Network toxicological analysis of sodium dehydroacetate in food safety

IF 3.9 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology Pub Date : 2025-04-22 DOI:10.1016/j.fct.2025.115469

Jing Jin , Yan Xue , Liang Tian

引用次数: 0

Abstract

Sodium dehydroacetate (Na-DHA), a synthetic preservative under tightened regulations, was evaluated for multi-organ toxicity using network toxicology. ADMETlab3.0 predicted genotoxicity, hepatotoxicity, and carcinogenicity risks. Target mining identified 13 cancer-related, 11 liver injury-related, and 8 genotoxicity-related core genes, with shared hubs (ALOX5, PTGS2, SMAD3, TNF) across pathologies. Functional analyses revealed inflammation, oxidative stress, and immune dysregulation as central mechanisms. KEGG pathway analysis linked cancer/liver injury to AGE-RAGE signaling (TNF, NOX4) and genotoxicity to efferocytosis impairment (PTGS2, ALOX5), suggesting DNA repair disruption. The integrated network demonstrated Na-DHA's pleiotropic effects through convergent pathways, transcending organ-specific toxicity. This systemic profile challenges conventional single-endpoint assessments, advocating comprehensive multi-organ risk evaluation.

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食品安全中脱氢乙酸钠网络毒理学分析

采用网络毒理学方法对脱氢乙酸钠（Na-DHA）进行了多器官毒性评价。ADMETlab3.0预测遗传毒性、肝毒性和致癌性风险。靶标挖掘确定了13个癌症相关基因、11个肝损伤相关基因和8个基因毒性相关核心基因，这些核心基因具有跨病理共享的枢纽（ALOX5、PTGS2、SMAD3、TNF）。功能分析显示炎症、氧化应激和免疫失调是主要机制。KEGG通路分析将癌症/肝损伤与AGE-RAGE信号（TNF, NOX4）和efferocytosis损伤（PTGS2, ALOX5）的遗传毒性联系起来，提示DNA修复中断。该综合网络通过聚合途径证明了Na-DHA的多效性，超越了器官特异性毒性。这一系统性概况挑战了传统的单终点评估，提倡全面的多器官风险评估。

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来源期刊

Food and Chemical Toxicology 工程技术-毒理学

CiteScore

10.90

自引率

4.70%

发文量

651

审稿时长

31 days

期刊介绍： Food and Chemical Toxicology (FCT), an internationally renowned journal, that publishes original research articles and reviews on toxic effects, in animals and humans, of natural or synthetic chemicals occurring in the human environment with particular emphasis on food, drugs, and chemicals, including agricultural and industrial safety, and consumer product safety. Areas such as safety evaluation of novel foods and ingredients, biotechnologically-derived products, and nanomaterials are included in the scope of the journal. FCT also encourages submission of papers on inter-relationships between nutrition and toxicology and on in vitro techniques, particularly those fostering the 3 Rs. The principal aim of the journal is to publish high impact, scholarly work and to serve as a multidisciplinary forum for research in toxicology. Papers submitted will be judged on the basis of scientific originality and contribution to the field, quality and subject matter. Studies should address at least one of the following: -Adverse physiological/biochemical, or pathological changes induced by specific defined substances -New techniques for assessing potential toxicity, including molecular biology -Mechanisms underlying toxic phenomena -Toxicological examinations of specific chemicals or consumer products, both those showing adverse effects and those demonstrating safety, that meet current standards of scientific acceptability. Authors must clearly and briefly identify what novel toxic effect (s) or toxic mechanism (s) of the chemical are being reported and what their significance is in the abstract. Furthermore, sufficient doses should be included in order to provide information on NOAEL/LOAEL values.