"210 ","pages":"Article 115936"},"PeriodicalIF":3.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145996777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Update to RIFM fragrance ingredient safety assessment, 3-hexanone, CAS Registry Number 589-38-8 更新RIFM香料成分安全性评估，3-己酮，CAS注册号589-38-8。
IF 3.5 3区 医学
Food and Chemical Toxicology Pub Date : 2026-04-01 Epub Date: 2026-01-17 DOI: 10.1016/j.fct.2026.115960
A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar
{"title":"Update to RIFM fragrance ingredient safety assessment, 3-hexanone, CAS Registry Number 589-38-8","authors":"A.M. Api ,&nbsp;A. Bartlett ,&nbsp;D. Belsito ,&nbsp;D. Botelho ,&nbsp;M. Bruze ,&nbsp;A. Bryant-Friedrich ,&nbsp;G.A. Burton Jr. ,&nbsp;M.A. Cancellieri ,&nbsp;H. Chon ,&nbsp;M. Cronin ,&nbsp;S. Crotty ,&nbsp;M.L. Dagli ,&nbsp;W. Dekant ,&nbsp;C. Deodhar ,&nbsp;K. Farrell ,&nbsp;A.D. Fryer ,&nbsp;L. Jones ,&nbsp;K. Joshi ,&nbsp;A. Lapczynski ,&nbsp;D.L. Laskin ,&nbsp;Y. Thakkar","doi":"10.1016/j.fct.2026.115960","DOIUrl":"10.1016/j.fct.2026.115960","url":null,"abstract":"","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"210 ","pages":"Article 115960"},"PeriodicalIF":3.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146002803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RIFM Natural Complex Substance (NCS) fragrance ingredient safety assessment, laurel leaf oil, CAS Registry Number 8007-48-5, RIFM ID 476-E2.12 天然复合物质（NCS）香料成分安全性评价，月桂叶油，CAS注册号8007-48-5，RIFM ID 476-E2.12。
IF 3.5 3区 医学
Food and Chemical Toxicology Pub Date : 2026-04-01 Epub Date: 2026-01-21 DOI: 10.1016/j.fct.2026.115948
A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar
{"title":"RIFM Natural Complex Substance (NCS) fragrance ingredient safety assessment, laurel leaf oil, CAS Registry Number 8007-48-5, RIFM ID 476-E2.12","authors":"A.M. Api ,&nbsp;A. Bartlett ,&nbsp;D. Belsito ,&nbsp;D. Botelho ,&nbsp;M. Bruze ,&nbsp;A. Bryant-Friedrich ,&nbsp;G.A. Burton Jr. ,&nbsp;M.A. Cancellieri ,&nbsp;H. Chon ,&nbsp;M. Cronin ,&nbsp;S. Crotty ,&nbsp;M.L. Dagli ,&nbsp;W. Dekant ,&nbsp;C. Deodhar ,&nbsp;K. Farrell ,&nbsp;A.D. Fryer ,&nbsp;L. Jones ,&nbsp;K. Joshi ,&nbsp;A. Lapczynski ,&nbsp;D.L. Laskin ,&nbsp;Y. Thakkar","doi":"10.1016/j.fct.2026.115948","DOIUrl":"10.1016/j.fct.2026.115948","url":null,"abstract":"","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"210 ","pages":"Article 115948"},"PeriodicalIF":3.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146027920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RIFM fragrance ingredient safety assessment, ethyl safranate, CAS registry number 35044-57-6 香料成分安全性评价，马红花酸乙酯，中国科学院登记号35044-57-6。
IF 3.5 3区 医学
Food and Chemical Toxicology Pub Date : 2026-04-01 Epub Date: 2026-01-16 DOI: 10.1016/j.fct.2026.115959
A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar
{"title":"RIFM fragrance ingredient safety assessment, ethyl safranate, CAS registry number 35044-57-6","authors":"A.M. Api ,&nbsp;A. Bartlett ,&nbsp;D. Belsito ,&nbsp;D. Botelho ,&nbsp;M. Bruze ,&nbsp;A. Bryant-Friedrich ,&nbsp;G.A. Burton ,&nbsp;M.A. Cancellieri ,&nbsp;H. Chon ,&nbsp;M. Cronin ,&nbsp;S. Crotty ,&nbsp;M.L. Dagli ,&nbsp;W. Dekant ,&nbsp;C. Deodhar ,&nbsp;K. Farrell ,&nbsp;A.D. Fryer ,&nbsp;L. Jones ,&nbsp;K. Joshi ,&nbsp;A. Lapczynski ,&nbsp;D.L. Laskin ,&nbsp;Y. Thakkar","doi":"10.1016/j.fct.2026.115959","DOIUrl":"10.1016/j.fct.2026.115959","url":null,"abstract":"","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"210 ","pages":"Article 115959"},"PeriodicalIF":3.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145996734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Update to RIFM fragrance ingredient safety assessment, dihydrocarvyl acetate, CAS Registry Number 20777-49-5 更新RIFM香料成分安全性评估，醋酸二氢乙烯酯，CAS注册号20777-49-5。
IF 3.5 3区 医学
Food and Chemical Toxicology Pub Date : 2026-04-01 Epub Date: 2026-01-14 DOI: 10.1016/j.fct.2026.115941
A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar
{"title":"Update to RIFM fragrance ingredient safety assessment, dihydrocarvyl acetate, CAS Registry Number 20777-49-5","authors":"A.M. Api ,&nbsp;A. Bartlett ,&nbsp;D. Belsito ,&nbsp;D. Botelho ,&nbsp;M. Bruze ,&nbsp;A. Bryant-Friedrich ,&nbsp;G.A. Burton Jr. ,&nbsp;M.A. Cancellieri ,&nbsp;H. Chon ,&nbsp;M. Cronin ,&nbsp;S. Crotty ,&nbsp;M.L. Dagli ,&nbsp;W. Dekant ,&nbsp;C. Deodhar ,&nbsp;K. Farrell ,&nbsp;A.D. Fryer ,&nbsp;L. Jones ,&nbsp;K. Joshi ,&nbsp;A. Lapczynski ,&nbsp;D.L. Laskin ,&nbsp;Y. Thakkar","doi":"10.1016/j.fct.2026.115941","DOIUrl":"10.1016/j.fct.2026.115941","url":null,"abstract":"","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"210 ","pages":"Article 115941"},"PeriodicalIF":3.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145987443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perfluorooctanoic acid affects in vitro adipogenesis in murine preadipocytes acting as an inducer of hypertrophic adipocytes 全氟辛酸作为肥厚型脂肪细胞的诱导剂，影响小鼠前脂肪细胞的体外脂肪形成。
IF 3.5 3区 医学
Food and Chemical Toxicology Pub Date : 2026-04-01 Epub Date: 2026-01-23 DOI: 10.1016/j.fct.2026.115977
Maria Sofia Molonia , Santi Trischitta , Giovanni Toscano , Federica Lina Salamone , Antonella Saija , Antonio Speciale , Francesco Cimino
{"title":"Perfluorooctanoic acid affects in vitro adipogenesis in murine preadipocytes acting as an inducer of hypertrophic adipocytes","authors":"Maria Sofia Molonia ,&nbsp;Santi Trischitta ,&nbsp;Giovanni Toscano ,&nbsp;Federica Lina Salamone ,&nbsp;Antonella Saija ,&nbsp;Antonio Speciale ,&nbsp;Francesco Cimino","doi":"10.1016/j.fct.2026.115977","DOIUrl":"10.1016/j.fct.2026.115977","url":null,"abstract":"<div><div>Peroxisome proliferator-activated receptor gamma (PPAR-γ) is a key regulator of adipose tissue expansion, coordinating adipocyte physiological differentiation and maturation. In this study we evaluated the PPAR-γ effects of perfluorooctanoic acid (PFOA), a perfluorinated alkylated environmental obesogen, associated with an increased risk of diabetes, during adipogenic differentiation of 3T3-L1 murine cells. In particular, using <em>in vitro</em> monoculture (differentiating preadipocytes exposed to PFOA) or co-culture systems (differentiating preadipocytes in contact with PFOA-induced dysfunctional mature adipocytes) we examined adipocytes morphology and biological functions such as adipogenesis, insulin sensitivity and lipolytic response to adrenergic compounds. Exposure to PFOA (0.1–10 μM) promoted adipocyte hypertrophy inducing the formation of larger lipid vacuoles. These effects were also evident in the co-culture system, where paracrine factors released by PFOA-induced hypertrophic adipocytes influenced preadipocytes differentiation. Furthermore, both in the mono-culture and in the co-culture systems, PFOA exposure induced a metabolically unhealthy adipocyte phenotype affecting insulin sensitivity. Finally, findings obtained in mono-culture system evidence that these effects induced by PFOA may be related to its capability to affect lipid metabolism and pro/anti-inflammatory adipokine expression. This study, therefore, draws attention on PFOA as an obesogenic factor promoting adipocyte metabolic dysregulation and dysfunctional paracrine signaling.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"210 ","pages":"Article 115977"},"PeriodicalIF":3.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146043685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Update to RIFM fragrance ingredient safety assessment, γ-undecalactone, CAS Registry Number 104-67-6 更新RIFM香料成分安全性评估，γ-癸内酯，CAS注册号104-67-6
IF 3.5 3区 医学
Food and Chemical Toxicology Pub Date : 2026-04-01 Epub Date: 2025-11-25 DOI: 10.1016/j.fct.2025.115866
A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar
{"title":"Update to RIFM fragrance ingredient safety assessment, γ-undecalactone, CAS Registry Number 104-67-6","authors":"A.M. Api ,&nbsp;A. Bartlett ,&nbsp;D. Belsito ,&nbsp;D. Botelho ,&nbsp;M. Bruze ,&nbsp;A. Bryant-Friedrich ,&nbsp;G.A. Burton Jr. ,&nbsp;M.A. Cancellieri ,&nbsp;H. Chon ,&nbsp;M. Cronin ,&nbsp;S. Crotty ,&nbsp;M.L. Dagli ,&nbsp;W. Dekant ,&nbsp;C. Deodhar ,&nbsp;K. Farrell ,&nbsp;A.D. Fryer ,&nbsp;L. Jones ,&nbsp;K. Joshi ,&nbsp;A. Lapczynski ,&nbsp;D.L. Laskin ,&nbsp;Y. Thakkar","doi":"10.1016/j.fct.2025.115866","DOIUrl":"10.1016/j.fct.2025.115866","url":null,"abstract":"","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"210 ","pages":"Article 115866"},"PeriodicalIF":3.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145623184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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