American journal of veterinary research最新文献

{"title":"Flumazenil has a dose-dependent effect on recovery from midazolam sedation in Rhode Island Red chickens (Gallus gallus domesticus).","authors":"Ashley R Souza, Olivia A Petritz, Andrea Thomson, Julie A Balko","doi":"10.2460/ajvr.26.01.0028","DOIUrl":"https://doi.org/10.2460/ajvr.26.01.0028","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the pharmacodynamics of 3 doses of IM flumazenil following 5 mg/kg midazolam, IM, in Rhode Island Red chickens.</p><p><strong>Methods: </strong>Using a randomized, crossover design, hens received IM midazolam followed 25 minutes later by 1 of 4 treatments IM: 0.02, 0.05, or 0.1 mg/kg flumazenil or an equal volume of 0.9% sodium chloride (control). Serial assessment of heart and respiratory rates, sedation scores, and times to recumbency and standing were recorded from midazolam administration until recovery. Chickens not recovered by 3 hours after midazolam received 0.05 mg/kg flumazenil, IM (rescue). Categorical variables were analyzed with the Cochran Q test, whereas noncategorical variables were evaluated with a mixed-effects γ regression model. The Pearson correlation and intraclass correlation coefficient measured correlation between observers.</p><p><strong>Results: </strong>All six Rhode Island Red hens became recumbent following midazolam administration. Heart and respiratory rates remained within clinically acceptable limits. Median (range) time to recovery following 0.02, 0.05, or 0.1 mg/kg flumazenil or control was 153.9 (55.2 to 180.0), 137.3 (35.5 to 181.0), 70.7 (29.6 to 182.0), and 173.0 (151.0 to 181.0) minutes, respectively. This was statistically significant between groups. Rescue flumazenil was administered in 3 of 6, 3 of 6, 1 of 6, and 5 of 6 birds in 0.02, 0.05, and 0.1 mg/kg flumazenil or control, respectively.</p><p><strong>Conclusions: </strong>In chickens sedated with 5 mg/kg midazolam, IM, 0.1 mg/kg flumazenil provided the fastest time to recovery compared to lower doses (0.02 and 0.05 mg/kg) or control.</p><p><strong>Clinical relevance: </strong>This study supports the use of 0.1 mg/kg flumazenil, IM, to expedite recovery in midazolam-sedated chickens.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-6"},"PeriodicalIF":1.4,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147632361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient safety investigative methods identify contributors to canine magnetic resonance imaging dermatologic thermal injuries in an academic hospital.","authors":"Darcy Adin, Corey Stockhaus, Taylor Reyes, Domenico Santoro, Chris Sanchez, Marta Romano, Mary Wilson, Aitor Gallastegui, Linda Allen, Aline Rodrigues Hoffmann","doi":"10.2460/ajvr.26.01.0022","DOIUrl":"https://doi.org/10.2460/ajvr.26.01.0022","url":null,"abstract":"<p><strong>Objective: </strong>To describe MRI-associated ECG electrode site thermal burns in dogs and the patient safety investigation that identified a reduction of radiofrequency energy output as a modifiable factor associated with their resolution.</p><p><strong>Animals: </strong>10 client-owned dogs undergoing MRI that experienced skin lesions at the ECG electrode site from April through December 2024.</p><p><strong>Clinical presentation: </strong>The reason for MRI was brain imaging in 5 dogs, spine imaging in 4 dogs, and both brain and spine imaging in 1 dog. Median weight was 14.7 kg (range, 3.1 to 31.5). Median age was 9 years (range, 1 to 13).</p><p><strong>Results: </strong>After an MRI upgrade, 10 dogs experienced skin lesions consistent with thermal injury at the ECG electrode site. Thermal injury was mild (7) and moderate to severe (3). Two dogs underwent skin biopsy, which confirmed second-degree burns. A comprehensive, systematic, iterative approach to investigate these patient harm events was undertaken, involving multiple investigations and procedural changes. Resolution came after MRI radiofrequency energy output was reduced despite being measured in the acceptable range.</p><p><strong>Clinical relevance: </strong>The approach used to investigate MRI-associated thermal burns in this study highlights the importance of identifying root causes to improve system safety and ultimately prevent future harm. Histologic confirmation of thermal injury has not previously been reported in dogs and was important because it refocused the investigation on MRI output as a potential cause.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-8"},"PeriodicalIF":1.4,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147632371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum protein alterations characterize feline chronic gingivostomatitis: a case-control study of electrophoresis, immunoglobulin, and cytokine profiles.","authors":"Emily R Tetlow, Luke A Wentlent, Patrick C Carney, Michael J Byron, Nadine Fiani, Alexandra L Wright, Emilia Chrostek, Matthew E Drozd, Cailin E Winokur, Eric M Davis, Santiago Peralta","doi":"10.2460/ajvr.26.02.0052","DOIUrl":"https://doi.org/10.2460/ajvr.26.02.0052","url":null,"abstract":"<p><strong>Objective: </strong>To characterize systemic immune alterations in feline chronic gingivostomatitis (FCGS) through serum protein electrophoresis (SPE), immunoglobulin (Ig), and cytokine profiling. We hypothesized that FCGS cases would exhibit polyclonal hyperglobulinemia, elevated Igs, and proinflammatory cytokine elevations compared to controls.</p><p><strong>Methods: </strong>Cats with FCGS and controls were prospectively enrolled in an observational case-control study at 2 veterinary dental practices. Exclusion criteria included FIV/FeLV infection, recent vaccination, corticosteroid administration, and systemic disease. A single preanesthetic serum sample was analyzed for 31 biomarkers, including SPE fractions, Ig concentrations, and cytokine levels.</p><p><strong>Results: </strong>13 FCGS cats and 14 controls were enrolled. Six biomarkers differed significantly after false discovery rate (FDR) correction, with very large effect sizes (Hedges g = 1.43 to 2.27): globulin, IgG, γ globulin, total protein, albumin, and albumin-to-globulin ratio. Polyclonal gammopathy was present in 76.9% of FCGS cases. Seven cytokines showed medium to large effect sizes (Hedges g = 0.57 to 0.88) without surviving FDR correction. Hierarchical clustering separated 85% of cases from 79% of controls based on coordinated cytokine profiles despite modest individual elevations.</p><p><strong>Conclusions: </strong>This study confirms FCGS as a disease with a quantifiable, systemic inflammatory response characterized by polyclonal hypergammaglobulinemia and mixed T helper 1/2 cytokine activation.</p><p><strong>Clinical relevance: </strong>FCGS extends beyond localized oral inflammation to involve measurable systemic immune dysregulation. Hyperglobulinemia, combined with oromucosal inflammation, should prompt diagnostic consideration of FCGS in cats. The coordinated activation of IL-8, IL-4, IFN-γ, and IL-6 identifies potential therapeutic targets for immunomodulatory intervention in refractory cases.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-10"},"PeriodicalIF":1.4,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147632463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma concentrations of terbinafine in Kemp's ridley sea turtles (Lepidochelys kempii) peak at 24 hours after a single oral dose.","authors":"Sarah E Balik, Melissa J Joblon, Deana Edmunds, Alexis E Wrate, Linda Lory, Kathryn A Tuxbury, Charles J Innis, Sherry Cox","doi":"10.2460/ajvr.26.01.0030","DOIUrl":"https://doi.org/10.2460/ajvr.26.01.0030","url":null,"abstract":"<p><strong>Objective: </strong>To determine the pharmacokinetic parameters of a single dose of terbinafine administered orally to Kemp's ridley sea turtles (Lepidochelys kempii).</p><p><strong>Methods: </strong>In the spring of 2025, convalescent juvenile Kemp's ridley sea turtles that were undergoing rehabilitation due to cold stunning in Quincy, Massachusetts, were given 20 mg/kg terbinafine orally in a food item. Samples were collected via a sparse-sampling protocol from 0 to 120 hours after drug administration. Plasma drug concentrations were determined via reverse-phase HPLC. Pharmacokinetic parameters were determined using noncompartmental analysis for sparse data.</p><p><strong>Results: </strong>15 turtles were included in this study. Terminal half-life was 24.1 hours, maximum plasma concentration was 1.17 µg/mL, time to maximum plasma concentration was 24 hours, area under the plasma concentration-versus-time curve from time 0 to the last point was 51.1 h•µg/mL, area under the plasma concentration-versus-time curve from time 0 to infinity was 53.8 h•µg/mL, and the percentage of the area under the plasma concentration-versus-time curve from time 0 to infinity extrapolated to infinity was 5.06%.</p><p><strong>Conclusions: </strong>Terbinafine plasma concentrations reached time to maximum plasma concentration at 24 hours and exceeded the MIC for several fungal pathogens that have previously been documented for Kemp's ridley sea turtles.</p><p><strong>Clinical relevance: </strong>The results of this study can inform the treatment of fungal infections in Kemp's ridley sea turtles. Additional studies are warranted to assess plasma and tissue concentrations after multiple terbinafine doses in order to determine appropriate dosage frequency.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-7"},"PeriodicalIF":1.4,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147632469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-guided injection of bupivacaine into the cricoarytenoid dorsalis muscle as a novel technique for transiently inducing laryngeal hemiplegia in horses.","authors":"Shannon Massie, Warwick M Bayly, Yuji Takahashi, Renaud Léguillette","doi":"10.2460/ajvr.26.01.0025","DOIUrl":"https://doi.org/10.2460/ajvr.26.01.0025","url":null,"abstract":"<p><strong>Objective: </strong>In clinical research, laryngeal hemiplegia (LH) is induced by temporarily supressing recurrent laryngeal nerve function; however, the technique is challenging. The aim was to develop a novel method to induce LH by injecting bupivacaine directly into the cricoarytenoid dorsalis (CAD) muscle with ultrasound guidance.</p><p><strong>Animals: </strong>5 cadaver larynges and 9 Thoroughbreds with normal laryngeal function.</p><p><strong>Methods: </strong>Part 1: A high-frequency (6.5- to 13.0-MHz) linear ultrasound probe was used to inject methylene blue (5 mL) into the CAD of 5 cadaver larynges. Part 2: The left side of the larynges of 9 horses were aseptically prepared, and the cricoid, thyroid, and arytenoid cartilages were identified with ultrasonography. With the use of a horizontal view dorsally, the cricoarytenoid lateralis muscle was visualized, followed by the arytenoid cartilage and CAD superficial to the cricoarytenoid joint. An 18-gauge, 3.5-inch spinal needle was advanced into the left CAD under ultrasound guidance. Bupivacaine was injected (0.5% concentration, 4.5 mL). Part 3: The efficiency, reversibility, and duration of LH was assessed at rest and during maximal treadmill exercise with overground endoscopy. Laryngeal function was reassessed 1 week later.</p><p><strong>Results: </strong>All cadaver larynges showed evidence of methylene blue in the CAD, confirming that ultrasonography can be used to inject the CAD. Laryngeal hemiplegia was observed within 5 minutes of injection (grade IV), continued throughout exercise (grade D), and persisted for 70 to 90 minutes after exercise (grade IV). Horses had normal CAD echogenicity and laryngeal function at rest and exercise 7 days after injection.</p><p><strong>Clinical relevance: </strong>Injecting bupivacaine into the CAD under ultrasound guidance is a practical technique for inducing transient LH that is sustainable during maximal exercise.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-2"},"PeriodicalIF":1.4,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147607759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neck flexion to 60° maximizes cisternal subarachnoid space for cerebrospinal fluid collection in dogs.","authors":"Junsoo Kim, Taehoon Sung, Changhoon Nam, Inhyung Lee, Won-Gyun Son","doi":"10.2460/ajvr.26.02.0058","DOIUrl":"https://doi.org/10.2460/ajvr.26.02.0058","url":null,"abstract":"<p><strong>Objective: </strong>To quantify ultrasonographic changes in cisternal subarachnoid space dimensions across graded neck-flexion angles and to identify the angle providing adequate expansion for CSF collection in dogs.</p><p><strong>Methods: </strong>The study included 6 healthy adult male Beagles at a single veterinary teaching hospital (July 14 through August 14, 2025). Under general anesthesia in right lateral recumbency, the neck was flexed to 10°, 15°, 20°, 30°, 60°, and 90°. Transverse-plane images were used to measure subarachnoid space depth and area, and sagittal-plane images were used to measure atlanto-occipital membrane length. Three measurements/angle/variable were obtained. Data were analyzed using repeated-measures ANOVA and linear mixed models.</p><p><strong>Results: </strong>All dogs completed the study without adverse events. Subarachnoid space depth increased from 1.31 ± 0.13 mm at 10° to 2.26 ± 0.51 mm at 60° and 2.19 ± 0.33 mm at 90° (60° vs 90°). Subarachnoid space area reached 29.9 ± 14.8 mm2 at 60° and then declined to 26.8 ± 9.9 mm2 at 90°. Membrane length rose from 7.6 ± 1.3 mm at 30° to 10.2 ± 1.0 mm at 60° and 11.4 ± 1.1 mm at 90°.</p><p><strong>Conclusions: </strong>Neck flexion up to 60° achieved sufficient expansion of the cisternal subarachnoid space and atlanto-occipital membrane, with no meaningful gain beyond this angle.</p><p><strong>Clinical relevance: </strong>Routine 90° flexion provides no benefit over 60° and may increase risk; practitioners who flex beyond 60° may compromise patient safety without enhancing access, supporting moderate positioning as effective and safe.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-5"},"PeriodicalIF":1.4,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147525440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dexmedetomidine constant-rate infusion suppresses insulin secretion and impairs glucose tolerance in healthy dogs.","authors":"Kenichi Maeda, Misaki Inada, Satomi Iwai, Shozo Okano","doi":"10.2460/ajvr.25.12.0427","DOIUrl":"https://doi.org/10.2460/ajvr.25.12.0427","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effects of dexmedetomidine (DEX) constant-rate infusion (CRI) on glucose tolerance and metabolic responses in healthy dogs.</p><p><strong>Methods: </strong>In a prospective, randomized, repeated-measures study, 5 healthy adult Beagles received 4 treatments: low-dose DEX (1 µg/kg loading; 1 µg/kg/h CRI), medium-dose DEX (5 µg/kg loading; 5 µg/kg/h CRI), high-dose DEX (10 µg/kg loading; 10 µg/kg/h CRI), or saline. An IV glucose tolerance test was performed 30 minutes after CRI initiation. Serum glucose and insulin were measured. Data were analyzed using linear mixed-effects models, with treatment, time, and their interaction as fixed effects and dog as a random effect. Results are reported as effect sizes with 95% CIs.</p><p><strong>Results: </strong>DEX CRI suppressed insulin secretion in a dose-related manner during the early phase of the glucose tolerance test. Compared with control, glucose disappearance rate was reduced at medium (mean difference, -1.37%/min; 95% CI, -2.32 to -0.42) and high (mean difference, -1.45%/min; 95% CI, -2.36 to -0.54) infusion rates, whereas the low-dose treatment did not differ meaningfully (mean difference, -0.68%/min; 95% CI, -1.63 to 0.27). No clinically relevant adverse events occurred.</p><p><strong>Conclusions: </strong>DEX CRI causes dose-related suppression of insulin secretion and impairs glucose tolerance at medium and high infusion rates in healthy dogs. In contrast, the clinically used low infusion rate did not substantially alter glucose tolerance under study conditions.</p><p><strong>Clinical relevance: </strong>Medium- and high-dose DEX CRI may impair glucose tolerance in healthy dogs, whereas the clinically used low-dose regimen appears unlikely to disrupt glucose homeostasis under controlled conditions.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-8"},"PeriodicalIF":1.4,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147519787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Center of pressure metrics are repeatable and reliable in healthy cats walking on a pressure-sensitive treadmill.","authors":"Monika Anna Mille, Dorothea Weissig, Britta Dobenecker, Erik Björn Mille, Yury Zablotski, Susanne Katja Lauer","doi":"10.2460/ajvr.26.01.0011","DOIUrl":"https://doi.org/10.2460/ajvr.26.01.0011","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the repeatability and test-retest reliability of dynamic center of pressure (COP) parameters in healthy cats walking on a pressure-sensitive treadmill.</p><p><strong>Methods: </strong>Healthy client-owned cats (n = 10) and cats housed at the Chair of Animal Nutrition and Dietetics (5) were enrolled from December 2019 through June 2021. Cats walked on a pressure-sensitive treadmill system (FDM-T-CanidGait; zebris Medical GmbH) at an individually adapted velocity. For each time point, 3 sequences of 5 valid step cycles/cat were analyzed. Center of pressure parameters were calculated paw-wise, including path length, mean velocity, mediolateral and craniocaudal displacement, and the area of the 95% confidence ellipse. Measurements were repeated within 2 weeks. Data were analyzed using a robust linear mixed-effects model and estimated marginal means.</p><p><strong>Results: </strong>COP path length decreased significantly in the forelimbs between time points (mean difference, 0.17 cm [5.3%]; small to moderate effect size) in cats with a mean age of 4.2 ± 1.8 years and weighing 4.8 ± 0.8 kg. In the hind limbs, COP velocity increased (-0.19 cm/s [-2.8%]; small effect size). Craniocaudal displacement decreased in the hind limbs (1.42%; small to moderate effect size). All other parameters did not change significantly.</p><p><strong>Conclusions: </strong>COP parameters demonstrated good test-retest reliability and repeatability in healthy cats. The observed changes likely reflect subtle adaptation, but further research is needed to evaluate learning effects in different feline populations.</p><p><strong>Clinical relevance: </strong>COP measurements obtained during treadmill walking may serve as a reliable tool for assessing gait stability and postural control in cats.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-8"},"PeriodicalIF":1.4,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147519811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aquatic animal health research enabled by biosecure hatchery and experimental fish facilities.","authors":"Larry Hanson","doi":"10.2460/ajvr.26.03.0106","DOIUrl":"10.2460/ajvr.26.03.0106","url":null,"abstract":"","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 2-day intensive research training program improves research self-efficacy but not research anxiety in North American private practice veterinary postgraduate clinical trainees.","authors":"Sarah Moore, Steven W Frederick, Virginia Sinnott-Stutzman","doi":"10.2460/ajvr.26.01.0005","DOIUrl":"https://doi.org/10.2460/ajvr.26.01.0005","url":null,"abstract":"<p><strong>Objective: </strong>To gather baseline self-reported research anxiety and clinical research self-efficacy information in veterinary residents and interns and to assess changes after an in-person clinical research training program.</p><p><strong>Methods: </strong>A previously modified version of the Clinical Research Appraisal Inventory-12 was distributed electronically to 78 North American private practice veterinary house officers before and after a 2-day in-person clinical research training program in August 2024 or August 2025. Research anxiety and self-efficacy scores were compared between aggregate pre- and postsession survey responses using a Mann-Whitney test. A Spearman correlation assessed the relationship between research anxiety and previous experience and training.</p><p><strong>Results: </strong>Respondents indicated at least moderate agreement with all statements related to research anxiety (median agreement, 4 to 5 of 7 for all questions). Previous research participation, but not previous didactic training, was associated with lower agreement with the statement \"Research makes me anxious\" (r = -0.417). Respondents reported higher baseline self-efficacy in tasks related to idea generation and working collaboratively and lower self-efficacy in data analysis, statistics, and identifying research funding.</p><p><strong>Conclusions: </strong>A 2-day research education program enhanced specific research competencies; it did not alleviate research anxiety.</p><p><strong>Clinical relevance: </strong>Given the shifting landscape toward house officer training and research activities in private practice, these results suggest that it might be useful to explore interventions tailored to reduce anxiety and promote sustained research involvement in this subset of veterinary postgraduate trainees.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-5"},"PeriodicalIF":1.4,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147508824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}