A retrospective study of oral tumors in cats in Switzerland identifies squamous cell carcinoma as the predominant tumor type.

IF 1.4 3区农林科学 Q2 VETERINARY SCIENCES

American journal of veterinary research Pub Date : 2025-07-31 Print Date: 2025-10-01 DOI:10.2460/ajvr.25.05.0161

Eva E Gasymova, Janny V Evenhuis, Stephanie Goldschmidt, Boaz Arzi, Natalia Vapniarsky

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引用次数: 0

Abstract

Objective: The study investigated the distribution, types, and geographic distribution of oral tumors in cats in Switzerland, providing insights into demographics, tumor features, and emerging trends.

Methods: We analyzed pathology records of oral tumors in cats diagnosed between 2012 and 2022 from diagnostic laboratories in Switzerland. Only histologically confirmed neoplasms were included; inflammatory and cystic lesions were excluded. Geographic distributions were assessed using postal addresses.

Results: Among 339 reports of oral tumors in cats, 294 met inclusion criteria. Malignant tumors dominated 82.0% (241 of 294), with squamous cell carcinoma most prevalent (70.5% [170 of 241]), followed by fibrosarcoma (7.2% [19 of 241]), melanoma (4.6% [11 of 241]), and adenocarcinoma (4.6% [11 of 241]). Benign tumors represented 18.0% (53 of 294), mostly with peripheral odontogenic fibroma (8.2% [24 of 294]). Squamous cell carcinoma was commonly located on the tongue (24.0% [33 of 137]), accounting for all tumors identified in the sublingual region (100% [17 of 17]). Peripheral odontogenic fibroma occurred mainly in caudal mandibles (41.7% [10 of 24]). Histopathologic analysis revealed that ulceration and necrosis were frequent in malignant cases, with a broader range and higher mitotic indices (P < .0001). The European Shorthair was the most commonly represented breed (80.6% [237 of 294]), and older cats (median age 13 years) were most affected.

Conclusions: The results emphasize the high frequency of malignant oral tumors, particularly squamous cell carcinoma, in cats in Switzerland, consistent with trends observed in other regions, and identified distinct histopathologic characteristics differentiating malignant from benign cases.

Clinical relevance: Investigating the prevalence, types, and geographic distribution of oral tumors in cats in Switzerland may support awareness, early detection, accurate diagnosis, and potentially better clinical outcomes.

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一项对瑞士猫口腔肿瘤的回顾性研究表明，鳞状细胞癌是主要的肿瘤类型。

目的：本研究调查了瑞士猫口腔肿瘤的分布、类型和地理分布，为人口统计学、肿瘤特征和新兴趋势提供见解。方法：我们分析了瑞士诊断实验室2012年至2022年诊断的猫口腔肿瘤的病理记录。仅包括组织学证实的肿瘤；排除炎性和囊性病变。使用邮政地址评估地理分布。结果：339例猫口腔肿瘤报告中，294例符合纳入标准。恶性肿瘤占82.0%（294例中有241例），其中鳞状细胞癌最常见（70.5%[170例]），其次是纤维肉瘤（7.2%[19例]）、黑色素瘤（4.6%[11例]）和腺癌（4.6%[11例]）。良性肿瘤占18.0%（294例中53例），主要为外周牙源性纤维瘤（8.2%[294例中24例]）。鳞状细胞癌通常位于舌上（24.0%[33 / 137]），占舌下区域所有肿瘤的100%[17 / 17])。外周牙源性纤维瘤主要发生在下颌尾侧（41.7% [10 of 24]）。组织病理学分析显示，恶性病例多见溃疡和坏死，范围更广，有丝分裂指数更高（P < 0.0001）。欧洲短毛猫是最常见的品种（80.6%[294只中的237只]），年龄较大的猫（中位年龄13岁）受影响最大。结论：结果强调了瑞士猫口腔恶性肿瘤，尤其是鳞状细胞癌的高频率，与其他地区观察到的趋势一致，并确定了区分恶性和良性病例的独特组织病理学特征。临床相关性：调查瑞士猫口腔肿瘤的患病率、类型和地理分布可能有助于提高认识、早期发现、准确诊断和潜在的更好的临床结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of veterinary research 农林科学-兽医学

CiteScore

1.70

自引率

10.00%

发文量

186

审稿时长

3 months

期刊介绍： The American Journal of Veterinary Research supports the collaborative exchange of information between researchers and clinicians by publishing novel research findings that bridge the gulf between basic research and clinical practice or that help to translate laboratory research and preclinical studies to the development of clinical trials and clinical practice. The journal welcomes submission of high-quality original studies and review articles in a wide range of scientific fields, including anatomy, anesthesiology, animal welfare, behavior, epidemiology, genetics, heredity, infectious disease, molecular biology, oncology, pharmacology, pathogenic mechanisms, physiology, surgery, theriogenology, toxicology, and vaccinology. Species of interest include production animals, companion animals, equids, exotic animals, birds, reptiles, and wild and marine animals. Reports of laboratory animal studies and studies involving the use of animals as experimental models of human diseases are considered only when the study results are of demonstrable benefit to the species used in the research or to another species of veterinary interest. Other fields of interest or animals species are not necessarily excluded from consideration, but such reports must focus on novel research findings. Submitted papers must make an original and substantial contribution to the veterinary medicine knowledge base; preliminary studies are not appropriate.