Food and Chemical Toxicology最新文献_第6页

Exposure to silver, aluminium, arsenic, cadmium, mercury, nickel and lead from food in Swedish children, adolescents and adults 瑞典儿童、青少年和成人从食物中接触银、铝、砷、镉、汞、镍和铅的情况。

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2025-09-06 DOI: 10.1016/j.fct.2025.115728

Helena Bjermo , Daniel Edgar , Sanna Lignell , Barbro Kollander

{"title":"Exposure to silver, aluminium, arsenic, cadmium, mercury, nickel and lead from food in Swedish children, adolescents and adults","authors":"Helena Bjermo , Daniel Edgar , Sanna Lignell , Barbro Kollander","doi":"10.1016/j.fct.2025.115728","DOIUrl":"10.1016/j.fct.2025.115728","url":null,"abstract":"<div><div>Total diet studies monitor exposure to contaminants from food. This study investigates the intakes of the harmful metals silver (Ag), aluminium (Al), arsenic (As), inorganic As, cadmium (Cd), mercury (Hg), nickel (Ni) and lead (Pb) in Swedish young children, adolescents and adults, and relate them to health-based guidance values (HBGV).</div><div>Whereas intakes of Ag and Al did not give rise to any concern for adverse health effects, most of the young children had intakes of inorganic As (≥97 %), Cd (≥71 %) and Ni (≥92 %, for acute effects) above the HBGV set by European Food Safety Authority. Some young children (2–3 %) also had higher intake of methyl-Hg (estimated by Hg from fish and eggs) than the HBGV. Whether the higher exposure to these metals during early childhood cause a greater risk of adverse health effects is unknown but our findings indicate that potential adverse health effects due to their exposure cannot be excluded. Hence, actions to reduce these intakes are desirable. Estimated intakes of Pb were below HBGV which partly disagree with blood Pb levels measured in previous studies, indicating that there are other important Pb sources than food.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"206 ","pages":"Article 115728"},"PeriodicalIF":3.5,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

South Asian cocktail disrupts testicular integrity, Steroidogenesis and Spermatogenesis by Targeting Steroidogenic Enzymes and germ cells via an Oxidative Stress Mediated Pathway 南亚鸡尾酒通过氧化应激介导的途径靶向类固醇生成酶和生殖细胞，破坏睾丸完整性、类固醇生成和精子发生。

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2025-09-06 DOI: 10.1016/j.fct.2025.115727

Moses Agbomhere HAMED , Victor Olukayode Ekundina , Linus Anderson Enye

{"title":"South Asian cocktail disrupts testicular integrity, Steroidogenesis and Spermatogenesis by Targeting Steroidogenic Enzymes and germ cells via an Oxidative Stress Mediated Pathway","authors":"Moses Agbomhere HAMED , Victor Olukayode Ekundina , Linus Anderson Enye","doi":"10.1016/j.fct.2025.115727","DOIUrl":"10.1016/j.fct.2025.115727","url":null,"abstract":"<div><div>Globally, the South Asian Cocktail (SAC), a substance of abuse, is becoming popular. The effects of SAC on male fertility are unknown; however, its component pharmaceuticals, such as codeine, rohypnol, and promethazine, have been linked to male infertility. Thus, this study assessed SAC's influence and putative mechanisms on male fertility among SAC consumers. Fifty adult male Wistar rats were randomly split into five groups (n = 10): control (5 ml D. H<sub>2</sub>0); codeine group (5 mg/kg), rohypnol (4 mg/kg), promethazine (50 mg/kg), and SAC group (codeine 5 mg/kg, rohypnol 4 mg/kg, and promethazine 50 mg/kg). The administration was via gavage for 56 days. Animals were sacrificed under intraperitoneal ketamine (4 mg/kg) and xylazine (40 mg/kg). We obtained blood samples via cardiac puncture and centrifuged them to obtain serum for biochemical analysis. We removed and weighed the testes, epididymis, prostate, and seminal vesicle. The samples were tested for oxidative stress markers, cytokines, and apoptotic markers using ELISA. There were elevated levels of oxidative stress, xanthine oxidase/uric acid levels, inflammation, and cell death resulting in compromised steroidogenesis and spermatogenesis and diminished sperm quality. This study revealed that SAC exposure might impair testicular function via oxidoreductase and TNF-α and IL1-β, and activation of caspase-3 signaling pathway.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"206 ","pages":"Article 115727"},"PeriodicalIF":3.5,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145013570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of cadmium and high fructose diet on metabolic and reproductive health in female CD-1 mice 镉和高果糖饮食对雌性CD-1小鼠代谢和生殖健康的影响

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2025-09-04 DOI: 10.1016/j.fct.2025.115726

Victoria R. Adams , Janice A. Dye , Micheal G. Narotsky , Makala L. Moore , Helen H. Nguyen , Aubrey L. Sasser , Kaberi P. Das , Lillian F. Strader , Joseph P. Pancras , Donna Hill , Chloe Davis , Wanda C. Williams , Rachel D. Grindstaff , William T. Padgett , Christopher Lau , Colette N. Miller

{"title":"The effects of cadmium and high fructose diet on metabolic and reproductive health in female CD-1 mice","authors":"Victoria R. Adams , Janice A. Dye , Micheal G. Narotsky , Makala L. Moore , Helen H. Nguyen , Aubrey L. Sasser , Kaberi P. Das , Lillian F. Strader , Joseph P. Pancras , Donna Hill , Chloe Davis , Wanda C. Williams , Rachel D. Grindstaff , William T. Padgett , Christopher Lau , Colette N. Miller","doi":"10.1016/j.fct.2025.115726","DOIUrl":"10.1016/j.fct.2025.115726","url":null,"abstract":"<div><h3>Background</h3><div>Evaluation of the combined effects of endocrine-disrupting chemicals and dietary factors provides critical information for cumulative health risk assessment. Herein, we investigated the effects of cadmium (Cd) exposure and high fructose (HFr) diet on metabolic and reproductive health in female mice.</div></div><div><h3>Methods</h3><div>Female CD-1 mice were exposed to cadmium chloride (CdCl<sub>2</sub>) (0.0 ppm, 0.5 ppm, or 5.0 ppm) in drinking water with or without 59 % high fructose (HFr) diet for 7.5 weeks. Body composition, serum chemistry, hepatic lipid composition and gene expression were evaluated for metabolic disruption. To assess reproductive health, steroid hormones and estrous cyclicity were measured.</div></div><div><h3>Results</h3><div>The combination of Cd and HFr diet did not alter body composition, adipokines, nor circulating lipids. Conversely, this combination exacerbated the independent Cd- and HFr diet–induced reductions in serum IL-1β. HFr diet drove the bulk of the effects on surveyed metabolic endpoints irrespective of Cd exposure. However, both Cd and HFr diet independently reduced serum estradiol and interfered with estrous cyclicity.</div></div><div><h3>Conclusion</h3><div>These results suggest that, at least for metabolic outcomes in females, HFr diet is the main driver of adverse effects. While limited interaction between these exposures was present, both stressors equally disrupted reproductive health endpoints in female mice.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"206 ","pages":"Article 115726"},"PeriodicalIF":3.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145004511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Update to RIFM fragrance ingredient safety assessment, 4,4a,5,9b-tetrahydroindeno[1,2-d]-1,3-dioxine, CAS Registry Number 18096-62-3 更新RIFM香料成分安全性评价，4,4a,5,9b-四氢茚[1,2-d]-1,3-二恶英，CAS注册号18096-62-3。

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2025-09-03 DOI: 10.1016/j.fct.2025.115720

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

Risk assessment from potential exposure to tetrabromobisphenol A (TBBPA) from its use in electronics 四溴双酚A （TBBPA）在电子产品中的潜在暴露风险评估

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2025-09-03 DOI: 10.1016/j.fct.2025.115724

T.G. Osimitz, W. Droege

{"title":"Risk assessment from potential exposure to tetrabromobisphenol A (TBBPA) from its use in electronics","authors":"T.G. Osimitz, W. Droege","doi":"10.1016/j.fct.2025.115724","DOIUrl":"10.1016/j.fct.2025.115724","url":null,"abstract":"<div><div>Tetrabromobisphenol A (TBBPA) is the most extensively used brominated flame retardant worldwide, primarily employed reactively in printed circuit boards and additively in plastic housings of electronic equipment. This study systematically evaluates human exposure to TBBPA from electronic devices and characterizes associated risks. A targeted literature review of 55 peer-reviewed studies published over the past 25 years was conducted, focusing on global TBBPA occurrence in environmental media, occupational and residential settings, and biological matrices. Exposure pathways assessed include dermal contact dust ingestion, and inhalation. Quantitative exposure estimates were generated or extracted where available and compared against established toxicological reference values, including the European Food Safety Authority (EFSA) tolerable daily intake (TDI) of 0.7 μg/kg body weight/day and a derived oral Reference Dose (RfD) of 0.26 mg/kg/day for cancer. Hazard Quotients (HQs) calculated across all exposure scenarios, including high-exposure e-waste settings, remained well below 1 indicating a low likelihood of adverse health effects. Likewise, a basic deterministic aggregate exposure assessment shows that upper bound exposure estimates for both an office worker and a worker in an electronics dismantling facility result in the Hazard Index (HI) < 1. Despite methodological variability and inherent uncertainties in exposure attribution, this risk assessment demonstrates that current exposures to TBBPA likely originating from electronic equipment are not of toxicological concern.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"206 ","pages":"Article 115724"},"PeriodicalIF":3.5,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145005635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the toxicological network of bleomycin-induced pulmonary fibrosis: The role of long non-coding RNAs 探索博莱霉素诱导肺纤维化的毒理学网络：长链非编码rna的作用

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2025-09-03 DOI: 10.1016/j.fct.2025.115723

Bingxin Li, Hongbin Shi, Yun Ma, Ruining Zhao, Haijun Zhang

{"title":"Exploring the toxicological network of bleomycin-induced pulmonary fibrosis: The role of long non-coding RNAs","authors":"Bingxin Li, Hongbin Shi, Yun Ma, Ruining Zhao, Haijun Zhang","doi":"10.1016/j.fct.2025.115723","DOIUrl":"10.1016/j.fct.2025.115723","url":null,"abstract":"<div><div>Bleomycin (BLM) is an effective anticancer agent; however, its clinical use is limited by its tendency to induce pulmonary fibrosis (PF), a complication whose molecular mechanisms remain unclear. In this study, we established a BLM-induced C57BL/6 mouse model of PF and applied total RNA-seq in combination with network toxicology approaches to investigate the role of long noncoding RNAs (lncRNAs) in this process. The lncRNA Xist was identified as a hub node in the network, regulating the expression of its target Mmp25 via interaction with miR-34a-5p and miR-449c-5p. Further Gene Ontology and KEGG pathway analyses suggested that BLM may promote PF by modulating the TGF-β signaling pathway. Importantly, siRNA-mediated knockdown of Xist in vitro significantly attenuated BLM-induced cellular injury and suppressed TGF-β pathway activation, confirming its functional involvement. These findings provide novel insights into the molecular basis of BLM-induced PF from an lncRNA perspective and highlight Xist as a potential therapeutic target for mitigating the drug's pulmonary toxicity.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"206 ","pages":"Article 115723"},"PeriodicalIF":3.5,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144996831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polyethylene Terephthalate Microplastics Induce Immune Evasion and Malignant Remodeling in Breast Cancer Through Multi-Omics-Identified Immune Checkpoints 聚对苯二甲酸乙二醇酯微塑料通过多组学鉴定的免疫检查点诱导乳腺癌的免疫逃避和恶性重塑

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2025-09-03 DOI: 10.1016/j.fct.2025.115725

Ying-chuan Yin , Wang Zhang , Jing He , Chong-xin He , Peng Xu

{"title":"Polyethylene Terephthalate Microplastics Induce Immune Evasion and Malignant Remodeling in Breast Cancer Through Multi-Omics-Identified Immune Checkpoints","authors":"Ying-chuan Yin , Wang Zhang , Jing He , Chong-xin He , Peng Xu","doi":"10.1016/j.fct.2025.115725","DOIUrl":"10.1016/j.fct.2025.115725","url":null,"abstract":"<div><div>Polyethylene terephthalate (PET) microplastics (MPs) have emerged as a significant environmental contaminant with potential adverse effects on human health, particularly in cancer biology. This study investigates the molecular and immunological mechanisms underlying the influence of PET-MPs on breast cancer (BC) progression. Employing an integrative approach that combines bioinformatics analysis of public cancer databases (TCGA), molecular docking simulations, and in vitro experiments, we identified four immune-related genes—CCL19, KLRB1, CD40LG, and IGLL5—that are potentially modulated by PET-MPs. Molecular docking indicated that bis(2-hydroxyethyl) terephthalate (BHET), a key PET oligomer, binds with high affinity to these proteins, suggesting that PET-MPs may alter immune homeostasis within the tumor microenvironment (TME). Additionally, PET-MPs induced a pro-inflammatory cytokine response, including elevated IL-6 and TNF-α secretion, which could promote tumor progression. Our findings further suggest that PET-MPs may enhance BC cell proliferation and survival through immune modulation. However, limitations include the lack of immune cell co-culture models and in vivo validation. This study provides essential insights into the immunotoxicity of PET-MPs and highlights the need for further research to explore their direct and indirect effects on cancer development.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"206 ","pages":"Article 115725"},"PeriodicalIF":3.5,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145004510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Update to RIFM fragrance ingredient safety assessment, 3-phenyl-1-propanol, CAS Registry Number 122-97-4 更新RIFM香料成分安全性评估，3-苯基-1-丙醇，CAS注册号122-97-4。

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2025-09-02 DOI: 10.1016/j.fct.2025.115721

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

Epigenetic transgenerational effects of prenatal exposure to 2,2′,4,4′-tetrabromodiphenyl ether on sperm function and DNA methylation in rat offspring 产前暴露于2,2 ',4,4 ' -四溴联苯醚对大鼠后代精子功能和DNA甲基化的表观遗传跨代影响

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2025-08-30 DOI: 10.1016/j.fct.2025.115716

Ching-Shu Lai , Wei-Cheng Hsu , Jenq-Renn Chen , Bing-Mu Hsu , Kuo-Hsin Lee , Ping-Hsun Wu , Ping-Chi Hsu

{"title":"Epigenetic transgenerational effects of prenatal exposure to 2,2′,4,4′-tetrabromodiphenyl ether on sperm function and DNA methylation in rat offspring","authors":"Ching-Shu Lai , Wei-Cheng Hsu , Jenq-Renn Chen , Bing-Mu Hsu , Kuo-Hsin Lee , Ping-Hsun Wu , Ping-Chi Hsu","doi":"10.1016/j.fct.2025.115716","DOIUrl":"10.1016/j.fct.2025.115716","url":null,"abstract":"<div><div>The global production and use of polybrominated diphenyl ethers, including 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47), have been substantially curtailed in recent decades. However, BDE-47 remains ubiquitously detectable in environmental matrices and human tissues worldwide. In this study, we investigated whether prenatal exposure to BDE-47 disrupts sperm function and DNA methylation in rat offspring. Pregnant rats were treated with BDE-47 from gestational day 0 to parturition. Sperm count, motility, morphology, mitochondrial membrane potential (MMP), reactive oxygen species (ROS) production, sperm chromatin DNA fragmentation index (DFI), serum testosterone, and histopathology were evaluated across generations. Testicular DNA methyltransferase expression and whole-genome bisulfite sequencing were performed to determine the DNA methylation in the F3 generation. BDE-47 exposure altered anogenital distance (AGD), sperm count, motility, morphology, MMP, ROS production, mean DFI, and %DFI in the F1 generation; AGD, morphology, and ROS production in the F2 generation; and AGD, motility, morphology, MMP, ROS production, mean DFI, %DFI, and testicular DNA methyltransferase expression in the F3 generation. Gene ontology analysis revealed that <em>SYCP2</em>, <em>ASMT</em>, and <em>MSH4</em> were associated with sex differentiation and reproductive development. Our findings indicate that prenatal exposure to BDE-47 exerts transgenerational epigenetic effects, inducing phenotypic changes in the male reproductive system.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"205 ","pages":"Article 115716"},"PeriodicalIF":3.5,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144921903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Substance depletion of monoterpenes in the mouse lymphoma assay: Quantification, impact and mitigation 单萜烯在小鼠淋巴瘤试验中的物质消耗：定量、影响和缓解

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2025-08-30 DOI: 10.1016/j.fct.2025.115722

Tobias Karl Jochum, Simone Stegmüller, Elke Richling

{"title":"Substance depletion of monoterpenes in the mouse lymphoma assay: Quantification, impact and mitigation","authors":"Tobias Karl Jochum, Simone Stegmüller, Elke Richling","doi":"10.1016/j.fct.2025.115722","DOIUrl":"10.1016/j.fct.2025.115722","url":null,"abstract":"<div><div>For test substances with unfavorable physicochemical properties, different pathways of substance depletion such as volatilization or sorption to polymers or serum constituents can decrease the bioavailable fraction during <em>in vitro</em> toxicity testing. If not accounted for, this can lead to underestimated toxicity or even false-negative results. Therefore a thorough understanding of the <em>in vitro</em> test system as well as potential pitfalls and analytical confirmation of substance concentrations are required for reliable results. Here, we investigated the genotoxicity of the monoterpenes (<em>R</em>)-(+)-limonene (<em>R</em>LIM) and β-myrcene (βMYR), the monoterpene alcohol (±)-linalool (LIN) and the known volatile mutagen 1-bromopopane (1-BP) in the mouse lymphoma assay (MLA) and quantified the exposure concentrations. Additionally, a headspace (HS)-free incubation setup is presented which allows for sufficient exposure of suspension cells with volatile test substances. <em>R</em>Lim, βMYR and 1-BP, showed rapid and quantitative evaporation during incubation, potentially confounding the outcome of the genotoxicity test which could be minimized in the HS-free incubation setup. Furthermore, extensive binding of <em>R</em>LIM and βMYR to serum constituents was shown to decrease bioavailability during HS-free incubation. While the HS-free incubation setup increased the sensitivity of the MLA for volatile genotoxins, no signs for mutagenicity were observed for the monoterpenes, underscoring their safety.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"206 ","pages":"Article 115722"},"PeriodicalIF":3.5,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144932680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0