American journal of veterinary research最新文献_第5页

Oral cannabidiol increases thermal threshold in horses without physiologic adverse effects. 口服大麻二酚增加马的热阈值而无生理不良反应。

IF 1.4 3区农林科学

American journal of veterinary research Pub Date : 2025-08-25 DOI: 10.2460/ajvr.25.05.0185

Anna T Carroll, Rachel A Reed, Londa J Berghaus, Danielle McNabney, Heather K Knych

{"title":"Oral cannabidiol increases thermal threshold in horses without physiologic adverse effects.","authors":"Anna T Carroll, Rachel A Reed, Londa J Berghaus, Danielle McNabney, Heather K Knych","doi":"10.2460/ajvr.25.05.0185","DOIUrl":"https://doi.org/10.2460/ajvr.25.05.0185","url":null,"abstract":"Objective: To investigate the effect of cannabidiol (CBD) on thermal and mechanical thresholds and physiologic variables in horses.Methods: 6 horses (3 geldings and 3 mares) were enrolled in a prospective, randomized, masked crossover design from March 18 through May 3, 2025. Horses received 3.48 mg/kg CBD oil or placebo (sesame oil) orally every 24 hours for 3 days. Thermal and mechanical thresholds were determined at baseline and 4 and 12 hours after treatment administration on each day. Physiologic variables, including heart rate, respiratory rate, and rectal temperature, were recorded at the same time points. Data were analyzed using a generalized mixed model with significance set at P < .05. A Student t test was used to compare time points.Results: Thermal threshold was elevated in the CBD group above baseline and placebo on day 2 at 12 hours and on day 3 at 4 hours. There was no effect of treatment on mechanical threshold. Overall least squares mean (95% CI) respiratory rate was 17 (15 to 20) and 18 (15 to 21) breaths/min in the CBD and placebo groups, respectively. There was no effect of treatment on heart rate or rectal temperature.Conclusions: CBD provided intermittent antinociception as measured by thermal threshold.Clinical relevance: Oral administration of CBD appears safe and well tolerated at the dose studied.","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-7"},"PeriodicalIF":1.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global adoption of porcine reproductive and respiratory syndrome-resistant pigs will have significant economic and market impacts. 在全球范围内采用猪繁殖和呼吸综合征抗性猪将产生重大的经济和市场影响。

IF 1.4 3区农林科学

American journal of veterinary research Pub Date : 2025-08-22 DOI: 10.2460/ajvr.25.05.0188

Jayson L Lusk

{"title":"Global adoption of porcine reproductive and respiratory syndrome-resistant pigs will have significant economic and market impacts.","authors":"Jayson L Lusk","doi":"10.2460/ajvr.25.05.0188","DOIUrl":"https://doi.org/10.2460/ajvr.25.05.0188","url":null,"abstract":"Objective: To evaluate the global economic impacts of adopting gene-edited pigs resistant to porcine reproductive and respiratory syndrome (PRRS) on pork markets and producer profitability.Methods: A model linking hog supply to consumer pork demand in 6 global regions, Canada, China, Japan, Mexico, the US, and the rest of the world, was constructed and parametrized using pork production and trade statistics, published supply and demand elasticities, PRRS prevalence rates, and productivity metrics by PRRS health status. The model projects changes in pork prices, production, trade, and producer profits.Results: In the baseline scenario (70% adoption over 12 years), assuming no change in pork demand or additional cost of swine genetics, the marginal cost of production declines and pork prices fall while pork production increases in adopting countries by 11% in China to 7% in the US and Canada, and pork production falls in nonadopting countries. In the 15th year after initial adoption, profits for pork producers increase, ranging from $33/head in China to $15/head in Canada relative to preadoption baseline. Producers in the rest of the world, who are assumed not to adopt, are less profitable.Conclusions: The adoption of PRRS-resistant pigs is likely to significantly increase productivity, which translates into market impacts that are substantial and likely positive for the adopting producers, assuming there is no significant demand reduction or exorbitant increase in the cost of swine genetics.Clinical relevance: Pork producers who adopt PRRS-resistant pigs experience higher productivity and lower veterinary costs.","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-7"},"PeriodicalIF":1.4,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Limited pharmacokinetic and safety study with daily feeding of hemp pellets in domestic goats: cannabidiolic acid is absorbed and retained better than cannabidiol. 每日饲喂大麻颗粒在山羊体内的有限药代动力学和安全性研究：大麻二酸比大麻二酚吸收和保留更好。

IF 1.4 3区农林科学

American journal of veterinary research Pub Date : 2025-08-21 DOI: 10.2460/ajvr.25.03.0089

Elizabeth Arnett-Chinn, James Morrisey, Eric Klaphake, Daniel Hughes, Wayne S Schwark, Joseph Wakshlag

{"title":"Limited pharmacokinetic and safety study with daily feeding of hemp pellets in domestic goats: cannabidiolic acid is absorbed and retained better than cannabidiol.","authors":"Elizabeth Arnett-Chinn, James Morrisey, Eric Klaphake, Daniel Hughes, Wayne S Schwark, Joseph Wakshlag","doi":"10.2460/ajvr.25.03.0089","DOIUrl":"https://doi.org/10.2460/ajvr.25.03.0089","url":null,"abstract":"Objective: To determine serum pharmacokinetics and evaluate safety after oral cannabidiol (CBD)/cannabidiolic acid (CBDA)-rich hemp pellets administrated to goats.Methods: Eight 7-year-old female goats received 3 mg/kg CBD and 2 mg/kg CBDA from hemp pellets daily for 14 days. Serum samples were collected at 0, 0.5, 1, 2, 4, 8, 12, and 24 hours and at 7 and 14 days, from September through November of 2023. Serum concentrations for 12 cannabinoid/metabolites were determined using LC-MS. Pharmacokinetic parameters were calculated using noncompartmental analysis. Chemistry panels and CBCs were performed before administration and after 14 doses.Results: Only CBDA was measurable within the first 24 hours. The maximum geometric mean serum concentration was 30.0 ng/mL (range, 21.3 to 59.2 mg/mL), the median time of maximum serum concentration was 18 hours (range, 4 to 24 hours), and the geometric mean area under the plasma concentration-versus-time curve was 410.2 ng·h/mL (range, 174.4 to 919.3 ng·h/mL). Mean ± SD serum concentrations 6 hours after administration on days 7 and 14 were 2.2 ng/mL ± 1.8 and 1.7 ng/mL, respectively, for CBD, and they were 52.4 ± 19.7 ng/mL and 53.0 ± 16.6 ng/mL, respectively, for CBDA.Conclusions: The absorption of CBDA was markedly higher than other cannabinoids, with no differences between days 7 and 14, suggesting stable serum concentrations within 7 days.Clinical relevance: Goats absorb CBDA from the rumen, and 3 mg/kg CBDA every 24 hours reaches similar serum concentrations to monogastric species. Due to low serum CBD concentrations and rapid metabolism, CBDA might be a preferable alternative to CBD in ruminant species.","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-7"},"PeriodicalIF":1.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computed tomography shows limited accuracy in differentiating histological types of canine ear canal masses. 计算机断层扫描在鉴别犬耳道肿块的组织学类型方面显示有限的准确性。

IF 1.4 3区农林科学

American journal of veterinary research Pub Date : 2025-08-21 DOI: 10.2460/ajvr.25.05.0180

Philippe Colombe, Yannick Ruel, Pascal Prélaud, Amaury Briand, Mélanie Moreira André, Albert Agoulon, Frédérique Degorce-Rubiales, Hugues Gaillot

{"title":"Computed tomography shows limited accuracy in differentiating histological types of canine ear canal masses.","authors":"Philippe Colombe, Yannick Ruel, Pascal Prélaud, Amaury Briand, Mélanie Moreira André, Albert Agoulon, Frédérique Degorce-Rubiales, Hugues Gaillot","doi":"10.2460/ajvr.25.05.0180","DOIUrl":"https://doi.org/10.2460/ajvr.25.05.0180","url":null,"abstract":"Objective: To describe the epidemiological characteristics and CT features in dogs with external ear canal (EEC) masses and assess the ability of CT to predict histopathological diagnosis.Methods: This was a retrospective, single-center study including 70 dogs that underwent otoendoscopic examination, head CT imaging, and histopathological analysis. Masses were categorized into 5 groups according to histopathological diagnosis. Computed tomography images were reviewed, and features were compared between groups.Results: 71 EEC masses were studied, including inflammatory polyps (31 of 71 [44%]), malignant tumors (17 of 71 [24%]), inflammatory masses in a context of chronic otitis externa (15 of 71 [21%]), benign tumors (4 of 71 [6%]), and unclassified masses (4 of 71 [6%]). French Bulldogs were overrepresented (26 of 70 [37%]) and mainly affected by inflammatory masses (22 of 26 [85%]). Fifty-nine of 71 masses (83%) visualized on otoendoscopy were delineated on CT. Partial or total obliteration of the ipsilateral tympanic bulla by soft tissue-attenuating material was noticed in 53 of 71 dogs (75%). An enhancing pedicle at the medial aspect of the masses was only seen in the polyp group (11 of 31 [35%]), and 9 of 11 pedicles were mineralized. No other CT variable allowed differentiation between histopathological groups.Conclusions: CT delineates EEC masses with a moderate sensitivity and shows a limited ability to predict histopathological diagnosis.Clinical relevance: A variably mineralized enhancing pedicle at the medial aspect of an EEC mass is strongly suggestive of an inflammatory polyp.","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-8"},"PeriodicalIF":1.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of 2 sedation protocols to successfully validate a sedation assessment scale in bearded dragons (Pogona vitticeps). 使用两种镇静方案成功验证胡须龙（Pogona vitticeps）的镇静评估量表。

IF 1.4 3区农林科学

American journal of veterinary research Pub Date : 2025-08-19 DOI: 10.2460/ajvr.25.05.0172

Renata H Pinho, Maya Reed, Kelsey Chapman, Daniel S J Pang

{"title":"Use of 2 sedation protocols to successfully validate a sedation assessment scale in bearded dragons (Pogona vitticeps).","authors":"Renata H Pinho, Maya Reed, Kelsey Chapman, Daniel S J Pang","doi":"10.2460/ajvr.25.05.0172","DOIUrl":"10.2460/ajvr.25.05.0172","url":null,"abstract":"Objective: To validate a sedation assessment scale by evaluating 2 sedation protocols in bearded dragons.Methods: In a randomized, blinded, crossover study, 10 bearded dragons were sedated IM with dexmedetomidine (0.1 mg/kg) and methadone (2 mg/kg; DM), and dexmedetomidine (0.1 mg/kg), methadone (2 mg/kg), and ketamine (10 mg/kg; DMK). Sedation assessment was performed with video recording at baseline (T0) and every 5 minutes from 10 to 60 minutes after injection (T10 to T60). After T60, atipamezole (1 mg/kg) was given IM. Behaviors used to assess sedation in several species were tested. Construct validity (ie, does a scale measure what is intended) was evaluated by comparing sedation scores over time using the Friedman and Dunn post hoc tests and between treatments, using a Mann-Whitney test. Scores of 25 videos randomly selected from a total of 216 recorded videos were used to calculate intra- and inter-rater reliability using the intraclass correlation coefficient. Internal consistency was calculated using the Cronbach α coefficient.Results: Data from a pilot animal (DM) and a misinjection (DMK) were excluded. No adverse events were observed. Six out of 10 evaluated items were selected for the sedation scale. Sedation scores were higher with DMK than DM (T10 to T60). The intraclass correlation coefficient > 0.81 for all raters indicates \"very good\" intra-rater (95% CI, 0.66 to 1) and inter-rater (95% CI, 0.71 to 1) reliability. Internal consistency was \"excellent\" (α = 0.904).Conclusions: Deep sedation occurred with DMK but not DM. The sedation scale demonstrated validity, responsiveness, and reliability.Clinical relevance: The validated sedation scale aids consistency in evaluating sedation in bearded dragons.","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-9"},"PeriodicalIF":1.4,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144881888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Celebrating Peer Review Week 2025. 庆祝2025年同行评议周。

IF 1.4 3区农林科学

American journal of veterinary research Pub Date : 2025-08-19 DOI: 10.2460/ajvr.86.09.editorial

Sarah E Wright

引用次数: 0

Hemoperfusion with a polymer-based column alters inflammatory responses in lipopolysaccharide-treated horses in vivo. 聚合物基柱血液灌流改变体内脂多糖处理马的炎症反应。

IF 1.4 3区农林科学

American journal of veterinary research Pub Date : 2025-08-18 DOI: 10.2460/ajvr.25.05.0189

Kallie J Hobbs, Yu Ueda, Andre N V Le Sueur, Bethanie L Cooper, Megan J Burke, M Katie Sheats

{"title":"Hemoperfusion with a polymer-based column alters inflammatory responses in lipopolysaccharide-treated horses in vivo.","authors":"Kallie J Hobbs, Yu Ueda, Andre N V Le Sueur, Bethanie L Cooper, Megan J Burke, M Katie Sheats","doi":"10.2460/ajvr.25.05.0189","DOIUrl":"10.2460/ajvr.25.05.0189","url":null,"abstract":"Objective: To determine the effect of hemoperfusion with a polymer-based column on systemic cytokine concentrations and neutrophil dysfunction in lipopolysaccharide-treated horses in vivo.Methods: 6 university-owned horses received 60 ng/kg lipopolysaccharide, IV, as a bolus and then 60 ng/kg, IV, as a constant rate infusion over 1 hour. Endotoxemia was confirmed by clinical signs and neutropenia. In a crossover model that was completed from January 2024 through July 2024, hemoperfusion was performed for 4 hours with either a sham or polymer column. Blood was collected at 5 time points over a 72-hour period for flow cytometry analysis and 14 time points for cytokine multiplex analysis.Results: There were significant differences between column treatment and sham treatment, including increased early and late neutrophil apoptosis and improved reactive oxygen species production in response to stimulation at the postfiltration time point. Additionally, 2 of 5 column-treated horses had improved CBC parameters compared to 0 of 5 sham-treated horses. Systemic cytokines were not significantly different between column and sham treatment.Conclusions: The results of this study provide proof of concept for hemoperfusion with a polymer-based column as a potential treatment to mitigate deleterious lipopolysaccharide-induced immune responses in adult horses.Clinical relevance: Further investigation and optimization of hemoperfusion as an adjunctive treatment for sepsis in the horse is warranted. Because there are known differences in lipopolysaccharide infusion and clinical sepsis, further investigation in horses with clinical sepsis is needed.","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-9"},"PeriodicalIF":1.4,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144881887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In silico modeling of total hip replacement with press-fit cementless system in dogs shows impingement-free motion is greater with larger head-to-neck ratios. 狗全髋关节置换术的计算机模拟显示，头颈比越大，无碰撞运动越大。

IF 1.4 3区农林科学

American journal of veterinary research Pub Date : 2025-08-14 DOI: 10.2460/ajvr.25.06.0223

Ming Lu, Ching-Ho Wu, Po-Yen Chou, Brett Morgan, Cheng-Chung Lin, Denis J Marcellin-Little

{"title":"In silico modeling of total hip replacement with press-fit cementless system in dogs shows impingement-free motion is greater with larger head-to-neck ratios.","authors":"Ming Lu, Ching-Ho Wu, Po-Yen Chou, Brett Morgan, Cheng-Chung Lin, Denis J Marcellin-Little","doi":"10.2460/ajvr.25.06.0223","DOIUrl":"https://doi.org/10.2460/ajvr.25.06.0223","url":null,"abstract":"Objective: To evaluate whether femoral head diameter and head-to-neck ratio (HNR) influence prosthetic impingement-free motion (IFM) in canine total hip replacement (THR) using a press-fit cementless hip system in silico.Methods: This was a descriptive study conducted from January through June 2025. Twenty-eight head-neck combinations were assembled using 3-D stereolithographic files of cementless THR implants (Universal Hip System; BioMedtrix). For each implant combination, IFM was evaluated using a custom-built computer simulation software program around 3 orthogonal axes: abduction-adduction, flexion-extension, and internal-external rotation. Impingement-free motion was also evaluated in 3-D, characterized as the envelope where the femoral neck axis has IFM. Head diameter, neck diameter, and HNR were calculated, and their effects on IFM were analyzed.Results: Larger femoral head diameters were associated with increased IFM in all directions. Each increase in head size corresponded to a 16% to 33% gain in IFM. The presence of a head collar reduced 3-D IFM by 10% to 36%. The IFM loss was larger for smaller head sizes. Higher HNRs were strongly and positively associated with 3-D IFM. The IFM in internal and external rotation occurred beyond estimated physiologic hip motion when HNR was larger than 1.6.Conclusions: Femoral head size and HNR are key determinants of IFM in the simulated canine THR model. The use of larger heads without collars improves prosthetic mobility and may reduce in vivo prosthetic impingement.Clinical relevance: The risk of postoperative prosthetic luxation in canine THR may be reduced through proper implant selection and maximizing IFM.","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-9"},"PeriodicalIF":1.4,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144858796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Classical and alternative renin-angiotensin-aldosterone systems in a feline remnant kidney model. 经典和替代肾素-血管紧张素-醛固酮系统在猫残肾模型。

IF 1.4 3区农林科学

American journal of veterinary research Pub Date : 2025-08-14 DOI: 10.2460/ajvr.25.06.0201

Jane H C Huang, Bianca N Lourenço, Chad W Schmiedt, Amanda E Coleman

{"title":"Classical and alternative renin-angiotensin-aldosterone systems in a feline remnant kidney model.","authors":"Jane H C Huang, Bianca N Lourenço, Chad W Schmiedt, Amanda E Coleman","doi":"10.2460/ajvr.25.06.0201","DOIUrl":"https://doi.org/10.2460/ajvr.25.06.0201","url":null,"abstract":"Objective: To characterize classical and alternative circulating renin-angiotensin-aldosterone system (RAAS) activities in cats with chronic kidney disease (CKD) induced by 11/12th functional nephrectomy.Methods: This was a prospective study performed from September 9, 2022, through August 16, 2023. Serum was collected at 2 time points 6 months apart from young-adult purpose-bred cats with remnant kidney model-induced CKD (n = 15; 6 hypertensive, chronically treated with amlodipine besylate) and at a single time point from young-adult community-owned healthy cats (n = 15). Equilibrium concentrations of angiotensin I, II, III, IV, 1-5, and 1-7 and aldosterone as well as angiotensin-converting enzyme 2 activity were measured using LC-MS/MS. Kidney function was assessed 10 months after baseline RAAS evaluation in amenable CKD cats (n = 12) to identify progression (ie, 25% increase in serum concentration[s] of creatinine, symmetric dimethylarginine, or both). Linear mixed models were used for intergroup comparisons, accounting for blood pressure and amlodipine therapy.Results: Serum aldosterone concentrations were higher in the CKD group than the healthy group; however, no angiotensin peptide concentrations differed significantly between groups. Amlodipine-treated CKD cats had higher concentrations of all RAAS markers than their nonhypertensive, amlodipine-naïve counterparts. Concentrations of RAAS markers at baseline in cats that experienced CKD progression (n = 3) were among the lowest of all CKD cats.Conclusions: Evidence of RAAS activation at the level of circulating angiotensin peptides was not found in cats with induced CKD.Clinical relevance: Although circulating aldosterone was increased in cats with induced CKD, this was not likely driven by an increase in other circulating RAAS components.","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-11"},"PeriodicalIF":1.4,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144858794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of cardiac volume loading on left atrial stiffness estimated by 2-dimensional echocardiography in healthy dogs. 用二维超声心动图估计心脏容积负荷对健康犬左心房僵硬度的影响。

IF 1.4 3区农林科学

American journal of veterinary research Pub Date : 2025-08-14 DOI: 10.2460/ajvr.25.04.0138

Tatsuyuki Osuga, Masahiro Tamura, Noboru Sasaki, Mitsuyoshi Takiguchi

{"title":"Effects of cardiac volume loading on left atrial stiffness estimated by 2-dimensional echocardiography in healthy dogs.","authors":"Tatsuyuki Osuga, Masahiro Tamura, Noboru Sasaki, Mitsuyoshi Takiguchi","doi":"10.2460/ajvr.25.04.0138","DOIUrl":"https://doi.org/10.2460/ajvr.25.04.0138","url":null,"abstract":"Objective: To elucidate the effect of cardiac volume loading, which should physiologically increase left atrial (LA) stiffness (LASt), on echocardiographically estimated LASt in healthy dogs.Methods: 6 healthy Beagle dogs were anesthetized. In each dog, a Swan-Ganz catheter was placed to measure the mean pulmonary capillary wedge pressure. Cardiac volume loading was performed by IV infusion with hydroxyethylated starch solution. Echocardiography was transthoracically conducted at the baseline and at mean pulmonary capillary wedge pressures of 10 to 15, 15 to 20, 20 to 25, and 25 to 30 mm Hg. The echocardiographic indicators of LA pressure, including the peak velocity of early diastolic transmitral flow (E), ratio of E to the isovolumic relaxation time (E/IVRT), ratio of E to the peak velocity of early diastolic mitral annular motion (E/E'), and LA reservoir strain, were determined to estimate LASt.Results: During cardiac volume loading, E, E/IVRT, and LA reservoir strain were increased, and E/E' was decreased, when compared with the baseline. Consequently, LASts estimated by using E, E/IVRT, and E/E' were decreased or remained unchanged during cardiac volume loading.Conclusions: Echocardiographically estimated LASt may not be increased by cardiac volume loading in healthy dogs.Clinical relevance: Healthy dogs may not be an appropriate model to elucidate the effect of cardiac volume loading on echocardiographically estimated LASt. This is problematic, especially for dogs with myxomatous mitral valve disease that are older and may have cardiac dysfunction.","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-7"},"PeriodicalIF":1.4,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144858795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0