American journal of veterinary research最新文献

{"title":"Retrospective analysis of dual-energy x-ray absorptiometry data demonstrates body composition changes with age in dogs and cats.","authors":"Allison P McGrath, Leslie Hancock, Cheryl A Stiers, John Brejda, Elizabeth M Morris","doi":"10.2460/ajvr.24.05.0132","DOIUrl":"10.2460/ajvr.24.05.0132","url":null,"abstract":"<p><strong>Objective: </strong>Use 18 years of dual-energy x-ray absorptiometry (DEXA) scan data to characterize how body composition changes with age in dogs and cats.</p><p><strong>Methods: </strong>This was a retrospective observational study using data obtained from DEXA scans performed between 2006 and 2023. A total of 6,973 observations from 1,273 colony-housed dogs ≤ 1 to 16.1 years old and 6,593 observations from 1,096 colony-housed cats ≤ 1 to 16.9 years old were obtained. Animal ages were rounded to the nearest 1/10-year intervals. Means for each interval were calculated and quadratic, cubic, and quartic polynomial models were fit to assess trends over age.</p><p><strong>Results: </strong>Age had an effect on all DEXA measurements. In dogs, lean mass increased early in life before slowing to a peak at age 6.3 and then declined gradually. Fat mass also increased until slowing to a peak at age 9.3 and then decreased. In cats, lean mass increased before slowing to a peak at age 4.5, decreased gradually until age 12.5, and then sharply declined. Fat mass increased until slowing to a peak at age 7.5 and then decreased gradually.</p><p><strong>Conclusions: </strong>This retrospective study provides a baseline for how body composition changes with age. Results suggest that lean mass loss may begin earlier than previously reported in dogs and cats.</p><p><strong>Clinical relevance: </strong>Sarcopenia and obesity are common conditions in aging pets. Results can be used to improve body composition assessment of patients and investigate the efficacy of nutritional interventions.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142405914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sidestream dark field video microscopy demonstrates shelf-stable blood products preserve the endothelial glycocalyx in a canine hemorrhagic shock model.","authors":"Mark A Ryan, Rebekah Ford, Nicole Ewer, Kelly E Hall, Julien Guillaumin, Thomas H Edwards, Emilee C Venn, Lonnie E Grantham, Guillaume L Hoareau","doi":"10.2460/ajvr.24.05.0152","DOIUrl":"10.2460/ajvr.24.05.0152","url":null,"abstract":"<p><strong>Objective: </strong>To utilize sidestream dark field video microscopic technology to evaluate the endothelium in a canine hemorrhagic shock and resuscitation model.</p><p><strong>Methods: </strong>6 purpose-bred adult dogs were anesthetized, instrumented, and subjected to hemorrhagic shock from September 2021 through June 2022. Each dog was resuscitated with 5 resuscitation strategies in an experimental crossover design study: (1) lactated Ringer's solution (LRS) and hydroxyethyl starch (HES) solution; (2) canine chilled whole blood (CWB); (3) canine fresh frozen plasma (FFP) and packed RBCs (pRBC); (4) canine freeze-dried plasma (FDP) and hemoglobin-based oxygen carrier (HBOC); or (5) HBOC/FDP and canine lyophilized platelets. Sidestream dark field video microscopic evaluation was performed at 5 time points: commencement, after hemorrhage, after shock, after resuscitation (T135), and conclusion (T180).</p><p><strong>Results: </strong>There was a significant difference between the perfused boundary region (PBR) measurements when comparing the LRS/HES resuscitation arm to the CWB and FFP/pRBC resuscitation arms at T180. A significant difference in PBR was appreciated in the LRS/HES arm at T135 and T180 compared to its baseline. No other significant differences in PBR were appreciated when resuscitation arms were compared longitudinally or to each other.</p><p><strong>Conclusions: </strong>Shelf-stable blood products preserved the endothelial glycocalyx similarly to CWB and pRBC/FFP as evaluated by sidestream dark field video microscopy. Lactated Ringer and HES solutions did not adequately preserve the endothelial glycocalyx compared to CWB and pRBC/FFP.</p><p><strong>Clinical relevance: </strong>Shelf-stable blood products are a viable option to preserve the endothelial glycocalyx when used during hemorrhagic resuscitation in dogs.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142399157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finite element analysis shows minimal stability difference between individualized mini-hemilaminectomy-corpectomy and partial lateral corpectomy in a dog model.","authors":"Yuki Kikuchi, Masakazu Shimada, Fumitaka Takahashi, Shinya Yamaguchi, Yasushi Hara","doi":"10.2460/ajvr.24.08.0244","DOIUrl":"10.2460/ajvr.24.08.0244","url":null,"abstract":"<p><strong>Objective: </strong>Use finite element analysis to evaluate the biomechanical effects of spinal decompression procedures in healthy Beagle dogs, comparing individualized mini-hemilaminectomy-corpectomy (iMHC), mini-hemilaminectomy, partial lateral corpectomy (PLC), and hemilaminectomy.</p><p><strong>Methods: </strong>A finite element model of the L1-L2 functional spinal unit was generated using CT data. For each decompression model, loads were applied in 0.2-Nm steps (maximum, 2.0 Nm) in 6 directions: flexion, extension, right and left lateral bending, and right and left axial rotation. The L1 spinous process tip displacement angle was quantified numerically.</p><p><strong>Results: </strong>Among the 4 techniques, mini-hemilaminectomy exhibited the smallest displacement angles across all directions. Hemilaminectomy exhibited the largest displacement angles in extension, flexion, right rotation, and left rotation across all techniques. Left and right lateral bending displacement angles were marginally larger for iMHC than for hemilaminectomy at 0.4 Nm; however, at 2.0 Nm, displacement angles were similar.</p><p><strong>Conclusions: </strong>Mini-hemilaminectomy minimizes functional spinal unit instability to the greatest extent. Hemilaminectomy is more unstable than iMHC and PLC in flexion, extension, and rotation. Mini-hemilaminectomy-corpectomy and PLC are more unstable than hemilaminectomy in lateral bending, with iMHC being slightly more unstable than PLC or nearly equal.</p><p><strong>Clinical relevance: </strong>Mini-hemilaminectomy minimizes instability to the greatest extent in cases of ventrolateral spinal compression. In cases of ventral spinal compression, iMHC may be preferable to PLC for providing equivalent stability without impeding spinal cord visualization, but both techniques can cause instability depending on loading direction, so careful attention to postoperative instability is necessary when excessive vertebral body resection is involved.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142399156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence of intervertebral disc degeneration in the cervical, thoracic, and lumbar spine in asymptomatic cats.","authors":"David Schmid, Valentina Lanzillotta, Richard Evans, Frank Steffen, Lucas A Smolders","doi":"10.2460/ajvr.24.04.0095","DOIUrl":"10.2460/ajvr.24.04.0095","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the prevalence and severity of intervertebral disc (IVD) degeneration (IVDD) throughout the spine of young, middle-aged, and old asymptomatic cats; identify differences between the cervical, thoracic, and lumbar spine; and investigate the influence of sex and neuter status on the prevalence of feline IVDD.</p><p><strong>Methods: </strong>60 cadavers were collected from asymptomatic cats and subdivided into 3 age groups: young (≥ 1 to < 6 years), middle aged (≥ 6 to < 12 years), and old (≥ 12 years). T2 weighted sagittal MRI studies of the spine were obtained. Each IVD was graded according to the modified Pfirrmann grading for feline IVDD. Cumulative link mixed models were used to analyze the significance of spinal region, age, sex, and neuter status on the degenerative state of the IVDs.</p><p><strong>Results: </strong>A total of 1,544 IVDs were evaluated; 884 (57.3%), 425 (27.5%), 147 (9.5%), 82 (5.3%), and 6 (0.4%) were graded Pfirrmann 1, 2, 3, 4, and 5, respectively. Irrespective of spinal region, middle-aged cats (OR, 4.03; P < .01) and old cats (OR, 12.5; P < .01) had significantly higher odds for IVDD compared to young cats. For old cats, thoracic (OR, 4.44; P < .01) and cervical IVDs (OR, 2.76; P < .01) had significantly higher odds of degenerating compared to lumbar IVDs. No significant effect of sex (P = .81) and neuter status (P = .61) was found.</p><p><strong>Clinical relevance: </strong>The prevalence of feline IVDD significantly increases with progressive age, with the thoracic and cervical IVDs showing the highest odds for degeneration. However, extreme stages of IVDD were only occasionally observed.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacokinetics of intramuscular L-carvone in sheep.","authors":"Robert J Brosnan, Heather K Knych, Alessia Cenani","doi":"10.2460/ajvr.24.08.0218","DOIUrl":"10.2460/ajvr.24.08.0218","url":null,"abstract":"<p><strong>Objective: </strong>To measure and model concentrations of the analgesic L-carvone, a natural component of spearmint, over time when administered IM to sheep and to characterize L-carvone's effects on CBCs and clinical biochemistry panels.</p><p><strong>Methods: </strong>L-carvone formulated as a 50% solution (v/v) in ethanol and propylene glycol was administered at 71.6 mg/kg IM, split between each semitendinosus muscle in 6 sheep. Venous blood was sampled over 24 hours, and plasma was separated by centrifugation. Additional blood was collected for CBC and serum biochemical analysis, and tissues were sampled after euthanasia. L-carvone concentrations in plasma and tissue homogenates were measured using HPLC-MS-MS. Plasma pharmacokinetic data were described using a nonlinear mixed effects model. Complete blood count and biochemistry data were compared to baseline values using repeated-measures ANOVA and Holm-Šidák tests (P < .05).</p><p><strong>Results: </strong>Maximum plasma concentrations ranged from 0.28 to 1.93 µg/mL and occurred within 9 to 15 minutes after injection. Pharmacokinetics were best described using 2 compartments. Elimination half-life was 33.7 minutes and 390.2 minutes in the central and peripheral compartments, respectively. Mild increases in neutrophil count and significant increases in creatinine kinase and aspartate aminotransferase were associated with injection site myonecrosis. No physical examination, behavioral, or other clinically significant laboratory changes were noted.</p><p><strong>Conclusions: </strong>Intramuscular L-carvone exhibits rapid time to peak concentration, relatively slow plasma elimination, and low tissue concentrations after 24 hours.</p><p><strong>Clinical relevance: </strong>L-carvone exhibits a favorable pharmacokinetic profile for an analgesic drug. A new L-carvone formulation or administration route is needed to reduce inflammation and necrosis at the injection site.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baseline cystometric parameters in conscious and anesthetized sheep: experimental data and systematic review.","authors":"Jon Prager, Benjamin Metcalfe, Shamin Sadrafshari, John Taylor, Nick Donaldson, Nicolas Granger","doi":"10.2460/ajvr.24.06.0173","DOIUrl":"10.2460/ajvr.24.06.0173","url":null,"abstract":"<p><strong>Objective: </strong>To characterize cystometry in conscious and anesthetized sheep, including bladder response to sacral root electrical stimulation, thereby providing a baseline set of values.</p><p><strong>Methods: </strong>Single-fill cystometries were repeated in adult mule ewes both conscious (n = 5) and under general anesthesia (18) using a commercial system. Parameters including bladder capacity, detrusor (bladder) pressure, urethral opening pressure, bladder compliance, number of nonvoiding detrusor contractions, and bladder pressure change in response to electrical stimulation of the sacral roots under general anesthesia are reported. Pubmed, Embase, and Web of Science databases were searched for studies relating to ovine cystometry, and a systematic review was conducted.</p><p><strong>Results: </strong>In awake sheep, mean ± SD bladder capacity was 79.6 ± 32.2 mL, urethral opening pressure was 26.0 ± 10.7 cm H2O, and compliance was 3.5 ± 1.9 mL/cm H2O. Peak detrusor pressures during micturition reached 57.7 ± 28.3 cm H2O. In anesthetized animals, mean bladder capacity (endpoint, 50 cm H2O) was 333 ± 191 mL, and mean bladder compliance was 7.7 ± 4.9 mL/cm H2O. Values for these parameters from our systematic review are presented for comparison and reference. Electrical stimulation of the second and third sacral roots caused a greater increase in detrusor pressure than stimulation of the first and fourth sacral roots.</p><p><strong>Conclusions: </strong>We present a comprehensive set of data for normal cystometry parameters in sheep, including the first report of detrusor response to sacral root stimulation in anesthetized sheep.</p><p><strong>Clinical relevance: </strong>This report provides a valuable set of baseline values for a potential translational model of value to neurourologic research and may be a useful reference for clinicians.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142374890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Botanical oleander extract and oleandrin have superior effects on innate immune functions pertaining to dermal allergic reactions in canine cells when compared to oclacitinib.","authors":"Theresa W Fossum, Gitte S Jensen, Robert A Newman, Jose R Matos","doi":"10.2460/ajvr.24.05.0153","DOIUrl":"10.2460/ajvr.24.05.0153","url":null,"abstract":"<p><strong>Objective: </strong>To perform testing for cytokines involved in dermal inflammatory reactions and to document and compare the effects of an oleander extract (OE), oleandrin, and oclacitinib on biomarkers relevant to allergic reactions. The effects of these compounds under inflamed culture conditions are of direct importance to the treatment of canine atopic dermatitis.</p><p><strong>Methods: </strong>Testing involved primary canine dermal fibroblasts and the canine DH82 macrophage cell line; both cell types are important for initiating, regulating, and resolving dermal allergic reactions via cytokine communication.</p><p><strong>Results: </strong>Under inflamed conditions, OE and oleandrin downregulated key cytokines secreted by canine dermal fibroblasts and the DH82 macrophage cell line; all of which are treatment targets in dermatitis. In the DH82 macrophage cultures, the most noteworthy reductions involved IL-6, IL-12/IL-23p40, interferon-γ, tumor necrosis factor-α, VEGF, and nerve growth factor-β. Oclacitinib triggered reductions of some cytokines involved in allergic reactions, including TGF-β1, IL-12/IL-23p40, and tumor necrosis factor-α; however, these reductions were less robust than the reductions triggered by OE and oleandrin and accompanied by increases in other cytokines involved in dermal inflammation, including IL-6, interferon-γ, and nerve growth factor-β. In cultures of primary dermal fibroblasts, OE and oleandrin reduced the levels of IL-8 and monocyte chemoattractant protein-1, whereas oclacitinib had little or no effect.</p><p><strong>Conclusions: </strong>Oleander extract and oleandrin directly modulate immune responses under inflamed conditions. Moreover, OE and oleandrin appear to provide a more beneficial overall cytokine regulation than oclacitinib under inflamed culture conditions.</p><p><strong>Clinical relevance: </strong>These results suggest that OE and oleandrin are efficacious agents to treat canine atopic dermatitis. Future studies should evaluate the efficacy of these compounds in dogs affected by atopic dermatitis.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142370774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Excretory urography can track down morphological changes in the urinary bladder associated with urachal anomalies in calves for early diagnosis.","authors":"Kazutaka Yamada, Itsuki Morita, Kei Kazama, Naoyuki Aihara, Kaoru Hori, Taro Kondo, Kazuhiro Kawai, Ken Onda","doi":"10.2460/ajvr.24.08.0246","DOIUrl":"10.2460/ajvr.24.08.0246","url":null,"abstract":"<p><strong>Objective: </strong>To investigate radiographic detection by excretory urography of morphological changes in the urinary bladder associated with urachal anomalies in calves.</p><p><strong>Methods: </strong>Excretory urography was performed to detect morphological changes in the urinary bladder of 13 calves, of which 6 were nondysuric with swelling of umbilical region and 7 were dysuric without clinical umbilical swelling from November 2022 through April 2024.</p><p><strong>Results: </strong>The urinary bladder was delineated in all 13 calves after excretory urography. The aspect ratios (length:height), which objectively evaluate the shape of the urinary bladder, ranged from 1.08 to 2.43 (1.90 in average) and 1.34 to 11.89 (4.75 in average) in nondysuric and dysuric calves, respectively. The ratios of calves with nondysuric were significantly lower than those of dysuric (P < .05).</p><p><strong>Conclusions: </strong>Excretory urography could play an important role in evaluating abnormal morphological changes due to urachus anomalies in the urinary bladder of calves.</p><p><strong>Clinical relevance: </strong>Among calves with dysuria, urachal anomaly should be included in the differential diagnosis. Excretory urography is proposed as an alternative option for early diagnosis among calves presenting with dysuria to improve livestock productivity.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142370776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vertebral heart score and vertebral left atrial size reference intervals in Jack Russell Terriers, Miniature Pinschers, and Brussels Griffons.","authors":"Gina M Battinelli, Nicole Piscitelli, Lisa Murphy, Jessica Gentile-Solomon, Donald Szlosek, Reid K Nakamura","doi":"10.2460/ajvr.24.07.0209","DOIUrl":"10.2460/ajvr.24.07.0209","url":null,"abstract":"<p><strong>Objective: </strong>The investigators' hypothesis is that Jack Russell Terriers (JRTs), Miniature Pinschers (MPs), and Brussels Griffons (BGs) without underlying cardiac disease have breed-specific vertebral heart size (VHS) reference intervals.</p><p><strong>Methods: </strong>The electronic medical records of IDEXX Telemedicine Consultants were searched for JRTs, MPs, and BGs undergoing radiography from January 1, 2023, through June 30, 2023. The study range was expanded to January 1 2022, through June 30, 2023, for BGs only to improve case volume. Dogs were included if they had 2- or 3-view thoracic radiographs performed and no evidence of cardiopulmonary or systemic disease. The VHS and vertebral left atrial size (VLAS) measurements were performed by the same board-certified cardiologist for all images.</p><p><strong>Results: </strong>During the study period, a total of 991 JRTs, 750 MPs, and 399 BGs were identified. Of these, 689 JRTs, 512 MPs, and 267 BGs were excluded, leaving 302 JRTs, 238 MPs, and 132 BGs available for analysis. The reference intervals for JRTs were 9.7v to 11.8v for VHS and 1.8v to 2.6v for VLAS. The reference intervals for MPs were 9.6v to 12.2v for VHS and 1.7v to 2.4v for VLAS. The reference intervals for BGs were 9.3v to 11.9v for VHS and 1.7v to 2.4v for VLAS.</p><p><strong>Conclusions: </strong>Jack Russell Terriers, MPs, and BGs have breed-specific VHS and VLAS reference intervals.</p><p><strong>Clinical relevance: </strong>Clinicians should be aware of these results to accurately diagnose cardiac disease in these 3 breeds.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142370777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of oscillometric blood pressure measurement using a Cardell Touch multiparameter monitor in anesthetized pigs.","authors":"Stephanie Zeitouneh, Joaquin Araos, Manuel Martin-Flores","doi":"10.2460/ajvr.24.05.0145","DOIUrl":"10.2460/ajvr.24.05.0145","url":null,"abstract":"<p><strong>Objective: </strong>To assess the accuracy of an oscillometric monitor in anesthetized pigs and its ability to track changes in mean arterial pressure (MAP) and to detect arterial hypotension and hypertension in reference to direct measurements.</p><p><strong>Methods: </strong>Mean arterial pressure was measured simultaneously from a catheter in a femoral artery and with an oscillometric cuff placed over the metatarsus in 9 anesthetized pigs (∼6 months old, 35 to 55 kg). Pigs were subjected to maneuvers to alter MAP. Paired values for invasive and noninvasive MAP (iMAP and NiMAP) were recorded every 2 minutes. Bland-Altman plots with bias, limits of agreement, and percentage error were constructed using each pair and the average of 5 consecutive values. Concordance was calculated using changes in MAP at 20-minute intervals. Receiver operating characteristics (ROC) curves were constructed to test NiMAP for detection of hypotension (< 70 mm Hg) and hypertension (≥ 120 mm Hg).</p><p><strong>Results: </strong>Bias of NiMAP was -8.59 mm Hg for consecutive pairs and -8.85 mm Hg for averaged pairs, relative to iMAP. Limits of agreement and percentage error were reduced for averages (19%) over individual pairs (26%). Concordance was 82%. The area under the ROC curve for detecting hypotension with NiMAP was 0.936, with a best cutoff value of 63 mm Hg NiMAP. The area under the ROC curve for hypertension was 0.940, with a best cutoff value of 101 mm Hg NiMAP.</p><p><strong>Conclusions: </strong>Averaging several consecutive values improves the accuracy of NiMAP measurements.</p><p><strong>Clinical relevance: </strong>This device correctly tracked changes in MAP approximately 80% of the time and appears reliable for diagnosing arterial hypotension.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142370773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}