Food and Chemical Toxicology最新文献_第6页

Risk assessment of aflatoxin exposure for consumers of in natura and blanched peanuts from Brazil from 2016 to 2019 2016年至2019年巴西天然花生和漂白花生消费者黄曲霉毒素暴露风险评估

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-05 DOI: 10.1016/j.fct.2025.115437

André Ribeiro da Silva , Elisabete Yurie Sataque Ono , Igor Massahiro de Souza Suguiura , Tuany Marin Pomini , Eiko Nakagawa Itano , Osamu Kawamura , Leonardo Fonseca Maciel , Elisa Yoko Hirooka

{"title":"Risk assessment of aflatoxin exposure for consumers of in natura and blanched peanuts from Brazil from 2016 to 2019","authors":"André Ribeiro da Silva , Elisabete Yurie Sataque Ono , Igor Massahiro de Souza Suguiura , Tuany Marin Pomini , Eiko Nakagawa Itano , Osamu Kawamura , Leonardo Fonseca Maciel , Elisa Yoko Hirooka","doi":"10.1016/j.fct.2025.115437","DOIUrl":"10.1016/j.fct.2025.115437","url":null,"abstract":"<div><div>Aflatoxins (AFs), carcinogenic secondary metabolites produced mainly by <em>Aspergillus flavus</em> and <em>A. parasiticus</em>, are frequently associated with the peanut chain worldwide, and affect grain quality, reducing the commercial value. Brazil is ranked as the third peanut producer in the American continent and the State of São Paulo produces 91 % of Brazilian peanuts, of which 80 % are exported to Russia, Algeria, South Africa and Poland. This study aimed to assess the risk of aflatoxin exposure for peanut consumers from Brazil. Aflatoxins in 426 peanut samples from a food industry located in the state of São Paulo, Brazil, belonging to three sequential crops (2016/17, n = 77; 2017/18, n = 150; 2018/19, n = 199) were analyzed by Immunoaffinity Column-fluorometry. Mean total AFs in positive samples ranged from 6.96 to 11.1 ng g<sup>−1</sup> (<em>in natura</em>, n = 363) and from 3.83 to 8.2 ng g<sup>−1</sup> (blanched, n = 63) in the peanut batches. The mean probable daily intake (PDI) of aflatoxins was 0.11 (2016/17), 0.06 (2017/18), and 0.12 ng kg<sup>−1</sup> body weight (bw) day<sup>−1</sup> (2018/19) for the Brazilian population. For countries that import Brazilian peanuts, the aflatoxin PDI ranged from 0.06 (Russia) to 0.19 ng kg <sup>˗1</sup> bw day <sup>˗1</sup> (Poland). MOE (margin of exposure) values ranged from 895 (Poland, 2018/19) to 2833 (Brazil and Russia, 2017/2018). Although the mean PDI values were lower than the provisional maximum tolerable daily intake of 1.0 ng kg <sup>˗1</sup> bw day <sup>˗1</sup>, MOE values indicated a possible health problem for the Brazilian population and for the populations in countries that import and consume Brazilian peanuts.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"201 ","pages":"Article 115437"},"PeriodicalIF":3.9,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RIFM fragrance ingredient safety assessment, lauryl alcohol, CAS Registry Number 112-53-8 RIFM香料成分安全性评估，十二烷基醇，CAS登记号112-53-8。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-04 DOI: 10.1016/j.fct.2025.115426

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

RIFM fragrance ingredient safety assessment, 1-tridecanol, CAS Registry Number 112-70-9 香料成分安全性评价，1-三十六醇，中国科学院登记号112-70-9。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-04 DOI: 10.1016/j.fct.2025.115434

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

RIFM fragrance ingredient safety assessment, ethyl maltol, CAS Registry Number 4940-11-8 香料成分安全性评价，乙基麦芽醇，中国科学院注册号4940-11-8。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-04 DOI: 10.1016/j.fct.2025.115424

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

RIFM fragrance ingredient safety assessment, hexyl alcohol, CAS Registry Number 111-27-3 RIFM 香料成分安全评估，己醇，化学文摘社登记号 111-27-3。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-04 DOI: 10.1016/j.fct.2025.115425

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

RIFM fragrance ingredient safety assessment, p-tolyl phenylacetate, CAS Registry Number 101-94-0 香料成分安全性评价，对苯乙酸甲酯，CAS登记号101-94-0。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-03 DOI: 10.1016/j.fct.2025.115423

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

Update to RIFM fragrance ingredient safety assessment, butyrophenone, CAS Registry Number 495-40-9 更新中国科学院登记号495-40-9的RIFM香料成分安全性评估，丁苯酮。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-03 DOI: 10.1016/j.fct.2025.115421

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

Editorial Note. 编辑的注意。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-03 DOI: 10.1016/j.fct.2025.115430

Matt Wright

引用次数: 0

Update to RIFM fragrance ingredient safety assessment, methyl decanoate, CAS Registry Number 110-42-9 RIFM 香料成分安全评估更新，癸酸甲酯，化学文摘社登记号 110-42-9。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-03 DOI: 10.1016/j.fct.2025.115420

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

Inhibiting fatty acid-binding protein 4 reverses inflammation and apoptosis in wasp sting-induced acute kidney injury 抑制脂肪酸结合蛋白4可逆转黄蜂蜇伤所致急性肾损伤的炎症和细胞凋亡

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-02 DOI: 10.1016/j.fct.2025.115428

Ling Li , Hai Yuan , Haoran Li , Rui Cheng , Zilin Zhou , Fengqi Hu , Liang Xu

{"title":"Inhibiting fatty acid-binding protein 4 reverses inflammation and apoptosis in wasp sting-induced acute kidney injury","authors":"Ling Li , Hai Yuan , Haoran Li , Rui Cheng , Zilin Zhou , Fengqi Hu , Liang Xu","doi":"10.1016/j.fct.2025.115428","DOIUrl":"10.1016/j.fct.2025.115428","url":null,"abstract":"<div><div>Fatty acid-binding protein 4 (FABP4) has been implicated in the pathogenesis of several forms of acute kidney injury (AKI), including rhabdomyolysis, ischemia/reperfusion, sepsis, and cisplatin-induced AKI. However, whether FABP4 inhibition confers a renoprotective effect in wasp sting-induced AKI remains unclear. Therefore, in this study, we investigated the role of FABP4 in wasp sting-induced AKI <em>in vivo</em> and <em>in vitro</em>. We assessed renal dysfunction, mitochondrial injury, cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling pathway-mediated inflammation, and apoptosis. FABP4 expression was significantly higher in wasp sting-induced models of AKI than in the control groups, and pharmacological inhibition of FABP4 attenuated renal dysfunction and tubular injury. Wasp sting-induced AKI was associated with mitochondrial damage induced by excessive mitochondrial fission, which was effectively mitigated by FABP4 inhibition. The FABP4 inhibitor reduced the release of mitochondrial DNA (mtDNA) and cytochrome c (Cyt-c) from damaged mitochondria. cGAS–STING activation induced by mtDNA was downregulated by FABP4 inhibition. Subsequently, inflammation and apoptosis in wasp sting-induced AKI were significantly alleviated, as evidenced by decreased levels of inflammatory mediators and apoptosis-related proteins. In conclusion, FABP4 was found to play a key role in the occurrence and progression of wasp sting-induced AKI.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115428"},"PeriodicalIF":3.9,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0