应用砷化镓粒子后人体皮肤中镓和砷的渗透：使用Franz细胞的离体研究。

IF 3.5 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology Pub Date : 2025-09-22 DOI:10.1016/j.fct.2025.115758

Marco Rizzo , Giovanna Marussi , Matteo Crosera , Mauro Marcella , Giorgio Biasiol , Gianpiero Adami , Greta Camilla Magnano , Francesca Larese Filon

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引用次数: 0

摘要

砷化镓（GaAs）是一种广泛应用于各种技术领域的半导体。本研究是在一个研究实验室进行的，目的是利用Franz扩散细胞的离体模型来评估砷化镓颗粒的皮肤渗透。溶解试验表明，镓在合成汗液中的解离率高于砷，但渗透实验表明，砷的渗透性更强，特别是在皮肤受损的情况下。暴露24小时后，受损皮肤中砷浓度（1558±546 ng/cm2）比未污染皮肤（458±144 ng/cm2）高3倍（p < 0.05）。受损皮肤中镓的浓度（244±5.29 ng/cm2）比未污染皮肤（37.1±11.9 ng/cm2）高6倍（p < 0.05），完整皮肤是有效的屏障，而受损皮肤显著增加了这两种元素的渗透。由于皮肤脂质结构受损，去污过程也增强了渗透。综上所述，砷化镓颗粒可以释放砷和镓，并穿透和渗透皮肤。这些发现强调了在职业环境中采取预防措施以确保充分保护的重要性。

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Gallium and arsenic human skin permeation after application of GaAs particles: an ex-vivo study using Franz cells

Gallium arsenide (GaAs) is a semiconductor widely used in various technological applications. This study, conducted in a research laboratory, aims to evaluate the cutaneous permeation of GaAs particles using an ex-vivo model with Franz diffusion cells.

Dissolution tests indicated that gallium dissociates at higher rates than arsenic in synthetic sweat, but permeation experiments revealed that arsenic is more permeable, particularly in damaged skin conditions. After 24 h of exposure, arsenic concentrations in the receiving compartment were three times higher in damaged skin (1558 ± 546 ng/cm²) than in decontaminated skin (458 ± 144 ng/cm²), (p < 0.05). Gallium

concentrations were six times higher in damaged skin (244 ± 5.29 ng/cm²) compared to decontaminated skin (37.1 ± 11.9 ng/cm²), (p < 0.05) Intact skin serves as an effective barrier, while damaged skin significantly increases the permeation of both elements. The decontamination process also enhances penetration due to impairment of the skin's lipid structure.

In conclusion, GaAs particles can release arsenic and gallium that penetrate and permeate the skin.

These findings highlight the importance of preventive measures in occupational settings to ensure adequate protection.

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来源期刊

Food and Chemical Toxicology 工程技术-毒理学

CiteScore

10.90

自引率

4.70%

发文量

651

审稿时长

31 days

期刊介绍： Food and Chemical Toxicology (FCT), an internationally renowned journal, that publishes original research articles and reviews on toxic effects, in animals and humans, of natural or synthetic chemicals occurring in the human environment with particular emphasis on food, drugs, and chemicals, including agricultural and industrial safety, and consumer product safety. Areas such as safety evaluation of novel foods and ingredients, biotechnologically-derived products, and nanomaterials are included in the scope of the journal. FCT also encourages submission of papers on inter-relationships between nutrition and toxicology and on in vitro techniques, particularly those fostering the 3 Rs. The principal aim of the journal is to publish high impact, scholarly work and to serve as a multidisciplinary forum for research in toxicology. Papers submitted will be judged on the basis of scientific originality and contribution to the field, quality and subject matter. Studies should address at least one of the following: -Adverse physiological/biochemical, or pathological changes induced by specific defined substances -New techniques for assessing potential toxicity, including molecular biology -Mechanisms underlying toxic phenomena -Toxicological examinations of specific chemicals or consumer products, both those showing adverse effects and those demonstrating safety, that meet current standards of scientific acceptability. Authors must clearly and briefly identify what novel toxic effect (s) or toxic mechanism (s) of the chemical are being reported and what their significance is in the abstract. Furthermore, sufficient doses should be included in order to provide information on NOAEL/LOAEL values.