American journal of veterinary research最新文献

{"title":"Expanding excellence in fish health.","authors":"Kevin Snekvik, Claire Burbick, Nora Hickey, Ryan Oliveira, Allan Pessier, Preeyanan Sriwanayos, Tom Waltzek","doi":"10.2460/ajvr.25.05.0160","DOIUrl":"10.2460/ajvr.25.05.0160","url":null,"abstract":"","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1"},"PeriodicalIF":1.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of amikacin antimicrobial intravenous regional limb perfusion in canine pelvic limbs.","authors":"Gillian Davies, Samantha L Morello, Tatiana H Ferreira, Kyle J Bartholomew, Brett Nemke, Jason A Bleedorn","doi":"10.2460/ajvr.25.03.0098","DOIUrl":"10.2460/ajvr.25.03.0098","url":null,"abstract":"<p><strong>Objective: </strong>To use contrast venography and intravascular pressure monitoring to determine optimal perfusion volumes during IV regional limb perfusion (IVRLP) and to determine systemic, articular, and osseous concentrations of amikacin achieved following IVRLP in dogs.</p><p><strong>Methods: </strong>Animals were anesthetized and had lateral saphenous vein catheters placed. Incremental IV contrast venography with pressure monitoring was performed on one limb with a tourniquet proximal to the stifle to estimate vascular filling volume. Intravenous regional limb perfusion was performed on the contralateral hindlimb using 5 mg/kg amikacin, IV, diluted to the total filling volume. Systemic blood samples and synovial fluid were collected prior to infusion and immediately prior to and 30 minutes after tourniquet removal. Tibial bone marrow aspirates were collected after tourniquet removal. Samples were analyzed for amikacin concentration.</p><p><strong>Results: </strong>Contrast IVRLP perfused the pelvic limb distal to the tourniquet with a median volume of 10 mL (range, 6 to 16 mL) and perfusion pressure of 77.5 mm Hg (range, 37 to 130 mm Hg). The median systemic amikacin concentration with the tourniquet in place was low (0.6 μg/mL) and increased to 11.5 μg/mL following removal. The amikacin concentrations in synovial fluid and bone marrow were 109.8 and 49.7 μg/mL, respectively, with high interdog variability.</p><p><strong>Conclusions: </strong>Contrast venography and tissue amikacin levels suggest that IVRLP is feasible in the canine pelvic limb as the amikacin concentrations in 75% of synovial fluid and 33% of bone marrow samples exceeded 10 times the MIC required to inhibit 90% of isolates (MIC90) reported for Staphylococcus pseudintermedius.</p><p><strong>Clinical relevance: </strong>This study offers a baseline protocol for canine IVRLP for use in limb infections. Further studies should focus on drug delivery optimization and clinical application.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invariant chain binds to both major histocompatibility complex I and major histocompatibility complex II in ducks.","authors":"Yibo Zhu, Jiayu Sun, Kewei Liu, Xuqing Zhou, Wen Lv, Jinchun Li, Fangfang Chen","doi":"10.2460/ajvr.24.12.0394","DOIUrl":"10.2460/ajvr.24.12.0394","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the intracellular localization and binding of duck invariant chain (Ii) to major histocompatibility complex (MHC) class Iα or MHC class IIβ molecules.</p><p><strong>Methods: </strong>First, the genes of duck Ii, MHC Iα, and MHC IIβ were amplified by PCR, cloned into expression plasmids, and then sequenced to compare homology between ducks and selected agricultural species. Second, Rosetta or 293T cells were transfected with plasmids encoding Ii, MHC Iα, and MHC IIβ either alone or in combination to interrogate binding following expression. The fluorescent reporter molecules used to tag/image transfected cells and expressed protein were identified by western blot. Additionally, the binding interaction of the expressed products was observed by affinity purification using pull-down assay and coimmunoprecipitation. Finally, intracellular colocalization was observed by laser confocal microscopy.</p><p><strong>Results: </strong>The results of western blots demonstrated that all constructed plasmids successfully expressed proteins. Pull down and coimmunoprecipitation revealed that Ii could bind Iα or IIβ, forming Ii-Iα or Ii-IIβ complexes, and they dissociated into single molecules after SDS treatment. In 293T cells, Ii interacts with MHC Iα or MHC IIβ chains and colocalizes intracellularly. Confocal fluorescence microscopy assay indicated that MHC Iα and IIβ were located in the endoplasmic reticulum and endosome.</p><p><strong>Conclusions: </strong>Both MHC and Ii proteins exhibit direct interactions and can colocalize in the endoplasmic reticulum and endosomes.</p><p><strong>Clinical relevance: </strong>This study investigates the relationship between duck Ii and MHC proteins, offering a theoretical foundation for exploring the role of Ii in immune responses and advancing the development of Ii-vectored avian vaccines.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-9"},"PeriodicalIF":1.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory marker analysis of uterine cytobrush samples helps identify mares with endometritis.","authors":"Jennine Lection, Maria Schnobrich, Bettina Wagner, Michael Byron, Bradley Back, Alicia Rollins, Rafaella F Castro Alves, Soon Hon Cheong, Mariana Diel de Amorim","doi":"10.2460/ajvr.25.02.0059","DOIUrl":"10.2460/ajvr.25.02.0059","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate inflammatory cytokine and chemokine concentrations in endometrial samples collected by cytobrush or swab as a potential screening diagnostic marker for equine endometritis.</p><p><strong>Methods: </strong>88 mares had endometrial samples collected, which included cytobrush, swab, and/or biopsy. Clinical reproductive records, reproductive ultrasound examination, endometrial cytology and culture results, and biopsy grading score were recorded. Fluorescent bead-based multiplex assays for the inflammatory markers interferon-γ, interferon-α, IL-1β, IL-4, IL-10, IL-17A, soluble CD14, tumor necrosis factor (TNF)-α, C-C motif chemokine ligand (CCL)-2, CCL3, CCL5, and CCL11 were carried out from the endometrial cytobrush and swab samples in reproductively healthy mares and mares with endometritis in a prospective cross-sectional study.</p><p><strong>Results: </strong>The endometrial cytobrush technique yielded higher inflammatory marker concentrations for mares with endometritis than endometrial swabs. Tumor necrosis factor-α was increased in endometrial cytobrush samples from estrous mares that had endometrial neutrophils on cytology (n = 14; median, 4,185 pg/mL; IQR, 1,318.8 to 7,530 pg/mL) compared to samples from mares without neutrophils on cytology (n = 68; median, 1,653 pg/mL; IQR, 672 to 3,606.8 pg/mL; CI, 288 to 3,715) and in mares with endometritis (n = 14; median, 4,185 pg/mL; IQR, 1,318.8 to 7,530 pg/mL) compared to mares without endometritis (n = 57; median, 1,718 pg/mL; IQR, 651.5 to 3,968 pg/mL; CI, 580 to 4,383). Finally, mares with uterine TNF-α concentrations < 3,942 pg/mL in combination with CCL5 concentrations < 15,985 pg/mL had a 100% chance of identifying as a mare with a healthy endometrium.</p><p><strong>Conclusions: </strong>Increased concentrations of TNF-α and CCL5 in endometrial cytobrush samples are identified in mares with inflammatory endometritis.</p><p><strong>Clinical relevance: </strong>Inflammatory markers measured from endometrial cytobrush samples could be used to identify mares for endometritis that may have false negative results.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-9"},"PeriodicalIF":1.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison of different fixation methods involving transarticular pins and locking plates for shoulder arthrodesis in dogs using finite element analysis.","authors":"Sawako Murakami, Masakazu Shimada, Yasushi Hara","doi":"10.2460/ajvr.25.03.0084","DOIUrl":"10.2460/ajvr.25.03.0084","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study is to compare 3 fixation methods for shoulder arthrodesis using finite element analysis.</p><p><strong>Methods: </strong>Three dogs from different breeds, previously evaluated for shoulder joint arthrodesis, were selected, and their scapula and humerus were extracted from 2019 CT data to create computer models of shoulder arthrodesis. They were fixed with transarticular pins, a plate and screws, or a combination of all 3. The stress distribution of the implants and the dislocation at the osteotomy site were compared under a compression load of 35 N, an internal rotation of 1 Nm, and an external rotation of 1 Nm.</p><p><strong>Results: </strong>The stress distribution on the implants was reduced when all 3 implants were used. The relative dislocation at the osteotomy site is the greatest when fixed solely with the transarticular pins and least when all the implants are used under any loads. The impact of adding transarticular pins was more prominent under the rotational load than under the compression load.</p><p><strong>Conclusions: </strong>The plate and screws are the primary load-bearing components under the compression and rotational loads. However, adding the pins decreases the stress distribution on other implants and prevents motion at the osteotomy site, particularly under rotational load.</p><p><strong>Clinical relevance: </strong>This study indicated that using transarticular pins in conjunction with a plate and screws for shoulder arthrodesis has the potential to reduce the risk of implant failure and may be advantageous for minimizing the risk of malunion or nonunion.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-7"},"PeriodicalIF":1.3,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin perfusion decreases after dexmedetomidine administration in dogs but remains stable for up to 60 minutes under general anesthesia.","authors":"Meghan Watt, James Bilof, Keila K Ida, Nicholas Jeffery, Vanna Dickerson","doi":"10.2460/ajvr.25.02.0057","DOIUrl":"https://doi.org/10.2460/ajvr.25.02.0057","url":null,"abstract":"<p><strong>Objective: </strong>To determine the effect of general anesthesia on skin perfusion in healthy dogs.</p><p><strong>Methods: </strong>Client-owned dogs (n = 22) undergoing a dental cleaning procedure were enrolled in a prospective study. All dogs were administered trazodone (4 to 6 mg/kg, PO) the evening prior to and morning of their dental procedure. After premedication (0.2 mg/kg of butorphanol and 4 μg/kg of dexmedetomidine, IM), anesthesia was induced with propofol (4 mg/kg, IV, to effect) and maintained with isoflurane in 100% oxygen. The mean speckle contrast (MSC; inversely proportional to perfusion) was recorded using laser speckle contrast imaging for the pinna, hind limb, neck, and ventral midline prior to any medication, after premedication, and every 15 minutes while under isoflurane anesthesia for 60 minutes. The percentage of change in MSC from baseline was recorded.</p><p><strong>Results: </strong>MSC increased after premedication versus prior to any medication for all sites, indicating a decrease in perfusion. The magnitude was greater for the ventral midline (37.2 ± 8.1%), neck (28.3 ± 9.5%), and pinna (26.8 ± 6.1%) compared to the hind limb (8.7 ± 3.1%). A mild decrease in MSC (increased perfusion) was observed over time during isoflurane anesthesia. The magnitude was greater for the pinna (-11.0 ± 3.5%) compared to the neck (-1.8 ± 1.6%), midline (8.1 ± 0.2%), and hind limb (3.5 ± 0.6%).</p><p><strong>Conclusions: </strong>A decrease in skin perfusion following IM dexmedetomidine was seen. No further decrease in skin perfusion was seen over time for up to 60 minutes under isoflurane anesthesia.</p><p><strong>Clinical relevance: </strong>Veterinarians should not hesitate to place patients under general anesthesia for short durations even when skin perfusion is a concern; however, it may be prudent to avoid dexmedetomidine.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-6"},"PeriodicalIF":1.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vertebral heart size and vertebral left atrial size reference intervals in Miniature Australian Shepherds, American Eskimos, Tibetan Terriers, and Border Terriers.","authors":"Maria L Wang, Yeram Hong, Charlotte I Zepeda, Lisa A Murphy, Nicole Piscitelli, Jessica Gentile-Solomon, Donald Szlosek, Reid K Nakamura","doi":"10.2460/ajvr.25.02.0058","DOIUrl":"10.2460/ajvr.25.02.0058","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate vertebral heart score (VHS) and vertebral left atrial reference intervals in Miniature Australian Shepherds, American Eskimos, Tibetan Terriers, and Border Terriers.</p><p><strong>Methods: </strong>The electronic medical records of IDEXX Telemedicine Consultants were searched for Miniature Australian Shepherds, American Eskimos, Tibetan Terriers, and Border Terriers undergoing radiography from January 1, 2022, through December 31, 2023. The same board-certified cardiologist performed the VHS and vertebral left atrial size (VLAS) measurements in all dogs.</p><p><strong>Results: </strong>During the study period, a total of 1,052 Miniature Australian Shepherds, 685 American Eskimos, 583 Tibetan Terriers, and 504 Border Terriers were identified. Of these, 844 Miniature Australian Shepherds, 495 American Eskimos, 453 Tibetan Terriers, and 360 Border Terriers were excluded, leaving 208 Miniature Australian Shepherds, 190 American Eskimos, 130 Tibetan Terriers, and 144 Border Terriers available for analysis. The reference interval for Miniature Australian Shepherds was 9.4v to 11.5v for VHS and 1.7v to 2.5v for VLAS. The reference interval for American Eskimos was 9.5v to 11.5v for VHS and 1.7v to 2.4v for VLAS. The reference interval for Tibetan Terriers was 9.2v to 11.4v for VHS and 1.7v to 2.3v for VLAS. The reference interval for Border Terriers was 9.3v to 11.6v for VHS and 1.7v to 2.3v for VLAS.</p><p><strong>Conclusions: </strong>Miniature Australian Shepherds, American Eskimo Dogs, Tibetan Terriers, and Border Terriers have breed-specific VHS and VLAS reference intervals.</p><p><strong>Clinical relevance: </strong>Clinicians should be aware of these results to accurately diagnose cardiac disease in these breeds.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-6"},"PeriodicalIF":1.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Average fluorescence intensity is affected by distance and penetration depth with near-infrared fluorescence imaging with indocyanine green in an ex vivo model.","authors":"Adrianna K Szostek, Janet A Grimes, Mandy L Wallace","doi":"10.2460/ajvr.25.01.0001","DOIUrl":"10.2460/ajvr.25.01.0001","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to evaluate the effect of indocyanine green (ICG) concentration, distance, angle, and penetration depth on average fluorescence intensity (AFI) when using 2 imaging devices in a canine ex vivo model.</p><p><strong>Methods: </strong>3 concentrations of ICG were evaluated (0.006, 0.011, and 0.022 mg/mL) for the effect of distance, penetration depth, angle, and ambient light on AFI. Penetration depth was assessed using serially stacked 1-mm sheets of a gelatin phantom. Each set of conditions was tested using a VITOM 3D and 30° 10-mm laparoscope. Polynomial regression was used to evaluate for significance.</p><p><strong>Results: </strong>Average fluorescence intensity increased with increasing distance for the 30° 10-mm laparoscope. The VITOM 3D displayed higher AFIs at closer and farther distances. Average fluorescence intensity decreased as penetration depth increased for both devices. Ambient light had no effect on AFI, and AFI varied by angle, but statistical analysis for these variables was limited by insufficient data points.</p><p><strong>Conclusions: </strong>Average fluorescence intensity was affected by distance, penetration depth, and angle for each ICG concentration and imaging device. There was no apparent effect on AFI with or without ambient light.</p><p><strong>Clinical relevance: </strong>The interest in near-infrared fluorescence with ICG is growing in veterinary medicine. Optimization of protocols using these techniques can provide veterinarians with guidelines for the implementation of near-infrared fluorescence with ICG. Further studies are needed to assess the relationship between distance, depth, angle, and ambient light with AFI in vivo.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-7"},"PeriodicalIF":1.3,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the left ventricular eccentricity index for assessing dogs classified by pulmonary hypertension probability.","authors":"Kyungyub Baek, Minsuk Kim, Minwoong Seo, Jae-Wan Jung, Chul Park","doi":"10.2460/ajvr.24.11.0339","DOIUrl":"10.2460/ajvr.24.11.0339","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the left ventricular eccentricity index (EI) across different pulmonary hypertension (PH) probability groups and cardiac cycle phases.</p><p><strong>Methods: </strong>This retrospective study enrolled 121 client-owned dogs with PH between February 2020 and July 2024. History, radiography, echocardiography, and other medical recordings were reviewed. Dogs with PH were diagnosed and classified according to the American College of Veterinary Internal Medicine consensus guidelines. The EI was measured at end diastole (EId) and end systole (EIs). The t, Mann-Whitney U, and Kruskal-Wallis tests were used to compare EI between PH groups. Receiver operating characteristic curve analysis was applied to assess the EI for predicting PH and right-sided congestive heart failure. Pearson correlation analysis was used to evaluate the correlation of EId and EIs with both tricuspid regurgitation velocity and right pulmonary artery distensibility index.</p><p><strong>Results: </strong>This study enrolled 37 healthy (control) and 84 dogs with PH. Both EId and EIs were significantly different between the control and PH groups (EId/EIs, 1.16/1.13 vs 1.31/1.66). An EIs value of 1.22 distinguished the 2 groups with a sensitivity of 0.7 and specificity of 1 (AUC, 0.78). Both EId and EIs were positively correlated with tricuspid regurgitation velocity but not with the right pulmonary artery distensibility index.</p><p><strong>Conclusions: </strong>The EI is useful for evaluating septal flattening in dogs with PH under various conditions. The EId showed inferior power to the EIs in assessing PH but aided screening for right-sided congestive heart failure and volume overload.</p><p><strong>Clinical relevance: </strong>The EI can help clinicians to more accurately assess PH probabilities, specifically regarding ventricles.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying genetic biomarkers as early indicators of response in cancer therapy.","authors":"Alastair Cribb","doi":"10.2460/ajvr.25.05.0153","DOIUrl":"10.2460/ajvr.25.05.0153","url":null,"abstract":"","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1"},"PeriodicalIF":1.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}