2002-2022年期间希腊食品中二恶英和多氯联苯的监测以及通过饮食对一般人群暴露的初步评估

IF 3.5 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology Pub Date : 2025-08-27 DOI:10.1016/j.fct.2025.115717

Danae Costopoulou, Irene Vassiliadou, Kleopatra Kedikoglou, Constantina Grigoriou, Leondios Leondiadis

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引用次数: 0

摘要

人类从饮食中暴露于多氯二苯并对二恶英（pcdd）、多氯二苯并呋喃（pcdf）、类二恶英多氯联苯（DL-PCBs）和非类二恶英多氯联苯（NDL-PCBs）是全世界科学界关注的问题，因为这些化合物与健康危害有关。在这项研究中，首次对希腊青少年和成人的膳食摄入量进行了估计。在21年（2002-2022年）期间，收集并分析了希腊广泛消费的食品类别的代表性样本。发现的发生数据与欧洲食品安全局综合食品消费数据库中提供的食品消费数据相结合，以评估希腊人口的饮食暴露。总（PCDD/Fs和DL-PCBs）平均上限浓度最高的食品组是“鱼和海鲜”，湿重（ww）为0.71 pg WHO-TEQ g−1 （9.68 pg WHO-TEQ g−1脂肪），平均WHO-TEQ浓度最低的是“植物油”组，脂肪为0.35 pg WHO-TEQ g−1。在“鱼类和海产品”类别中检测到的指示多氯联苯（吲哚-多氯联苯）含量最高（5.25 ng g - 1 ww， 86.8 ng g - 1脂肪），而平均浓度最低的是鸡蛋（1.56 ng g - 1脂肪）。希腊成年人PCDD/Fs和DL-PCBs的平均每日摄入量为1.02 pg WHO-TEQ kg体重−1 (bw)，相当于每周摄入量7.14 pg WHO-TEQ kg bw−1，而ind - pcbs的平均每日摄入量为5.51 ng kg bw−1。多氯联苯/多氯联苯和多氯联苯的总膳食摄入量的主要贡献者是“鱼类和海鲜”类别。据估计，希腊人口对PCDD/Fs和DL-PCBs的一般背景饮食暴露在1998年世卫组织提出的1 - 4 pg WHO- teq kg bw - 1的可耐受日摄入量（TDI）范围内，但超过了2018年EFSA控制专家组更新科学意见中提出的2 pg WHO- teq kg bw - 1的可耐受周摄入量（TWI）。

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Dioxin and PCB monitoring in Greek food products during the period 2002–2022 and preliminary assessment of general population exposure through the diet

Human dietary exposure to polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), dioxin-like polychlorinated biphenyls (DL-PCBs) and non dioxin-like polychlorinated biphenyls (NDL-PCBs) is of worldwide scientific concern due to the health hazards associated with these compounds. In this study an estimation of the dietary intake of adolescents and adults in Greece was attempted for the first time. Representative samples from food categories widely consumed in Greece were collected and analyzed during a period of 21 years (2002–2022). Occurrence data found were combined with food consumption data available in the EFSA Comprehensive Food Consumption Database, to assess the dietary exposure of the Greek population. The food group with the highest total (PCDD/Fs and DL-PCBs) mean upperbound concentration was “fish and seafood” with 0.71 pg WHO-TEQ g⁻¹ wet weight (ww) (9.68 pg WHO-TEQ g⁻¹ fat) and the one with the lowest mean WHO-TEQ concentration was the “vegetable oil” group, 0.35 pg WHO-TEQ g⁻¹ fat. The highest amounts of indicator PCBs (ind-PCBs), were detected in the “fish and seafood’’ category (5.25 ng g⁻¹ ww, 86.8 ng g⁻¹ fat) whereas the lowest mean concentration was found in eggs (1.56 ng g⁻¹ fat). For adult Greek population the average daily intake in PCDD/Fs and DL-PCBs is 1.02 pg WHO-TEQ kg body weight⁻¹ (bw), which corresponds to 7.14 pg WHO-TEQ kg bw⁻¹ weekly intake whereas the average daily intake in ind.-PCBs is 5.51 ng kg bw⁻¹. The main contributor to the total dietary intake in PCDD/Fs and PCBs is the “fish and seafood” category. The general background dietary exposure of the Greek population to PCDD/Fs and DL-PCBs estimated is within the tolerable daily intake (TDI) value range of 1–4 pg WHO-TEQ kg bw ⁻¹ proposed by the WHO in 1998, but exceeds the tolerable weekly intake (TWI) of 2 pg WHO-TEQ kg bw⁻¹ proposed in the updated scientific opinion of the EFSA CONTAM Panel in 2018.

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来源期刊

Food and Chemical Toxicology 工程技术-毒理学

CiteScore

10.90

自引率

4.70%

发文量

651

审稿时长

31 days

期刊介绍： Food and Chemical Toxicology (FCT), an internationally renowned journal, that publishes original research articles and reviews on toxic effects, in animals and humans, of natural or synthetic chemicals occurring in the human environment with particular emphasis on food, drugs, and chemicals, including agricultural and industrial safety, and consumer product safety. Areas such as safety evaluation of novel foods and ingredients, biotechnologically-derived products, and nanomaterials are included in the scope of the journal. FCT also encourages submission of papers on inter-relationships between nutrition and toxicology and on in vitro techniques, particularly those fostering the 3 Rs. The principal aim of the journal is to publish high impact, scholarly work and to serve as a multidisciplinary forum for research in toxicology. Papers submitted will be judged on the basis of scientific originality and contribution to the field, quality and subject matter. Studies should address at least one of the following: -Adverse physiological/biochemical, or pathological changes induced by specific defined substances -New techniques for assessing potential toxicity, including molecular biology -Mechanisms underlying toxic phenomena -Toxicological examinations of specific chemicals or consumer products, both those showing adverse effects and those demonstrating safety, that meet current standards of scientific acceptability. Authors must clearly and briefly identify what novel toxic effect (s) or toxic mechanism (s) of the chemical are being reported and what their significance is in the abstract. Furthermore, sufficient doses should be included in order to provide information on NOAEL/LOAEL values.