Human exposure to persistent organic pollutants in Switzerland: The role of diet, age, smoking, and body composition

IF 3.5 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology Pub Date : 2025-08-22 DOI:10.1016/j.fct.2025.115711

C. Oltramare , J. Riou , M. Bochud , M. Zennegg , D. Vernez , A. Berthet

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引用次数: 0

Abstract

Persistent organic pollutants (POPs), including polychlorinated dibenzo-p-dioxin/dibenzofuran (PCDD/Fs) and polychlorinated biphenyls (PCBs), are widespread environmental contaminants that bioaccumulate in human, primarily through dietary intake. We conducted a cross-sectional study performed in Lausanne, Switzerland to investigate the association between the serum concentrations of POPs and individual characteristics. We measured 17 PCDD/Fs, 12 dl-PCBs and 6 i-PCBs in 80 volunteers. Participants provided demographic and lifestyle data and completed a food frequency questionnaire. Geometric mean concentrations were 6.2 pgTEQ/g lipid for PCDD/Fs, 4.2 pgTEQ/g lipid for dl-PCBs and 117.3 ng/g lipid for i-PCBs. Age, body fat mass, smoking status were statistically associated with serum concentrations. Dietary associations were congener-specific; notably, egg consumption correlated with higher PCDF concentrations, and plant-based foods were, unexpectedly, linked to increased overall POP levels. Active smoking was associated with higher PCB serum concentrations. We highlighted divergent association (smoking status or body fat mass) between PCDD/Fs and PCBs although they share similar physico-chemical properties. The ubiquity of pollutants in the environment has led to their widespread presence in human body, despite stringent regulation. There is an urgent need to investigate the food contamination origin to reduce the general population exposure to environmental pollutants.

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瑞士人类对持久性有机污染物的暴露：饮食、年龄、吸烟和身体成分的作用

持久性有机污染物（POPs），包括多氯二苯并-对二恶英/二苯并呋喃（PCDD/Fs）和多氯联苯（PCBs），是广泛存在的环境污染物，主要通过饮食摄入在人体中进行生物积累。我们在瑞士洛桑进行了一项横断面研究，以调查持久性有机污染物的血清浓度与个体特征之间的关系。我们测量了80名志愿者的17个PCDD/Fs， 12个dl-PCBs和6个i-PCBs。参与者提供了人口统计和生活方式数据，并完成了一份食物频率调查问卷。PCDD/Fs的几何平均脂质浓度为6.2 pgTEQ/g， dl- pcb为4.2 pgTEQ/g， i- pcb为117.3 ng/g。年龄、体脂量、吸烟状况与血清浓度有统计学相关性。饮食关联是同属特异性的；值得注意的是，鸡蛋消费与较高的PCDF浓度相关，而植物性食物出人意料地与总体POP水平增加有关。主动吸烟与较高的多氯联苯血清浓度有关。我们强调了PCDD/Fs和PCBs之间的不同关联（吸烟状况或体脂量），尽管它们具有相似的物理化学性质。环境中无处不在的污染物导致它们在人体中广泛存在，尽管有严格的监管。研究食品污染的来源，减少普通人群对环境污染物的暴露，是迫切需要的。

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来源期刊

Food and Chemical Toxicology 工程技术-毒理学

CiteScore

10.90

自引率

4.70%

发文量

651

审稿时长

31 days

期刊介绍： Food and Chemical Toxicology (FCT), an internationally renowned journal, that publishes original research articles and reviews on toxic effects, in animals and humans, of natural or synthetic chemicals occurring in the human environment with particular emphasis on food, drugs, and chemicals, including agricultural and industrial safety, and consumer product safety. Areas such as safety evaluation of novel foods and ingredients, biotechnologically-derived products, and nanomaterials are included in the scope of the journal. FCT also encourages submission of papers on inter-relationships between nutrition and toxicology and on in vitro techniques, particularly those fostering the 3 Rs. The principal aim of the journal is to publish high impact, scholarly work and to serve as a multidisciplinary forum for research in toxicology. Papers submitted will be judged on the basis of scientific originality and contribution to the field, quality and subject matter. Studies should address at least one of the following: -Adverse physiological/biochemical, or pathological changes induced by specific defined substances -New techniques for assessing potential toxicity, including molecular biology -Mechanisms underlying toxic phenomena -Toxicological examinations of specific chemicals or consumer products, both those showing adverse effects and those demonstrating safety, that meet current standards of scientific acceptability. Authors must clearly and briefly identify what novel toxic effect (s) or toxic mechanism (s) of the chemical are being reported and what their significance is in the abstract. Furthermore, sufficient doses should be included in order to provide information on NOAEL/LOAEL values.