Food and Chemical Toxicology最新文献_第3页

RIFM fragrance ingredient safety assessment, 1-tetradecanol, CAS Registry Number 112-72-1.

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2024-12-28 DOI: 10.1016/j.fct.2024.115226

A M Api, A Bartlett, D Belsito, D Botelho, M Bruze, A Bryant-Friedrich, G A Burton, M A Cancellieri, H Chon, M L Dagli, W Dekant, C Deodhar, K Farrell, A D Fryer, L Jones, K Joshi, A Lapczynski, M Lavelle, I Lee, H Moustakas, J Muldoon, T M Penning, G Ritacco, N Sadekar, I Schember, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura

引用次数: 0

E-Cigarette effects on oral health: A molecular perspective.

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2024-12-28 DOI: 10.1016/j.fct.2024.115216

Vengatesh Ganapathy, Ravindran Jaganathan, Mayilvanan Chinnaiyan, Gautham Chengizkhan, Balaji Sadhasivam, Jimmy Manyanga, Ilangovan Ramachandran, Lurdes Queimado

{"title":"E-Cigarette effects on oral health: A molecular perspective.","authors":"Vengatesh Ganapathy, Ravindran Jaganathan, Mayilvanan Chinnaiyan, Gautham Chengizkhan, Balaji Sadhasivam, Jimmy Manyanga, Ilangovan Ramachandran, Lurdes Queimado","doi":"10.1016/j.fct.2024.115216","DOIUrl":"10.1016/j.fct.2024.115216","url":null,"abstract":"Electronic cigarettes (e-cigarettes) have emerged as a potential alternative to traditional smoking and may aid in tobacco harm reduction and smoking cessation. E-cigarette use has notably increased, especially among young non-tobacco users, raising concerns due to the unknown long-term health effects. The oral cavity is the first and one of the most crucial anatomical sites for the deposition of e-cigarette aerosols. E-cigarette aerosols contain nicotine, flavors, volatile organic compounds, heavy metals, carcinogens, and other hazardous substances. These aerosols impact the oral cavity, disrupting host-microbial interactions and triggering gingivitis and systemic diseases. Furthermore, oral inflammation and periodontitis can be caused by proinflammatory cytokines induced by e-cigarette aerosols. The toxic components of e-cigarette aerosols increase the cellular reactive oxygen species (ROS) levels, reduce antioxidant capacity, increase DNA damage, and disrupt repair processes, which may further contribute to harmful effects on oral epithelum, leading to inflammatory and pre-malignant oral epithelial lesions. In this review, we analyze the toxicological properties of compounds in e-cigarette aerosols, exploring their cytotoxic, genotoxic, and inflammatory effects on oral health and delving into the underlying molecular mechanisms. Further research is essential to understand the impact of e-cigarettes on oral health and make informed regulatory decisions based on reliable scientific evidence.","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":" ","pages":"115216"},"PeriodicalIF":3.9,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methyl donor ameliorates CCl₄-induced liver fibrosis by inhibiting inflammation, and fibrosis through the downregulation of EGFR and DNMT-1 expression.

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2024-12-28 DOI: 10.1016/j.fct.2024.115230

Manish Bishnolia, Poonam Yadav, Sumeet Kumar Singh, Nirmal Manhar, Sonu Rajput, Amit Khurana, Jasvinder Singh Bhatti, Umashanker Navik

{"title":"Methyl donor ameliorates CCl4-induced liver fibrosis by inhibiting inflammation, and fibrosis through the downregulation of EGFR and DNMT-1 expression.","authors":"Manish Bishnolia, Poonam Yadav, Sumeet Kumar Singh, Nirmal Manhar, Sonu Rajput, Amit Khurana, Jasvinder Singh Bhatti, Umashanker Navik","doi":"10.1016/j.fct.2024.115230","DOIUrl":"10.1016/j.fct.2024.115230","url":null,"abstract":"Methyl donors regulate the one-carbon metabolism and have significant potential to reduce oxidative stress and inflammation. Therefore, this study aims to investigate the protective effect of methyl donors against CCl4-induced liver fibrosis. Liver fibrosis was induced in male Sprague Dawley rats using CCl4 at a dose of 1 ml/kg (twice a week for a 4-week, via intraperitoneal route). Subsequently, methyl donor treatments were given orally for the next six weeks while continuing CCl4 administration. After 10 weeks, biochemical, histopathology, immunohistochemistry, western blotting, and qRT-PCR were performed. Methyl donor treatment significantly ameliorated ALT, AST, ALP levels, and oxidative stress associated with CCl4-induced liver injury. The histopathological investigation also demonstrated the hepatoprotective effect of methyl donors against CCl4-induced liver fibrosis, showing reduced tissue damage, collagen deposition, and attenuating the expression of the COL1A1 gene. Further, methyl donors inhibited the CCl4-induced increase in DNMT-1 and NF-κB p65 expression with an upregulation of AMPK. Methyl donor downregulated the CCl4-induced increase in inflammatory and fibrosis related gene expression and inhibited the apoptosis with a downregulation of EGFR expression. Here, we provide the first evidence that methyl donor combinations prevent liver fibrosis by attenuating oxidative stress, inflammation, and fibrosis through DNMT-1 and EGFR downregulation.","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":" ","pages":"115230"},"PeriodicalIF":3.9,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RIFM fragrance ingredient safety assessment, 3-(4-methyl-3-cyclohexenyl)butanol, CAS Registry Number 15760-18-6. RIFM 香料成分安全评估，3-(4-甲基-3-环己烯基)丁醇，化学文摘社登记号 15760-18-6。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2024-12-28 DOI: 10.1016/j.fct.2024.115222

A M Api, A Bartlett, D Belsito, D Botelho, M Bruze, A Bryant-Friedrich, G A Burton, M A Cancellieri, H Chon, M L Dagli, W Dekant, C Deodhar, K Farrell, A D Fryer, L Jones, K Joshi, A Lapczynski, M Lavelle, I Lee, H Moustakas, J Muldoon, T M Penning, G Ritacco, N Sadekar, I Schember, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura

引用次数: 0

Update to RIFM fragrance ingredient safety assessment, dihydro-β-ionol, CAS Registry Number 3293-47-8.

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2024-12-28 DOI: 10.1016/j.fct.2024.115225

A M Api, A Bartlett, D Belsito, D Botelho, M Bruze, A Bryant-Friedrich, G A Burton, M A Cancellieri, H Chon, M L Dagli, W Dekant, C Deodhar, K Farrell, A D Fryer, L Jones, K Joshi, A Lapczynski, M Lavelle, I Lee, H Moustakas, J Muldoon, T M Penning, G Ritacco, N Sadekar, I Schember, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura

引用次数: 0

Update to RIFM fragrance ingredient safety assessment, methyl 2-nonynoate, CAS Registry Number 111-80-8.

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2024-12-28 DOI: 10.1016/j.fct.2024.115227

A M Api, A Bartlett, D Belsito, D Botelho, M Bruze, A Bryant-Friedrich, G A Burton, M A Cancellieri, H Chon, M L Dagli, W Dekant, C Deodhar, K Farrell, A D Fryer, L Jones, K Joshi, A Lapczynski, M Lavelle, I Lee, H Moustakas, J Muldoon, T M Penning, G Ritacco, N Sadekar, I Schember, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura

引用次数: 0

RIFM fragrance ingredient safety assessment, p-tolylacetaldehyde, CAS Registry Number 104-09-6. RIFM 香料成分安全评估，对甲苯乙醛，化学文摘社登记号 104-09-6。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2024-12-27 DOI: 10.1016/j.fct.2024.115223

A M Api, A Bartlett, D Belsito, D Botelho, M Bruze, A Bryant-Friedrich, G A Burton, M A Cancellieri, H Chon, M L Dagli, W Dekant, C Deodhar, K Farrell, A D Fryer, L Jones, K Joshi, A Lapczynski, M Lavelle, I Lee, H Moustakas, J Muldoon, T M Penning, G Ritacco, N Sadekar, I Schember, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura

引用次数: 0

Therapeutic potential of 2S-hesperidin against the hepatotoxic effects of dichlorvos in rats.

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2024-12-27 DOI: 10.1016/j.fct.2024.115231

Adio J Akamo, Adetutu O Ojelabi, Naomi M Akamo, Ibiyemi O Opowoye, Boluwatife A Olagunju, Oluwatobi T Somade, Ofem E Eteng, Adedayo A Adebisi, Taiwo S Oguntona, Mushafau A Akinsanya, Abiola F Adenowo, Tolani E Oladele, Adewale M Taiwo, Iyabode A Kehinde, Jacob K Akintunde, Regina N Ugbaja

{"title":"Therapeutic potential of 2S-hesperidin against the hepatotoxic effects of dichlorvos in rats.","authors":"Adio J Akamo, Adetutu O Ojelabi, Naomi M Akamo, Ibiyemi O Opowoye, Boluwatife A Olagunju, Oluwatobi T Somade, Ofem E Eteng, Adedayo A Adebisi, Taiwo S Oguntona, Mushafau A Akinsanya, Abiola F Adenowo, Tolani E Oladele, Adewale M Taiwo, Iyabode A Kehinde, Jacob K Akintunde, Regina N Ugbaja","doi":"10.1016/j.fct.2024.115231","DOIUrl":"10.1016/j.fct.2024.115231","url":null,"abstract":"Dichlorvos (DDVP) is an organophosphate insecticide that enhances food production and repels disease vectors. However, it provokes cytotoxicity. 2S-hesperidin (2S-HES) is a potent antioxidant, anti-inflammatory, and anti-lipidemic flavanone. Regardless, the 2S-HES impact on DDVP-occupied hepatic injury remains fuzzy. We evaluated the therapeutic potential of 2S-HES in a rat model of DDVP-elicited hepatic intoxication. Forty-two rats were randomly allotted to seven groups (n = 6/condition): control, DDVP (8 mg kg⁻1day⁻1), DDVP with 2S-HES (50 and 100 mg kg⁻1day⁻1), DDVP with atropine, and 2S-HES alone (50 and 100 mg kg⁻1day⁻1). DDVP was administered orally for 7 days, followed by 14 days of 2S-HES chemotherapy. 2S-HES intervention partially mitigated DDVP-triggered alterations in leakage enzymes (ALT, AST, ALP, LDH-5), total protein, albumin, globulin, bilirubin, electrolytes, ion-transporters, lipid profiles, and HMG-CoA reductase. Furthermore, 2S-HES partially reversed DDVP-provoked increases in hepatic H₂O₂, NO, and malondialdehyde; transposed DDVP-mediated decreased liver GSH amount and activities of GST, SOD, catalase, and GPx; attenuated DDVP-triggered upregulated NF-κB-p65 and caspase-3; and abated DDVP-engendered repressed interleukin-10 mRNA expression. Cytoarchitectural analyses authenticated the 2-HES reduction in DDVP-evoked hepatocellular vacuolation. Altogether, 2S-HES elicited promising alternative or adjunctive therapy for partially mitigating DDVP-incited hepatic injury by attenuating leakage enzymes, ionoregulatory disruptions, ion pump inhibition, dyslipidemias, oxidative stress, inflammation, and apoptosis.","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":" ","pages":"115231"},"PeriodicalIF":3.9,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142902405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RIFM fragrance ingredient safety assessment, geranyl crotonate, CAS Registry Number 56172-46-4.

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2024-12-26 DOI: 10.1016/j.fct.2024.115220

A M Api, A Bartlett, D Belsito, D Botelho, M Bruze, A Bryant-Friedrich, G A Burton, M A Cancellieri, H Chon, M L Dagli, W Dekant, C Deodhar, K Farrell, A D Fryer, L Jones, K Joshi, A Lapczynski, M Lavelle, I Lee, H Moustakas, J Muldoon, T M Penning, G Ritacco, N Sadekar, I Schember, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura

引用次数: 0

Update to RIFM fragrance ingredient safety assessment, 2-methyl-4(2,2,3-trimethyl-3-cyclopentenyl)butanol, CAS Registry Number 72089-08-8.

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2024-12-26 DOI: 10.1016/j.fct.2024.115221

A M Api, A Bartlett, D Belsito, D Botelho, M Bruze, A Bryant-Friedrich, G A Burton, M A Cancellieri, H Chon, M L Dagli, W Dekant, C Deodhar, K Farrell, A D Fryer, L Jones, K Joshi, A Lapczynski, M Lavelle, I Lee, H Moustakas, J Muldoon, T M Penning, G Ritacco, N Sadekar, I Schember, T W Schultz, F Siddiqi, I G Sipes, G Sullivan, Y Thakkar, Y Tokura

引用次数: 0