Food and Chemical Toxicology最新文献_第5页

RIFM fragrance ingredient safety assessment, 4-(p-methoxyphenyl)-2-butanone, CAS Registry Number 104-20-1

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-03 DOI: 10.1016/j.fct.2025.115366

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

Update to RIFM fragrance ingredient safety assessment, isobutyl propionate, CAS Registry Number 540-42-1

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-03 DOI: 10.1016/j.fct.2025.115367

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

Regulatory effect of curcumin on CD40:CD40L interaction and therapeutic implications

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-03 DOI: 10.1016/j.fct.2025.115369

Fatemeh Askarizadeh , Alexandra E. Butler , Prashant Kesharwani , Amirhossein Sahebkar

{"title":"Regulatory effect of curcumin on CD40:CD40L interaction and therapeutic implications","authors":"Fatemeh Askarizadeh , Alexandra E. Butler , Prashant Kesharwani , Amirhossein Sahebkar","doi":"10.1016/j.fct.2025.115369","DOIUrl":"10.1016/j.fct.2025.115369","url":null,"abstract":"<div><div>Natural compounds have garnered significant attention as potential therapeutic agents due to their inherent properties. Their notable qualities, including safety, efficacy, favorable pharmacokinetic properties, and heightened effectiveness against certain diseases, particularly inflammatory conditions, make them particularly appealing. Among these compounds, curcumin has attracted considerable interest for its unique therapeutic properties and has therefore been extensively studied as a potential therapeutic agent for treating various diseases. Curcumin exhibits diverse anti-inflammatory, antioxidant, and antimicrobial effects. Curcumin's immune system regulatory ability has made it a promising compound for treatment of various inflammatory diseases, such as psoriasis, atherosclerosis, asthma, colitis, IBD, and arthritis. Among the signaling pathways implicated in these conditions, the CD40 receptor together with its ligand, CD40L, are recognized as central players. Studies have demonstrated that the interaction between CD40 and CD40L interaction acts as the primary mediator of the immune response in inflammatory diseases. Numerous studies have explored the impact of curcumin on the CD40:CD40L pathway, highlighting its regulatory effects on this inflammatory pathway and its potential therapeutic use in related inflammatory conditions. In this review, we will consider the evidence concerning curcumin's modulatory effects in inflammatory disease and its potential therapeutic role in regulating the CD40:CD40L pathway.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115369"},"PeriodicalIF":3.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143565534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of pesticide contamination in pomegranates: A multivariate approach and health risk evaluation

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-01 DOI: 10.1016/j.fct.2025.115363

Emrah Gormez , Eylem Odabas , Ozgur Golge , Miguel Ángel González-Curbelo , Bulent Kabak

{"title":"Assessment of pesticide contamination in pomegranates: A multivariate approach and health risk evaluation","authors":"Emrah Gormez , Eylem Odabas , Ozgur Golge , Miguel Ángel González-Curbelo , Bulent Kabak","doi":"10.1016/j.fct.2025.115363","DOIUrl":"10.1016/j.fct.2025.115363","url":null,"abstract":"<div><div>Pesticide residues in pomegranates pose a significant food safety concern, particularly given the rising global consumption of this fruit. This study monitored 316 pesticide residues in 342 pomegranate samples from Turkey's three primary pomegranate production regions using liquid chromatography-tandem mass spectrometry. Pesticide residues were detected in 72.8% of the samples, with 40 different pesticides identified, 15 of which were unauthorized. Spirotetramat, acetamiprid, and fludioxonil were among the most frequently detected, with concentrations exceeding the maximum residue levels set by the European Union in 40.6% of the contaminated samples. Multivariate analysis revealed strong correlations between specific pesticide pairs, suggesting common usage patterns. The chronic hazard index was 0.0132 for adults and 0.0403 for children, indicating no significant chronic health risks. The acute health risks for all pesticides remained below acceptable limits, except for acetamiprid, which exceeded the threshold (1.186) for children. However, the presence of non-approved pesticides, such as omethoate, raises concerns about regulatory compliance. Continued surveillance and risk assessment are essential to minimize potential health risks, particularly for vulnerable populations consuming pomegranates.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115363"},"PeriodicalIF":3.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elaidic acid induces testicular oxidative stress, inflammation, Wnt/β-catenin disruption and abnormalities in steroidogenesis, spermatogenesis and histo-architecture in Sprague Dawley rats

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-01 DOI: 10.1016/j.fct.2025.115365

Fuad M. Alzahrani , Muhammad Faisal Hayat , Ali Akbar , Syeda Sania Zahara , Meshari A. Alsuwat , Khalid J. Alzahrani , Ahmed El-Emam

{"title":"Elaidic acid induces testicular oxidative stress, inflammation, Wnt/β-catenin disruption and abnormalities in steroidogenesis, spermatogenesis and histo-architecture in Sprague Dawley rats","authors":"Fuad M. Alzahrani , Muhammad Faisal Hayat , Ali Akbar , Syeda Sania Zahara , Meshari A. Alsuwat , Khalid J. Alzahrani , Ahmed El-Emam","doi":"10.1016/j.fct.2025.115365","DOIUrl":"10.1016/j.fct.2025.115365","url":null,"abstract":"<div><div>Elaidic Acid (EA) is a major <em>trans</em>-fatty acid that has garnered significant attention due to its potential role in inducing systemic toxicity. The current investigation was conducted to assess the toxic effects of EA (50 mg/kg, 100 mg/kg, and 150 mg/kg) on testicular tissues of Sprague Dawley rats. EA intoxication disrupted Wnt/β-catenin via downregulating the expression of WNT3A and TCF7L2 while upregulating the expression of AXIN1 and GSK-3β. The activities of antioxidant enzymes were reduced while the levels of cellular oxidative stress were escalated following the EA exposure. EA administration disrupted the process of steroidogenesis as well as spermatogenesis through the downregulation of CYP11A1, 5α-reductase, 3β-HSD, CYP17A1, and StAR while elevating spermatogenic abnormalities in head, tail and neck of sperm cells. The levels of LH, androgen binding protein, FSH, inhibin B, plasma testosterone and estradiol were lowered after EA administration. Testicular tissues showed inflammatory responses after EA exposure that is evident by elevated levels of TNF-α, IL-1β, COX-2, IL-6 and NF-κB. The expressions of Bax and Caspase-3 were upsurged while expression of Bcl-2 was reduced following the EA intoxication. These findings showed EA exerted toxic effects on testicular tissues via elevating oxidative stress, inflammation and apoptosis.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115365"},"PeriodicalIF":3.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety of Nutmeg powder by oral exposure: Toxicity prediction and in vivo evaluation

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-02-28 DOI: 10.1016/j.fct.2025.115364

Wei Lv , Xin Zhang , Hongli Zhang , Alitanhua , Yunfeng Xiao

{"title":"Safety of Nutmeg powder by oral exposure: Toxicity prediction and in vivo evaluation","authors":"Wei Lv , Xin Zhang , Hongli Zhang , Alitanhua , Yunfeng Xiao","doi":"10.1016/j.fct.2025.115364","DOIUrl":"10.1016/j.fct.2025.115364","url":null,"abstract":"<div><div>Nutmeg (Myristica fragrans Houtt.) is widely cultivated in tropical regions and valued for its culinary and medicinal uses. However, its safety profile remains underexplored. This study aimed to evaluate the safety of nutmeg powder through in-silico toxicity predictions, acute oral toxicity, and a 13-week repeated-dose toxicity assessment. In the in-silico study, bioactive compounds identified via High-Performance Liquid Chromatography (HPLC) were analyzed for toxicity parameters using the ProTox II server. For acute toxicity, a single dose of nutmeg powder was administered to mice, with no mortality observed over 14 days, and an LD<sub>50</sub> greater than 5000 mg/kg body weight was determined. In the sub-chronic toxicity study, rats received nutmeg powder at 1400 mg/kg and 3500 mg/kg (35 and 87.5 times the human therapeutic dosage, respectively) for 90 days. A 28-day recovery phase was included to assess delayed or reversible effects. The results indicate that a dose of 1400 mg/kg leads to liver damage and hemosiderin deposition in the spleen, while a dose of 3500 mg/kg causes liver and kidney damage, as well as hemosiderin deposition in the spleen. These findings highlight the potential toxicity of long-term nutmeg consumption and underscore the need for further research to ensure its safety in preclinical.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115364"},"PeriodicalIF":3.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inorganic arsenic in aquatic products in Shenzhen, China from 2018 to 2024: Levels, temporal variation and health risk assessment

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-02-28 DOI: 10.1016/j.fct.2025.115353

Bo Fu , Kai Lin , Sisi Yu , Yiming Ge , Xinjie Li , Wenchao Zhu , Lei Tan , Rui Wang , Jixi Ou , Shaoyou Lu

{"title":"Inorganic arsenic in aquatic products in Shenzhen, China from 2018 to 2024: Levels, temporal variation and health risk assessment","authors":"Bo Fu , Kai Lin , Sisi Yu , Yiming Ge , Xinjie Li , Wenchao Zhu , Lei Tan , Rui Wang , Jixi Ou , Shaoyou Lu","doi":"10.1016/j.fct.2025.115353","DOIUrl":"10.1016/j.fct.2025.115353","url":null,"abstract":"<div><div>Aquatic products are a significant source of arsenic exposure, with inorganic arsenic (iAs) posing a significant risk to humans. This study assessed iAs levels in 1191 aquatic products from Shenzhen, China (2018–2024), and estimated health risks. Shellfish had lower mean iAs levels (0.01 mg/kg ∼ 0.07 mg/kg), while crab, fish, and shrimp had higher levels (0.04 mg/kg ∼ 0.06 mg/kg). The iAs levels in shellfish were stable from 2018 to 2024. Health risk assessments showed estimated daily intake values ranging from 0.01 μg/kg·bw/day to 0.39 μg/kg·bw/day, with children having the highest exposure. The target hazard quotient exceeded 1 for fish and shrimp in high-consumption scenarios for children, indicating potential non-carcinogenic risks. Cancer risk estimates surpassed acceptable thresholds, especially for children and adolescents, suggesting an increased cancer risk with high consumption. Authorities should strengthen surveillance of iAs in aquatic products, especially shellfish and shrimp, and enhance environmental monitoring in Shenzhen.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115353"},"PeriodicalIF":3.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatic antifibrotic effects of bezafibrate in vitro and in vivo models of liver fibrosis

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-02-28 DOI: 10.1016/j.fct.2025.115351

Camille Kirinus Reghelin , Matheus Scherer Bastos , Bruno de Souza Basso , Bruna Pasqualotto Costa , Arieli Cruz de Sousa , Bianca Andrade Martha , Géssica Luana Antunes , Marcella Tornquist Nassr , Maria Claudia Rosa Garcia , Lucas Strassburguer Matzenbarcher , Vitor Giancarlo Schneider Levorse , Fatima Theresinha Costa Rodrigues Guma , Márcio Vinícius Fagundes Donadio , Jarbas Rodrigues de Oliveira , Denizar Alberto da Silva Melo

{"title":"Hepatic antifibrotic effects of bezafibrate in vitro and in vivo models of liver fibrosis","authors":"Camille Kirinus Reghelin , Matheus Scherer Bastos , Bruno de Souza Basso , Bruna Pasqualotto Costa , Arieli Cruz de Sousa , Bianca Andrade Martha , Géssica Luana Antunes , Marcella Tornquist Nassr , Maria Claudia Rosa Garcia , Lucas Strassburguer Matzenbarcher , Vitor Giancarlo Schneider Levorse , Fatima Theresinha Costa Rodrigues Guma , Márcio Vinícius Fagundes Donadio , Jarbas Rodrigues de Oliveira , Denizar Alberto da Silva Melo","doi":"10.1016/j.fct.2025.115351","DOIUrl":"10.1016/j.fct.2025.115351","url":null,"abstract":"<div><div>Bezafibrate (BZF) is a drug that reduces cholesterol and triglyceride levels in the blood. Research indicates that BZF, through activation of PPAR receptors, regulates the expression of genes involved in lipid homeostasis, inflammation, cell differentiation, and proliferation. This study investigated the <em>in vitro</em> and <em>in vivo</em> effects of BZF on activated hepatic stellate cells (HSCs) and on carbon tetrachloride-induced liver fibrosis in mice. After 72 h of treatment <em>in vitro</em>, BZF decreased cell proliferation, reversed the phenotype, decreased cell contraction, and induced autophagy. In addition, BZF promoted a protective effect on tetrachloride-induced liver fibrosis in mice, through antifibrotic actions. These findings suggest that BZF may have a potential antifibrotic effect, which could emerge as a possible new therapy for the treatment of liver fibrosis.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115351"},"PeriodicalIF":3.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distribution and health risk assessment of heavy metals in the octopus (Octopus hubbsorum) in the Mexican Pacific

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-02-28 DOI: 10.1016/j.fct.2025.115362

María Azucena Alba-Preciado , José Belisario Leyva-Morales , Jasmin Granados-Amores , Jaqueline García-Hernández , Daniela Aguilera-Márquez , Pedro de Jesús Bastidas-Bastidas , Nydia Yuriana Zamora-Arellano , César Abelardo González-Ramírez , Andrés Granados-Amores , José de Jesús Dueñas-Romero

{"title":"Distribution and health risk assessment of heavy metals in the octopus (Octopus hubbsorum) in the Mexican Pacific","authors":"María Azucena Alba-Preciado , José Belisario Leyva-Morales , Jasmin Granados-Amores , Jaqueline García-Hernández , Daniela Aguilera-Márquez , Pedro de Jesús Bastidas-Bastidas , Nydia Yuriana Zamora-Arellano , César Abelardo González-Ramírez , Andrés Granados-Amores , José de Jesús Dueñas-Romero","doi":"10.1016/j.fct.2025.115362","DOIUrl":"10.1016/j.fct.2025.115362","url":null,"abstract":"<div><div>Heavy metal (HM) concentrations in coastal marine species and the health risks (HR) for the consumption of these resources remain relatively unknown. We determined the concentrations of Cd, Cu, Hg, Pb, and Zn in the arm and mantle tissues of 150 <em>Octopus hubbsorum</em> specimens collected from seven sites in the Mexican Pacific in 2021. Samples were processed by microwave-assisted acid digestion, and concentrations were determined by anodic stripping voltammetry. The HR for adults and children exposed to HM through the consumption of <em>O. hubbsorum</em> was determined by the hazard quotient (HQ) and risk index (HI). Five HM were found in all samples. The concentrations followed the order of Zn > Cu > Cd > Pb > Hg, with most sites exhibiting Cd and Pb concentrations above the maximum permissible limit (MPL) established by national and international standards. However, the values of HQ and HI did not exceed one (<1) for any heavy metal, indicating that there is no HR due to consuming octopus. Nonetheless, <em>O. hubbsorum</em> exhibited concentrations of some HM above the MPL; therefore, caution should be taken when consuming this species considering the additive and/or potentiation effect that could occur, especially in coastal communities where consumption is higher.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115362"},"PeriodicalIF":3.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the toxic dose of the potent antioxidant 3,5-dihydroxy-4-methoxybenzyl alcohol in rats

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-02-27 DOI: 10.1016/j.fct.2025.115360

Mitsugu Watanabe , Kenji Yoshiike , Hideaki Watanabe , Masayoshi Yamaguchi

{"title":"Assessing the toxic dose of the potent antioxidant 3,5-dihydroxy-4-methoxybenzyl alcohol in rats","authors":"Mitsugu Watanabe , Kenji Yoshiike , Hideaki Watanabe , Masayoshi Yamaguchi","doi":"10.1016/j.fct.2025.115360","DOIUrl":"10.1016/j.fct.2025.115360","url":null,"abstract":"<div><div>3,5-dihydroxy-4-methoxybenzyl alcohol (DHMBA), identified from the Pacific oyster <em>Crassostrea gigas</em>, has dual properties to block oxidative stress as a radical scavenger and a potential cell function regulator. DHMBA has been shown to suppress adipogenesis, inflammatory activated macrophages, osteoclastogenesis, osteoblastic bone formation, and anti-cancer activity <em>in vitro</em>, suggesting its role in preventing and treating several diseases. The toxicological effects of DHMBA may be important for the development of its pharmacological application. However, the toxicity of DHMBA has not been determined. To evaluate the no-observed-adverse-effect level of synthetic DHMBA, this study was conducted in male and female rats at a single oral dose of DHMBA 500, 1000, or 2000 mg/kg body weight, for 14 days at 30, 100, 300, and 1000 mg/kg/day, and for 91 days at the DHMBA 1, 5, and 25 mg/kg/day dose in male and female rats. The toxicological effects of DHMBA were evaluated by analyzing the changes in general condition, including body weight, behavior, body temperature, abnormal gait, decreased mobility, decreased alternate, slowed approach response, slowed touch response, slowed auditory response, abnormal righting reflex in air, and decreased abdominal muscle tone, blood biochemistry test, macroscopic pathological examination, organ weight, histopathological examination, inflammatory changes, or obvious abnormalities in the hematopoietic system. As a result, this study demonstrated that the no-observed-adverse-effect level of synthetic DHMBA in male and female rats was 25 mg/kg/day when administered for 91 days. This result may provide important toxicological information in the use of the DHMBA as a pharmacological tool.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115360"},"PeriodicalIF":3.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143528670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0