Food and Chemical Toxicology最新文献_第4页

Subchronic arsenic exposure induced intestinal microbiota dysbiosis and intestinal inflammation via activating the NF-κB signaling pathway 亚慢性砷暴露通过激活NF-κB信号通路诱导肠道菌群失调和肠道炎症。

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2026-05-01 Epub Date: 2026-02-05 DOI: 10.1016/j.fct.2026.115991

Siyan Cao , Runzhi Cai , Shuhua Xi , Yue Wang

{"title":"Subchronic arsenic exposure induced intestinal microbiota dysbiosis and intestinal inflammation via activating the NF-κB signaling pathway","authors":"Siyan Cao , Runzhi Cai , Shuhua Xi , Yue Wang","doi":"10.1016/j.fct.2026.115991","DOIUrl":"10.1016/j.fct.2026.115991","url":null,"abstract":"<div><div>Arsenic is a prevalent environmental contaminant found in contaminated drinking water. However, the effects of arsenic exposure on the intestinal tract and the specific mechanisms of action remain unclear. In this study, we utilized subchronic sodium arsenite (NaAsO2)-exposed mice and the NaAsO2-treated human colon mucosal epithelial cell line 460 (NCM460) models to investigate the intestinal damage induced by arsenic. Hematoxylin-eosin (HE) staining revealed that the intestines of mice exposed to arsenic exhibited histological damage, characterized by the destruction of epithelial cells, a reduction in the thickness of the muscularis propria, and an increased infiltration of inflammatory cells within the colonic tissue. Mice exposed to arsenic demonstrated a significant reduction in the expression levels of the Occludin protein, accompanied by elevated concentrations of two biomarkers indicative of intestinal barrier damage: serum diamine oxidase (DAO) and lactate (D-LA). Analysis using 16S rRNA sequencing revealed that arsenic exposure did not significantly affect the α and β diversity of the mouse gut microbiota. However, it resulted in changes in the abundance of Clostridiaceae, Burkholderiaceae, Erysipelotrichaceae, and Helicobacteraceae increased, while Muribaculaceae decreased. Furthermore, exposure to arsenic led to increased protein levels of IL-1β, IL-6, and TNF-α, while simultaneously decreasing the expression of IL-10. Arsenic activated NF-κB signaling pathway, which involved in colonic inflammation. Finally, intervention with Pyrrolidine dithiocarbamate (PDTC) significantly attenuated arsenic-induced intestinal inflammation. In conclusion, arsenic exposure compromises the integrity of the intestinal mucosa and disrupts the homeostasis of the intestinal microbiota. Additionally, arsenic mediates intestinal inflammation through the NF-κB signaling pathway.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"211 ","pages":"Article 115991"},"PeriodicalIF":3.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146136971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Evaluation of the enantioselective in vitro metabolism of the chiral pesticide fipronil employing a human model: Risk assessment through in vitro-in vivo correlation and prediction of toxicokinetic parameters” [Food Chem. Toxicol. 123 (2019) 225–232] 使用人体模型评估手性农药氟虫腈的体外对映选择性代谢：通过体内外相关性和毒性动力学参数预测进行风险评估[食品化学]。毒物，123 (2019)225-232 [j]

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2026-05-01 Epub Date: 2026-01-29 DOI: 10.1016/j.fct.2026.115985

Daniel Blascke Carrão , Isabel Cristina dos Reis Gomes , Fernando Barbosa Junior , Anderson Rodrigo Moraes de Oliveira

引用次数: 0

Co-exposure to benzoic acid and acesulfame K synergistically induces nephrotoxicity through the CTNNB1/STAT3 axis 苯甲酸和乙酰磺胺K共同暴露通过CTNNB1/STAT3轴协同诱导肾毒性。

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2026-05-01 Epub Date: 2026-02-07 DOI: 10.1016/j.fct.2026.116004

Yufeng Ma , Xinyue Mai , Wenxi Fan , Xue Sun , Yongsen He , Jielu Zhang , Tianbao Wang , Yi Zuo , Tingting Zhang , Jun Lu

{"title":"Co-exposure to benzoic acid and acesulfame K synergistically induces nephrotoxicity through the CTNNB1/STAT3 axis","authors":"Yufeng Ma , Xinyue Mai , Wenxi Fan , Xue Sun , Yongsen He , Jielu Zhang , Tianbao Wang , Yi Zuo , Tingting Zhang , Jun Lu","doi":"10.1016/j.fct.2026.116004","DOIUrl":"10.1016/j.fct.2026.116004","url":null,"abstract":"<div><div>Benzoic acid (BA) and acesulfame K (ACE) are commonly co-present food additives, yet their combined nephrotoxic risk remains poorly understood. Employing network toxicology, molecular simulations, and <em>in vitro</em> assays, we systematically evaluated their individual and combined effects on nephrotoxicity. Computational predictions indicated that both compounds exhibited nephrotoxic propensity, with shared targets enriched in pathways such as “response to xenobiotic stimulus” and metabolic disruption. Protein–protein interaction network analysis identified CTNNB1 and STAT3 as the respective core targets for BA and ACE, with molecular simulations confirming their stable binding. <em>In vitro</em> experiments showed that BA alone inhibited HK2 cell proliferation, and downregulated β-catenin (encoded by CTNNB1). ACE alone did not significantly suppress proliferation but activated STAT3 signaling. Notably, combined exposure produced a marked synergistic anti-proliferative effect, attributable to a dual mechanism: BA impaired renal tubular repair capacity by suppressing the CTNNB1/β-catenin pathway, while ACE exacerbated inflammatory and injury responses via STAT3 activation, thereby simultaneously impairing repair and exacerbating damage in the kidney. This study is the first to reveal that BA and ACE have the potential to synergistically induce nephrotoxicity via the CTNNB1/STAT3 signaling axis, providing new scientific evidence for the systematic safety assessment of mixed food-additive exposures.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"211 ","pages":"Article 116004"},"PeriodicalIF":3.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146140559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Micro- and nanoplastics and PM2.5 in cardiovascular disease: Emerging mechanisms, impacts, and therapeutic insights 微、纳米塑料和PM2.5在心血管疾病中的作用：新兴机制、影响和治疗见解。

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2026-05-01 Epub Date: 2026-02-06 DOI: 10.1016/j.fct.2026.115982

Silin Kong , Kexin Zhang , Jiajun Sang , Jingwen Zhang , Chengxia Kan , Xiaodong Sun , Ningning Hou

{"title":"Micro- and nanoplastics and PM2.5 in cardiovascular disease: Emerging mechanisms, impacts, and therapeutic insights","authors":"Silin Kong , Kexin Zhang , Jiajun Sang , Jingwen Zhang , Chengxia Kan , Xiaodong Sun , Ningning Hou","doi":"10.1016/j.fct.2026.115982","DOIUrl":"10.1016/j.fct.2026.115982","url":null,"abstract":"<div><div>Micro- and nanoplastics (MNPs) and fine particulate matter (PM2.5) have emerged as independent yet underrecognized environmental risk factors for cardiovascular disease (CVD). Their ultrafine size, large surface area, and high adsorptive capacity not only facilitate epithelial penetration and systemic translocation but also enable direct interactions with vascular and cardiac tissues. Growing epidemiological and experimental evidence links chronic exposure to MNPs and PM2.5 with endothelial dysfunction, atherogenesis, arrhythmogenesis, and myocardial injury. To ensure comprehensive coverage, we systematically searched PubMed, Web of Science, Embase, and Scopus for studies that investigated cardiovascular or metabolic effects of MNP and PM2.5 exposure. We synthesized available epidemiological and mechanistic evidence, focusing on the central role of oxidative stress, mitochondrial dysfunction, ferroptosis, immunometabolic reprogramming, endocrine disruption, and epigenetic remodeling in pollutant-induced cardiovascular pathology. These interrelated processes collectively impair endothelial function, promote atherosclerosis, and compromise cardiac integrity. This narrative review integrates emerging mechanistic insights, identifies potential early diagnostic biomarkers and therapeutic targets, and discusses prevention and policy strategies.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"211 ","pages":"Article 115982"},"PeriodicalIF":3.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146140514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A >8-year two-generation study on the long-term effects of genetically modified maize (Zea mays) containing cry1Ab/cry2Aj and EPSPS genes on cardiac function and arrhythmia risk of cynomolgus macaques 研究了含cry1Ab/cry2Aj和EPSPS基因的转基因玉米（Zea mays）对食蟹猴心功能和心律失常风险的长期影响。

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2026-05-01 Epub Date: 2026-02-03 DOI: 10.1016/j.fct.2026.115990

Chenyun Wang , Minghao Li , Yulong Guo , Zheli Li , Weihu Long , Kuanchao Sun , Feiling Song , Yunguang Hu , Anguo Yin , Yuping Zhang , Jiye Yin , Qing Xia , Donghong Tang

{"title":"A >8-year two-generation study on the long-term effects of genetically modified maize (Zea mays) containing cry1Ab/cry2Aj and EPSPS genes on cardiac function and arrhythmia risk of cynomolgus macaques","authors":"Chenyun Wang , Minghao Li , Yulong Guo , Zheli Li , Weihu Long , Kuanchao Sun , Feiling Song , Yunguang Hu , Anguo Yin , Yuping Zhang , Jiye Yin , Qing Xia , Donghong Tang","doi":"10.1016/j.fct.2026.115990","DOIUrl":"10.1016/j.fct.2026.115990","url":null,"abstract":"<div><div>The long-term safety of genetically-modified (GM) crops, particularly their effects on cardiovascular health, remains a subject of scientific debate. This study systematically evaluated the effects of GM maize (<em>Zea mays</em>) feed on cardiovascular function in cynomolgus macaques (<em>Macaca fascicularis</em>) through two-generation feeding over 8 years. A comprehensive assessment of effects of the GM diet on myocardial injury, cardiac function, and arrhythmia risk was conducted using cardiac-specific biomarker assays, echocardiography, surface electrocardiography (ECG), and implantable cardiac monitoring. The F0 and F1 generations were included to explore the direct and potential transgenerational effects, respectively, of the GM diet. The results demonstrated no significant differences in either generation between the GM diet and control groups (normal feed and non-GM parental feed) in any of the markers assessed. These findings indicate that long-term feeding with GM maize-based diets does not significantly affect the cardiovascular function or increase the risk of arrhythmias in cynomolgus macaques.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"211 ","pages":"Article 115990"},"PeriodicalIF":3.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146123094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Read-across prediction of nongenotoxic thyroid carcinogenicity of pesticides in rats using mechanism-based in vitro assay data 利用基于机制的体外分析数据预测农药对大鼠的非遗传毒性甲状腺致癌性。

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2026-05-01 Epub Date: 2026-02-12 DOI: 10.1016/j.fct.2026.116006

Kosuke Mizuno , Nana Uchida , Jun-ichi Takeshita , Akira Ooka , Ryota Shizu , Kouichi Yoshinari

{"title":"Read-across prediction of nongenotoxic thyroid carcinogenicity of pesticides in rats using mechanism-based in vitro assay data","authors":"Kosuke Mizuno , Nana Uchida , Jun-ichi Takeshita , Akira Ooka , Ryota Shizu , Kouichi Yoshinari","doi":"10.1016/j.fct.2026.116006","DOIUrl":"10.1016/j.fct.2026.116006","url":null,"abstract":"<div><div>Developing alternatives to rat carcinogenicity studies remains a major challenge. In our previous study, we found that while structural similarity provided a basis for grouping carcinogens, integrating mechanistically relevant <em>in vitro</em> cytotoxicity data substantially increased the accuracy of read-across predictions for tumors in the nasal cavity, stomach, and bladder/urethra. In this study, using the same dataset of 126 pesticides, we investigated whether a toxicity mechanism-based read-across approach could be applied to predict thyroid carcinogenicity. We evaluated nuclear receptor activation, which is relevant to thyroid carcinogenic mechanisms, using <em>in vitro</em> assays. Read-across predictions were performed by first selecting neighboring substances based on Euclidean distances calculated from molecular descriptors, and then further refining them based on concordance in <em>in vitro</em> assay results. Our results demonstrated that selecting neighboring substances based on both molecular descriptors and <em>in vitro</em> assay data improved prediction accuracy (balanced accuracy: 0.722) compared to selecting substances based on molecular descriptors alone (balanced accuracy: 0.566). This suggests that combining molecular descriptors with mechanistically relevant <em>in vitro</em> assay data is effective for predicting thyroid tumors in rats, further supporting our integrated read-across approach for carcinogenicity prediction.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"211 ","pages":"Article 116006"},"PeriodicalIF":3.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146193819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amino-modified polystyrene nanoplastics induce endothelial pyroptosis and pro-atherogenic cellular responses 氨基修饰聚苯乙烯纳米塑料诱导内皮细胞焦亡和促动脉粥样硬化细胞反应。

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2026-05-01 Epub Date: 2026-01-30 DOI: 10.1016/j.fct.2026.115983

Junliang Chen , Ye Cheng , Jining Wang, Xiaodan Sun, Le Wang, Dan Liu, Xiangyu Cao

{"title":"Amino-modified polystyrene nanoplastics induce endothelial pyroptosis and pro-atherogenic cellular responses","authors":"Junliang Chen , Ye Cheng , Jining Wang, Xiaodan Sun, Le Wang, Dan Liu, Xiangyu Cao","doi":"10.1016/j.fct.2026.115983","DOIUrl":"10.1016/j.fct.2026.115983","url":null,"abstract":"<div><div>Nanoplastics (NPs) contamination in food has become a critical issue due to the potential impacts on human health. Currently, NPs have the potential to induce cardiovascular damage, but the exact mechanism at the cellular level is unclear. In addition, environmental factors can modify the surface functional groups of NPs, among which amino-modified NPs (NH<sub>2</sub>-NPs) significantly affect their toxicity. This study aimed to investigate the effects of NPs with different particle sizes and amino modifications on human umbilical vein endothelial cells (HUVECs). Results demonstrated that 20 nm NH<sub>2</sub>-NPs exerted the most significant effect on the expression levels of pyroptosis-related proteins. The pyroptosis inhibitor VX-765 reduced PI-positive cells and the expression of pyroptosis proteins in HUVECs, supporting a critical role of pyroptosis in NH<sub>2</sub>-NPs-induced injury. Subsequently, exposure to 20 nm NH<sub>2</sub>-NPs resulted in HUVECs injury, which promoted the recruitment of human acute monocytic leukemia (THP-1) cells, with increased adhesion, migration, and lipid accumulation. These findings indicated that PS-NPs induced injury in HUVECs by NF-κB/NLRP3/GSDMD-mediated pyroptosis pathway and influenced THP-1 cells adhesion, migration, and foam cell formation. This study provided insights into the vascular toxicity mechanisms of PS-NPs and highlighted the critical role of surface chemical modifications in modulating their toxicological effects.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"211 ","pages":"Article 115983"},"PeriodicalIF":3.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146099565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxic metals in fish from polish market, health risk assessment 波兰市场鱼类的有毒金属含量，健康风险评估。

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2026-05-01 Epub Date: 2026-01-26 DOI: 10.1016/j.fct.2026.115974

Lucyna Polak-Juszczak, Leszek Barcz

{"title":"Toxic metals in fish from polish market, health risk assessment","authors":"Lucyna Polak-Juszczak, Leszek Barcz","doi":"10.1016/j.fct.2026.115974","DOIUrl":"10.1016/j.fct.2026.115974","url":null,"abstract":"<div><div>Despite health benefits, fish consumption poses risks of exposure to toxic substances. Concentrations of toxic metals were determined in 20 fish species available on the Polish market. Cadmium (Cd) concentrations were within the range 0.003–0.005 mg/kg, lead (Pb) 0.011–0.033 mg/kg, total mercury (THg) 0.014–0.133 mg/kg, methylmercury (MeHg) 0.010 mg/kg - 0.108 mg/kg, inorganic arsenic (iAs) below 0.02 mg/kg. Mercury and methylmercury in tuna were at higher levels. The average contents 0.919 mg/kg and 0.684 mg/kg, were close to the limit for THg 1 mg/kg (Commission Regulation (EU) 2023/915).</div><div>Risks to consumer health were estimated on the base on toxicity markers non-carcinogenic (THQ) for Cd, Pb, MeHg and iAs, and carcinogenic (CR) coefficient for iAs. Values THQ were low for Cd (0.5 x 10<sup>−3</sup> – 2 x 10<sup>−3</sup>), Pb (0.7 x 10<sup>−3</sup> - 2.4 x 10<sup>−3</sup>), MeHg (2.8 x 10<sup>−2</sup> – 31 x 10<sup>−2</sup>) and for iAs (1.9 x 10<sup>−2</sup>). The CR marker for iAs was also low at 0.86 x 10<sup>−5</sup>. Low values for toxic metals and toxicity markers in fish from the Polish market confirms their safe consumption. Only in tuna the marker THQ for MeHg was twice the recommended safe value. The high methylmercury contents and high THQ in tuna indicates limitations in consumption this fish. Over the past decade, levels of toxic metals in fishes on the Polish market have remained stable. The only significant change was the increased THg and MeHg in tuna.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"211 ","pages":"Article 115974"},"PeriodicalIF":3.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146117124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of dietary salmon intake on the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in peripubertal male Wistar Han rats 食用鲑鱼对青春期雄性Wistar Han大鼠2,3,7,8-四氯二苯并-对二恶英（TCDD）毒性的影响

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2026-05-01 Epub Date: 2026-02-05 DOI: 10.1016/j.fct.2026.115992

Ole Jakob Nøstbakken, Helene Lorgen Leithe, Lene S. Myrmel, Even Fjære, Anne-Katrine Lundebye, Josef D. Rasinger, Annette Bernhard

{"title":"Effects of dietary salmon intake on the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in peripubertal male Wistar Han rats","authors":"Ole Jakob Nøstbakken, Helene Lorgen Leithe, Lene S. Myrmel, Even Fjære, Anne-Katrine Lundebye, Josef D. Rasinger, Annette Bernhard","doi":"10.1016/j.fct.2026.115992","DOIUrl":"10.1016/j.fct.2026.115992","url":null,"abstract":"<div><div>Dioxins and dioxin-like polychlorinated biphenyls (dl-PCBs) are persistent organic pollutants with known reproductive toxicity, particularly related to sperm quality. To explore the effects of dietary TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) exposure and the potential modulating influence of seafood nutrients, a 90-day feeding trial was conducted using prepubertal Wistar Han rats. The study used a 2 × 2 factorial design comparing diets based either solely on casein, or diets containing Atlantic salmon fillet as 50% of the protein source, with or without TCDD (200 ng/kg feed). The reproductive outcomes assessed were sperm count and plasma testosterone levels. Proteomic profiling of testis and hypothalamus was performed to provide further mechanistic insights.</div><div>TCDD exposure resulted in significant accumulation in liver tissue but did not affect sperm count or testosterone levels. However, proteomic analysis revealed 247 differentially expressed proteins in testis tissue (FDR <0.1), indicating effects on the redox balance, mitochondrial function, and cellular metabolism. No significant proteomic changes were observed in the hypothalamus, and no interactions between TCDD and the salmon-based diet were found with regards to molecular or reproductive endpoints.</div><div>These findings suggest that moderate, subchronic dietary TCDD exposure induces subcellular stress responses in testis tissue without overt effects on sperm parameters in peripubertal rats. Inclusion of salmon fillet in the diet did not mitigate TCDD toxicity under these experimental conditions.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"211 ","pages":"Article 115992"},"PeriodicalIF":3.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146136927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety evaluation of pasteurized Akkermansia muciniphila YGMCC2645 巴氏灭菌的嗜粘阿克曼菌YGMCC2645的安全性评价

IF 3.5 3区医学

Food and Chemical Toxicology Pub Date : 2026-04-01 Epub Date: 2026-01-13 DOI: 10.1016/j.fct.2026.115940

Jie Tian , Zhili He , Minlei Zhao , Xianghong Ke , Yinjing Zhang , Jingjing Qu , Ying Xia , Shaohua Fu , Wenxiang Yang , Lanjie Pei , Jun Fan , Jianguo Chen , Bolin Fan

{"title":"Safety evaluation of pasteurized Akkermansia muciniphila YGMCC2645","authors":"Jie Tian , Zhili He , Minlei Zhao , Xianghong Ke , Yinjing Zhang , Jingjing Qu , Ying Xia , Shaohua Fu , Wenxiang Yang , Lanjie Pei , Jun Fan , Jianguo Chen , Bolin Fan","doi":"10.1016/j.fct.2026.115940","DOIUrl":"10.1016/j.fct.2026.115940","url":null,"abstract":"<div><div>Due to the potential benefits of <em>Akkermansia muciniphila</em> (<em>A. muciniphila</em>) to humans, it is considered a promising next-generation probiotic. To better develop and utilise <em>A. muciniphila</em>, a systematic safety assessment is necessary. This study involved conducting a series of tests to determine the safety of pasteurized <em>A. muciniphila</em> YGMCC2645. Results were shown that there was no antibiotic-resistance, virulence, and pathogenicity genes in the YGMCC2645. The LD<sub>50</sub> of acute oral toxicity in rats was greater than 10.0 g/kg BW (3.0 × 10<sup>12</sup> TFU/kg BW). No genotoxicity was found in the Ames test, the chromosome aberration mammalian assay, or the erythrocyte micronucleus assay. In the 90-day oral toxicity (with a dose of up to 2.5 × 10<sup>11</sup> TFU/kg BW), no treatment–related toxicological changes were observed in terms of body weight, food intake, food efficiency, hematological and biochemical indexes, urine indexes, and pathological indexes. In terms of teratogenic toxicity, there were no significant differences in the reproductive parameters of pregnant rats and developmental parameters of fetal rats. These results supported <em>A. muciniphila</em> YGMCC2645 is safe for use as a food ingredient.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"210 ","pages":"Article 115940"},"PeriodicalIF":3.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145973039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0