American journal of veterinary research最新文献_第2页

Distal limb immersion in ice and water is the most effective means of cooling the equine hoof lamellae under clinically relevant conditions.

IF 1.3 3区农林科学

American journal of veterinary research Pub Date : 2025-01-21 DOI: 10.2460/ajvr.24.10.0291

Sarah Ciamillo, Darko Stefanovski, Jeaneen Kulp, Andrew van Eps

{"title":"Distal limb immersion in ice and water is the most effective means of cooling the equine hoof lamellae under clinically relevant conditions.","authors":"Sarah Ciamillo, Darko Stefanovski, Jeaneen Kulp, Andrew van Eps","doi":"10.2460/ajvr.24.10.0291","DOIUrl":"https://doi.org/10.2460/ajvr.24.10.0291","url":null,"abstract":"Objective: To determine the relationship between hoof surface (HS), hoof wall (HW), and lamellar tissue (LAM) temperature during distal limb cooling and evaluate 4 cooling methods in ambulatory horses over extended periods using HW to estimate LAM temperature.Methods: 8 healthy, university-owned horses were enrolled. Temperature was measured over 4 hours at LAM, HS, and HW for 4 cooling methods: ice sleeve (SLEEVE), ice pack system (ICEPACK), low-volume ice water immersion (LV-IMMERSION), and high-volume ice water immersion (HV-IMMERSION). The relationship between HW, HS, and LAM was mathematically modeled, generating a method-specific correction factor to predict LAM based on HW. Hoof wall temperature was then measured over 8 hours with horses free in a stall (LAM was estimated using HW). Mixed-effects linear regression was used to compare cooling methods.Results: HV-IMMERSION and LV-IMMERSION significantly decreased LAM temperature over 4 hours (P < .001), whereas ICEPACK and SLEEVE did not. Lamellar tissue temperature estimated using HW showed good concordance (ρc = 0.93 [0.93 to 0.94]; P < .001) and correlation (r = 0.93; P < .001) with measured LAM temperature. In horses free in the stall for 8 hours, the estimated LAM temperature decreased significantly with HV-IMMERSION (-20.4 °C [-22.9 to -17.8]) and LV-IMMERSION (-14.9 °C [-17.7 to -12.1]) compared to control (32.7 °C [32.2 to 33.2]; P < .001) but did not decrease with ICEPACK (-2.7 °C [-5.6 to -0.3]; P < .08) or SLEEVE (-1.8 °C [-5.6 to -2.0]; P < .4).Conclusions: HV-IMMERSION and LV-IMMERSION were superior to ICEPACK and SLEEVE for lamellar cooling.Clinical relevance: Immersion of the distal limb in ice and water is most effective for cooling the digital lamellae under clinically relevant conditions.","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-9"},"PeriodicalIF":1.3,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143021876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of computed tomography angiography has potential in planning surgical treatment of an extrahepatic portosystemic shunt in dogs.

IF 1.3 3区农林科学

American journal of veterinary research Pub Date : 2025-01-21 DOI: 10.2460/ajvr.24.11.0333

Ryo Takeuchi, Kumiko Ishigaki, Kaito Iida, Chieko Ishikawa, Naoko Shiozawa, Shoko Yamaoka, Naoki Yamada, Yumi Sakamoto, Manabu Sakai, Kazushi Asano

{"title":"Use of computed tomography angiography has potential in planning surgical treatment of an extrahepatic portosystemic shunt in dogs.","authors":"Ryo Takeuchi, Kumiko Ishigaki, Kaito Iida, Chieko Ishikawa, Naoko Shiozawa, Shoko Yamaoka, Naoki Yamada, Yumi Sakamoto, Manabu Sakai, Kazushi Asano","doi":"10.2460/ajvr.24.11.0333","DOIUrl":"https://doi.org/10.2460/ajvr.24.11.0333","url":null,"abstract":"Objective: To evaluate the impact of intrahepatic portal vein branching (IHPB)-grade assessment using preoperative CT angiography (CTA) on the surgical procedure and prognosis prediction for dogs with an extrahepatic portosystemic shunt (EHPSS).Methods: This study involved 146 client-owned dogs with EHPSS. The shunt morphology of EHPSS and IHPB grades was determined using CTA. All dogs underwent surgical attenuation of the shunt with intraoperative portal vein pressure (PVP) measurement, followed by a liver biopsy of the left lateral lobe. The preoperative CTA findings were analyzed according to surgical procedures, intraoperative PVP, hepatic histopathology, and postoperative complications.Results: The grade of IHPB did not correlate with baseline PVP while it significantly correlated with PVP during temporary occlusion and the difference in PVP between before and during the temporary occlusion. The grade of IHPB and PVP had significant differences between the dogs with partial ligation compared with those with complete ligation. The portal vein hypoplasia score on histopathology was generally higher in the dogs with low-grade IHPB than in those with high-grade IHPB. The IHPB grade had no significant influence on postoperative complications and prognosis.Conclusions: This study demonstrated that although the grade assessment system of IHPB using preoperative CTA was unable to predict the prognosis of dogs with a single EHPSS, it may be useful for determining surgical procedure selection.Clinical relevance: Preoperative CTA is suggested to not only be useful for the diagnosis and classification of EHPSS but also for surgical planning of EHPSS in dogs.","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-9"},"PeriodicalIF":1.3,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143021853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of urinary cortisol, urinary cortisol-to-creatinine ratio, and basal serum cortisol as screening tests for hypoadrenocorticism in dogs.

IF 1.3 3区农林科学

American journal of veterinary research Pub Date : 2025-01-21 DOI: 10.2460/ajvr.24.10.0296

Federico Fracassi, Alessandro Tirolo, Matteo Galeotti, Andrea Corsini, Andrea Bertolazzi, Amtonio M Tardo, Stefania Golinelli, Walter Bertazzolo, Ugo Bonfanti, Fabio Procoli, Francesca Del Baldo

{"title":"Comparison of urinary cortisol, urinary cortisol-to-creatinine ratio, and basal serum cortisol as screening tests for hypoadrenocorticism in dogs.","authors":"Federico Fracassi, Alessandro Tirolo, Matteo Galeotti, Andrea Corsini, Andrea Bertolazzi, Amtonio M Tardo, Stefania Golinelli, Walter Bertazzolo, Ugo Bonfanti, Fabio Procoli, Francesca Del Baldo","doi":"10.2460/ajvr.24.10.0296","DOIUrl":"https://doi.org/10.2460/ajvr.24.10.0296","url":null,"abstract":"Objective: This study investigates whether urinary cortisol (UC) and UC-to-creatinine ratio (UCCR) perform better than basal serum cortisol (BSC) in identifying dogs with hypoadrenocorticism (HA).Methods: A retrospective, multicenter study with 120 client-owned dogs included: 20 with HA, 42 healthy, and 60 with diseases mimicking HA. The UC and UCCR were determined on urine samples using a chemiluminescent enzyme immunoassay. The diagnostic performance of the UC and UCCR were assessed based on receiver operating characteristics (ROC) curves.Results: A cutoff value of UC < 2 µg/dL revealed 100% sensitivity (95% CI, 83.2 to 100) and 90.0% specificity (95% CI, 79.5 to 96.2) in diagnosing HA. A cutoff value of UCCR < 8.5 X 10-6 revealed 100% sensitivity (95% CI, 83.1 to 100) and 71.7% specificity (95% CI, 58.6 to 82.6) in diagnosing HA. A cutoff value of BSC < 2 µg/dL and < 1 µg/dL revealed 100% sensitivity (95% CI, 83.2 to 100) and 51.7% specificity (95% CI, 38.5 to 64.8) and 100% sensitivity (95% CI, 83.9 to 100) and 90% specificity (95% CI, 79.8 to 95.3) in diagnosing HA, respectively.Conclusions: BSC < 1 µg/dL showed the same sensitivity but higher specificity than BSC < 2 µg/dL. The UC < 2 µg/dL showed noninferior performance compared with the BSC < 1 µg/dL.Clinical relevance: UC should be considered a promising screening test for canine HA.","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-7"},"PeriodicalIF":1.3,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143021868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increases in mean arterial blood pressure during electrical stimulation are unreliable indicators of anesthetic depth measured with electroencephalogram in dogs anesthetized with sevoflurane.

IF 1.3 3区农林科学

American journal of veterinary research Pub Date : 2025-01-21 DOI: 10.2460/ajvr.24.08.0232

Carrisa Thomas, Daniel M Sakai, Jane E Quandt, Michele Barletta, Rachel A Reed

{"title":"Increases in mean arterial blood pressure during electrical stimulation are unreliable indicators of anesthetic depth measured with electroencephalogram in dogs anesthetized with sevoflurane.","authors":"Carrisa Thomas, Daniel M Sakai, Jane E Quandt, Michele Barletta, Rachel A Reed","doi":"10.2460/ajvr.24.08.0232","DOIUrl":"https://doi.org/10.2460/ajvr.24.08.0232","url":null,"abstract":"Objective: To evaluate the sparing effects of fentanyl and maropitant on sevoflurane minimum alveolar concentrations that block autonomic responses (MACBAR) and the hemodynamic and electroencephalographic responses to noxious stimuli in dogs.Methods: The sevoflurane MACBAR was determined in 5 healthy male Beagles with or without continuous infusions of fentanyl and maropitant. Then, intermittent noxious stimulation was applied at 1.3, 1.0, and 0.7 MACBAR. Heart rate (HR), mean arterial pressure (MAP), and Patient State Index (PSI) were measured for 6 minutes before and during 6 minutes of stimulation and analyzed with generalized linear mixed-effects models. Patient State Index occurrences above 50 during stimulation were noted. The effective dose for burst suppression was determined.Results: The baseline MACBAR was 2.26% (1.34, 3.19). No MACBAR-sparing effect of fentanyl and maropitant was observed. At 1.3 MACBAR, MAP, HR, and PSI were 50 (41, 91) mm Hg, 90 (64, 112) beats/min, and 2 (0, 44). Mean arterial pressure and PSI increased, but not HR, with lower MACBAR multiples (P < .001). Noxious stimulation did not alter HR or PSI but elevated MAP. No PSI above 50 occurred at 1.3 MACBAR; however, 2 and 3 dogs showed brief PSI increases at 1.0 and 0.7 MACBAR. The effective dose for burst suppression was 3.15% (2.75, 3.75).Conclusions: Fentanyl and maropitant showed no MACBAR-sparing effect. At higher sevoflurane concentrations, noxious stimuli triggered an autonomic response; however, burst suppression was observed in the electroencephalogram.Clinical relevance: Variations in HR and MAP are unreliable indicators of anesthetic depth measured by electroencephalogram.","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143021880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Demystifying artificial intelligence for veterinary professionals: practical applications and future potential.

IF 1.3 3区农林科学

American journal of veterinary research Pub Date : 2025-01-20 DOI: 10.2460/ajvr.24.09.0275

K E Sobkowich

{"title":"Demystifying artificial intelligence for veterinary professionals: practical applications and future potential.","authors":"K E Sobkowich","doi":"10.2460/ajvr.24.09.0275","DOIUrl":"https://doi.org/10.2460/ajvr.24.09.0275","url":null,"abstract":"The field of veterinary medicine, like many others, is expected to undergo a significant transformation due to artificial intelligence (AI), although the full extent remains unclear. Artificial intelligence is already becoming prominent throughout daily life (eg, recommending movies, completing text messages, predicting traffic), yet many people do not realize they interact with it regularly. Despite its prevalence, opinions on AI in veterinary medicine range from skepticism to optimism to indifference. However, we are living through a key moment that calls for a balanced perspective, as the way we choose to address AI now will shape the future of the field. Future generations may view us as either overly optimistic, blinded by AI's allure, or overly pessimistic, failing to recognize its potential. By understanding how algorithms function and predictions are made, we can begin to demystify AI, seeing it not as an all-knowing entity but as a powerful tool that will assist veterinary professionals in providing high-level care and progressing in the field. Building awareness allows us to appreciate its strengths and limitations and recognize the ethical dilemmas that may arise. This review aims to provide an accessible overview of the status of AI in veterinary medicine. This review is not intended to be an exhaustive account of AI.","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-10"},"PeriodicalIF":1.3,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143021871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial intelligence and machine learning in veterinary medicine: a regulatory perspective on current initiatives and future prospects. 兽医学中的人工智能和机器学习：当前举措和未来前景的监管视角。

IF 1.3 3区农林科学

American journal of veterinary research Pub Date : 2025-01-16 DOI: 10.2460/ajvr.24.09.0285

Hesha J Duggirala, Jennifer L Johnson, Daniel A Tadesse, Chih-Hao Hsu, Alexis L Norris, Joseph Faust, Linda Walter-Grimm, Tristan Colonius

{"title":"Artificial intelligence and machine learning in veterinary medicine: a regulatory perspective on current initiatives and future prospects.","authors":"Hesha J Duggirala, Jennifer L Johnson, Daniel A Tadesse, Chih-Hao Hsu, Alexis L Norris, Joseph Faust, Linda Walter-Grimm, Tristan Colonius","doi":"10.2460/ajvr.24.09.0285","DOIUrl":"https://doi.org/10.2460/ajvr.24.09.0285","url":null,"abstract":"The US FDA's Center for Veterinary Medicine (CVM) is advancing its leadership in veterinary science by integrating AI and machine learning (ML) into its regulatory framework and scientific initiatives. This paper explores the CVM's strategic approach to harnessing these technologies to enhance human and animal health by supporting innovative products and methods. Key areas of focus include regulatory adaptation, genomic research, and information technology modernization. The Animal and Veterinary Innovation Agenda outlines the Center's commitment to fostering innovation in veterinary medicine while addressing emerging challenges. This includes developing AI/ML-driven tools for antimicrobial resistance research, genome editing safety, and postmarketing safety surveillance. The paper discusses the CVM's participation in the FDA's role in shaping guidance documents for AI in regulatory decision making. In genomic research, the CVM is utilizing AI/ML to study antimicrobial resistance and improve genomic editing techniques. These technologies enhance the understanding of resistance mechanisms and facilitate the precise identification of genetic alterations. Artificial intelligence is also pivotal in information technology modernization efforts, aimed at streamlining data management and enhancing operational efficiency. The paper highlights the efforts to integrate AI/ML in safety surveillance, including signal detection and case processing. It emphasizes the importance of human-led governance, data quality, and model validation in ensuring the ethical deployment of AI technologies. The CVM's initiatives represent a transformative shift toward more efficient and innovative regulatory approaches. The paper concludes with a call for continued collaboration among researchers, industry, and regulatory bodies to advance AI integration and achieve mutual goals in animal health.","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-6"},"PeriodicalIF":1.3,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cats with inflammatory gastrointestinal or dermatological disorders exhibit increased care-soliciting and anxious behaviors. 患有胃肠或皮肤疾病的猫表现出更多的关心和焦虑行为。

IF 1.3 3区农林科学

American journal of veterinary research Pub Date : 2025-01-14 DOI: 10.2460/ajvr.24.10.0312

Eilidh J Gilbert, Lauren Powell, Carlo Siracusa

{"title":"Cats with inflammatory gastrointestinal or dermatological disorders exhibit increased care-soliciting and anxious behaviors.","authors":"Eilidh J Gilbert, Lauren Powell, Carlo Siracusa","doi":"10.2460/ajvr.24.10.0312","DOIUrl":"https://doi.org/10.2460/ajvr.24.10.0312","url":null,"abstract":"Objective: This study investigated whether the behavior profiles of cats with inflammatory gastrointestinal or skin diseases differ from those of healthy cats.Methods: We identified adult cats within the patient database at the University of Pennsylvania's veterinary hospital that had been diagnosed with inflammatory gastrointestinal (n = 22) or skin disorders (17) and a control group of healthy cats (58). We collected data via owner completion of the Feline Behavioral Assessment & Research Questionnaire from March to May 2023 and conducted an observational study comparing the Feline Behavioral Assessment & Research Questionnaire scores between groups.Results: Cats with inflammatory gastrointestinal or skin disease exhibited more etepimeletic (care-soliciting) behaviors than healthy cats, including purring (U = 1,396.50, Z = 2.03, r = 0.21, 95% CI, 0.00 to 0.50), trainability (U = 1,303.50, Z = 2.33, r = 0.24, 95% CI, 0.00 to 1.00), and sociability to people (U = 367.50, Z = 2.21, r = 0.26, 95% CI, 0.00 to 1.57). The inflammatory group also exhibited more anxious behaviors than the healthy group, including compulsive grooming (U = 1,736.00, Z = 4.91, r = 0.50, 95% CI, 0.33 to 1.00) and fear of novelty (U = 603.00, Z = 2.14, r = 0.25, 95% CI, 0.00 to 1.00). Additionally, cats treated with corticosteroids exhibited more anxious behaviors than healthy and nonsteroid treatment groups, including separation behaviors (χ2[2] = 8.22, η2 = 0.08) and compulsive grooming (χ2[2] = 25.35, η2 = 0.25).Conclusions: Chronic inflammatory response is associated with increased etepimeletic and anxious behaviors in cats, and corticosteroid treatment is associated with anxious behaviors.Clinical relevance: These findings suggest that monitoring anxious and etepimeletic behaviors may be relevant when assessing inflammatory disease in cats.","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-10"},"PeriodicalIF":1.3,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rebound tonometry intraocular pressure reference values for conscious adult Egyptian vultures (Neophron percnopterus). 有意识的成年埃及秃鹫（Neophron percnopterus）的回弹眼压测量参考值。

IF 1.3 3区农林科学

American journal of veterinary research Pub Date : 2025-01-13 DOI: 10.2460/ajvr.24.10.0308

Lucia Gomez Prieto, Dominic Byron-Chance, Ashton J Hollwarth, Thomas A G Dutton

{"title":"Rebound tonometry intraocular pressure reference values for conscious adult Egyptian vultures (Neophron percnopterus).","authors":"Lucia Gomez Prieto, Dominic Byron-Chance, Ashton J Hollwarth, Thomas A G Dutton","doi":"10.2460/ajvr.24.10.0308","DOIUrl":"https://doi.org/10.2460/ajvr.24.10.0308","url":null,"abstract":"Objective: To obtain standard reference values of intraocular pressure measured with rebound tonometry in conscious healthy Egyptian vultures (Neophron percnopterus).Methods: 17 Egyptian vultures presented for a routine health check, involving a full physical examination, blood film examination, Hct, manual total leukocyte count, and plasma biochemistry. 15 animals considered healthy and with no signs of stress underwent an ophthalmic examination, including observation of facial symmetry, adnexa, and direct fundoscopy to screen for ocular disease. Healthy animals, with no evidence of ocular disease and no signs of stress, were included in the study. The birds were manually restraint in an upright position for rebound tonometry of the right and left eyes.Results: Mean and SD of intraocular pressure were 27.33 ± 3.54 mm Hg for the right eye and 27.00 ± 4.11 mm Hg for the left eye. There was no statistical difference when comparing the right and left eyes. The combined mean ± SD for both eyes was 27.2 ± 3.76 mm Hg.Conclusions: Rebound tonometry was well tolerated in all animals included in the study. The results of intraocular pressure with rebound tonometry can be used as reference values during the ophthalmological examination of Egyptian vultures.Clinical relevance: The investigation of vision threatening diseases in Egyptian vultures may necessitate rebound tonometry as part of a comprehensive ophthalmologic examination. Rebound tonometry values obtained from anesthetized Egyptian vultures, or Egyptian vultures restrained in lateral, dorsal, or sternal positions, may differ from those reported here.","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-6"},"PeriodicalIF":1.3,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of oral premedication with gabapentin and trazodone combination on the MAC of isoflurane in dogs. 加巴喷丁与曲唑酮联合口服预用药对犬异氟醚MAC的影响。

IF 1.3 3区农林科学

American journal of veterinary research Pub Date : 2025-01-10 DOI: 10.2460/ajvr.24.09.0254

Jacob Aiello, Brittney Carson, Turi Aarnes, Audrey Wanstrath, Mary McLoughlin

{"title":"Effect of oral premedication with gabapentin and trazodone combination on the MAC of isoflurane in dogs.","authors":"Jacob Aiello, Brittney Carson, Turi Aarnes, Audrey Wanstrath, Mary McLoughlin","doi":"10.2460/ajvr.24.09.0254","DOIUrl":"10.2460/ajvr.24.09.0254","url":null,"abstract":"Objective: To determine the effect of the administration of oral gabapentin (20 mg/kg) and trazodone (8 mg/kg) on the MAC of isoflurane in dogs.Methods: 6 adult dogs (3 castrated males and 3 spayed females), aged 13.3 ± 1.5 months and weighing 36.8 ± 3.4 kg (mean ± SD), were each anesthetized twice, separated by at least 7 days. Dogs were randomly assigned to receive gabapentin (20 mg/kg orally) and trazodone (8 mg/kg orally) followed by maintenance isoflurane or maintenance isoflurane alone. For their second event, dogs received the other treatment. The MAC was determined using an iterative bracketing technique with electric stimulation. Hemodynamic variables and vital parameters were assessed throughout the anesthetic episode. The effect of treatment on outcome variables was analyzed by use of a paired t test (P < .05).Results: The mean ± SD MAC of isoflurane in dogs was significantly lower with gabapentin and trazodone premedication and isoflurane (0.625 ± 0.18%) compared with isoflurane alone (0.95 ± 0.14%). The mean MAC of isoflurane reduction was 0.33 ± 0.04%. Heart rate was decreased but still within normal limits in premedicated dogs. Other hemodynamic variables did not differ significantly between treatments.Conclusions: Oral administration of gabapentin (20 mg/kg) and trazodone (8 mg/kg) 2 hours before anesthesia maintained with isoflurane had a MAC-sparing effect with no significant effect on hemodynamic variables in dogs.Clinical relevance: Oral premedication with gabapentin and trazodone could be administered before anesthesia to decrease MAC, thus limiting dose-dependent anesthetic risks.","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-6"},"PeriodicalIF":1.3,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of transpulmonary thermodilution, ultrasound dilution, and esophageal Doppler against direct pulmonary artery flow for cardiac output monitoring in anesthetized cats. 经肺热稀释、超声稀释和食管多普勒对直接肺动脉流量监测麻醉猫心输出量的评估。

IF 1.3 3区农林科学

American journal of veterinary research Pub Date : 2025-01-09 DOI: 10.2460/ajvr.24.09.0263

Pen-Ting Liao, Michael Tillson, Stuart Clark-Price, Kendon Kuo, Katherine Gerken, Aina Claret

{"title":"Assessment of transpulmonary thermodilution, ultrasound dilution, and esophageal Doppler against direct pulmonary artery flow for cardiac output monitoring in anesthetized cats.","authors":"Pen-Ting Liao, Michael Tillson, Stuart Clark-Price, Kendon Kuo, Katherine Gerken, Aina Claret","doi":"10.2460/ajvr.24.09.0263","DOIUrl":"10.2460/ajvr.24.09.0263","url":null,"abstract":"Objective: To assess the agreement of transpulmonary thermodilution (TPTD) and transpulmonary ultrasound dilution (TPUD) against direct measurement of main pulmonary artery flow with an ultrasound transit time flow probe (UTF) over a wide range of conditions in anesthetized cats. Additionally, the trending ability of TPTD, TPUD, and esophageal Doppler ultrasonography (EDU) was evaluated against UTF.Methods: 12 purpose-bred cats were used. One cat was used for a pilot study. The cats were instrumented according to the manufacturer's recommendation. Paired measurements were made over a wide range of cardiac output. Agreement was analyzed with Bland-Altman analysis with repeated measures, and trending ability was assessed by 4-quadrant plot and concordance rate. Interchangeable was defined as percentage error less than simplified total error. Acceptable trending was defined as concordance rate > 95%.Results: Bias and percentage error were -0.084 L·min-1 and 38.2% for TPTD and -0.041 L·min-1 and 52.9% for TPUD. The concordance rate was 100%, 95.5%, and 64% to 65% for TPTD, TPUD, and EDU, respectively.Conclusions: Both TPTD and TPUD were not interchangeable to UTF. Both TPTD and TPUD provided acceptable trending ability but not EDU.Clinical relevance: Transpulmonary thermodilution and TPUD allow detection of the direction of cardiac output changes in anesthetized cats but not EDU. Clinical and research use of these 3 devices warrants careful consideration of the limitations presented in this study.","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-10"},"PeriodicalIF":1.3,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0