Food and Chemical Toxicology最新文献_第4页

RIFM fragrance ingredient safety assessment, β-pinene, CAS Registry Number 127-91-3.

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2024-12-26 DOI: 10.1016/j.fct.2024.115224

A M Api, A Bartlett, D Belsito, D Botelho, M Bruze, A Bryant-Friedrich, G A Burton, M A Cancellieri, H Chon, M L Dagli, W Dekant, C Deodhar, K Farrell, A D Fryer, L Jones, K Joshi, A Lapczynski, M Lavelle, I Lee, H Moustakas, J Muldoon, T M Penning, G Ritacco, N Sadekar, I Schember, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura

引用次数: 0

RIFM fragrance ingredient safety assessment, octanal, CAS Registry Number 124-13-0.

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2024-12-24 DOI: 10.1016/j.fct.2024.115214

A M Api, A Bartlett, D Belsito, D Botelho, M Bruze, A Bryant-Friedrich, G A Burton, M A Cancellieri, H Chon, M L Dagli, W Dekant, C Deodhar, K Farrell, A D Fryer, L Jones, K Joshi, A Lapczynski, M Lavelle, I Lee, H Moustakas, J Muldoon, T M Penning, G Ritacco, N Sadekar, I Schember, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura

引用次数: 0

Update to RIFM fragrance ingredient safety assessment, 3-methylbutyl valerate, CAS Registry Number 2050-09-1.

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2024-12-24 DOI: 10.1016/j.fct.2024.115211

A M Api, A Bartlett, D Belsito, D Botelho, M Bruze, A Bryant-Friedrich, G A Burton, M A Cancellieri, H Chon, M Cronin, S Crotty, M L Dagli, W Dekant, C Deodhar, K Farrell, A D Fryer, L Jones, K Joshi, A Lapczynski, D L Laskin, M Lavelle, I Lee, H Moustakas, J Muldoon, T M Penning, A H Piersma, G Ritacco, N Sadekar, I Schember, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar

引用次数: 0

Update to RIFM fragrance ingredient safety assessment, 2-methylbutyl butyrate, CAS Registry Number 51115-64-1.

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2024-12-24 DOI: 10.1016/j.fct.2024.115210

A M Api, A Bartlett, D Belsito, D Botelho, M Bruze, A Bryant-Friedrich, G A Burton, M A Cancellieri, H Chon, M Cronin, S Crotty, M L Dagli, W Dekant, C Deodhar, K Farrell, A D Fryer, L Jones, K Joshi, A Lapczynski, D L Laskin, M Lavelle, I Lee, H Moustakas, J Muldoon, T M Penning, A H Piersma, G Ritacco, N Sadekar, I Schember, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar

引用次数: 0

18β-glycyrrhetinic acid Mitigates bisphenol A-induced liver and renal damage: Inhibition of TNF-α/NF-κB/p38-MAPK, JAK1/STAT1 pathways, oxidative stress and apoptosis.

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2024-12-24 DOI: 10.1016/j.fct.2024.115218

Ekrem Darendelioglu, Cuneyt Caglayan, Sefa Küçükler, İbrahim Bayav, Fatih Mehmet Kandemir, Adnan Ayna, Sevda Sağ

{"title":"18β-glycyrrhetinic acid Mitigates bisphenol A-induced liver and renal damage: Inhibition of TNF-α/NF-κB/p38-MAPK, JAK1/STAT1 pathways, oxidative stress and apoptosis.","authors":"Ekrem Darendelioglu, Cuneyt Caglayan, Sefa Küçükler, İbrahim Bayav, Fatih Mehmet Kandemir, Adnan Ayna, Sevda Sağ","doi":"10.1016/j.fct.2024.115218","DOIUrl":"https://doi.org/10.1016/j.fct.2024.115218","url":null,"abstract":"Bisphenol A (BPA) has been commonly used in various consumer products, including water bottles, food containers, and canned food linings. However, there are concerns about its potential toxicity to human health, particularly its impact on the liver and kidneys. The objective of this research was to investigate the potential ameliorative effects of 18β-glycyrrhetinic acid (GA) against BPA-induced hepatotoxicity and nephrotoxicity in rats. The animals were supplemented with BPA (250 mg/kg b.w.) alone or with GA (50 and 100 mg/kg b.w.) for 14 days. GA treatment alleviated the BPA-induced hepato-renal tissue injuries through reducing the serum ALT, AST and ALP levels, and urea and creatinine levels. GA co-treatment also increased activities of SOD, CAT and GPx enzymes and levels of GSH, and suppressed MDA levels in BPA induced tissues. BPA also induced inflammation by increasing the levels of TNF-α, NF-κB, JAK1, STAT1, P38 MAPK and JNK in liver and kidney tissues and GA treatment ameliorated these effects. BPA triggered apoptosis by increasing caspase-3, Bax, and cytochrome c at protein levels and also by decreasing the antiapoptotic Bcl-2 level. However, treatment with GA (50 and 100 mg/kg) decreased apoptosis. Overall, our results have revealed the potential ameliorative mechanisms of GA, as a possible agent for BPA-induced hepatotoxicity and nephrotoxicity.","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"196 ","pages":"115218"},"PeriodicalIF":3.9,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142890905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RIFM fragrance ingredient safety assessment, tricyclo[3.3.1.1.(3.7)]decan-2-ol, 4-methyl-8-methylene-, CAS Registry Number 122760-84-3.

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2024-12-24 DOI: 10.1016/j.fct.2024.115213

A M Api, A Bartlett, D Belsito, D Botelho, M Bruze, A Bryant-Friedrich, G A Burton, M A Cancellieri, H Chon, M L Dagli, W Dekant, C Deodhar, K Farrell, A D Fryer, L Jones, K Joshi, A Lapczynski, M Lavelle, I Lee, H Moustakas, J Muldoon, T M Penning, G Ritacco, N Sadekar, I Schember, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura

引用次数: 0

Update to RIFM fragrance ingredient safety assessment, amyl alcohol, CAS Registry Number 71-41-0.

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2024-12-24 DOI: 10.1016/j.fct.2024.115212

A M Api, A Bartlett, D Belsito, D Botelho, M Bruze, A Bryant-Friedrich, G A Burton, M A Cancellieri, H Chon, M Cronin, S Crotty, M L Dagli, W Dekant, C Deodhar, K Farrell, A D Fryer, L Jones, K Joshi, A Lapczynski, D L Laskin, M Lavelle, I Lee, H Moustakas, J Muldoon, T M Penning, A H Piersma, G Ritacco, N Sadekar, I Schember, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar

引用次数: 0

RIFM fragrance ingredient safety assessment, heptanal, CAS registry number 111-71-7.

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2024-12-24 DOI: 10.1016/j.fct.2024.115215

A M Api, A Bartlett, D Belsito, D Botelho, M Bruze, A Bryant-Friedrich, G A Burton, M A Cancellieri, H Chon, M L Dagli, W Dekant, C Deodhar, K Farrell, A D Fryer, L Jones, K Joshi, A Lapczynski, M Lavelle, I Lee, H Moustakas, J Muldoon, T M Penning, G Ritacco, N Sadekar, I Schember, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura

引用次数: 0

Black phosphorus nanomaterials mediate size-dependent acute lung injury by promoting macrophage polarization.

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2024-12-22 DOI: 10.1016/j.fct.2024.115219

Mingtao Wu, Jie Zeng, Wanru Huang, Fengkai Ruan, Zhenghong Zuo, Liang Bu, Chengyong He

{"title":"Black phosphorus nanomaterials mediate size-dependent acute lung injury by promoting macrophage polarization.","authors":"Mingtao Wu, Jie Zeng, Wanru Huang, Fengkai Ruan, Zhenghong Zuo, Liang Bu, Chengyong He","doi":"10.1016/j.fct.2024.115219","DOIUrl":"10.1016/j.fct.2024.115219","url":null,"abstract":"Black phosphorus nanomaterials (BPNM) exhibit excellent properties and potential applications in electronics, but workers may face inhalation exposure during BPNM production. In addition, there is a lack of biosafety assessments regarding respiratory exposure to BPNM of different sizes. In this study, we investigated the lung toxicity in mice exposed to 5, 50, 500 μg/kg of black phosphorus quantum dots (BPQDs) and black phosphorus nanosheet (BPNS) via single tracheal instillation. The average diameter of the BPQDs and BPNS were 13.48 ± 4.82 nm and 325.53 ± 165.17 nm, respectively. Twenty-four hours after exposure, both BPQDs and BPNS caused acute lung injury, characterized by bronchial wall thickening, alveolar collapse, increased lamellar bodies, and immune cell infiltration. BPNS exposure resulted in reduced gene expression of pulmonary surfactant proteins Spb and Spc. Additionally, both BPQDs and BPNS increased inflammatory factors gene expression and induced lung macrophages polarization, with BPNS demonstrating a more significant effect. This study is the first to show that BPQDs and BPNS induced acute lung injury and inflammation in mice, with BPNS being more toxic. These findings are crucial for enhancing the biosafety assessment of BPNM and advancing technologies to improve the safety of nanomaterials.","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":" ","pages":"115219"},"PeriodicalIF":3.9,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142884926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From food-to-human microplastics and nanoplastics exposure and health effects: A review on food, animal and human monitoring data.

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2024-12-20 DOI: 10.1016/j.fct.2024.115209

Flavia Ruggieri, Beatrice Battistini, Angela Sorbo, Marta Senofonte, Veruscka Leso, Ivo Iavicoli, Beatrice Bocca

{"title":"From food-to-human microplastics and nanoplastics exposure and health effects: A review on food, animal and human monitoring data.","authors":"Flavia Ruggieri, Beatrice Battistini, Angela Sorbo, Marta Senofonte, Veruscka Leso, Ivo Iavicoli, Beatrice Bocca","doi":"10.1016/j.fct.2024.115209","DOIUrl":"10.1016/j.fct.2024.115209","url":null,"abstract":"This review figures out the overall status on the presence of microplastics (MPs) and nanoplastics (NPs) in food and their bioaccumulation in animal and human tissues, providing critical insights into possible human health impacts. Data are discussed on both in-vivo and ex-vivo animal and human studies, and the role of physicochemical properties in determining the biological fate and toxicological effects of MPs and NPs. Particular attention is given to dietary exposure assessments, specifically evaluating daily intake through the consumption of contaminated food items. The current limitations in the body of knowledge and some considerations for future assessments are also reported. Overall, there is a pressing need to establish more robust biomarker research and develop standardized methodologies, for a better understanding of MPs and NPs fate and associated effects in more realistic scenarios for their safe consumption. The review underscores the importance of integrating the human biomonitoring into monitoring programs and interdisciplinary research to ultimately inform on MPs and NPs real burden in the human body.","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":" ","pages":"115209"},"PeriodicalIF":3.9,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142875708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0