Meghan Watt, James Bilof, Keila K Ida, Nicholas Jeffery, Vanna Dickerson
{"title":"Skin perfusion decreases after dexmedetomidine administration in dogs but remains stable for up to 60 minutes under general anesthesia.","authors":"Meghan Watt, James Bilof, Keila K Ida, Nicholas Jeffery, Vanna Dickerson","doi":"10.2460/ajvr.25.02.0057","DOIUrl":"https://doi.org/10.2460/ajvr.25.02.0057","url":null,"abstract":"<p><strong>Objective: </strong>To determine the effect of general anesthesia on skin perfusion in healthy dogs.</p><p><strong>Methods: </strong>Client-owned dogs (n = 22) undergoing a dental cleaning procedure were enrolled in a prospective study. All dogs were administered trazodone (4 to 6 mg/kg, PO) the evening prior to and morning of their dental procedure. After premedication (0.2 mg/kg of butorphanol and 4 μg/kg of dexmedetomidine, IM), anesthesia was induced with propofol (4 mg/kg, IV, to effect) and maintained with isoflurane in 100% oxygen. The mean speckle contrast (MSC; inversely proportional to perfusion) was recorded using laser speckle contrast imaging for the pinna, hind limb, neck, and ventral midline prior to any medication, after premedication, and every 15 minutes while under isoflurane anesthesia for 60 minutes. The percentage of change in MSC from baseline was recorded.</p><p><strong>Results: </strong>MSC increased after premedication versus prior to any medication for all sites, indicating a decrease in perfusion. The magnitude was greater for the ventral midline (37.2 ± 8.1%), neck (28.3 ± 9.5%), and pinna (26.8 ± 6.1%) compared to the hind limb (8.7 ± 3.1%). A mild decrease in MSC (increased perfusion) was observed over time during isoflurane anesthesia. The magnitude was greater for the pinna (-11.0 ± 3.5%) compared to the neck (-1.8 ± 1.6%), midline (8.1 ± 0.2%), and hind limb (3.5 ± 0.6%).</p><p><strong>Conclusions: </strong>A decrease in skin perfusion following IM dexmedetomidine was seen. No further decrease in skin perfusion was seen over time for up to 60 minutes under isoflurane anesthesia.</p><p><strong>Clinical relevance: </strong>Veterinarians should not hesitate to place patients under general anesthesia for short durations even when skin perfusion is a concern; however, it may be prudent to avoid dexmedetomidine.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-6"},"PeriodicalIF":1.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria L Wang, Yeram Hong, Charlotte I Zepeda, Lisa A Murphy, Nicole Piscitelli, Jessica Gentile-Solomon, Donald Szlosek, Reid K Nakamura
{"title":"Vertebral heart size and vertebral left atrial size reference intervals in Miniature Australian Shepherds, American Eskimos, Tibetan Terriers, and Border Terriers.","authors":"Maria L Wang, Yeram Hong, Charlotte I Zepeda, Lisa A Murphy, Nicole Piscitelli, Jessica Gentile-Solomon, Donald Szlosek, Reid K Nakamura","doi":"10.2460/ajvr.25.02.0058","DOIUrl":"10.2460/ajvr.25.02.0058","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate vertebral heart score (VHS) and vertebral left atrial reference intervals in Miniature Australian Shepherds, American Eskimos, Tibetan Terriers, and Border Terriers.</p><p><strong>Methods: </strong>The electronic medical records of IDEXX Telemedicine Consultants were searched for Miniature Australian Shepherds, American Eskimos, Tibetan Terriers, and Border Terriers undergoing radiography from January 1, 2022, through December 31, 2023. The same board-certified cardiologist performed the VHS and vertebral left atrial size (VLAS) measurements in all dogs.</p><p><strong>Results: </strong>During the study period, a total of 1,052 Miniature Australian Shepherds, 685 American Eskimos, 583 Tibetan Terriers, and 504 Border Terriers were identified. Of these, 844 Miniature Australian Shepherds, 495 American Eskimos, 453 Tibetan Terriers, and 360 Border Terriers were excluded, leaving 208 Miniature Australian Shepherds, 190 American Eskimos, 130 Tibetan Terriers, and 144 Border Terriers available for analysis. The reference interval for Miniature Australian Shepherds was 9.4v to 11.5v for VHS and 1.7v to 2.5v for VLAS. The reference interval for American Eskimos was 9.5v to 11.5v for VHS and 1.7v to 2.4v for VLAS. The reference interval for Tibetan Terriers was 9.2v to 11.4v for VHS and 1.7v to 2.3v for VLAS. The reference interval for Border Terriers was 9.3v to 11.6v for VHS and 1.7v to 2.3v for VLAS.</p><p><strong>Conclusions: </strong>Miniature Australian Shepherds, American Eskimo Dogs, Tibetan Terriers, and Border Terriers have breed-specific VHS and VLAS reference intervals.</p><p><strong>Clinical relevance: </strong>Clinicians should be aware of these results to accurately diagnose cardiac disease in these breeds.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-6"},"PeriodicalIF":1.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"What new skills would you like to acquire?","authors":"Lisa A Fortier","doi":"10.2460/ajvr.86.06.editorial","DOIUrl":"10.2460/ajvr.86.06.editorial","url":null,"abstract":"","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":"86 6","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adrianna K Szostek, Janet A Grimes, Mandy L Wallace
{"title":"Average fluorescence intensity is affected by distance and penetration depth with near-infrared fluorescence imaging with indocyanine green in an ex vivo model.","authors":"Adrianna K Szostek, Janet A Grimes, Mandy L Wallace","doi":"10.2460/ajvr.25.01.0001","DOIUrl":"10.2460/ajvr.25.01.0001","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to evaluate the effect of indocyanine green (ICG) concentration, distance, angle, and penetration depth on average fluorescence intensity (AFI) when using 2 imaging devices in a canine ex vivo model.</p><p><strong>Methods: </strong>3 concentrations of ICG were evaluated (0.006, 0.011, and 0.022 mg/mL) for the effect of distance, penetration depth, angle, and ambient light on AFI. Penetration depth was assessed using serially stacked 1-mm sheets of a gelatin phantom. Each set of conditions was tested using a VITOM 3D and 30° 10-mm laparoscope. Polynomial regression was used to evaluate for significance.</p><p><strong>Results: </strong>Average fluorescence intensity increased with increasing distance for the 30° 10-mm laparoscope. The VITOM 3D displayed higher AFIs at closer and farther distances. Average fluorescence intensity decreased as penetration depth increased for both devices. Ambient light had no effect on AFI, and AFI varied by angle, but statistical analysis for these variables was limited by insufficient data points.</p><p><strong>Conclusions: </strong>Average fluorescence intensity was affected by distance, penetration depth, and angle for each ICG concentration and imaging device. There was no apparent effect on AFI with or without ambient light.</p><p><strong>Clinical relevance: </strong>The interest in near-infrared fluorescence with ICG is growing in veterinary medicine. Optimization of protocols using these techniques can provide veterinarians with guidelines for the implementation of near-infrared fluorescence with ICG. Further studies are needed to assess the relationship between distance, depth, angle, and ambient light with AFI in vivo.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-7"},"PeriodicalIF":1.3,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kyungyub Baek, Minsuk Kim, Minwoong Seo, Jae-Wan Jung, Chul Park
{"title":"Evaluation of the left ventricular eccentricity index for assessing dogs classified by pulmonary hypertension probability.","authors":"Kyungyub Baek, Minsuk Kim, Minwoong Seo, Jae-Wan Jung, Chul Park","doi":"10.2460/ajvr.24.11.0339","DOIUrl":"10.2460/ajvr.24.11.0339","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the left ventricular eccentricity index (EI) across different pulmonary hypertension (PH) probability groups and cardiac cycle phases.</p><p><strong>Methods: </strong>This retrospective study enrolled 121 client-owned dogs with PH between February 2020 and July 2024. History, radiography, echocardiography, and other medical recordings were reviewed. Dogs with PH were diagnosed and classified according to the American College of Veterinary Internal Medicine consensus guidelines. The EI was measured at end diastole (EId) and end systole (EIs). The t, Mann-Whitney U, and Kruskal-Wallis tests were used to compare EI between PH groups. Receiver operating characteristic curve analysis was applied to assess the EI for predicting PH and right-sided congestive heart failure. Pearson correlation analysis was used to evaluate the correlation of EId and EIs with both tricuspid regurgitation velocity and right pulmonary artery distensibility index.</p><p><strong>Results: </strong>This study enrolled 37 healthy (control) and 84 dogs with PH. Both EId and EIs were significantly different between the control and PH groups (EId/EIs, 1.16/1.13 vs 1.31/1.66). An EIs value of 1.22 distinguished the 2 groups with a sensitivity of 0.7 and specificity of 1 (AUC, 0.78). Both EId and EIs were positively correlated with tricuspid regurgitation velocity but not with the right pulmonary artery distensibility index.</p><p><strong>Conclusions: </strong>The EI is useful for evaluating septal flattening in dogs with PH under various conditions. The EId showed inferior power to the EIs in assessing PH but aided screening for right-sided congestive heart failure and volume overload.</p><p><strong>Clinical relevance: </strong>The EI can help clinicians to more accurately assess PH probabilities, specifically regarding ventricles.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Identifying genetic biomarkers as early indicators of response in cancer therapy.","authors":"Alastair Cribb","doi":"10.2460/ajvr.25.05.0153","DOIUrl":"10.2460/ajvr.25.05.0153","url":null,"abstract":"","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1"},"PeriodicalIF":1.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Krystle L Reagan, Karen Boudreaux, Stefan M Keller
{"title":"Veterinary students exhibit low artificial intelligence literacy but agree it will be deployed to improve veterinary medicine.","authors":"Krystle L Reagan, Karen Boudreaux, Stefan M Keller","doi":"10.2460/ajvr.25.03.0082","DOIUrl":"10.2460/ajvr.25.03.0082","url":null,"abstract":"<p><strong>Objective: </strong>To determine the perceptions and self-reported knowledge base of AI and machine learning (AI/ML) among professional veterinary students.</p><p><strong>Methods: </strong>First-, second-, third-, and fourth-year professional veterinary students from the School of Veterinary Medicine at the University of California-Davis were surveyed in a cross-sectional study regarding their knowledge level, attitudes, and feelings regarding AI/ML in veterinary medicine. Responses were summarized, and descriptive statistics were performed.</p><p><strong>Results: </strong>One hundred seventy-six of 594 (29.6%) veterinary students responded to the survey. One hundred forty-one out of 176 (80%) students reported slight or no knowledge surrounding AI/ML, and 139/176 (79%) of students were moderately to extremely interested in learning about AI/ML applications in veterinary medicine. Sixty-five out of 176 (37%) students reported learning about AI/ML concepts in their veterinary curriculum. Most students expect to use these tools in their practice (104/176 [59%]) and suspect that AI/ML will improve veterinary medicine (135/176 [77%]).</p><p><strong>Conclusions: </strong>Artificial intelligence and machine learning applications in veterinary medicine are increasingly available. Professional veterinary students are eager to learn about these technologies and recognize their relevance to their future careers.</p><p><strong>Clinical relevance: </strong>Many professional veterinary programs do not provide structured AI/ML literacy training. Artificial intelligence education should be incorporated into the curriculum to ensure that future veterinarians can critically evaluate and effectively integrate AI/ML tools into clinical practice.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-6"},"PeriodicalIF":1.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura Hebrard, Anne Copet, Margaux Blondel, Thibaut Cachon
{"title":"Video-assisted ligamentoplasty effectively treats medial shoulder instability in dogs: a retrospective study of 6 cases.","authors":"Laura Hebrard, Anne Copet, Margaux Blondel, Thibaut Cachon","doi":"10.2460/ajvr.24.12.0388","DOIUrl":"10.2460/ajvr.24.12.0388","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical feasibility and efficacy of a video-assisted ligamentoplasty of the medial glenohumeral ligament for the treatment of medial shoulder joint instability in dogs.</p><p><strong>Animals: </strong>This retrospective study included 6 dogs with medial shoulder instability treated by video-assisted ligamentoplasty of the medial glenohumeral ligament. Inclusion criteria required documented medical records containing signalment, clinical history, diagnostic imaging, surgical details, and postoperative assessments, along with a minimum follow-up period of 6 months. Complications and midterm outcomes were recorded.</p><p><strong>Clinical presentation: </strong>The 6 dogs exhibited a weight-bearing lameness, and during the orthopedic examination under sedation, an abduction angle exceeding 35° was observed.</p><p><strong>Results: </strong>All joints were stabilized successfully. The abduction angle immediately after repair was 17.5 ± 1.2° and after 6 months 24.6 ± 1.8°. Postoperative shoulder stability was satisfactory, with excellent functional recovery in 5 dogs and good recovery in 1 dog. No complications occurred.</p><p><strong>Clinical relevance: </strong>Video-assisted shoulder stabilization is feasible in dogs and appears to yield satisfactory clinical results. This novel technique shows promising results and encourages the development of minimally invasive techniques for an optimal patient recovery.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-9"},"PeriodicalIF":1.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cody B Westmoreland, Sara D Lawhon, Jing Wu, Nicholas D Jeffery, Vanna M Dickerson
{"title":"Lavage with at least 2.5 mL/cm sterile saline reduces bacterial load in a subcutaneous tissue model.","authors":"Cody B Westmoreland, Sara D Lawhon, Jing Wu, Nicholas D Jeffery, Vanna M Dickerson","doi":"10.2460/ajvr.25.01.0030","DOIUrl":"10.2460/ajvr.25.01.0030","url":null,"abstract":"<p><strong>Objective: </strong>To quantify the volume of lavage required to decrease the bacterial load below a standard of 105 CFUs/mL on a subcutaneous tissue model.</p><p><strong>Methods: </strong>This was a benchtop experimental study conducted between May 1, 2023, through July 31, 2023 that included 20 sterile silicone skin models with a 10-cm incision. The silicone skin model was inoculated with a 1,000-fold dilution of approximately 1.5 X 108 CFUs/mL of isolated Staphylococcus pseudintermedius or Escherichia coli. Bacterial quantification samples were taken preinoculation, 20 minutes postinoculation, and after incremental saline lavage to total a volume of 2.5, 5, and 10 mL/cm incisional length bacterial quantification.</p><p><strong>Results: </strong>For S pseudintermedius and E coli, a reduction of bacterial colonies below 105 CFUs/mL was noted in all lavage volumes, with an initial 3-log decrease from postinoculation to the 2.5 mL/cm lavage for both S pseudintermedius and E coli. Microbial growth demonstrated a 1-log reduction with increased lavage volumes from 2.5 mL/cm to 10 mL/cm for S pseudintermedius. For E coli, microbial growth demonstrated a 1-log reduction with the second lavage (total of 5 mL/cm) and a half-log reduction with the third lavage (total of 10 mL/cm).</p><p><strong>Conclusions: </strong>Surgeons should consider a minimum of 2.5 mL/cm lavage when aiming to decontaminate SC tissues in linear surgical wounds. Further work in clinical cases is required to evaluate differences in live tissue compared to this model.</p><p><strong>Clinical relevance: </strong>This work provides surgeons with a reference point for deciding what volume of lavage to use for purposes of decontaminating an SC space.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-5"},"PeriodicalIF":1.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Robert J Barnett, Samuel J Tidwell, Xiaojuan Zhu, Jeffrey N Peck
{"title":"Perfect patient position is not maintained during total hip replacement in dogs using a vacuum bean bag positioner.","authors":"Robert J Barnett, Samuel J Tidwell, Xiaojuan Zhu, Jeffrey N Peck","doi":"10.2460/ajvr.24.12.0404","DOIUrl":"10.2460/ajvr.24.12.0404","url":null,"abstract":"<p><strong>Objective: </strong>To assess changes in patient positioning prior to acetabular cup impaction during total hip replacement (THR) procedures in dogs.</p><p><strong>Methods: </strong>In a prospective, analytical study, 26 client-owned dogs were evaluated for changes in patient positioning during THR procedures. Following initial patient positioning in true lateral recumbency, fluoroscopic measurement of changes in positioning was performed for each plane at 2 separate time points: after draping (M1) and immediately prior to cup impaction (M2).</p><p><strong>Results: </strong>Patient positioning was significantly altered at time point M1 in the transverse plane, with a mean change of 2.8° (range, 0° to 12°); this change in position was most often toward the dorsum, occurring in 16 of 26 cases (62%). Significant shifting was found at time point M2 in the transverse plane, with a mean change of 2.6° (range, 0° to 10.3°); this change, however, did not significantly correlate with a particular direction. Positioning shifts found at M1 and M2 were not consistently in the same direction in either plane. Body condition score had no effect on shifting found at M1 or M2 in either plane.</p><p><strong>Conclusions: </strong>Perfect patient positioning is not maintained with the use of bean bag positioners. Despite accurate initial positioning and the use of this positioning device, shifting does occur.</p><p><strong>Clinical relevance: </strong>Unrecognized shifts in pelvic position during THR procedures may occur, which could contribute to inappropriate implant positioning. Pelvic alignment should be evaluated during THR procedures to minimize the risk of complications.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}