Food and Chemical Toxicology最新文献_第4页

Identification of the metabolomic alterations associated with the formation of bisphenol-A sulfate metabolite in HepG2 cells

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-07 DOI: 10.1016/j.fct.2025.115382

Hui-Jun Jin , Zi-Dong Qiu , Cen Qian , Chun-Yun Zhang , Yu Peng

{"title":"Identification of the metabolomic alterations associated with the formation of bisphenol-A sulfate metabolite in HepG2 cells","authors":"Hui-Jun Jin , Zi-Dong Qiu , Cen Qian , Chun-Yun Zhang , Yu Peng","doi":"10.1016/j.fct.2025.115382","DOIUrl":"10.1016/j.fct.2025.115382","url":null,"abstract":"<div><div>The elucidation of the causal relationship between bisphenol-A (BPA) exposure and hepatoxic outcomes is challenging because of the complexity in both the BPA-derived metabolites formed in the liver and the associated endogenous molecular responses. We performed parallel metabolism experiments with BPA to characterize the BPA sulfate formation and the associated alterations in the metabolome level in HepG2 cells using mass spectrometry-based metabolome wide association study. Briefly, HepG2 cells were exposed for 8 or 24 h to 1 or 10 μM BPA in DMSO or DMSO alone. The levels of BPA sulfate in the cell culture media were quantified, and the sulfation efficiency was about 0.4 % observed for both 1 and 10 μM BPA in HepG2 cells. Targeted metabolomic analyses revealed alterations belonging to forty metabolic pathways following BPA exposure. Featured by the decreasing of estrone sulfate, estrogen metabolism was observed as the top 1 enriched pathway in response to BPA exposure. MWAS suggests that BPA sulfate formation in HepG2 cells resulted in vitamin B6 deficiency and dysregulated vitamin B6-dependent processes, for example, the kynurenine pathway in tryptophan metabolism. These findings collectively provide insights into the linkage between exogenous and endogenous metabolism and the potential initial events in BPA exposure-relevant hepatoxicity.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115382"},"PeriodicalIF":3.9,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spectrum-effect relationship of the cardiovascular-protective effect of with Chrysanthemi Flos by UPLC-MS/MS and component knock-out method

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-05 DOI: 10.1016/j.fct.2025.115372

Ranran Cheng , Xiang Cheng , Dongliang Jiang , Junwei Xiong , Yangfei Ding , Juan Liu , Hongsu Zhao , Hangmin Feng , Deling Wu , Wei Zhang

{"title":"Spectrum-effect relationship of the cardiovascular-protective effect of with Chrysanthemi Flos by UPLC-MS/MS and component knock-out method","authors":"Ranran Cheng , Xiang Cheng , Dongliang Jiang , Junwei Xiong , Yangfei Ding , Juan Liu , Hongsu Zhao , Hangmin Feng , Deling Wu , Wei Zhang","doi":"10.1016/j.fct.2025.115372","DOIUrl":"10.1016/j.fct.2025.115372","url":null,"abstract":"<div><div><em>Chrysanthemi Flos</em> (CF), as one of the important ‘dual-use’ plants, possesses great pharmacological research and development potential. This work aimed to find the pharmacodynamic material basis of CF in cardiovascular-protection by spectrum-effect relationship and component knock-out method. The fingerprint was established by ultra-high performance liquid chromatography and 25 peaks were picked out as common peaks. The common peaks were identified by ultra-performance liquid chromatography-quadrupole-orbitrap-mass spectrometry including twelve flavonoids, nine phenylpropanoids, three organic acids, and one nucleoside. The cardiovascular-protective effect of CF was determined by angiotensin II-induced injury model of human umbilical vein endothelial cells. Grey relation analysis, partial least squares regression analysis and Pearson's correlation analysis were performed to assess the relationship between the cardiovascular-protective effect and ingredients. Spectrum-effect relationship and component knock-out method revealed that P11 (luteolin-7-<em>O</em>-<em>β</em>-D-glucoside), P14 (3,4-<em>O</em>-dicaffeoylquinic acid), P16 (1,5-<em>O</em>-dicaffeoylquinic acid), and P17 (3,5-<em>O</em>-dicaffeoylquinic acid) were the pharmacological material basis for the cardiovascular-protective effect of CF. This work preliminarily elucidated the pharmacodynamic material basis of cardiovascular-protective effect of CF, which could be used to considerable methods and insight for the fundamental research of the pharmacodynamic material basis of Traditional Chinese Medicine.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115372"},"PeriodicalIF":3.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Derivation of a health-based guidance value for bisphenol A via the weight of evidence approach

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-05 DOI: 10.1016/j.fct.2025.115370

Xiaomeng Li , Yu Lu , Daoyuan Yang , Jiabin Guo , Guojun Li , Qian Bian , Keliang Liu , Yan Song , Zhaoping Liu , Haixia Sui , Jinyao Chen

{"title":"Derivation of a health-based guidance value for bisphenol A via the weight of evidence approach","authors":"Xiaomeng Li , Yu Lu , Daoyuan Yang , Jiabin Guo , Guojun Li , Qian Bian , Keliang Liu , Yan Song , Zhaoping Liu , Haixia Sui , Jinyao Chen","doi":"10.1016/j.fct.2025.115370","DOIUrl":"10.1016/j.fct.2025.115370","url":null,"abstract":"<div><div>There remains a debate over the health-based guidance value of bisphenol A (BPA) worldwide. Through the weight of evidence approach, this study systematically searched and evaluated the updated BPA toxicological data following the guidelines for evaluating the relevance and reliability of toxicological data developed by the China National Center for Food Safety Risk Assessment. Benchmark dose and no observed adverse effect dose/lowest observed adverse effect level methods were used for dose–relationship analysis. A total of 334 articles were used for evidence integration and included in this hazard assessment of BPA. General toxicity, toxicity to the reproductive system, and neurological (developmental) toxicity were included as possible critical effects in the present assessment. With a point of departure of 2310 μg/kg body weight (BW) based on the decreased round spermatid count in rat seminiferous tubules and the human equivalent dose factor of 0.185 using the constructed physiologically based toxicokinetic model of oral intake of BPA in Chinese population, a human equivalent dose of 427 μg/kg BW was obtained. Applying an overall uncertainty factor of 100, the present assessment established a temporary-tolerable daily intake of 4 μg/kg BW for oral exposure of humans to BPA.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115370"},"PeriodicalIF":3.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143578804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

4th generation of warfare agents – Novichoks: Threats, problems, challenges for the security of the armed forces and civilian population

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-04 DOI: 10.1016/j.fct.2025.115371

Barbara Wiaderek , Monika Wiśnik-Sawka , Dorota Gajda , Klaudia Rzadkowska , Patrycja Bryczek-Wróbel , Tomasz Sałaciński

{"title":"4th generation of warfare agents – Novichoks: Threats, problems, challenges for the security of the armed forces and civilian population","authors":"Barbara Wiaderek , Monika Wiśnik-Sawka , Dorota Gajda , Klaudia Rzadkowska , Patrycja Bryczek-Wróbel , Tomasz Sałaciński","doi":"10.1016/j.fct.2025.115371","DOIUrl":"10.1016/j.fct.2025.115371","url":null,"abstract":"<div><div>This publication explores the characteristics, threats, and challenges posed by fourth-generation chemical warfare agents - Novichoks. These highly toxic agents, recently introduced to the international security landscape, represent a significant risk not only to military forces, but also to civilian populations, especially in the context of potential terrorist attacks. The study examines the molecular structure, toxicity, and physiological effects of Novichoks, underscoring their resistance to conventional decontamination methods and their rapid, severe impact on human health. Through the case studies, including the poisoning incidents involving Sergei Skripal, Alexei Navalny, and other high-profile cases, this publication illustrates the real-world implications of these agents in acts of targeted violence. It also discusses the international regulatory measures established by organizations such as the Organization for the Prohibition of Chemical Weapons (OPCW) and highlights EU and NATO policies aimed at preventing the proliferation and use of Novichoks and similar agents.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115371"},"PeriodicalIF":3.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhibitory effect and mechanism of purified saponin from Polygonatum cyrtonema Hua on human ovarian cancer cell A2780

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-04 DOI: 10.1016/j.fct.2025.115368

Qile Xia , Beiqiong Hao , Chenxing Liu, Yan Cao

{"title":"Inhibitory effect and mechanism of purified saponin from Polygonatum cyrtonema Hua on human ovarian cancer cell A2780","authors":"Qile Xia , Beiqiong Hao , Chenxing Liu, Yan Cao","doi":"10.1016/j.fct.2025.115368","DOIUrl":"10.1016/j.fct.2025.115368","url":null,"abstract":"<div><div><em>Polygonatum cyrtonema</em> Hua (PcH) is a traditional medicinal and edible homologous plant. Here, the anticancer activity of different purified PcH saponins (PcHs) on the ovarian cancer (OC) cell A2780 were investigated. The PcHs were purified by AB-8. Their effects on the apoptosis, migration and invasion of A2780 were explored by CCK8, wound healing assay, Hoechst 33258 staining, Annexin V-FITC/PI and intracellular reactive oxygen species (ROS) measurement. Moreover, western blot and realtime-PCR confirmation were performed for the associated protein and mRNA targets. The results showed that the content of PcHs increased from 0.31 ± 0.02 mg/mL to 0.79 ± 0.02 mg/mL after purification. The inhibition rate of purified PcHs on A2780 could reach 66.76 ± 0.56%. Specifically, it promoted cell apoptosis, disturbed the cell cycle, increased the ROS levels, regulated the expression levels of pro-apoptotic and anti-apoptotic proteins. PcHs can also regulate the expression level of proteins related to the invasion and migration characteristics of A2780, the mRNA expression level related to the P13K-Akt signal transduction process, and the extracellular matrix-receptor interaction pathway, as well as drug resistance. Overall, this study provides a new idea for the treatment of OC.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115368"},"PeriodicalIF":3.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RIFM fragrance ingredient safety assessment, 4-(p-methoxyphenyl)-2-butanone, CAS Registry Number 104-20-1

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-03 DOI: 10.1016/j.fct.2025.115366

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

Update to RIFM fragrance ingredient safety assessment, isobutyl propionate, CAS Registry Number 540-42-1

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-03 DOI: 10.1016/j.fct.2025.115367

A.M. Api , A. Bartlett , D. Belsito , D. Botelho , M. Bruze , A. Bryant-Friedrich , G.A. Burton Jr. , M.A. Cancellieri , H. Chon , M. Cronin , S. Crotty , M.L. Dagli , W. Dekant , C. Deodhar , K. Farrell , A.D. Fryer , L. Jones , K. Joshi , A. Lapczynski , D.L. Laskin , Y. Thakkar

引用次数: 0

Regulatory effect of curcumin on CD40:CD40L interaction and therapeutic implications

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-03 DOI: 10.1016/j.fct.2025.115369

Fatemeh Askarizadeh , Alexandra E. Butler , Prashant Kesharwani , Amirhossein Sahebkar

{"title":"Regulatory effect of curcumin on CD40:CD40L interaction and therapeutic implications","authors":"Fatemeh Askarizadeh , Alexandra E. Butler , Prashant Kesharwani , Amirhossein Sahebkar","doi":"10.1016/j.fct.2025.115369","DOIUrl":"10.1016/j.fct.2025.115369","url":null,"abstract":"<div><div>Natural compounds have garnered significant attention as potential therapeutic agents due to their inherent properties. Their notable qualities, including safety, efficacy, favorable pharmacokinetic properties, and heightened effectiveness against certain diseases, particularly inflammatory conditions, make them particularly appealing. Among these compounds, curcumin has attracted considerable interest for its unique therapeutic properties and has therefore been extensively studied as a potential therapeutic agent for treating various diseases. Curcumin exhibits diverse anti-inflammatory, antioxidant, and antimicrobial effects. Curcumin's immune system regulatory ability has made it a promising compound for treatment of various inflammatory diseases, such as psoriasis, atherosclerosis, asthma, colitis, IBD, and arthritis. Among the signaling pathways implicated in these conditions, the CD40 receptor together with its ligand, CD40L, are recognized as central players. Studies have demonstrated that the interaction between CD40 and CD40L interaction acts as the primary mediator of the immune response in inflammatory diseases. Numerous studies have explored the impact of curcumin on the CD40:CD40L pathway, highlighting its regulatory effects on this inflammatory pathway and its potential therapeutic use in related inflammatory conditions. In this review, we will consider the evidence concerning curcumin's modulatory effects in inflammatory disease and its potential therapeutic role in regulating the CD40:CD40L pathway.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115369"},"PeriodicalIF":3.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143565534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of pesticide contamination in pomegranates: A multivariate approach and health risk evaluation

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-01 DOI: 10.1016/j.fct.2025.115363

Emrah Gormez , Eylem Odabas , Ozgur Golge , Miguel Ángel González-Curbelo , Bulent Kabak

{"title":"Assessment of pesticide contamination in pomegranates: A multivariate approach and health risk evaluation","authors":"Emrah Gormez , Eylem Odabas , Ozgur Golge , Miguel Ángel González-Curbelo , Bulent Kabak","doi":"10.1016/j.fct.2025.115363","DOIUrl":"10.1016/j.fct.2025.115363","url":null,"abstract":"<div><div>Pesticide residues in pomegranates pose a significant food safety concern, particularly given the rising global consumption of this fruit. This study monitored 316 pesticide residues in 342 pomegranate samples from Turkey's three primary pomegranate production regions using liquid chromatography-tandem mass spectrometry. Pesticide residues were detected in 72.8% of the samples, with 40 different pesticides identified, 15 of which were unauthorized. Spirotetramat, acetamiprid, and fludioxonil were among the most frequently detected, with concentrations exceeding the maximum residue levels set by the European Union in 40.6% of the contaminated samples. Multivariate analysis revealed strong correlations between specific pesticide pairs, suggesting common usage patterns. The chronic hazard index was 0.0132 for adults and 0.0403 for children, indicating no significant chronic health risks. The acute health risks for all pesticides remained below acceptable limits, except for acetamiprid, which exceeded the threshold (1.186) for children. However, the presence of non-approved pesticides, such as omethoate, raises concerns about regulatory compliance. Continued surveillance and risk assessment are essential to minimize potential health risks, particularly for vulnerable populations consuming pomegranates.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115363"},"PeriodicalIF":3.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elaidic acid induces testicular oxidative stress, inflammation, Wnt/β-catenin disruption and abnormalities in steroidogenesis, spermatogenesis and histo-architecture in Sprague Dawley rats

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-01 DOI: 10.1016/j.fct.2025.115365

Fuad M. Alzahrani , Muhammad Faisal Hayat , Ali Akbar , Syeda Sania Zahara , Meshari A. Alsuwat , Khalid J. Alzahrani , Ahmed El-Emam

{"title":"Elaidic acid induces testicular oxidative stress, inflammation, Wnt/β-catenin disruption and abnormalities in steroidogenesis, spermatogenesis and histo-architecture in Sprague Dawley rats","authors":"Fuad M. Alzahrani , Muhammad Faisal Hayat , Ali Akbar , Syeda Sania Zahara , Meshari A. Alsuwat , Khalid J. Alzahrani , Ahmed El-Emam","doi":"10.1016/j.fct.2025.115365","DOIUrl":"10.1016/j.fct.2025.115365","url":null,"abstract":"<div><div>Elaidic Acid (EA) is a major <em>trans</em>-fatty acid that has garnered significant attention due to its potential role in inducing systemic toxicity. The current investigation was conducted to assess the toxic effects of EA (50 mg/kg, 100 mg/kg, and 150 mg/kg) on testicular tissues of Sprague Dawley rats. EA intoxication disrupted Wnt/β-catenin via downregulating the expression of WNT3A and TCF7L2 while upregulating the expression of AXIN1 and GSK-3β. The activities of antioxidant enzymes were reduced while the levels of cellular oxidative stress were escalated following the EA exposure. EA administration disrupted the process of steroidogenesis as well as spermatogenesis through the downregulation of CYP11A1, 5α-reductase, 3β-HSD, CYP17A1, and StAR while elevating spermatogenic abnormalities in head, tail and neck of sperm cells. The levels of LH, androgen binding protein, FSH, inhibin B, plasma testosterone and estradiol were lowered after EA administration. Testicular tissues showed inflammatory responses after EA exposure that is evident by elevated levels of TNF-α, IL-1β, COX-2, IL-6 and NF-κB. The expressions of Bax and Caspase-3 were upsurged while expression of Bcl-2 was reduced following the EA intoxication. These findings showed EA exerted toxic effects on testicular tissues via elevating oxidative stress, inflammation and apoptosis.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115365"},"PeriodicalIF":3.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0