法匹拉韦（T-705）致大鼠肝肾毒性的实验评价

IF 3.9 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology Pub Date : 2025-04-23 DOI:10.1016/j.fct.2025.115472

Menekşe Ülger, Işıl Tuğçe Turan, Ayşegül Si̇pahi̇, Gözde Özge Önder

{"title":"法匹拉韦（T-705）致大鼠肝肾毒性的实验评价","authors":"Menekşe Ülger, Işıl Tuğçe Turan, Ayşegül Si̇pahi̇, Gözde Özge Önder","doi":"10.1016/j.fct.2025.115472","DOIUrl":null,"url":null,"abstract":"<div><div>Favipiravir is an antiviral drug that selectively and potently inhibits RNA-dependent RNA polymerase of various RNA viruses. Its empirical use has increased with the COVID-19 pandemic. This study aimed to investigate the potential toxicological effects of favipiravir administration on healthy rats' liver and kidney tissues. Four groups were established in the survey (n = 10): Control, Low-dose favipiravir (100 mg/kg/d), Medium-dose favipiravir (200 mg/kg/d), and High-dose favipiravir (300 mg/kg/d). On the first day of the study, a loading dose equivalent to twice the maintenance dose was administered. On the eleventh day, liver and kidney tissues were collected for histopathological and immunohistochemical analyses. According to our results, favipiravir caused various histopathological damages in the liver and kidneys and led to alterations in the levels of cytokines associated with inflammation (IL-6, TGF-β, TNF-α, IL-1β, IFN-γ). Co-administration of favipiravir with various protective agents may be needed to mitigate potential damage to the liver and kidneys.</div></div>","PeriodicalId":317,"journal":{"name":"Food and Chemical Toxicology","volume":"202 ","pages":"Article 115472"},"PeriodicalIF":3.9000,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Experimental evaluation of favipiravir (T-705)-induced liver and kidney toxicity in rats\",\"authors\":\"Menekşe Ülger, Işıl Tuğçe Turan, Ayşegül Si̇pahi̇, Gözde Özge Önder\",\"doi\":\"10.1016/j.fct.2025.115472\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Favipiravir is an antiviral drug that selectively and potently inhibits RNA-dependent RNA polymerase of various RNA viruses. Its empirical use has increased with the COVID-19 pandemic. This study aimed to investigate the potential toxicological effects of favipiravir administration on healthy rats' liver and kidney tissues. Four groups were established in the survey (n = 10): Control, Low-dose favipiravir (100 mg/kg/d), Medium-dose favipiravir (200 mg/kg/d), and High-dose favipiravir (300 mg/kg/d). On the first day of the study, a loading dose equivalent to twice the maintenance dose was administered. On the eleventh day, liver and kidney tissues were collected for histopathological and immunohistochemical analyses. According to our results, favipiravir caused various histopathological damages in the liver and kidneys and led to alterations in the levels of cytokines associated with inflammation (IL-6, TGF-β, TNF-α, IL-1β, IFN-γ). Co-administration of favipiravir with various protective agents may be needed to mitigate potential damage to the liver and kidneys.</div></div>\",\"PeriodicalId\":317,\"journal\":{\"name\":\"Food and Chemical Toxicology\",\"volume\":\"202 \",\"pages\":\"Article 115472\"},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2025-04-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Food and Chemical Toxicology\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0278691525002406\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"FOOD SCIENCE & TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Food and Chemical Toxicology","FirstCategoryId":"97","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0278691525002406","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

Favipiravir是一种抗病毒药物，选择性和有效抑制各种RNA病毒的RNA依赖性RNA聚合酶。随着COVID-19大流行，其经验性使用有所增加。本研究旨在探讨favipiravir给药对健康大鼠肝肾组织的潜在毒理学影响。调查共设4组（n = 10）：对照组、低剂量法匹拉韦（100 mg/kg/d）、中剂量法匹拉韦（200 mg/kg/d）、高剂量法匹拉韦（300 mg/kg/d）。在研究的第一天，给予相当于维持剂量两倍的负荷剂量。第11天取肝、肾组织进行组织病理学和免疫组化分析。根据我们的研究结果，favipiravir引起肝脏和肾脏的各种组织病理学损伤，并导致与炎症相关的细胞因子（IL-6, TGF-β, TNF-α, IL-1β, IFN-γ）水平的改变。为了减轻对肝脏和肾脏的潜在损害，可能需要favipiravir与各种保护剂共同给药。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Experimental evaluation of favipiravir (T-705)-induced liver and kidney toxicity in rats

Favipiravir is an antiviral drug that selectively and potently inhibits RNA-dependent RNA polymerase of various RNA viruses. Its empirical use has increased with the COVID-19 pandemic. This study aimed to investigate the potential toxicological effects of favipiravir administration on healthy rats' liver and kidney tissues. Four groups were established in the survey (n = 10): Control, Low-dose favipiravir (100 mg/kg/d), Medium-dose favipiravir (200 mg/kg/d), and High-dose favipiravir (300 mg/kg/d). On the first day of the study, a loading dose equivalent to twice the maintenance dose was administered. On the eleventh day, liver and kidney tissues were collected for histopathological and immunohistochemical analyses. According to our results, favipiravir caused various histopathological damages in the liver and kidneys and led to alterations in the levels of cytokines associated with inflammation (IL-6, TGF-β, TNF-α, IL-1β, IFN-γ). Co-administration of favipiravir with various protective agents may be needed to mitigate potential damage to the liver and kidneys.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Food and Chemical Toxicology 工程技术-毒理学

CiteScore

10.90

自引率

4.70%

发文量

651

审稿时长

31 days

期刊介绍： Food and Chemical Toxicology (FCT), an internationally renowned journal, that publishes original research articles and reviews on toxic effects, in animals and humans, of natural or synthetic chemicals occurring in the human environment with particular emphasis on food, drugs, and chemicals, including agricultural and industrial safety, and consumer product safety. Areas such as safety evaluation of novel foods and ingredients, biotechnologically-derived products, and nanomaterials are included in the scope of the journal. FCT also encourages submission of papers on inter-relationships between nutrition and toxicology and on in vitro techniques, particularly those fostering the 3 Rs. The principal aim of the journal is to publish high impact, scholarly work and to serve as a multidisciplinary forum for research in toxicology. Papers submitted will be judged on the basis of scientific originality and contribution to the field, quality and subject matter. Studies should address at least one of the following: -Adverse physiological/biochemical, or pathological changes induced by specific defined substances -New techniques for assessing potential toxicity, including molecular biology -Mechanisms underlying toxic phenomena -Toxicological examinations of specific chemicals or consumer products, both those showing adverse effects and those demonstrating safety, that meet current standards of scientific acceptability. Authors must clearly and briefly identify what novel toxic effect (s) or toxic mechanism (s) of the chemical are being reported and what their significance is in the abstract. Furthermore, sufficient doses should be included in order to provide information on NOAEL/LOAEL values.