Food and Chemical Toxicology最新文献_第4页

Curcumin modulates the PTEN/PI3K/AKT pathway to alleviate inflammation and oxidative stress in PM2.5-Induced chronic obstructive pulmonary disease 姜黄素调节PTEN/PI3K/AKT通路，减轻PM2.5诱导的慢性阻塞性肺病的炎症和氧化应激反应

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-15 DOI: 10.1016/j.fct.2025.115460

Kai Liu , Meng Shi , Xin Li , Xiaoli Zeng , Xiaoju Liu

{"title":"Curcumin modulates the PTEN/PI3K/AKT pathway to alleviate inflammation and oxidative stress in PM2.5-Induced chronic obstructive pulmonary disease","authors":"Kai Liu , Meng Shi , Xin Li , Xiaoli Zeng , Xiaoju Liu","doi":"10.1016/j.fct.2025.115460","DOIUrl":"10.1016/j.fct.2025.115460","url":null,"abstract":"<div><div>Ambient fine particulate matter (PM2.5) contributes to the onset and escalation of chronic obstructive pulmonary disease (COPD) through the induction of inflammatory reactions and oxidative stress. Curcumin is a natural polyphenolic compound renowned for the potent antioxidant and anti-inflammatory properties. This research utilized a PM2.5-induced COPD mouse model and BEAS-2B cell line to explore the protective mechanisms of curcumin. The results showed that PM2.5 impaired pulmonary function, exacerbated airway inflammation, and caused structural damage to lung tissue. Elevated levels of inflammatory cytokines such as IL-6, IL-1β, and TNF-α, increased malondialdehyde, and reduced activities of antioxidant enzymes catalase and superoxide dismutase were observed in both mice and BEAS-2B cell line. PM2.5 exposure also suppressed PTEN expression and activated PI3K/AKT signal, and the downstream molecule NF-κB was activated and FoxO1 activity was inhibited. PTEN overexpression partially reversed PM2.5-induced inflammation and oxidative stress <em>in vitro</em>. Curcumin enhanced PTEN expression, inhibited PI3K/AKT and NF-κB activation, and restored FoxO1 activity, alleviating airway inflammation and oxidative stress, while PTEN inhibition attenuated the ameliorating effects of curcumin <em>in vitro</em> and <em>in vivo</em>. In summary, PM2.5 exposure induces COPD inflammation and oxidative stress by disrupting PTEN/PI3K/AKT signaling and curcumin significantly alleviates these effects partially through PTEN/PI3K/AKT signal.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"201 ","pages":"Article 115460"},"PeriodicalIF":3.9,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review on fumonisin B1-induced mitochondrial dysfunction and its impact on mitophagy and DNA methylation 伏马菌素b1诱导线粒体功能障碍及其对线粒体自噬和DNA甲基化影响的研究进展

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-14 DOI: 10.1016/j.fct.2025.115458

Anthia C. Govender, Anil A. Chuturgoon, Terisha Ghazi

{"title":"A review on fumonisin B1-induced mitochondrial dysfunction and its impact on mitophagy and DNA methylation","authors":"Anthia C. Govender, Anil A. Chuturgoon, Terisha Ghazi","doi":"10.1016/j.fct.2025.115458","DOIUrl":"10.1016/j.fct.2025.115458","url":null,"abstract":"<div><div>Fumonisin B<sub>1</sub> (FB<sub>1</sub>) is a food-borne mycotoxin synthesized by <em>Fusarium verticillioides</em> and has been identified as a group 2B carcinogen. Recent research shows that the mitochondria and DNA in cells are targets of FB<sub>1</sub>. Mitophagy is a form of autophagy that functions to break down impaired mitochondria to preserve the overall functionality of the cell. DNA methylation is an epigenetic process that involves the enzymatic transfer of methyl groups from S-adenosylmethionine (SAM) to the C-5 region of the DNA cytosine ring by DNA methyltransferases (DNMTs). DNA methylation plays a key role in maintaining DNA integrity and FB<sub>1</sub> disrupts DNA methylation via FB<sub>1</sub>-induced folate deficiency. However, there is limited research available on the impact of FB<sub>1</sub> on mitophagy as well as FB<sub>1</sub>-induced oxidative stress and its influence on DNA methylation regulation. In this review, we aim to combine and summarize the current information on FB<sub>1</sub>-induced mitochondrial dysfunction, its impact on mitophagy as well as its DNA methylation effects.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"201 ","pages":"Article 115458"},"PeriodicalIF":3.9,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bayesian benchmark dose assessment of per- and polyfluorinated substances exposure-associated thyroid function disruption during pregnancy 妊娠期间全氟和多氟物质暴露相关甲状腺功能破坏的贝叶斯基准剂量评估

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-14 DOI: 10.1016/j.fct.2025.115456

Shiwen Li , Jingguang Li , Yongning Wu , Xin Liu , Lei Zhang

{"title":"Bayesian benchmark dose assessment of per- and polyfluorinated substances exposure-associated thyroid function disruption during pregnancy","authors":"Shiwen Li , Jingguang Li , Yongning Wu , Xin Liu , Lei Zhang","doi":"10.1016/j.fct.2025.115456","DOIUrl":"10.1016/j.fct.2025.115456","url":null,"abstract":"<div><div>Epidemiological evidence on maternal thyroid function disruption by prenatal exposure to perfluorinated and polyfluorinated substances (PFASs) is limited and inconsistent. The study examined the effects of PFASs exposure during early pregnancy on maternal thyroid function [free thyroxine (FT4), thyroid stimulating hormone (TSH), thyroid peroxidase antibodies (TPOAb) and FT4/TSH ratio]. The associations were evaluated using both single and mixed pollutant models, statistical analyses were further utilized in benchmark dose (BMD) estimations to offer critical references for human health risk assessment. Linear regression was used and then Bonferroni correction adjustment was set up to correct for multiple comparisons. The results revealed a significant association between PFHxS exposure and TSH (β = 0.473; 95 % CI: 0.180, 0.767). According to BKMR mixed-effects models, PFHxS was significantly positively correlated with TSH at the 25th percentile. PFASs were associated with the FT4/TSH ratio at the 25th to 40th percentile. The BMD value of the increasing FT4 effect induced by PFBA and PFPeA in pregnant women were 6.68 ng/mL and 1.37 ng/mL, respectively. The BMDs were obtained for TSH in the case of PFBA (0.33 ng/mL), PFHxS (0.28 ng/mL). Although BMDL<sub>10</sub> is higher than observed for maternal TSH elevation in animal studies, both studies agree that thyroid homeostasis is the sensitive target. The fact that BMD results at this stage are lower than current exposure levels to PFHxS underscores the urgency of prioritizing endocrine end points in PFASs risk assessment.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"201 ","pages":"Article 115456"},"PeriodicalIF":3.9,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GC-MS and HPLC-FLD for sensitive assay of toxic cyclohexylamine in artificial sweetener tablets and human biological fluids GC-MS和HPLC-FLD对人工甜味剂片剂和人体生物体液中有毒环己胺的灵敏测定

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-11 DOI: 10.1016/j.fct.2025.115447

Hazim M. Ali , Amr A. Essawy , Ahmed Hamad Alanazi , Arafa Musa , Ahmed Emad F. Abbas , Ibrahim Bayoumi Abdel-Farid , Mohammed Gamal

{"title":"GC-MS and HPLC-FLD for sensitive assay of toxic cyclohexylamine in artificial sweetener tablets and human biological fluids","authors":"Hazim M. Ali , Amr A. Essawy , Ahmed Hamad Alanazi , Arafa Musa , Ahmed Emad F. Abbas , Ibrahim Bayoumi Abdel-Farid , Mohammed Gamal","doi":"10.1016/j.fct.2025.115447","DOIUrl":"10.1016/j.fct.2025.115447","url":null,"abstract":"<div><div>Cyclohexylamine (CHA) is a precursor in the synthesis of artificial sweeteners cyclamate and its major metabolite. CHA is toxic to the nervous system, kidneys, and liver in animal studies. In the present work, gas chromatography-mass spectrometry (GC-MS) and high-performance liquid chromatography-fluorescence detection (HPLC-FLD) were introduced for the first time to the determination of nano-level concentration of CHA in artificial sweetener tablets and human biological fluids. According to the obtained results, HPLC-FLD and GC-MS of CHA exhibit a wide linear range from 1 to 1250 ng/mL and 5–1500 ng/mL within limits of detection of 0.49 and 1.55 ng/mL, respectively. Furthermore, both chromatographic techniques exhibited high accuracy and precision, yielding recovery estimates ranging from 95.85 % to 100.70 % for the HPLC-FLD method and 91.54 %–99.64 % for the other while the corresponding values of relative standard deviation (RSD%) range from 0.25 to 0.82 % and 1.25–3.97 %. The accuracies for HPLC-FLD and GC-MS method in serum and urine samples are within the range of 90.29–99.94 %. On the other hand, CHA was detected in all studied artificial sweetener tablets, its level ranged from 1.35 to 102.64 ng/tablet. Also, the results obtained from the HPLC-FLD and GC-MS methods were statistically compared, and no significant difference was found.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"201 ","pages":"Article 115447"},"PeriodicalIF":3.9,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Montelukast's potential as a neuroprotective agent against acrylamide induced neurotoxicity: In vivo and computational modelling 孟鲁司特作为抗丙烯酰胺诱导的神经毒性的神经保护剂的潜力：体内和计算模型

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-11 DOI: 10.1016/j.fct.2025.115448

Abdulaziz Arif A. Alshammari , Minhajul Arfeen , Abdullah Saleh Alkhamiss , Mai B. Alwesmi , Vasudevan Mani

{"title":"Montelukast's potential as a neuroprotective agent against acrylamide induced neurotoxicity: In vivo and computational modelling","authors":"Abdulaziz Arif A. Alshammari , Minhajul Arfeen , Abdullah Saleh Alkhamiss , Mai B. Alwesmi , Vasudevan Mani","doi":"10.1016/j.fct.2025.115448","DOIUrl":"10.1016/j.fct.2025.115448","url":null,"abstract":"<div><div>Tobacco consumption, a leading cause of over 8 million deaths annually, exposes individuals to acrylamide (ACY), a neurotoxin in cigarette smoke that disrupts neurotransmitter function and induces oxidative stress, contributing to neurodegeneration. This study evaluated neuroprotective potential of montelukast (MTLU), a leukotriene receptor antagonist with anti-inflammatory and antioxidant properties, against ACY-induced neurotoxicity. Cognitive performance was assessed using elevated plus maze, novel object recognition, and Y-maze tests over 14 days. Biomarkers associated with neurodegeneration (BACE1, GSK-3β, AChE), neuroinflammation (COX-2, PGE2, TNF-α, NF-κB), oxidative stress (GSH, MDA, CAT), and apoptosis (Bcl-2, Caspase-3, Bax) were analyzed. Histopathological analyses of brain tissues were conducted to examine structural damage, and computational studies provided additional support for selected in vivo findings. MTLU significantly ameliorated ACY-induced cognitive deficits and reduced levels of GSK-3β, AChE, COX-2, PGE2, TNF-α, NF-κB, MDA, Bax, and Caspase-3 while enhancing antioxidant defenses (GSH) and upregulating Bcl-2. Histopathological analysis confirmed reduced structural brain damage, and molecular docking indicated strong binding potential for MTLU with AChE, COX-2, GSK-3β, BACE-1, and Caspase-3. While these findings suggest a protective role for MTLU in mitigating ACY-induced cognitive impairments, oxidative stress, neuroinflammation, and apoptosis, further research is needed to confirm its therapeutic potential and clinical relevance.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"201 ","pages":"Article 115448"},"PeriodicalIF":3.9,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143834881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distribution of polycyclic aromatic hydrocarbons (PAH) in smoked pork tissue of different characteristic 多环芳烃（PAH）在不同特征熏猪肉组织中的分布

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-11 DOI: 10.1016/j.fct.2025.115435

Kurzyca Iwona , Czerwińska Sandra , Zioła-Frankowska Anetta , Kowalski Artur , Frankowski Marcin

{"title":"Distribution of polycyclic aromatic hydrocarbons (PAH) in smoked pork tissue of different characteristic","authors":"Kurzyca Iwona , Czerwińska Sandra , Zioła-Frankowska Anetta , Kowalski Artur , Frankowski Marcin","doi":"10.1016/j.fct.2025.115435","DOIUrl":"10.1016/j.fct.2025.115435","url":null,"abstract":"<div><div>This study investigates the distribution of 16 polycyclic aromatic hydrocarbons (PAH) in traditionally and industrially smoked pork (loin, neck, bacon), focusing on differences between tissue types. The samples were analyzed using GC-FID after solid-liquid and solid-phase extraction.</div><div>In traditionally smoked loin (median 9.73 μg/kg), the highest PAH concentration was in the skin (14.95 μg/kg), followed by exterior (6.46 μg/kg), interior (1.72 μg/kg) and center (0.10 μg/kg). In industrially smoked lion, median concentration was 0.61 μg/kg in the skin, no PAH were detected in the interior. For traditionally smoked neck (median 28.38 μg/kg) adipose tissue contained about 20 % less PAH than skin, but about 30 % more than marble and 60 % more than lean tissue. In traditionally smoked bacon (median 52.71 μg/kg), fat tissue contained 10 % less than skin and 20 % more than lean layer. Industrially smoked bacon had PAH levels below 1 μg/kg; light hydrocarbons prevailed.</div><div>Post-smoking stages (drying, aging, vacuum wrapping) reduced PAH levels by 11–32 % (up to 24 % in exterior and 10 % in interior).</div><div>Risk assessment indicated that weekly consumption of 50 g of smoked pork posed negligible cancer risk for all meat species, though daily bacon intake may pose a slight risk.</div><div>The study highlights PAH variability across pork tissues, helping consumers make health-conscious dietary choices while preserving smoked pork consumption traditions.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"201 ","pages":"Article 115435"},"PeriodicalIF":3.9,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between internal metal exposure and thyroid cancer incidence: a case-control study simultaneously validated by BKMR and WQS models 内部金属暴露与甲状腺癌发病率的关系：BKMR和WQS模型同时验证的病例对照研究

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-10 DOI: 10.1016/j.fct.2025.115443

Muke Yu , Jingyu Xun , Yiming Ge , Xinjie Li , Xulong Chen , Lingfei Cui , Xidi Wang , Mingxia Zhang , Zhaomin Xing , Liang Deng , NiJiati AiErken , Shaoyou Lu , Kefeng Lei

{"title":"Relationship between internal metal exposure and thyroid cancer incidence: a case-control study simultaneously validated by BKMR and WQS models","authors":"Muke Yu , Jingyu Xun , Yiming Ge , Xinjie Li , Xulong Chen , Lingfei Cui , Xidi Wang , Mingxia Zhang , Zhaomin Xing , Liang Deng , NiJiati AiErken , Shaoyou Lu , Kefeng Lei","doi":"10.1016/j.fct.2025.115443","DOIUrl":"10.1016/j.fct.2025.115443","url":null,"abstract":"<div><div>The global incidence of thyroid cancer is increasing, attracting great attention. Heavy metals affect human health and cause different diseases through various mechanisms. Several studies have identified heavy metals as risk factors for thyroid cancer and examined the association between heavy metals and the development of thyroid cancer. However, the mixed effects of multiple heavy metals on thyroid cancer are still unknown. In this study, twelve heavy metals including iron (Fe), nickel (Ni), copper (Cu), zinc (Zn), arsenic (As), selenium (Se), strontium (Sr), cadmium (Cd), cesium (Cs), palladium (Ba), mercury (Hg), and lead (Pb), in urine from thyroid cancer patients and healthy adults, were measured. The results revealed that the levels of Fe, Ni, and Cu were significantly higher in the case group than in the control group. Weighted quantile sum (WQS) and Bayesian kernel-machine regression (BKMR) analyses consistently showed that heavy metal mixtures in urine were positively associated with the risk of thyroid cancer, with metals such as Fe and Ni being the main contributors. Further epidemiological surveys are needed in the future to investigate the effects of individual or multiple heavy metals on thyroid disease.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"201 ","pages":"Article 115443"},"PeriodicalIF":3.9,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143823949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RIFM fragrance ingredient safety assessment, undecanal, CAS Registry Number 112-44-7 RIFM香精成分安全性评价，十一醛，中国科学院登记号112-44-7

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-10 DOI: 10.1016/j.fct.2025.115440

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , M. Lavelle , I. Lee , H. Moustakas , Y. Tokura

引用次数: 0

Short-chain chlorinated paraffins induce hippocampal damage and glycerophospholipids disruption contributing to neurobehavioral deficits in mice 短链氯化石蜡诱导海马损伤和甘油磷脂破坏，导致小鼠神经行为缺陷

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-10 DOI: 10.1016/j.fct.2025.115444

Xi Ma , Wenzhu Wang , Qingju Mao

{"title":"Short-chain chlorinated paraffins induce hippocampal damage and glycerophospholipids disruption contributing to neurobehavioral deficits in mice","authors":"Xi Ma , Wenzhu Wang , Qingju Mao","doi":"10.1016/j.fct.2025.115444","DOIUrl":"10.1016/j.fct.2025.115444","url":null,"abstract":"<div><div>Short-chain chlorinated paraffins (SCCPs), a class of widely used industrial chemicals, have raised significant health concerns due to their persistence, bioaccumulation, and potential neurotoxicity. This study investigated the neurotoxic effects of SCCPs on the hippocampus and their impact on brain glycerophospholipid metabolism in mice. Behavioral tests revealed that 50 mg/kg SCCPs exposure significantly reduced spontaneous activity and impaired learning and memory. Pathological examination showed neuronal damage, including nuclear pyknosis and cytoplasmic vacuolization, in the hippocampus. Biochemical analyses indicated elevated oxidative stress markers (reactive oxygen species, malondialdehyde) and decreased antioxidant levels (glutathione, superoxide dismutase), alongside reduced levels of neurotransmitters (5-Hydroxytryptamine, dopamine, brain-derived neurotrophic factor). Lipidomics analysis identified significant alterations in glycerophospholipid metabolites, such as decreased levels of phosphatidylcholine and phosphatidylserine. Immunohistochemistry demonstrated downregulation of tight junction proteins (Claudin-1, ZO-1), suggesting blood-brain barrier disruption. These findings highlight SCCPs’ potential to induce hippocampal oxidative stress, neurotransmitter dysregulation, decreased claudin-1 expression and glycerophospholipid metabolism disruption, contributing to neurobehavioral deficits. This study provides insights into the mechanisms of SCCPs-induced neurotoxicity and emphasizes their potential implications for brain health.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"201 ","pages":"Article 115444"},"PeriodicalIF":3.9,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined quercetin with phosphodiesterase inhibitors; sildenafil and pentoxifylline alleviated CCl4-induced chronic hepatic fibrosis: Role of redox-sensitive pathways 槲皮素联合磷酸二酯酶抑制剂；西地那非和己酮茶碱减轻ccl4诱导的慢性肝纤维化：氧化还原敏感通路的作用

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-04-10 DOI: 10.1016/j.fct.2025.115442

Gehad Nasr , Doaa Mohamed Elroby Ali , Michael A. Fawzy , Fares E.M. Ali , Moustafa Fathy

{"title":"Combined quercetin with phosphodiesterase inhibitors; sildenafil and pentoxifylline alleviated CCl4-induced chronic hepatic fibrosis: Role of redox-sensitive pathways","authors":"Gehad Nasr , Doaa Mohamed Elroby Ali , Michael A. Fawzy , Fares E.M. Ali , Moustafa Fathy","doi":"10.1016/j.fct.2025.115442","DOIUrl":"10.1016/j.fct.2025.115442","url":null,"abstract":"<div><div>Liver fibrosis is a common pathological condition that is caused by complicated molecular and cellular processes. This study evaluated the therapeutic potential of combined quercetin (QU) with either sildenafil (Sild) or pentoxifylline (PTX) in chronic carbon tetrachloride (CCl4)-induced liver fibrosis in Wistar albino rats. Fibrosis was induced by CCl<sub>4</sub> injections (1.5 mg/kg, i.p.) three times weekly for 10 weeks. After six weeks, rats received oral QU (50 mg/kg/day), Sild (50 mg/kg/day), or PTX (10 mg/kg twice/day) individually or in combination for the remaining four weeks. Results showed significant alterations in liver biochemical markers, histopathology, oxidative stress, inflammation, apoptosis, and hypoxic responses due to CCl<sub>4</sub> exposure. These changes included reduced expression of Nrf-2, HO-1, and cytoglobin, alongside increased levels of NF-κB, cleaved caspase-3, TNF-α, IL-1β, and HIF-1. Notably, QU, Sild, and PTX, individually or in combination, improved these parameters. The combination of QU with Sild or PTX proved more effective than single treatments, modulating anti-oxidant (Nrf2/HO-1/cytoglobin), anti-inflammatory (NF-κB/TNF-α), and hypoxic signaling pathways (HIF-1α). In conclusion, QU combined with phosphodiesterase inhibitors shows promise as a therapy for liver fibrosis, offering enhanced protection through anti-oxidants and anti-inflammatory mechanisms.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"201 ","pages":"Article 115442"},"PeriodicalIF":3.9,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0