Food and Chemical Toxicology最新文献_第5页

Short-chain chlorinated paraffins induce hippocampal damage and glycerophospholipids disruption contributing to neurobehavioral deficits in mice 短链氯化石蜡诱导海马损伤和甘油磷脂破坏，导致小鼠神经行为缺陷

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-10 DOI: 10.1016/j.fct.2025.115444

Xi Ma , Wenzhu Wang , Qingju Mao

{"title":"Short-chain chlorinated paraffins induce hippocampal damage and glycerophospholipids disruption contributing to neurobehavioral deficits in mice","authors":"Xi Ma , Wenzhu Wang , Qingju Mao","doi":"10.1016/j.fct.2025.115444","DOIUrl":"10.1016/j.fct.2025.115444","url":null,"abstract":"<div><div>Short-chain chlorinated paraffins (SCCPs), a class of widely used industrial chemicals, have raised significant health concerns due to their persistence, bioaccumulation, and potential neurotoxicity. This study investigated the neurotoxic effects of SCCPs on the hippocampus and their impact on brain glycerophospholipid metabolism in mice. Behavioral tests revealed that 50 mg/kg SCCPs exposure significantly reduced spontaneous activity and impaired learning and memory. Pathological examination showed neuronal damage, including nuclear pyknosis and cytoplasmic vacuolization, in the hippocampus. Biochemical analyses indicated elevated oxidative stress markers (reactive oxygen species, malondialdehyde) and decreased antioxidant levels (glutathione, superoxide dismutase), alongside reduced levels of neurotransmitters (5-Hydroxytryptamine, dopamine, brain-derived neurotrophic factor). Lipidomics analysis identified significant alterations in glycerophospholipid metabolites, such as decreased levels of phosphatidylcholine and phosphatidylserine. Immunohistochemistry demonstrated downregulation of tight junction proteins (Claudin-1, ZO-1), suggesting blood-brain barrier disruption. These findings highlight SCCPs’ potential to induce hippocampal oxidative stress, neurotransmitter dysregulation, decreased claudin-1 expression and glycerophospholipid metabolism disruption, contributing to neurobehavioral deficits. This study provides insights into the mechanisms of SCCPs-induced neurotoxicity and emphasizes their potential implications for brain health.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"201 ","pages":"Article 115444"},"PeriodicalIF":3.9,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined quercetin with phosphodiesterase inhibitors; sildenafil and pentoxifylline alleviated CCl4-induced chronic hepatic fibrosis: Role of redox-sensitive pathways 槲皮素联合磷酸二酯酶抑制剂；西地那非和己酮茶碱减轻ccl4诱导的慢性肝纤维化：氧化还原敏感通路的作用

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-10 DOI: 10.1016/j.fct.2025.115442

Gehad Nasr , Doaa Mohamed Elroby Ali , Michael A. Fawzy , Fares E.M. Ali , Moustafa Fathy

{"title":"Combined quercetin with phosphodiesterase inhibitors; sildenafil and pentoxifylline alleviated CCl4-induced chronic hepatic fibrosis: Role of redox-sensitive pathways","authors":"Gehad Nasr , Doaa Mohamed Elroby Ali , Michael A. Fawzy , Fares E.M. Ali , Moustafa Fathy","doi":"10.1016/j.fct.2025.115442","DOIUrl":"10.1016/j.fct.2025.115442","url":null,"abstract":"<div><div>Liver fibrosis is a common pathological condition that is caused by complicated molecular and cellular processes. This study evaluated the therapeutic potential of combined quercetin (QU) with either sildenafil (Sild) or pentoxifylline (PTX) in chronic carbon tetrachloride (CCl4)-induced liver fibrosis in Wistar albino rats. Fibrosis was induced by CCl<sub>4</sub> injections (1.5 mg/kg, i.p.) three times weekly for 10 weeks. After six weeks, rats received oral QU (50 mg/kg/day), Sild (50 mg/kg/day), or PTX (10 mg/kg twice/day) individually or in combination for the remaining four weeks. Results showed significant alterations in liver biochemical markers, histopathology, oxidative stress, inflammation, apoptosis, and hypoxic responses due to CCl<sub>4</sub> exposure. These changes included reduced expression of Nrf-2, HO-1, and cytoglobin, alongside increased levels of NF-κB, cleaved caspase-3, TNF-α, IL-1β, and HIF-1. Notably, QU, Sild, and PTX, individually or in combination, improved these parameters. The combination of QU with Sild or PTX proved more effective than single treatments, modulating anti-oxidant (Nrf2/HO-1/cytoglobin), anti-inflammatory (NF-κB/TNF-α), and hypoxic signaling pathways (HIF-1α). In conclusion, QU combined with phosphodiesterase inhibitors shows promise as a therapy for liver fibrosis, offering enhanced protection through anti-oxidants and anti-inflammatory mechanisms.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"201 ","pages":"Article 115442"},"PeriodicalIF":3.9,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RIFM fragrance ingredient safety assessment, N-benzoylanthranilic acid, CAS Registry Number 579-93-1 香料成分安全性评价，n -苯甲酰氨基苯甲酸，中国科学院注册号579-93-1

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-09 DOI: 10.1016/j.fct.2025.115432

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

Bavachinin causes cholestasis by down-regulating BAAT expression and disrupting glycocholic acid synthesis in human liver organoids 巴伐利亚蛋白通过下调人肝类器官中BAAT的表达和破坏糖胆酸的合成而引起胆汁淤滞

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-09 DOI: 10.1016/j.fct.2025.115438

Xue Wang , Yu Su , Xiaomeng Chen , Lin Liu , Xinyan Zhao , Jidong Jia

{"title":"Bavachinin causes cholestasis by down-regulating BAAT expression and disrupting glycocholic acid synthesis in human liver organoids","authors":"Xue Wang , Yu Su , Xiaomeng Chen , Lin Liu , Xinyan Zhao , Jidong Jia","doi":"10.1016/j.fct.2025.115438","DOIUrl":"10.1016/j.fct.2025.115438","url":null,"abstract":"<div><div>Psoraleae Fructus (Bu Gu Zhi, BGZ) is extensively utilized for dermatological and osseous disorders in China. BGZ-induced liver injury has become one of the major concerns, which predominantly cause cholestasis, with the pathogenesis not being fully elucidated. Currently, studies on hepatotoxic mechanisms of BGZ have mainly been conducted on 2D cell culture systems or rodent models, which may not fully encapsulate human pathophysiology. Therefore, we generated human liver organoids (HLOs) from healthy donor(s) for living-related liver transplantation to explore the hepatotoxic mechanism. We identified bavachinin (BVC) as the most hepatotoxic component for cholestasis. After validating by CLF tests, we identified BVC caused cholestasis by down-regulating <em>BAAT</em>, which catalyzes the amidation of bile acids. We also found that up-regulating BAAT with harmaline could mitigate cholestasis and enhance cell viabilities in HLOs. We further demonstrated that glycocholic acid (GCA) levels decreased in BVC-treated HLOs. Supplementation of GCA to BVC-treated HLOs significantly improved cell viabilities. Collectively, our data suggested that BVC impaired the GCA synthesis by down-regulating the expression of <em>BAAT</em>, thereby inducing cholestasis.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"201 ","pages":"Article 115438"},"PeriodicalIF":3.9,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RIFM fragrance ingredient safety assessment, undecyl alcohol, CAS Registry Number 112-42-5 香料成分安全性评价，十一烷基醇，中国科学院登记号112-42-5

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-08 DOI: 10.1016/j.fct.2025.115433

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

Applying Monte Carlo simulation to assess health risks of potentially toxic elements in fruits and nuts grown in the capital of Iran 应用蒙特卡罗模拟评估在伊朗首都种植的水果和坚果中潜在有毒元素的健康风险

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-07 DOI: 10.1016/j.fct.2025.115431

Maryam Hydarian , Azadeh Kazemi , Zohreh Ahmadi , Afsane Chavoshani , Elaheh Ghanbari , Ali Kazemi , Amin Mohammadpour

{"title":"Applying Monte Carlo simulation to assess health risks of potentially toxic elements in fruits and nuts grown in the capital of Iran","authors":"Maryam Hydarian , Azadeh Kazemi , Zohreh Ahmadi , Afsane Chavoshani , Elaheh Ghanbari , Ali Kazemi , Amin Mohammadpour","doi":"10.1016/j.fct.2025.115431","DOIUrl":"10.1016/j.fct.2025.115431","url":null,"abstract":"<div><div>This study investigated harmful elements (PHEs) in three fruits (figs, oranges, persimmons) and two nuts (walnuts, hazelnuts) grown in Tehran, Iran, using inductively coupled plasma mass spectrometry (ICP-MS) to evaluate health risks. The results showed that chromium (Cr) exceeded the 0.1 mg/kg standard in walnuts (mean = 6.15 mg/kg) and figs (mean = 5.23 mg/kg). Copper (Cu) surpassed 2 mg/kg in all produce except figs. Arsenic (As) exceeded the standard in walnuts, persimmons, and oranges, while cadmium (Cd) surpassed the limit only in persimmons. Iron (Fe) levels were significantly high, peaking in persimmons (mean = 71.79 mg/kg). Lead (Pb), manganese (Mn), and mercury (Hg) exceeded safety limits in all samples, while barium (Ba) was the most abundant metal, especially in hazelnuts and oranges. The correlation and clustering analysis indicated that the sources of PHEs may be influenced by a combination of agricultural practices, atmospheric transport, traffic emissions, historical pollution, and natural background levels. Monte Carlo simulation results show Pb poses the highest non-carcinogenic risk for children (TTHQ<sub>50th</sub>: 12.56) and adults (TTHQ<sub>50th</sub>: 5.62). Ni presents the highest carcinogenic risk (TCR<sub>50th</sub>: 1.58E-03 for children, 3.50E-03 for adults. Hence, urgent monitoring of PHEs in local produce is essential.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"201 ","pages":"Article 115431"},"PeriodicalIF":3.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143825760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glyphosate exposure impairs glucose and lipid metabolism by disturbing the circadian clock system in mice liver 草甘膦暴露通过扰乱小鼠肝脏生物钟系统损害糖脂代谢

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-07 DOI: 10.1016/j.fct.2025.115436

Bonan Xiao , Haizhen Jiang , Hao Dong , Chao Li , Haisen Zhang , Dengke Gao , Aihua Wang , Yaping Jin , Huatao Chen

{"title":"Glyphosate exposure impairs glucose and lipid metabolism by disturbing the circadian clock system in mice liver","authors":"Bonan Xiao , Haizhen Jiang , Hao Dong , Chao Li , Haisen Zhang , Dengke Gao , Aihua Wang , Yaping Jin , Huatao Chen","doi":"10.1016/j.fct.2025.115436","DOIUrl":"10.1016/j.fct.2025.115436","url":null,"abstract":"<div><div>Glyphosate, the most extensively applied organophosphonate herbicide, poses risks to aquatic ecosystems and potentially compromises human health via dietary exposure. Although toxicological assessments have confirmed glyphosate-induced hepatotoxicity in mammalian systems, the cellular pathogenesis involving metabolic disruption warrants further mechanistic investigation. This study aimed to elucidate the effect of glyphosate exposure on hepatic glucose/lipid metabolism and its association with circadian clock disruption using murine hepatocytes (AML12) and mice models. Time-course analysis revealed that glyphosate exposure significantly suppressed core circadian and metabolic transcripts in AML12 hepatocytes, with corresponding reduction in NR1D1 protein level. Longitudinal locomotor activity monitoring revealed that glyphosate exposure caused photophase-specific hyperlocomotion and circadian period elongation in mice. Glyphosate exposure elicited marked depletion of hepatic glycogen reserves and serum total cholesterol concentrations. Notably, glyphosate also disrupted the expression of hepatic metabolic genes, paralleled by alterations of circadian clock genes expression at both mRNA and protein levels in mice. Additionally, <em>Hmgcr</em> and <em>Glut2</em> mRNA levels were significantly decreased in <em>Bmal1</em><sup>−/−</sup> AML12 cells compared to their control groups, no further significant reduction was detected in <em>Bmal1</em><sup>−/−</sup> AML12 cells with glyphosate exposure. Collectively, the current study demonstrated that glyphosate exposure impairs glucose and lipid metabolism by disturbing the circadian clock system.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"201 ","pages":"Article 115436"},"PeriodicalIF":3.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143823948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The reno-protective effect of Empagliflozin against carbon tetrachloride (CCl4)-induced nephrotoxicity in mice halting JNK/MKK4/NRF2/NF-KB pathway Empagliflozin阻止JNK/MKK4/NRF2/NF-KB通路对四氯化碳（CCl4）诱导的小鼠肾毒性的肾保护作用

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-07 DOI: 10.1016/j.fct.2025.115439

Amany A. Alzokaky , Shimaa K. Saber , Mennatallah O. Zaki

{"title":"The reno-protective effect of Empagliflozin against carbon tetrachloride (CCl4)-induced nephrotoxicity in mice halting JNK/MKK4/NRF2/NF-KB pathway","authors":"Amany A. Alzokaky , Shimaa K. Saber , Mennatallah O. Zaki","doi":"10.1016/j.fct.2025.115439","DOIUrl":"10.1016/j.fct.2025.115439","url":null,"abstract":"<div><h3>Aim</h3><div>This study designed to evaluate the reno-protective effects of Empagliflozin (EMPA), a sodium-glucose co-transporter 2 (SGLT2) inhibitor, against carbon tetrachloride (CCl4)-induced nephrotoxicity in mice targeting JNK/MKK4/NRF2/NF-KB pathway.</div></div><div><h3>Methods</h3><div>Male albino mice were given EMPA (10 mg/kg, orally) for 4 weeks prior to a single i.p. injection of 10 % CCl4 (20 ml/kg). Mice were sacrificed 48 h post CCl4 injection.</div></div><div><h3>Key findings</h3><div>EMPA attenuated CCl4-induced renal injury, as reflected by a decrease in serum urea and creatinine levels, also preserved the histological integrity of kidney tissue. Theses reno-protective effects of EMPA can be mainly due to its <strong>1.</strong> Antioxidant, (↑CAT, ↑SOD, ↑Nrf-2 and ↑ARE), <strong>2.</strong> Anti-inflammatory (↓NF-κB and ↓TNF-α) and <strong>3.</strong> Anti-apoptotic (↓Caspase-3) proprieties. EMPA also inhibited JNK/MKK4 signaling pathway, which plays a critical role in kidney damage.</div></div><div><h3>Conclusion</h3><div>These finding confirm the reno-protective effect of EMPA with a modulatory impact on JNK/MKK4/Nrf2/NF-κB signaling network; suggesting its therapeutic utility to minimize acute kidney injury (AKI) in clinical setting in the future.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"201 ","pages":"Article 115439"},"PeriodicalIF":3.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk assessment of aflatoxin exposure for consumers of in natura and blanched peanuts from Brazil from 2016 to 2019 2016年至2019年巴西天然花生和漂白花生消费者黄曲霉毒素暴露风险评估

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-05 DOI: 10.1016/j.fct.2025.115437

André Ribeiro da Silva , Elisabete Yurie Sataque Ono , Igor Massahiro de Souza Suguiura , Tuany Marin Pomini , Eiko Nakagawa Itano , Osamu Kawamura , Leonardo Fonseca Maciel , Elisa Yoko Hirooka

{"title":"Risk assessment of aflatoxin exposure for consumers of in natura and blanched peanuts from Brazil from 2016 to 2019","authors":"André Ribeiro da Silva , Elisabete Yurie Sataque Ono , Igor Massahiro de Souza Suguiura , Tuany Marin Pomini , Eiko Nakagawa Itano , Osamu Kawamura , Leonardo Fonseca Maciel , Elisa Yoko Hirooka","doi":"10.1016/j.fct.2025.115437","DOIUrl":"10.1016/j.fct.2025.115437","url":null,"abstract":"<div><div>Aflatoxins (AFs), carcinogenic secondary metabolites produced mainly by <em>Aspergillus flavus</em> and <em>A. parasiticus</em>, are frequently associated with the peanut chain worldwide, and affect grain quality, reducing the commercial value. Brazil is ranked as the third peanut producer in the American continent and the State of São Paulo produces 91 % of Brazilian peanuts, of which 80 % are exported to Russia, Algeria, South Africa and Poland. This study aimed to assess the risk of aflatoxin exposure for peanut consumers from Brazil. Aflatoxins in 426 peanut samples from a food industry located in the state of São Paulo, Brazil, belonging to three sequential crops (2016/17, n = 77; 2017/18, n = 150; 2018/19, n = 199) were analyzed by Immunoaffinity Column-fluorometry. Mean total AFs in positive samples ranged from 6.96 to 11.1 ng g<sup>−1</sup> (<em>in natura</em>, n = 363) and from 3.83 to 8.2 ng g<sup>−1</sup> (blanched, n = 63) in the peanut batches. The mean probable daily intake (PDI) of aflatoxins was 0.11 (2016/17), 0.06 (2017/18), and 0.12 ng kg<sup>−1</sup> body weight (bw) day<sup>−1</sup> (2018/19) for the Brazilian population. For countries that import Brazilian peanuts, the aflatoxin PDI ranged from 0.06 (Russia) to 0.19 ng kg <sup>˗1</sup> bw day <sup>˗1</sup> (Poland). MOE (margin of exposure) values ranged from 895 (Poland, 2018/19) to 2833 (Brazil and Russia, 2017/2018). Although the mean PDI values were lower than the provisional maximum tolerable daily intake of 1.0 ng kg <sup>˗1</sup> bw day <sup>˗1</sup>, MOE values indicated a possible health problem for the Brazilian population and for the populations in countries that import and consume Brazilian peanuts.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"201 ","pages":"Article 115437"},"PeriodicalIF":3.9,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RIFM fragrance ingredient safety assessment, lauryl alcohol, CAS Registry Number 112-53-8 RIFM香料成分安全性评估，十二烷基醇，CAS登记号112-53-8。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-04 DOI: 10.1016/j.fct.2025.115426

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0