Food and Chemical Toxicology最新文献_第3页

Assessment of toxic metals and trace elements in breast milk of mothers and their health risks to infants: A cross-sectional study in Ardabil, Northwest Iran 母亲母乳中有毒金属和微量元素及其对婴儿健康风险的评估：伊朗西北部阿尔达比勒的一项横断面研究。

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-12 DOI: 10.1016/j.fct.2025.115389

Abdollah Dargahi , Hamed Zandian , Fateme Samiee , Shahla Farzipour , Negin Sheikhmemari , Salva Kazemipour-Khabbazi

{"title":"Assessment of toxic metals and trace elements in breast milk of mothers and their health risks to infants: A cross-sectional study in Ardabil, Northwest Iran","authors":"Abdollah Dargahi , Hamed Zandian , Fateme Samiee , Shahla Farzipour , Negin Sheikhmemari , Salva Kazemipour-Khabbazi","doi":"10.1016/j.fct.2025.115389","DOIUrl":"10.1016/j.fct.2025.115389","url":null,"abstract":"<div><div>This research aimed to assess the potential health risks for infants and measure the concentrations of heavy metal substances in the breast milk of mothers residing in Ardabil, Iran. The study was descriptive and cross-sectional in nature. Ten health centers in Ardabil City were selected for the research. The ages of participating mothers ranged from 19 to 39 years, and breast milk samples were collected from those who were 1–12 months postpartum. A 25-item questionnaire was used to evaluate the participants' exposure to heavy metals in their environment and diet. Data analysis was performed using the non-parametric Mann-Whitney <em>U</em> test, resulting in a p-value greater than 0.05. The average body mass index (BMI) of breastfeeding mothers was 26.26 ± 3.73. Spike recovery values ranged from 92 % to 106 %, indicating reliable performance within the ICP-MS range. The limit of detection (LOD) during routine sample analysis was 0.001 μg/L. The daily intake (DI) of lead (Pb), arsenic (As), and chromium (Cr) for infants was calculated. According to the findings, copper (Cu) had the highest average concentration in breast milk at 803.94 μg/L, while cadmium (Cd) had the lowest at 1.87 μg/L. Additionally, potassium (K) exhibited the highest average concentration at 490.49 mg/L, whereas molybdenum (Mo) had the lowest at 0.8 μg/L. The average daily intake of Pb, As, and Cr through breastfeeding was measured at 3.39, 0.799, and 3.47 μg/kg-bw/day, respectively. The results confirmed the presence of mercury (Hg), As, and Pb in every milk sample collected from lactating mothers in Ardabil, indicating potential exposure of infants to elevated levels of toxic heavy metals.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115389"},"PeriodicalIF":3.9,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interaction of environmental fluoride exposure and gut microbes: Potential implication in the development of fluorosis in human subjects

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-12 DOI: 10.1016/j.fct.2025.115388

Neha Rawat , Saravanadevi Sivanesan , Gajanan Sitaramji Kanade , Amit Bafana

{"title":"Interaction of environmental fluoride exposure and gut microbes: Potential implication in the development of fluorosis in human subjects","authors":"Neha Rawat , Saravanadevi Sivanesan , Gajanan Sitaramji Kanade , Amit Bafana","doi":"10.1016/j.fct.2025.115388","DOIUrl":"10.1016/j.fct.2025.115388","url":null,"abstract":"<div><div>Fluoride exposure primarily occurs through contaminated water and leads to fluorosis, which is a global health concern. After ingestion, fluoride is absorbed via gastrointestinal tract, where it interacts with the gut microbiota. While animal studies have explored fluoride's effects on gut microbiota, no human studies have yet been conducted. Most research emphasizes metagenomic diversity, neglecting isolation and characterization of pure cultures for further applications. Additionally, the association between gut microbiota with fluorosis outcomes in fluoride-exposed populations is unexplored. This study characterizes and compares the cultivable gut microbiota in the fluoride-exposed population with (symptomatic, group II) or without (asymptomatic, group I) signs of skeletal fluorosis along with unexposed control (group III). Group I displayed higher abundance of Firmicutes (58.58 %), group II had predominance of Proteobacteria (61.25 %) while group III showed similar abundance of Proteobacteria (50.38 %) and Firmicutes (49.51 %). On analyzing short-chain fatty acid (SCFA) profiles, group I isolates produced higher isobutyric acid (1.31 ± 0.9 mM) than group II (0.71 ± 0.35 mM), while group II produced more isovaleric acid (0.8 ± 0.41 mM) than group I (0.61 ± 0.08 mM) (p < 0.05). These findings suggest that gut microbiota and SCFAs alteration may influence bone metabolism, affecting the fluorosis progression.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115388"},"PeriodicalIF":3.9,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigallocatechin-3-gallate as an effective inhibitor of vascular endothelial dysfunction induced by endothelial-localized myeloperoxidase

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-12 DOI: 10.1016/j.fct.2025.115392

Rong Tian, Ya-Di Yang, Naihao Lu

{"title":"Epigallocatechin-3-gallate as an effective inhibitor of vascular endothelial dysfunction induced by endothelial-localized myeloperoxidase","authors":"Rong Tian, Ya-Di Yang, Naihao Lu","doi":"10.1016/j.fct.2025.115392","DOIUrl":"10.1016/j.fct.2025.115392","url":null,"abstract":"<div><div>In inflammatory vasculature, the leukocyte-released myeloperoxidase (MPO) is internalized by endothelial cells and this enzyme promotes endothelial dysfunction by catalytically producing strong oxidant, hypochlorous acid (HOCl). Herein, we developed epigallocatechin-3-gallate (EGCG, the main polyphenolic flavonoid found in green tea) as a novel endothelial-targeted MPO inhibitor. It was shown that culture of MPO and EGCG with vascular endothelial cells could result in their transport into the sub-endothelial space. EGCG significantly suppressed the consumption of enzyme's substrate H<sub>2</sub>O<sub>2</sub> and generation of HOCl catalyzed by endothelial-transcytosed MPO. The binding of EGCG to the hydrophobic domain near the distal active heme cavity of enzyme was proposed by molecular docking and was suggested for the inhibitive effect of flavonoid on MPO activity. In vivo, EGCG attenuated lipopolysaccharide (LPS)-induced endothelial dysfunction in mouse aortas, while it inhibited the infiltration of active MPO into vascular walls. Furthermore, MPO-deficient mice were resistant to the protective effects of EGCG on LPS-induced vascular dysfunction, as compared to wild-type mice. These studies showed that EGCG effectively inhibited local oxidative reactions and endothelial dysfunction catalyzed by vascular-bound MPO. EGCG represents a versatile class of natural antioxidant drugs applicable to target endothelial-transcytosed MPO in inflammatory vasculature.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115392"},"PeriodicalIF":3.9,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in mycotoxin detection techniques and the crucial role of reference material in ensuring food safety. A review

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-11 DOI: 10.1016/j.fct.2025.115387

Tiisetso Colleen Maphaisa , Oluwakamisi Festus Akinmoladun , Oluwasola Abayomi Adelusi , Mulanda Mwanza , Fabian Fon , Emmanuel Tangni , Patrick Berka Njobeh

{"title":"Advances in mycotoxin detection techniques and the crucial role of reference material in ensuring food safety. A review","authors":"Tiisetso Colleen Maphaisa , Oluwakamisi Festus Akinmoladun , Oluwasola Abayomi Adelusi , Mulanda Mwanza , Fabian Fon , Emmanuel Tangni , Patrick Berka Njobeh","doi":"10.1016/j.fct.2025.115387","DOIUrl":"10.1016/j.fct.2025.115387","url":null,"abstract":"<div><div>Mycotoxins, toxic secondary metabolites produced by fungi, pose a significant threat to food safety and human health. The occurrence of mycotoxins in food commodities necessitates accurate and reliable detection methods. Advanced detection techniques, such as chromatographic techniques and immunochemical assays, have improved sensitivity and specificity. However, the lack of standardized reference material, particularly in less privileged countries, hinders method validation and proficiency testing, ultimately affecting mycotoxin testing and regulation. Moreover, these techniques are complex as they require specialized equipment, and well-trained personnel, thus limiting their practical applications. This comprehensive review provides an up-to-date overview of the occurrence of mycotoxins and recent advancements in detection methods. It examines the crucial role of mycotoxin standards as reference materials for ensuring reliable results in mycotoxins analysis in agriculture commodities. The review addresses emerging challenges, knowledge gaps, and future research directions in mycotoxin detection and reference material development. By synthesizing existing literature, this review aims to provide valuable resources for researchers, policymakers, and other stakeholders in food safety, highlighting the importance of integrated approaches to mitigate mycotoxin contamination and ensuring food safety.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115387"},"PeriodicalIF":3.9,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effects of anthocyanins on the nervous system injury caused by fluoride-induced endoplasmic reticulum stress in rats

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-10 DOI: 10.1016/j.fct.2025.115386

Dan Wei , Shiwen Tan , Shujuan Pang , Bingshu Liu , Qiong Zhang , Siqi Zhu , Guiyu Fu , Dianjun Sun , Wei Wei

{"title":"Protective effects of anthocyanins on the nervous system injury caused by fluoride-induced endoplasmic reticulum stress in rats","authors":"Dan Wei , Shiwen Tan , Shujuan Pang , Bingshu Liu , Qiong Zhang , Siqi Zhu , Guiyu Fu , Dianjun Sun , Wei Wei","doi":"10.1016/j.fct.2025.115386","DOIUrl":"10.1016/j.fct.2025.115386","url":null,"abstract":"<div><div>Long-term fluoride exposure can produce neurotoxicity. Anthocyanins, as antioxidants, have a certain protective effect in nerve damage. This study aimed to investigate the protective role of anthocyanins in fluoride-induced neurological damage due to endoplasmic reticulum stress (ERS). Using a fluoride-exposed Wistar rat model, we assessed learning memory capacity and pathologic and ultrastructural injury. The level of oxidative stress (OS) in vivo was detected by colorimetric method, the level of ERS was analyzed by immunohistochemistry, and the apoptosis of neuronal cells was observed by TUNEL staining. The results showed that fluoride exposure could decrease the learning and memory ability in rats, and led to histopathological and ultrastructural damage in the hippocampal CA1, CA3 and cortical regions. Fluoride exposure-induced OS in vivo, which further activates ERS, which was manifested by increased levels of ERS-related proteins GRP78, Caspase 12, and Caspase 3 in hippocampal CA1, CA3, and cortical regions, and eventually led to a significant increase in neuronal apoptosis rate. Notably, after anthocyanins treatment, pathological and ultrastructural damage was restored, the level of OS and ERS were significantly restored, and the apoptosis rate of neuronal cells was significantly reduced. In summary, as nutritional interventions, anthocyanins exert a protective role in fluoride-induced neurological injury.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115386"},"PeriodicalIF":3.9,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

20-Week toxicity study of rotigotine behenate extended-release microspheres for intramuscular injection in sprague dawley rats

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-10 DOI: 10.1016/j.fct.2025.115384

Wenjing Lv , Hong Zhang , Yumeng Chen , Mengting Wu , Caiyi Qin , Zhicong Yin , Xinyu Zhao , Wei Guo , Xiaobo Cen , Xin Yu , Jingwei Tian

{"title":"20-Week toxicity study of rotigotine behenate extended-release microspheres for intramuscular injection in sprague dawley rats","authors":"Wenjing Lv , Hong Zhang , Yumeng Chen , Mengting Wu , Caiyi Qin , Zhicong Yin , Xinyu Zhao , Wei Guo , Xiaobo Cen , Xin Yu , Jingwei Tian","doi":"10.1016/j.fct.2025.115384","DOIUrl":"10.1016/j.fct.2025.115384","url":null,"abstract":"<div><div>Based on the concept of continuous dopaminergic stimulation (CDS), Rotigotine Behenate extended-release microspheres for injection (RBEM) are currently under development. To support human clinical trials of RBEM, a 20-week repeat-dose toxicity study was conducted. SD rats intramuscularly received RBEM (60, 180, and 540 mg/kg) once every 4 weeks for 5 repeated doses followed by a 12-week recovery period, no clear sex difference was noted in the plasma exposure of rotigotine in rats, and the exposure generally increased in a dose-proportional manner. No obvious systemic toxicity occurred. Ovarian corpus luteum and breast acinar hypertrophy in rats were believed to be associated with the activation of dopamine receptors by RBEM and decreased prolactin levels. The reversible vacuolar degeneration or foamy macrophage infiltration at the injection site, adjacent tissues, and alveoli of rats were associated with local inflammation and foreign body removal reaction caused by PLGA and SCMC. In this study, the non-observed-adverse-effect-level (NOAEL) in rats was 540 mg/kg (based on rotigotine), which was equivalent to 24 times the maximum clinical recommended dose of RBEM, 448 mg/person/28 days (expressed as the dose of rotigotine behenate). In conclusion, RBEM exhibited a good safety margin and can be used in phase I clinical trials. <strong>Keywords</strong>: Parkinson's disease; RBEM; Continuous dopaminergic stimulation; Repeated dose toxicity.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115384"},"PeriodicalIF":3.9,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute ivermectin toxicity on skin and brain tissue of adult albino rats: Evaluation of the role of Flumazenil and Vitamin C as new treatment modalities

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-08 DOI: 10.1016/j.fct.2025.115383

Fatma Nada Khalifa , Sara Adel Hosny , Lamiaa Mohammed Matter , Dena Mohamed Naguib Abdel Moawed , Basant Adel Al Dreny , Hind A. Elsawi , Asmaa Mohammad Moawad

{"title":"Acute ivermectin toxicity on skin and brain tissue of adult albino rats: Evaluation of the role of Flumazenil and Vitamin C as new treatment modalities","authors":"Fatma Nada Khalifa , Sara Adel Hosny , Lamiaa Mohammed Matter , Dena Mohamed Naguib Abdel Moawed , Basant Adel Al Dreny , Hind A. Elsawi , Asmaa Mohammad Moawad","doi":"10.1016/j.fct.2025.115383","DOIUrl":"10.1016/j.fct.2025.115383","url":null,"abstract":"<div><div>Ivermectin, a natural antiviral drug, has been recommended for treating various diseases, including Coronavirus Disease 2019. This study aimed to evaluate the potential histopathological and biochemical changes in the skin and brain of adult albino rats treated with ivermectin, as well as the effectiveness of Vitamin C and flumazenil in their treatment. Thirty rats were divided into five treatment groups, each containing six rats. After a week of acclimatization, different doses of ivermectin, Vitamin C, and flumazenil were administered to the rats. The rats were then euthanized. Histological and micro ribonucleic acid (miRNA) analysis of the skin and brain tissues, immunohistochemistry, and plasma collection from tail vein puncture were conducted to measure dopamine and interleukin 5 levels. The control group showed minimal acute toxicity, with an increase in hsa-miR535a-5p, dopamine, interleukin 5 (IL-5), and p-glycoprotein levels. In conclusion, the acute toxic effects of ivermectin in rats led to significant histological and morphological changes in both brain and skin tissues, along with oxidative stress and disruptions in P-glycoprotein, inflammatory cytokines, and the inflammatory response. Flumazenil and vitamin C may help normalize neuronal signaling, alleviate oxidative stress, and enhance dopamine release.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115383"},"PeriodicalIF":3.9,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of the metabolomic alterations associated with the formation of bisphenol-A sulfate metabolite in HepG2 cells

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-07 DOI: 10.1016/j.fct.2025.115382

Hui-Jun Jin , Zi-Dong Qiu , Cen Qian , Chun-Yun Zhang , Yu Peng

{"title":"Identification of the metabolomic alterations associated with the formation of bisphenol-A sulfate metabolite in HepG2 cells","authors":"Hui-Jun Jin , Zi-Dong Qiu , Cen Qian , Chun-Yun Zhang , Yu Peng","doi":"10.1016/j.fct.2025.115382","DOIUrl":"10.1016/j.fct.2025.115382","url":null,"abstract":"<div><div>The elucidation of the causal relationship between bisphenol-A (BPA) exposure and hepatoxic outcomes is challenging because of the complexity in both the BPA-derived metabolites formed in the liver and the associated endogenous molecular responses. We performed parallel metabolism experiments with BPA to characterize the BPA sulfate formation and the associated alterations in the metabolome level in HepG2 cells using mass spectrometry-based metabolome wide association study. Briefly, HepG2 cells were exposed for 8 or 24 h to 1 or 10 μM BPA in DMSO or DMSO alone. The levels of BPA sulfate in the cell culture media were quantified, and the sulfation efficiency was about 0.4 % observed for both 1 and 10 μM BPA in HepG2 cells. Targeted metabolomic analyses revealed alterations belonging to forty metabolic pathways following BPA exposure. Featured by the decreasing of estrone sulfate, estrogen metabolism was observed as the top 1 enriched pathway in response to BPA exposure. MWAS suggests that BPA sulfate formation in HepG2 cells resulted in vitamin B6 deficiency and dysregulated vitamin B6-dependent processes, for example, the kynurenine pathway in tryptophan metabolism. These findings collectively provide insights into the linkage between exogenous and endogenous metabolism and the potential initial events in BPA exposure-relevant hepatoxicity.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115382"},"PeriodicalIF":3.9,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spectrum-effect relationship of the cardiovascular-protective effect of with Chrysanthemi Flos by UPLC-MS/MS and component knock-out method

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-05 DOI: 10.1016/j.fct.2025.115372

Ranran Cheng , Xiang Cheng , Dongliang Jiang , Junwei Xiong , Yangfei Ding , Juan Liu , Hongsu Zhao , Hangmin Feng , Deling Wu , Wei Zhang

{"title":"Spectrum-effect relationship of the cardiovascular-protective effect of with Chrysanthemi Flos by UPLC-MS/MS and component knock-out method","authors":"Ranran Cheng , Xiang Cheng , Dongliang Jiang , Junwei Xiong , Yangfei Ding , Juan Liu , Hongsu Zhao , Hangmin Feng , Deling Wu , Wei Zhang","doi":"10.1016/j.fct.2025.115372","DOIUrl":"10.1016/j.fct.2025.115372","url":null,"abstract":"<div><div><em>Chrysanthemi Flos</em> (CF), as one of the important ‘dual-use’ plants, possesses great pharmacological research and development potential. This work aimed to find the pharmacodynamic material basis of CF in cardiovascular-protection by spectrum-effect relationship and component knock-out method. The fingerprint was established by ultra-high performance liquid chromatography and 25 peaks were picked out as common peaks. The common peaks were identified by ultra-performance liquid chromatography-quadrupole-orbitrap-mass spectrometry including twelve flavonoids, nine phenylpropanoids, three organic acids, and one nucleoside. The cardiovascular-protective effect of CF was determined by angiotensin II-induced injury model of human umbilical vein endothelial cells. Grey relation analysis, partial least squares regression analysis and Pearson's correlation analysis were performed to assess the relationship between the cardiovascular-protective effect and ingredients. Spectrum-effect relationship and component knock-out method revealed that P11 (luteolin-7-<em>O</em>-<em>β</em>-D-glucoside), P14 (3,4-<em>O</em>-dicaffeoylquinic acid), P16 (1,5-<em>O</em>-dicaffeoylquinic acid), and P17 (3,5-<em>O</em>-dicaffeoylquinic acid) were the pharmacological material basis for the cardiovascular-protective effect of CF. This work preliminarily elucidated the pharmacodynamic material basis of cardiovascular-protective effect of CF, which could be used to considerable methods and insight for the fundamental research of the pharmacodynamic material basis of Traditional Chinese Medicine.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115372"},"PeriodicalIF":3.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Derivation of a health-based guidance value for bisphenol A via the weight of evidence approach

IF 3.9 3区医学

Food and Chemical Toxicology Pub Date : 2025-03-05 DOI: 10.1016/j.fct.2025.115370

Xiaomeng Li , Yu Lu , Daoyuan Yang , Jiabin Guo , Guojun Li , Qian Bian , Keliang Liu , Yan Song , Zhaoping Liu , Haixia Sui , Jinyao Chen

{"title":"Derivation of a health-based guidance value for bisphenol A via the weight of evidence approach","authors":"Xiaomeng Li , Yu Lu , Daoyuan Yang , Jiabin Guo , Guojun Li , Qian Bian , Keliang Liu , Yan Song , Zhaoping Liu , Haixia Sui , Jinyao Chen","doi":"10.1016/j.fct.2025.115370","DOIUrl":"10.1016/j.fct.2025.115370","url":null,"abstract":"<div><div>There remains a debate over the health-based guidance value of bisphenol A (BPA) worldwide. Through the weight of evidence approach, this study systematically searched and evaluated the updated BPA toxicological data following the guidelines for evaluating the relevance and reliability of toxicological data developed by the China National Center for Food Safety Risk Assessment. Benchmark dose and no observed adverse effect dose/lowest observed adverse effect level methods were used for dose–relationship analysis. A total of 334 articles were used for evidence integration and included in this hazard assessment of BPA. General toxicity, toxicity to the reproductive system, and neurological (developmental) toxicity were included as possible critical effects in the present assessment. With a point of departure of 2310 μg/kg body weight (BW) based on the decreased round spermatid count in rat seminiferous tubules and the human equivalent dose factor of 0.185 using the constructed physiologically based toxicokinetic model of oral intake of BPA in Chinese population, a human equivalent dose of 427 μg/kg BW was obtained. Applying an overall uncertainty factor of 100, the present assessment established a temporary-tolerable daily intake of 4 μg/kg BW for oral exposure of humans to BPA.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"200 ","pages":"Article 115370"},"PeriodicalIF":3.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143578804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0