Food and Chemical Toxicology最新文献_第5页

Update to RIFM fragrance ingredient safety assessment, decanal dimethyl acetal, CAS Registry Number 7779-41-1 更新RIFM香料成分安全评估，癸醛二甲基缩醛，CAS注册号7779-41-1

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-05-08 DOI: 10.1016/j.fct.2025.115515

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

RIFM fragrance ingredient safety assessment, 3-buten-2-one, 4-(2,2,3-trimethyl-6-methylenecyclohexyl)-, CAS registry number 79-68-5 香料成分安全性评价，3-丁烯-2- 1,4 -（2,2,3-三甲基-6-亚甲基环己基）-，CAS注册号79-68-5。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-05-08 DOI: 10.1016/j.fct.2025.115509

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

Update to RIFM fragrance ingredient safety assessment, heptanal dimethyl acetal, CAS registry number 10032-05-0 更新RIFM香料成分安全性评估，庚醛缩二甲基缩醛，CAS登记号10032-05-0

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-05-08 DOI: 10.1016/j.fct.2025.115507

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

Update to RIFM fragrance ingredient safety assessment, 1,1-diethoxyhexane, CAS registry number 3658-93-3 更新RIFM香料成分安全评估，1,1-二氧基己烷，CAS登记号3658-93-3

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-05-08 DOI: 10.1016/j.fct.2025.115506

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

RIFM fragrance ingredient safety assessment, 1,1-diethoxy-3,5,5-trimethylhexane, CAS registry number 86198-35-8 香料成分安全性评价，1,1-二氧基-3,5,5-三甲基己烷，中国科学院登记号86198-35-8。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-05-08 DOI: 10.1016/j.fct.2025.115527

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

{"title":"RIFM fragrance ingredient safety assessment, 1,1-diethoxy-3,5,5-trimethylhexane, CAS registry number 86198-35-8","authors":"A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar","doi":"10.1016/j.fct.2025.115527","DOIUrl":"10.1016/j.fct.2025.115527","url":null,"abstract":"<div><div>1, 1-Diethoxy-3,5,5-trimethylhexane was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog 2-methylundecanal dimethyl acetal (CAS # 68141-17-3) show that 1,1-diethoxy-3,5,5-trimethylhexane is not expected to be genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class I material, and the exposure to 1,1-diethoxy-3,5,5-trimethylhexane is below the TTC (0.03 mg/kg/day, 0.03 mg/kg/day, and 1.4 mg/day, respectively). Data from read-across analog hydroxycitronellal dimethyl acetal (CAS # 141-92-4) show that there are no safety concerns for 1,1-diethoxy-3,5,5-trimethylhexane for skin sensitization under the current declared levels of use. The photoirritation/photoallergenicity endpoints were evaluated based on ultraviolet/visible (UV/Vis) spectra; 1,1-diethoxy-3,5,5-trimethylhexane is not expected to be photoirritating/photoallergenic. The environmental endpoints were evaluated; for the hazard assessment based on the screening data, 1,1-diethoxy-3,5,5-trimethylhexane is not Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards. For the risk assessment, 1,1-diethoxy-3,5,5-trimethylhexane was not able to be risk screened as there were no reported volumes of use (VoU) for either North America or Europe in the 2019 IFRA Survey.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"201 ","pages":"Article 115527"},"PeriodicalIF":3.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RIFM fragrance ingredient safety assessment, 2-(methylpropyl)quinoline, CAS registry number 1333-58-0 2-（甲基丙基）喹啉，中国科学院登记号1333-58-0。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-05-08 DOI: 10.1016/j.fct.2025.115524

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

{"title":"RIFM fragrance ingredient safety assessment, 2-(methylpropyl)quinoline, CAS registry number 1333-58-0","authors":"A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar","doi":"10.1016/j.fct.2025.115524","DOIUrl":"10.1016/j.fct.2025.115524","url":null,"abstract":"<div><div>2-(Methylpropyl)quinoline was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog 2-isobutylquinoline (CAS # 93-19-6) show that 2-(methylpropyl)quinoline is not expected to be genotoxic. The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class III material, and the exposure to 2-(methylpropyl)quinoline is below the TTC (0.0015 mg/kg/day, 0.0015 mg/kg/day, and 0.47 mg/day, respectively). Data from read-across analog quinoline (CAS # 91-22-5) show that there are no safety concerns for 2-(methylpropyl)quinoline for skin sensitization under the current declared levels of use. The photoirritation/photoallergenicity endpoints were evaluated based on ultraviolet/visible (UV/Vis) spectra; 2-(methylpropyl)quinoline is not expected to be photoirritating/photoallergenic. The environmental endpoints were evaluated; 2-(methylpropyl)quinoline was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use (VoU) in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"201 ","pages":"Article 115524"},"PeriodicalIF":3.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Update to RIFM fragrance ingredient safety assessment, nonane, 1,1-diethoxy-, CAS Registry Number 54815-13-3 更新RIFM香料成分安全性评估，壬烷，1,1-二氧基-，CAS注册号54815-13-3

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-05-08 DOI: 10.1016/j.fct.2025.115525

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

RIFM fragrance ingredient safety assessment, 4-isopropylphenol, CAS Registry Number 99-89-8 香料成分安全性评价，4-异丙基苯酚，CAS注册号99-89-8

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-05-08 DOI: 10.1016/j.fct.2025.115526

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

{"title":"RIFM fragrance ingredient safety assessment, 4-isopropylphenol, CAS Registry Number 99-89-8","authors":"A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar","doi":"10.1016/j.fct.2025.115526","DOIUrl":"10.1016/j.fct.2025.115526","url":null,"abstract":"<div><div>4-Isopropylphenol was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analog <em>p-</em>cresol (CAS # 106-44-5) show that 4-isopropylphenol is not expected to be genotoxic. Data on read-across analog <em>p-</em>cresol (CAS # 106-44-5) provide a calculated Margin of Exposure (MOE) > 100 for the repeated dose toxicity and reproductive toxicity endpoints. Data from read-across analog thymol (CAS # 89-83-8) show that there are no safety concerns for 4-isopropylphenol for skin sensitization under the current declared levels of use. The photoirritation/photoallergenicity endpoints were evaluated based on ultraviolet/visible (UV/Vis) spectra; 4-isopropylphenol is not expected to be photoirritating/photoallergenic. The local respiratory toxicity endpoint was evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class I material, and the exposure to 4-isopropylphenol is below the TTC (1.4 mg/day). The environmental endpoints were evaluated; 4-isopropylphenol was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use (VoU) in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are <1.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"201 ","pages":"Article 115526"},"PeriodicalIF":3.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143941294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RIFM fragrance ingredient safety assessment, 2-acetyl-5-methylfuran, CAS Registry Number 1193-79-9 RIFM香料成分安全性评价，2-乙酰-5-甲基呋喃，CAS登记号1193-79-9

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-05-07 DOI: 10.1016/j.fct.2025.115508

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

Determination of acrylamide levels in chips/crisps on the Italian market and exposure risk assessment 意大利市场薯片/薯片丙烯酰胺含量测定及风险评估

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-05-07 DOI: 10.1016/j.fct.2025.115539

Antonio Cristaldi , Eloise Pulvirenti , Paola Rapisarda , Claudia Favara , Maria Castrogiovanni , Gea Oliveri Conti , Margherita Ferrante

{"title":"Determination of acrylamide levels in chips/crisps on the Italian market and exposure risk assessment","authors":"Antonio Cristaldi , Eloise Pulvirenti , Paola Rapisarda , Claudia Favara , Maria Castrogiovanni , Gea Oliveri Conti , Margherita Ferrante","doi":"10.1016/j.fct.2025.115539","DOIUrl":"10.1016/j.fct.2025.115539","url":null,"abstract":"<div><div>Acrylamide is an important concern in the food industry because it can form during cooking at high temperatures of foods, mainly of vegetable origin, and rich in carbohydrates. In this study, we detected the acrylamide levels in chips/crisps from five brands available on the Italian market and performed the risk assessment related to the exposure to acrylamide through the consumption of chips/crisps.</div><div>A total of 50 samples were prepared and the acrylamide levels were determined by HPLC.</div><div>The mean acrylamide value was 1116.6 ± 585 μg/kg, and two out of five brands showed higher values. EDI values were between 0.172 and 0.901 μg/kg bw/day. The LCR values ranged from 8.61 × 10<sup>−5</sup> to 4.51 × 10<sup>−4</sup>. The THQ values were all below 1. The MOEc values ranged from 189 to 987 (mean 478), significantly lower than the 10000 threshold, indicating a potential carcinogenic risk. MOEn values ranged from 477 to 2496 (mean 1208), with values above 100 suggesting no neurotoxic risk.</div><div>Further research is needed to suggest appropriate interventions to reduce acrylamide levels in foods.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"202 ","pages":"Article 115539"},"PeriodicalIF":3.9,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0