American journal of veterinary research最新文献

{"title":"Retrospective evaluation of outpatient management following parathyroidectomy for treatment of primary hyperparathyroidism in dogs.","authors":"Sarah M Duke, Cassandra Y Prpich","doi":"10.2460/ajvr.26.01.0021","DOIUrl":"https://doi.org/10.2460/ajvr.26.01.0021","url":null,"abstract":"<p><strong>Objective: </strong>To describe outcomes following outpatient management of dogs with primary hyperparathyroidism treated with parathyroidectomy between 2015 and 2025.</p><p><strong>Methods: </strong>The medical records of 43 client-owned dogs with primary hyperparathyroidism treated with parathyroidectomy at a private specialty hospital (2015 to 2025) were observationally, retrospectively analyzed. Pre- and postoperative variables examined included demographics, biochemical markers (ionized calcium [iCa], parathyroid hormone, and parathyroid hormone-related protein), imaging and histopathology findings, postoperative iCa nadir and time to nadir, and incidence of hypocalcemia and supplementation. Data were compared between clinically hypocalcemic, nonclinically hypocalcemic, and normocalcemic groups. Morbidity and mortality over a 14-day follow-up period were reported. Feline patients, those without accessible medical records, and those hospitalized for unrelated illnesses were excluded.</p><p><strong>Results: </strong>No variables were significantly correlated with or predictive of clinical postoperative hypocalcemia. Dogs presenting with gastrointestinal upset (n = 6) had a significantly higher preoperative iCa than those without (37). The mean iCa nadir was significantly lower in dogs receiving supplementation (0.92; 95% CI, 0.85 to 0.98; n = 8) than those that did not (1.19; 95% CI, 1.15 to 1.23; 35). Three of 8 supplemented dogs demonstrated clinical signs before supplementation. One dog received emergent IV calcium. No mortality was reported over the 14-day follow-up period.</p><p><strong>Conclusions: </strong>Outpatient postparathyroidectomy management was not associated with mortality over 14 days. Hypocalcemia-related morbidity was transient, manageable, and infrequent. No predictive variables for clinical postoperative hypocalcemia were identified.</p><p><strong>Clinical relevance: </strong>Select postoperative parathyroidectomy patients can be managed on an outpatient basis.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-10"},"PeriodicalIF":1.4,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147715661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practice ownership aspirations among veterinary students and recent graduates are influenced by autonomy, perceived responsibility, and career interests.","authors":"Lauren Compton, Gary Vroegindewey, Lauren Wisnieski","doi":"10.2460/ajvr.26.02.0047","DOIUrl":"10.2460/ajvr.26.02.0047","url":null,"abstract":"<p><strong>Objective: </strong>To identify factors influencing veterinary students and recently graduated veterinarians in the desire to pursue practice ownership.</p><p><strong>Methods: </strong>This observational cross-sectional study distributed a 28-item online survey via social media and email from June to December 2024 to veterinary students and recent graduates (< 5 years) in the US. Participants ranked factors influencing practice ownership, and logistic regression analyses assessed associations with demographic characteristics, education, and previous experiences.</p><p><strong>Results: </strong>We analyzed responses from 282 participants. Overall, 50.4% of participants aspired to own a practice. Among aspiring practice owners, the most frequently ranked reason was freedom to practice medicine how they desire, followed by job satisfaction and leadership opportunities. Conversely, among participants not interested in practice ownership, the most frequently ranked factor was the responsibility of practice ownership, followed by back-office tasks, liability and legal responsibilities, and stress/burnout. Logistic regression analyses revealed that men, Veterinary Business Management Association members, and those interested in/currently working in mixed-animal practice had higher odds of interest in practice ownership.</p><p><strong>Conclusions: </strong>Approximately 50% of participants reported an interest in practice ownership, a proportion higher than reported in profession-wide surveys. Consistent with prior research, barriers to practice ownership included the responsibilities associated with ownership and concerns about work-life balance.</p><p><strong>Clinical relevance: </strong>This study highlights the need to integrate more comprehensive practice management education into the veterinary curriculum. Experiential learning opportunities, such as externships focused on practice management or ownership, may help bridge gaps between clinical training and business skills.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-6"},"PeriodicalIF":1.4,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term sacubitril/valsartan is well tolerated in dogs with heart failure and myxomatous mitral valve disease and suggests excellent survival benefits.","authors":"Justin A Carlson, Joshua A Stern","doi":"10.2460/ajvr.26.02.0048","DOIUrl":"https://doi.org/10.2460/ajvr.26.02.0048","url":null,"abstract":"<p><strong>Objective: </strong>To determine the safety and survival data for dogs with congestive heart failure (CHF) and myxomatous mitral valve disease (MMVD) treated chronically with sacubitril/valsartan.</p><p><strong>Methods: </strong>A retrospective cohort study was completed by identifying dogs with CHF from MMVD and a prescription for sacubitril/valsartan over a 2.8-year period (from February 2023 to December 2025). Dogs that had surgical intervention, left atrial decompression, or an adverse event that necessitated discontinuation of sacubitril/valsartan therapy were removed from survival analysis.</p><p><strong>Results: </strong>50 dogs with CHF and MMVD, treated with sacubitril/valsartan (mean ± SD dosage, 18.1 ± 5.4 mg/kg, PO, q 12 h) were identified. Five dogs were removed prior to survival analysis. The median survival time after the first episode of CHF was 577 days (range, 431 to 751) for 45 dogs. The survival time in 28 stage D MMVD-affected dogs, 446.5 days (283; 619), was lower than that of 17 stage C MMVD-affected dogs, who had a median survival time of 1,149 (570; infinity) days. Three dogs (6%) had adverse events, suggesting that adverse events secondary to sacubitril/valsartan were rare in this population. After initiation of sacubitril/valsartan and titration to the target dose, the most common improvements were in energy level and exercise capacity (83% of dogs).</p><p><strong>Conclusions: </strong>Sacubitril/valsartan therapy in dogs appears safe and suggests median survival times that eclipse those of prior canine MMVD stage C or D CHF studies.</p><p><strong>Clinical relevance: </strong>This study reports a dosing schedule and clinical tolerance of sacubitril/valsartan. It further provides important data for planning future prospective studies.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-7"},"PeriodicalIF":1.4,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147687787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enucleations performed by the ophthalmology service have lower complication rates when compared to enucleations performed by the emergency service.","authors":"Samantha H Byrne, Stephanie Pumphrey, Elizabeth A Rozanski, Noa Berlin","doi":"10.2460/ajvr.25.12.0439","DOIUrl":"https://doi.org/10.2460/ajvr.25.12.0439","url":null,"abstract":"<p><strong>Objective: </strong>To compare patient characteristics, surgical techniques, and outcomes of enucleations performed by emergency service (ES) versus ophthalmology service (OPH) clinicians at a veterinary teaching hospital.</p><p><strong>Methods: </strong>Medical records over a 5-year period were reviewed for signalment, indication, surgeon affiliation, surgical technique, perioperative management, and complications.</p><p><strong>Results: </strong>Records from 576 dogs and cats (468 OPH cases and 118 ES cases) were identified for review. Emergency service enucleations were more often performed after hours (16.1% vs 1.3%) and on weekends (37.3% vs 3.3%) and were primarily performed by rotating interns and ES residents, whereas OPH cases were typically performed on weekdays by ophthalmology residents or specialty interns or faculty. Common ES indications were proptosis (24.6%) and perforated corneal ulcers (39.0%), whereas OPH cases most often involved glaucoma (21.4%), uveitis (18.8%), or neoplasia (11.6%). Cases from ES were significantly less likely to receive preoperative bloodwork, intraoperative antibiotics, or local anesthetic blocks. Intraoperative hemorrhage occurred in 14.4% of ES versus 0.4% of OPH cases. Postoperative complications, including dehiscence (6.8%), infection (6.8%), and draining tracts (2.5%), were also significantly more frequent in ES cases (16.9% vs 0.7%). Financial limitations were commonly cited as the reason for ES enucleations.</p><p><strong>Conclusions: </strong>Patient and procedure characteristics differed between ES and OPH cases. Dogs and cats enucleated by ES experienced significantly more intraoperative and postoperative complications.</p><p><strong>Clinical relevance: </strong>Findings support the need to train ES clinicians to perform enucleations. Specific training focusing on circumstances surrounding ES cases can potentially mitigate complications and improve outcomes.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-8"},"PeriodicalIF":1.4,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147687692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atropine induces narrowing of the superior and inferior iridocorneal angle and ciliary cleft in normal horse eyes.","authors":"Victoria C Priester, Kelly E Knickelbein","doi":"10.2460/ajvr.26.02.0063","DOIUrl":"https://doi.org/10.2460/ajvr.26.02.0063","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effects of atropine on the iridocorneal angle (ICA) and ciliary cleft (CC) of normal equine eyes using ultrasound biomicroscopy (UBM).</p><p><strong>Methods: </strong>12 normal adult horses underwent measurement of intraocular pressure (IOP), vertical and horizontal pupil diameter, and UBM of the superior, temporal, inferior, and nasal ICA/CC in both eyes. Measurements were repeated 2 hours following ophthalmic atropine 1% solution application. Measurements of the ICA and CC, including pectinate ligament distance (PLD), CC length (CCL), height of opening distance (HOD), CC area (CCA), and pectinate ligament angle (PLA) were performed.</p><p><strong>Results: </strong>Mean IOP significantly decreased following atropine administration (14.17 ± 2.34 mm Hg vs 12.67 ± 1.14 mm Hg). No significant differences in pre- or post-atropine ICA/CC measurements occurred nasally or temporally. Superiorly, a significant decrease in mean CCL (2.74 ± 0.52 mm vs 2.62 ± 0.43 mm), CCA (2.67 ± 0.72 mm2 vs 2.42 ± 0.66 mm2), HOD (1.15 ± 0.26 mm vs 1.06 ± 0.20 mm), and PLA (80.33 ± 7.02° vs 73.67 ± 8.50°) occurred. Inferiorly, a significant decrease in PLD (1.46 ± 0.23 mm vs 1.39 ± 0.17 mm), HOD (1.44 ± 0.24 mm vs 1.33 ± 0.15 mm), and PLA (73.18 ± 6.81° vs 69.98 ± 8.92°) occurred.</p><p><strong>Conclusions: </strong>Atropine causes narrowing of the superior and inferior ICA and CC in normal horse eyes.</p><p><strong>Clinical relevance: </strong>Due to its effect in narrowing the ICA and CC, atropine should be used with caution in horses with elevated intraocular pressure or glaucoma.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-7"},"PeriodicalIF":1.4,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147643628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A positive view of the lifestyle of food animal veterinarians is the strongest predictor for interest in food animal medicine among students: a survey study.","authors":"Ana R S Oliveira, Richard V Pereira, Ian Dohoo, John Angelos, Grace VanHoy, Sarah Depenbrock, Deniece R Williams, Margaret C Barr, Gabriele U Maier","doi":"10.2460/ajvr.25.12.0453","DOIUrl":"https://doi.org/10.2460/ajvr.25.12.0453","url":null,"abstract":"<p><strong>Objective: </strong>To develop, validate, and use a survey tool to investigate veterinary students' attitudes toward careers in food animal veterinary medicine (FAVM).</p><p><strong>Methods: </strong>A prompt in an end-of-year questionnaire among veterinary students at the University of California-Davis identified latent constructs describing motivation and perception of careers in FAVM. Latent constructs were used to develop a survey distributed to veterinary students at Kansas State University, University of California-Davis, and Western University of Health Sciences from May 2023 through May 2024. Logistic regression correlated summary estimates of attitudes about working in FAVM as θ values from item response theory models to the outcome self-declared interest in FAVM careers. Latent class analysis evaluated subgroups of students to identify significant factors driving interest in FAVM careers.</p><p><strong>Results: </strong>From 1,536 elicited students, a combined total of 491 usable surveys were received. The θ values for the construct \"Lifestyle/work conditions/clients and industry-perception of FAVM\" had the strongest association with the outcome in all 3 schools. Latent class analysis among students with an interest in FAVM showed 4 classes of students with differing profiles of their perception of careers in FAVM.</p><p><strong>Conclusions: </strong>A positive view of the lifestyle of food animal veterinarians (FAV) (workdays per week, time on call, work location) was the most important predictor for student interest in careers in FAVM.</p><p><strong>Clinical relevance: </strong>Availability of more flexible employment opportunities that improve student perceptions of the lifestyle of FAV may help expand the FAVM workforce.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-10"},"PeriodicalIF":1.4,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147637931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flumazenil has a dose-dependent effect on recovery from midazolam sedation in Rhode Island Red chickens (Gallus gallus domesticus).","authors":"Ashley R Souza, Olivia A Petritz, Andrea Thomson, Julie A Balko","doi":"10.2460/ajvr.26.01.0028","DOIUrl":"https://doi.org/10.2460/ajvr.26.01.0028","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the pharmacodynamics of 3 doses of IM flumazenil following 5 mg/kg midazolam, IM, in Rhode Island Red chickens.</p><p><strong>Methods: </strong>Using a randomized, crossover design, hens received IM midazolam followed 25 minutes later by 1 of 4 treatments IM: 0.02, 0.05, or 0.1 mg/kg flumazenil or an equal volume of 0.9% sodium chloride (control). Serial assessment of heart and respiratory rates, sedation scores, and times to recumbency and standing were recorded from midazolam administration until recovery. Chickens not recovered by 3 hours after midazolam received 0.05 mg/kg flumazenil, IM (rescue). Categorical variables were analyzed with the Cochran Q test, whereas noncategorical variables were evaluated with a mixed-effects γ regression model. The Pearson correlation and intraclass correlation coefficient measured correlation between observers.</p><p><strong>Results: </strong>All six Rhode Island Red hens became recumbent following midazolam administration. Heart and respiratory rates remained within clinically acceptable limits. Median (range) time to recovery following 0.02, 0.05, or 0.1 mg/kg flumazenil or control was 153.9 (55.2 to 180.0), 137.3 (35.5 to 181.0), 70.7 (29.6 to 182.0), and 173.0 (151.0 to 181.0) minutes, respectively. This was statistically significant between groups. Rescue flumazenil was administered in 3 of 6, 3 of 6, 1 of 6, and 5 of 6 birds in 0.02, 0.05, and 0.1 mg/kg flumazenil or control, respectively.</p><p><strong>Conclusions: </strong>In chickens sedated with 5 mg/kg midazolam, IM, 0.1 mg/kg flumazenil provided the fastest time to recovery compared to lower doses (0.02 and 0.05 mg/kg) or control.</p><p><strong>Clinical relevance: </strong>This study supports the use of 0.1 mg/kg flumazenil, IM, to expedite recovery in midazolam-sedated chickens.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-6"},"PeriodicalIF":1.4,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147632361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient safety investigative methods identify contributors to canine magnetic resonance imaging dermatologic thermal injuries in an academic hospital.","authors":"Darcy Adin, Corey Stockhaus, Taylor Reyes, Domenico Santoro, Chris Sanchez, Marta Romano, Mary Wilson, Aitor Gallastegui, Linda Allen, Aline Rodrigues Hoffmann","doi":"10.2460/ajvr.26.01.0022","DOIUrl":"https://doi.org/10.2460/ajvr.26.01.0022","url":null,"abstract":"<p><strong>Objective: </strong>To describe MRI-associated ECG electrode site thermal burns in dogs and the patient safety investigation that identified a reduction of radiofrequency energy output as a modifiable factor associated with their resolution.</p><p><strong>Animals: </strong>10 client-owned dogs undergoing MRI that experienced skin lesions at the ECG electrode site from April through December 2024.</p><p><strong>Clinical presentation: </strong>The reason for MRI was brain imaging in 5 dogs, spine imaging in 4 dogs, and both brain and spine imaging in 1 dog. Median weight was 14.7 kg (range, 3.1 to 31.5). Median age was 9 years (range, 1 to 13).</p><p><strong>Results: </strong>After an MRI upgrade, 10 dogs experienced skin lesions consistent with thermal injury at the ECG electrode site. Thermal injury was mild (7) and moderate to severe (3). Two dogs underwent skin biopsy, which confirmed second-degree burns. A comprehensive, systematic, iterative approach to investigate these patient harm events was undertaken, involving multiple investigations and procedural changes. Resolution came after MRI radiofrequency energy output was reduced despite being measured in the acceptable range.</p><p><strong>Clinical relevance: </strong>The approach used to investigate MRI-associated thermal burns in this study highlights the importance of identifying root causes to improve system safety and ultimately prevent future harm. Histologic confirmation of thermal injury has not previously been reported in dogs and was important because it refocused the investigation on MRI output as a potential cause.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-8"},"PeriodicalIF":1.4,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147632371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum protein alterations characterize feline chronic gingivostomatitis: a case-control study of electrophoresis, immunoglobulin, and cytokine profiles.","authors":"Emily R Tetlow, Luke A Wentlent, Patrick C Carney, Michael J Byron, Nadine Fiani, Alexandra L Wright, Emilia Chrostek, Matthew E Drozd, Cailin E Winokur, Eric M Davis, Santiago Peralta","doi":"10.2460/ajvr.26.02.0052","DOIUrl":"https://doi.org/10.2460/ajvr.26.02.0052","url":null,"abstract":"<p><strong>Objective: </strong>To characterize systemic immune alterations in feline chronic gingivostomatitis (FCGS) through serum protein electrophoresis (SPE), immunoglobulin (Ig), and cytokine profiling. We hypothesized that FCGS cases would exhibit polyclonal hyperglobulinemia, elevated Igs, and proinflammatory cytokine elevations compared to controls.</p><p><strong>Methods: </strong>Cats with FCGS and controls were prospectively enrolled in an observational case-control study at 2 veterinary dental practices. Exclusion criteria included FIV/FeLV infection, recent vaccination, corticosteroid administration, and systemic disease. A single preanesthetic serum sample was analyzed for 31 biomarkers, including SPE fractions, Ig concentrations, and cytokine levels.</p><p><strong>Results: </strong>13 FCGS cats and 14 controls were enrolled. Six biomarkers differed significantly after false discovery rate (FDR) correction, with very large effect sizes (Hedges g = 1.43 to 2.27): globulin, IgG, γ globulin, total protein, albumin, and albumin-to-globulin ratio. Polyclonal gammopathy was present in 76.9% of FCGS cases. Seven cytokines showed medium to large effect sizes (Hedges g = 0.57 to 0.88) without surviving FDR correction. Hierarchical clustering separated 85% of cases from 79% of controls based on coordinated cytokine profiles despite modest individual elevations.</p><p><strong>Conclusions: </strong>This study confirms FCGS as a disease with a quantifiable, systemic inflammatory response characterized by polyclonal hypergammaglobulinemia and mixed T helper 1/2 cytokine activation.</p><p><strong>Clinical relevance: </strong>FCGS extends beyond localized oral inflammation to involve measurable systemic immune dysregulation. Hyperglobulinemia, combined with oromucosal inflammation, should prompt diagnostic consideration of FCGS in cats. The coordinated activation of IL-8, IL-4, IFN-γ, and IL-6 identifies potential therapeutic targets for immunomodulatory intervention in refractory cases.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-10"},"PeriodicalIF":1.4,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147632463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma concentrations of terbinafine in Kemp's ridley sea turtles (Lepidochelys kempii) peak at 24 hours after a single oral dose.","authors":"Sarah E Balik, Melissa J Joblon, Deana Edmunds, Alexis E Wrate, Linda Lory, Kathryn A Tuxbury, Charles J Innis, Sherry Cox","doi":"10.2460/ajvr.26.01.0030","DOIUrl":"https://doi.org/10.2460/ajvr.26.01.0030","url":null,"abstract":"<p><strong>Objective: </strong>To determine the pharmacokinetic parameters of a single dose of terbinafine administered orally to Kemp's ridley sea turtles (Lepidochelys kempii).</p><p><strong>Methods: </strong>In the spring of 2025, convalescent juvenile Kemp's ridley sea turtles that were undergoing rehabilitation due to cold stunning in Quincy, Massachusetts, were given 20 mg/kg terbinafine orally in a food item. Samples were collected via a sparse-sampling protocol from 0 to 120 hours after drug administration. Plasma drug concentrations were determined via reverse-phase HPLC. Pharmacokinetic parameters were determined using noncompartmental analysis for sparse data.</p><p><strong>Results: </strong>15 turtles were included in this study. Terminal half-life was 24.1 hours, maximum plasma concentration was 1.17 µg/mL, time to maximum plasma concentration was 24 hours, area under the plasma concentration-versus-time curve from time 0 to the last point was 51.1 h•µg/mL, area under the plasma concentration-versus-time curve from time 0 to infinity was 53.8 h•µg/mL, and the percentage of the area under the plasma concentration-versus-time curve from time 0 to infinity extrapolated to infinity was 5.06%.</p><p><strong>Conclusions: </strong>Terbinafine plasma concentrations reached time to maximum plasma concentration at 24 hours and exceeded the MIC for several fungal pathogens that have previously been documented for Kemp's ridley sea turtles.</p><p><strong>Clinical relevance: </strong>The results of this study can inform the treatment of fungal infections in Kemp's ridley sea turtles. Additional studies are warranted to assess plasma and tissue concentrations after multiple terbinafine doses in order to determine appropriate dosage frequency.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-7"},"PeriodicalIF":1.4,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147632469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}