Food and Chemical Toxicology最新文献

{"title":"Update to RIFM fragrance ingredient safety assessment, nonanoic acid, CAS Registry Number 112-05-0.","authors":"A M Api, A Bartlett, D Belsito, D Botelho, M Bruze, A Bryant-Friedrich, G A Burton, M A Cancellieri, H Chon, M Cronin, S Crotty, M L Dagli, W Dekant, C Deodhar, K Farrell, A D Fryer, L Jones, K Joshi, A Lapczynski, D L Laskin, M Lavelle, I Lee, H Moustakas, J Muldoon, T M Penning, A H Piersma, G Ritacco, N Sadekar, I Schember, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar","doi":"10.1016/j.fct.2025.115755","DOIUrl":"https://doi.org/10.1016/j.fct.2025.115755","url":null,"abstract":"","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":" ","pages":"115755"},"PeriodicalIF":3.5,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Update to RIFM fragrance ingredient safety assessment, 4H-4a,9-methanoazuleno[5,6-d]-1,3-dioxole, octahydro-2,2,5,8,8,9a-hexamethyl-, (4aR,5R,7aS,9R)-, CAS Registry Number 211299-54-6","authors":"A.M. Api ,&nbsp;A. Bartlett ,&nbsp;D. Belsito ,&nbsp;D. Botelho ,&nbsp;M. Bruze ,&nbsp;A. Bryant-Friedrich ,&nbsp;G.A. Burton Jr. ,&nbsp;M.A. Cancellieri ,&nbsp;H. Chon ,&nbsp;M. Cronin ,&nbsp;S. Crotty ,&nbsp;M.L. Dagli ,&nbsp;W. Dekant ,&nbsp;C. Deodhar ,&nbsp;K. Farrell ,&nbsp;A.D. Fryer ,&nbsp;L. Jones ,&nbsp;K. Joshi ,&nbsp;A. Lapczynski ,&nbsp;D.L. Laskin ,&nbsp;Y. Thakkar","doi":"10.1016/j.fct.2025.115749","DOIUrl":"10.1016/j.fct.2025.115749","url":null,"abstract":"<div><div>4H-4a,9-Methanoazuleno[5,6-d]-1,3-dioxole, octahydro-2,2,5,8,8,9a-hexamethyl-, (4aR,5R,7aS,9R)- was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety. Data show that 4H-4a,9-methanoazuleno[5,6-d]-1,3-dioxole, octahydro-2,2,5,8,8,9a-hexamethyl-, (4aR,5R,7aS,9R)- is not genotoxic and provide a calculated Margin of Exposure (MOE) &gt; 100 for the repeated dose toxicity endpoint. The reproductive and local respiratory toxicity endpoints were evaluated using the Threshold of Toxicological Concern (TTC) for a Cramer Class III material, and the exposure to 4H-4a,9-methanoazuleno[5,6-d]-1,3-dioxole, octahydro-2,2,5,8,8,9a-hexamethyl-, (4aR,5R,7aS,9R)- is below the TTC (0.0015 mg/kg/day and 0.47 mg/day, respectively). Data show that there are no safety concerns for 4H-4a,9-methanoazuleno[5,6-d]-1,3-dioxole, octahydro-2,2,5,8,8,9a-hexamethyl-, (4aR,5R,7aS,9R)- for skin sensitization under the current declared levels of use. The photoirritation/photoallergenicity endpoints were evaluated based on ultraviolet/visible (UV/Vis) spectra; 4H-4a,9-methanoazuleno[5,6-d]-1,3-dioxole, octahydro-2,2,5,8,8,9a-hexamethyl-, (4aR,5R,7aS,9R)- is not expected to be photoirritating/photoallergenic. The environmental endpoints were evaluated; 4H-4a,9-methanoazuleno[5,6-d]-1,3-dioxole, octahydro-2,2,5,8,8,9a-hexamethyl-, (4aR,5R,7aS,9R)- was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards, and its risk quotients, based on its current volume of use (VoU) in Europe and North America (i.e., Predicted Environmental Concentration/Predicted No Effect Concentration [PEC/PNEC]), are &lt;1.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"206 ","pages":"Article 115749"},"PeriodicalIF":3.5,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Update to RIFM fragrance ingredient safety assessment, 1-ethynylcyclohexyl acetate, CAS Registry Number 5240-32-4.","authors":"A M Api, A Bartlett, D Belsito, D Botelho, M Bruze, A Bryant-Friedrich, G A Burton, M A Cancellieri, H Chon, M Cronin, S Crotty, M L Dagli, W Dekant, C Deodhar, K Farrell, A D Fryer, L Jones, K Joshi, A Lapczynski, D L Laskin, M Lavelle, I Lee, H Moustakas, J Muldoon, T M Penning, A H Piersma, G Ritacco, N Sadekar, I Schember, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar","doi":"10.1016/j.fct.2025.115752","DOIUrl":"https://doi.org/10.1016/j.fct.2025.115752","url":null,"abstract":"","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":" ","pages":"115752"},"PeriodicalIF":3.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Update to RIFM fragrance ingredient safety assessment, 2-methyl-4-phenyl-1,3-dioxolane, CAS Registry Number 33941-99-0","authors":"A.M. Api ,&nbsp;A. Bartlett ,&nbsp;D. Belsito ,&nbsp;D. Botelho ,&nbsp;M. Bruze ,&nbsp;A. Bryant-Friedrich ,&nbsp;G.A. Burton Jr. ,&nbsp;M.A. Cancellieri ,&nbsp;H. Chon ,&nbsp;M. Cronin ,&nbsp;S. Crotty ,&nbsp;M.L. Dagli ,&nbsp;W. Dekant ,&nbsp;C. Deodhar ,&nbsp;K. Farrell ,&nbsp;A.D. Fryer ,&nbsp;L. Jones ,&nbsp;K. Joshi ,&nbsp;A. Lapczynski ,&nbsp;D.L. Laskin ,&nbsp;Y. Thakkar","doi":"10.1016/j.fct.2025.115750","DOIUrl":"10.1016/j.fct.2025.115750","url":null,"abstract":"","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"206 ","pages":"Article 115750"},"PeriodicalIF":3.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Update to RIFM fragrance ingredient safety assessment, hexanoic acid, CAS Registry Number 142-62-1","authors":"A.M. Api ,&nbsp;A. Bartlett ,&nbsp;D. Belsito ,&nbsp;D. Botelho ,&nbsp;M. Bruze ,&nbsp;A. Bryant-Friedrich ,&nbsp;G.A. Burton Jr. ,&nbsp;M.A. Cancellieri ,&nbsp;H. Chon ,&nbsp;M. Cronin ,&nbsp;S. Crotty ,&nbsp;M.L. Dagli ,&nbsp;W. Dekant ,&nbsp;C. Deodhar ,&nbsp;K. Farrell ,&nbsp;A.D. Fryer ,&nbsp;L. Jones ,&nbsp;K. Joshi ,&nbsp;A. Lapczynski ,&nbsp;D.L. Laskin ,&nbsp;Y. Thakkar","doi":"10.1016/j.fct.2025.115756","DOIUrl":"10.1016/j.fct.2025.115756","url":null,"abstract":"","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"206 ","pages":"Article 115756"},"PeriodicalIF":3.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Update to RIFM fragrance ingredient safety assessment, 4-isopropyl-2-methoxy-1-methylbenzene, CAS Registry Number 6379-73-3","authors":"A.M. Api ,&nbsp;A. Bartlett ,&nbsp;D. Belsito ,&nbsp;D. Botelho ,&nbsp;M. Bruze ,&nbsp;A. Bryant-Friedrich ,&nbsp;G.A. Burton Jr. ,&nbsp;M.A. Cancellieri ,&nbsp;H. Chon ,&nbsp;M. Cronin ,&nbsp;S. Crotty ,&nbsp;M.L. Dagli ,&nbsp;W. Dekant ,&nbsp;C. Deodhar ,&nbsp;K. Farrell ,&nbsp;A.D. Fryer ,&nbsp;L. Jones ,&nbsp;K. Joshi ,&nbsp;A. Lapczynski ,&nbsp;D.L. Laskin ,&nbsp;Y. Thakkar","doi":"10.1016/j.fct.2025.115754","DOIUrl":"10.1016/j.fct.2025.115754","url":null,"abstract":"","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"206 ","pages":"Article 115754"},"PeriodicalIF":3.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gallium and arsenic human skin permeation after application of GaAs particles: an ex-vivo study using Franz cells","authors":"Marco Rizzo ,&nbsp;Giovanna Marussi ,&nbsp;Matteo Crosera ,&nbsp;Mauro Marcella ,&nbsp;Giorgio Biasiol ,&nbsp;Gianpiero Adami ,&nbsp;Greta Camilla Magnano ,&nbsp;Francesca Larese Filon","doi":"10.1016/j.fct.2025.115758","DOIUrl":"10.1016/j.fct.2025.115758","url":null,"abstract":"<div><div>Gallium arsenide (GaAs) is a semiconductor widely used in various technological applications. This study, conducted in a research laboratory, aims to evaluate the cutaneous permeation of GaAs particles using an ex-vivo model with Franz diffusion cells.</div><div>Dissolution tests indicated that gallium dissociates at higher rates than arsenic in synthetic sweat, but permeation experiments revealed that arsenic is more permeable, particularly in damaged skin conditions. After 24 h of exposure, arsenic concentrations in the receiving compartment were three times higher in damaged skin (1558 ± 546 ng/cm²) than in decontaminated skin (458 ± 144 ng/cm²), (p &lt; 0.05). Gallium</div><div>concentrations were six times higher in damaged skin (244 ± 5.29 ng/cm²) compared to decontaminated skin (37.1 ± 11.9 ng/cm²), (p &lt; 0.05) Intact skin serves as an effective barrier, while damaged skin significantly increases the permeation of both elements. The decontamination process also enhances penetration due to impairment of the skin's lipid structure.</div><div>In conclusion, GaAs particles can release arsenic and gallium that penetrate and permeate the skin.</div><div>These findings highlight the importance of preventive measures in occupational settings to ensure adequate protection.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"206 ","pages":"Article 115758"},"PeriodicalIF":3.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward a stronger evidence base for heavy metal mixtures and prostate cancer risk","authors":"Yuekun Fang ,&nbsp;Shengyi Chen ,&nbsp;Bin Cheng","doi":"10.1016/j.fct.2025.115757","DOIUrl":"10.1016/j.fct.2025.115757","url":null,"abstract":"","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"206 ","pages":"Article 115757"},"PeriodicalIF":3.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Update to RIFM fragrance ingredient safety assessment, 2-hydroxyacetophenone, CAS Registry Number CAS # 118-93-4","authors":"A.M. Api ,&nbsp;A. Bartlett ,&nbsp;D. Belsito ,&nbsp;D. Botelho ,&nbsp;M. Bruze ,&nbsp;A. Bryant-Friedrich ,&nbsp;G.A. Burton Jr. ,&nbsp;M.A. Cancellieri ,&nbsp;H. Chon ,&nbsp;M. Cronin ,&nbsp;S. Crotty ,&nbsp;M.L. Dagli ,&nbsp;W. Dekant ,&nbsp;C. Deodhar ,&nbsp;K. Farrell ,&nbsp;A.D. Fryer ,&nbsp;L. Jones ,&nbsp;K. Joshi ,&nbsp;A. Lapczynski ,&nbsp;D.L. Laskin ,&nbsp;Y. Thakkar","doi":"10.1016/j.fct.2025.115753","DOIUrl":"10.1016/j.fct.2025.115753","url":null,"abstract":"","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"206 ","pages":"Article 115753"},"PeriodicalIF":3.5,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary prebiotics combined with iron supplementation: A two-pronged approach to reduce rice cadmium bioavailability","authors":"Rong-Yue Xue ,&nbsp;Yao-Sheng Zhang ,&nbsp;Jin-Feng Xi,&nbsp;Lei Zhou,&nbsp;Xin-Ying Lin,&nbsp;Tian-Wen Ye,&nbsp;Yu-Hang Bao,&nbsp;Dongmei Zhou,&nbsp;Hong-Bo Li","doi":"10.1016/j.fct.2025.115745","DOIUrl":"10.1016/j.fct.2025.115745","url":null,"abstract":"<div><div>While the role of improving gut microbiota and elevating dietary iron (Fe) in reducing cadmium (Cd) oral bioavailability has been assessed, the role of dietary prebiotics combined with Fe in synergistically reducing Cd bioavailability from rice remains underexplored. This study utilized mouse bioassays to investigate the potential of prebiotics alone or combined with Fe in reducing rice Cd bioavailability. In experiments with mice fed Fe-sufficient diets (60.6 μg g⁻¹) supplemented with Cd, dietary fructooligosaccharides (FOS), galactooligosaccharides (GOS), and inulin (at 5 % w/w) enhanced Fe absorption and reduced Cd uptake. However, in mice consuming Cd-contaminated rice with low Fe content (6.81 μg g⁻¹), these prebiotics did not increase Fe absorption but lowered mouse kidney Cd by 12.1–20.7 % by improving gut microbiota. Combining 5 % GOS with 100 μg Fe g⁻¹ in Cd-contaminated rice diets resulted in a 59 % reduction in kidney Cd accumulation, more effective than the reduction with either GOS (8.66 %) or Fe (31.9 %) alone, due to the combination of the role of GOS in improving gut microbiota and enhancing intestinal barrier functions and the role of Fe in lowering intestinal Fe transporters. These findings propose a combined dietary strategy to efficiently mitigate the health risks associated with rice Cd exposure.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"206 ","pages":"Article 115745"},"PeriodicalIF":3.5,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145099561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}