American journal of veterinary research最新文献_第7页

Clinical value of blood glucose concentrations in a large population of unhealthy client-owned chelonians. 大量不健康患者的血糖浓度的临床价值。

IF 1.4 3区农林科学

American journal of veterinary research Pub Date : 2026-03-06 DOI: 10.2460/ajvr.26.01.0007

Marta Bakaj, Violaine Colon, Nicola Di Girolamo

{"title":"Clinical value of blood glucose concentrations in a large population of unhealthy client-owned chelonians.","authors":"Marta Bakaj, Violaine Colon, Nicola Di Girolamo","doi":"10.2460/ajvr.26.01.0007","DOIUrl":"https://doi.org/10.2460/ajvr.26.01.0007","url":null,"abstract":"Objective: To describe variations in blood glucose concentrations depending on their clinical diagnosis in a large cohort of chelonians.Methods: Data on species, sex, habitat, blood glucose, appetite, organ category, and disease type data were extracted and analyzed using commercial statistical software. Generalized linear models were built to evaluate the association between blood glucose concentrations and organ system or disease type while accounting for other predictor variables.Results: After exclusion of healthy chelonians and chelonians missing glucose measurements, 967 chelonians were included in this study. The most represented chelonians were red-eared sliders (Trachemys scripta elegans; n = 413), followed by African spurred tortoises (Centrochelys sulcata; 102). After multivariable adjustment, compared to chelonians with trauma, chelonians with infectious disease, inflammatory disease, metabolic disease, neoplastic disease, and vascular disease had glucose concentrations that were 33.3% to 48.2% lower. Compared to chelonians with urinary tract involvement, chelonians with different organ systems affected had blood glucose concentrations 16.4% to 61.9% lower. There were no associations between gout, dystocia, or urolithiasis and glucose concentrations. Chelonians with hyperuricemia had blood glucose concentrations 47.8% higher than those without hyperuricemia.Conclusions: Blood glucose concentrations may vary in chelonian patients depending on the type of disease and the organ affected, among other factors. Certain conditions result in increased or decreased glucose concentrations.Clinical relevance: When testing blood glucose in unhealthy chelonians, results should be interpreted considering species and disease context.","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-8"},"PeriodicalIF":1.4,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147368982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive equations measuring lung and lung lobe volumes in dogs based on thoracic height and width show promise with adjustments for some breeds. 基于胸高和胸宽测量狗肺和肺叶体积的预测方程显示出对某些品种进行调整的希望。

IF 1.4 3区农林科学

American journal of veterinary research Pub Date : 2026-03-03 DOI: 10.2460/ajvr.25.11.0420

Kentaro Yamazaki, Airi Kaneyama, Kosei Teraoka, Chiharu Ito, Akari Taniguchi, Kodai Tashiro, Masayoshi Nagakawa, Kija Lee, Yukiko Sassa-O'Brien, Masaaki Katayama, Ryuji Fukushima, Miori Kishimoto

{"title":"Predictive equations measuring lung and lung lobe volumes in dogs based on thoracic height and width show promise with adjustments for some breeds.","authors":"Kentaro Yamazaki, Airi Kaneyama, Kosei Teraoka, Chiharu Ito, Akari Taniguchi, Kodai Tashiro, Masayoshi Nagakawa, Kija Lee, Yukiko Sassa-O'Brien, Masaaki Katayama, Ryuji Fukushima, Miori Kishimoto","doi":"10.2460/ajvr.25.11.0420","DOIUrl":"https://doi.org/10.2460/ajvr.25.11.0420","url":null,"abstract":"Objective: To develop and assess predictive equations for calculating lung and lung lobe volumes based on thoracic CT measurements in Shiba Inus, French Bulldogs, Chihuahuas, Miniature Dachshunds, and Toy Poodles.Methods: This retrospective analysis utilized CT data acquired from April 27, 2018, through November 8, 2024, from 5 dog breeds without respiratory or circulatory diseases. Volumes of the 7 lobes and thoracic cavity were measured. The total lung volume (TLV) was defined as the sum of all lobar volumes. Lobar volume proportions, interlobar volume ratios, and TLV-to-thoracic volume ratios were analyzed across breeds. Predictive equations for TLV and lobar volumes were derived using linear regression and lobar proportions.Results: A total of 47 dogs were included. Significant between-breed differences were observed for all lobar volumes and TLV proportions of the middle, accessory, and caudal part of the left cranial lobe, whereas the TLV-to-thoracic volume ratio showed no differences among breeds. Within breeds, the volume of the entire left cranial lobe, combining cranial and caudal parts, was equivalent to the right cranial lobe in most breeds. Most breeds showed no significant differences in volume between the left and right caudal lobes or between the middle and accessory lobes. Mean error rates obtained from predictive equations were around 20% for all volumes.Conclusions: This study revealed breed differences in pulmonary lobe volumes and proportions.Clinical relevance: The baseline data on CT-derived lobar volumes for each dog breed might provide a foundation for future research investigating changes in lobar volumes.","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-9"},"PeriodicalIF":1.4,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147347050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypochloremia is negatively associated with outcomes in cats with stable congestive heart failure. 低氯血症与稳定型充血性心力衰竭猫的预后呈负相关。

IF 1.4 3区农林科学

American journal of veterinary research Pub Date : 2026-03-02 DOI: 10.2460/ajvr.26.01.0023

Corine Lavigne, Darcy B Adin, Natasha Gurdyal, Alexis Cooper, Autumn N Harris

{"title":"Hypochloremia is negatively associated with outcomes in cats with stable congestive heart failure.","authors":"Corine Lavigne, Darcy B Adin, Natasha Gurdyal, Alexis Cooper, Autumn N Harris","doi":"10.2460/ajvr.26.01.0023","DOIUrl":"https://doi.org/10.2460/ajvr.26.01.0023","url":null,"abstract":"Objective: To assess the association between serum chloride concentration (s[Cl-]) and survival outcomes in cats with stable congestive heart failure (CHF).Methods: This was a single-institution retrospective study. Medical record reviews of 178 client-owned cats from 2014 through 2024 identified 84 cats meeting inclusion criteria of stable CHF at least 1 week after hospitalization. Cats with significant gastrointestinal disease were excluded. Biochemical parameters, medications, and survival were analyzed using Kaplan-Meier methods. Forward stepwise Cox proportional hazards regression was used to identify independent predictors of death risk.Results: Hypochloremia was defined as s[Cl-] < 112 mEq/L (the lower limit of the reference range). Fifteen cats were hypochloremic, and 69 cats were normochloremic. Hypochloremia was independently associated with a higher risk of death (hazard ratio, 2.82), and survival was shorter for cats with s[Cl-] < 112 mEq/L (159 days) compared to cats with s[Cl-] > 112 mEq/L (392 days). Diuretic dose was significantly higher in the hypochloremic group but was not an independent predictor of outcome in multivariable modeling. Two other confounders independently predicted outcome in the multivariable model (higher death risk with pimobendan use; hazard ratio, 1.96; lower death risk with normal BUN < 28 mg/dL; hazard ratio, 0.45).Conclusions: In this cohort of cats with stable CHF, hypochloremia was independently associated with significantly shorter survival and increased mortality risk.Clinical relevance: Efforts to normalize s[Cl-] in cats with CHF merit consideration.","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-7"},"PeriodicalIF":1.4,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

10-millimeter radial tibial plateau-leveling osteotomy can achieve favorable outcomes with low complication rates in small-breed dogs. 10毫米桡骨胫骨平台水平截骨术在小品种犬中可以获得良好的效果，并发症发生率低。

IF 1.4 3区农林科学

American journal of veterinary research Pub Date : 2026-03-02 DOI: 10.2460/ajvr.25.12.0443

Changsu Jung, Joomin Kim, Seo-Young Yun, Balkeum Lee, Byung-Jae Kang

{"title":"10-millimeter radial tibial plateau-leveling osteotomy can achieve favorable outcomes with low complication rates in small-breed dogs.","authors":"Changsu Jung, Joomin Kim, Seo-Young Yun, Balkeum Lee, Byung-Jae Kang","doi":"10.2460/ajvr.25.12.0443","DOIUrl":"https://doi.org/10.2460/ajvr.25.12.0443","url":null,"abstract":"Objective: To evaluate clinical outcomes and complications of 10-mm radial tibial plateau-leveling osteotomy (TPLO) using a 10-mm radial blade in small dogs with cranial cruciate ligament disease.Methods: This retrospective, observational study reviewed medical records of small-breed dogs with cranial cruciate ligament disease that underwent unilateral or bilateral 10-mm radial TPLO at 2 veterinary referral hospitals from August 2022 through May 2025. Clinical and radiographic outcomes were assessed at 8 to 14 weeks and ≥ 6 months postoperatively. Kinetic gait analysis was performed preoperatively and at 2 to 24 weeks postoperatively in a subset. Long-term outcomes were supplemented by owner interviews ≥ 6 months postoperatively.Results: Lameness scores improved from 3.2 ± 1.5 preoperatively to 0.9 ± 1.0 (short-term) and 0.1 ± 0.3 at long-term follow-up. Bone healing scores improved from 1.5 ± 0.6 at short-term to 1.0 ± 0.0 at long-term evaluation, indicating complete union in all cases. Peak vertical force, vertical impulse, and symmetry indices improved over time. Owner-assessed outcomes (n = 40) were excellent in 36 stifles (90%) and good in 4 (10%). Complications occurred in 3 stifles (6.0%), 2 major and 1 minor; all resolved without long-term morbidity.Conclusions: TPLO performed with a 10-mm radial blade was associated with significant improvements in clinical, kinetic, and radiographic outcomes with a low overall complication rate in small-breed dogs, although kinetic data were available only for a subset of cases.Clinical relevance: The 10-mm radial TPLO achieved excellent clinical, kinetic, and radiographic outcomes with a low complication rate in small-breed dogs.","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-8"},"PeriodicalIF":1.4,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacokinetics of intra-articular delivery of flavopiridol-loaded microparticles reveal sustained effects in Lewis rats. 路易斯大鼠关节内递送黄嘌呤微颗粒的药代动力学揭示了持续的效应。

IF 1.4 3区农林科学

American journal of veterinary research Pub Date : 2026-03-02 DOI: 10.2460/ajvr.25.10.0380

Yihan Li

{"title":"Pharmacokinetics of intra-articular delivery of flavopiridol-loaded microparticles reveal sustained effects in Lewis rats.","authors":"Yihan Li","doi":"10.2460/ajvr.25.10.0380","DOIUrl":"https://doi.org/10.2460/ajvr.25.10.0380","url":null,"abstract":"Objective: Osteoarthritis (OA) is a prevalent and debilitating degenerative joint disease in both humans and companion animals, leading to chronic pain and mobility loss. The inflammation has been identified to play a critical role in OA progression. Our prior work revealed that cyclin-dependent kinase 9 acts as a key regulator of early inflammatory gene activation and found an effective inhibitor, flavopiridol. To develop flavopiridol into an effective prevention and treatment of OA, this study focuses on the pharmacokinetics of our flavopiridol formulations upon IA injection.Methods: 12 male 14-week-old Lewis rats (n = 4 per group) received IA administration of flavopiridol in either free form or encapsulated in poly(lactic-co-glycolic acid) microparticles. Blood samples were collected via the saphenous vein at multiple time points. Plasma flavopiridol concentrations were quantified using a validated liquid chromatography-mass spectrometry assay. Pharmacokinetic parameters were determined by noncompartmental analysis.Results: Free flavopiridol exhibited a higher peak plasma concentration and a shorter elimination half-life than that of poly(lactic-co-glycolic acid) microparticle encapsulated formulations. In contrast, microparticle formulation provided sustained release of flavopiridol for at least 3 weeks, with a significantly lower mean peak plasma concentration and prolonged elimination half-life.Conclusions: Free flavopiridol has a short elimination half-life and limited systemic retention. In contrast, IA administration of microparticle encapsulated inhibitors offers sustained release and prolonged drug exposure at the target site while minimizing systemic side effects.Clinical relevance: The microparticle-based sustained-release formulation provides a promising means for the prevention and long-term treatment of joint inflammation and OA in both humans and animals.","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-7"},"PeriodicalIF":1.4,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histoplasma antigen test results are influenced by the urine collection method in dogs. 犬组织浆抗原检测结果受尿液采集方法的影响。

IF 1.4 3区农林科学

American journal of veterinary research Pub Date : 2026-03-02 DOI: 10.2460/ajvr.25.12.0457

Katie Como, Kathleen M Aicher, Song Zhang, Andrew S Hanzlicek, Emily N Gould

{"title":"Histoplasma antigen test results are influenced by the urine collection method in dogs.","authors":"Katie Como, Kathleen M Aicher, Song Zhang, Andrew S Hanzlicek, Emily N Gould","doi":"10.2460/ajvr.25.12.0457","DOIUrl":"https://doi.org/10.2460/ajvr.25.12.0457","url":null,"abstract":"Objective: A commercially available Histoplasma urine antigen enzyme immunoassay (MV antigen EIA; MiraVista Diagnostics) is widely used to support the diagnosis of histoplasmosis in dogs; however, a standardized urine collection technique does not exist. The objective was to evaluate agreement between 3 urine collection techniques (free catch [FC], cystocentesis [cysto], and iatrogenically hospital-contaminated cystocentesis [contam]) using the MV antigen EIA in dogs and to determine associated false-positive rates (FPRs).Methods: Participants were 30 dogs suspected of histoplasmosis and 30 temporally matched, healthy controls. In this 12-month prospective study (December 2023 to 2024), 3 urine samples (FC, cysto, and contam) were collected within 24 hours from each dog. Agreement between methods was assessed using the McNemar test and Cohen κ coefficients. False-positive rates were calculated using clinical diagnosis as the reference standard.Results: 3 clinically ill dogs were definitively diagnosed with histoplasmosis. Agreement was substantial between cysto and contam samples (κ = 0.68; 95% CI, 0.39 to 0.97) and moderate between cysto and FC (κ = 0.45; 95% CI, 0.07 to 0.82) and FC and contam samples (κ = 0.42; 95% CI, 0.10 to 0.75). The overall FPR was 16% (9 of 57; 95% CI, 6 to 25%). The cysto samples had the lowest FPR (4% [2 of 57]; 95% CI, 1 to 12%), followed by FC (7% [4 of 57]; 95% CI, 3 to 17%) and contam (11% [6 of 57]; 95% CI, 5 to 21%).Conclusions: While all collection techniques demonstrated reasonable agreement, FC and contam samples were more prone to false positives.Clinical relevance: Clinicians should confirm contam low-level positive results with sterile cysto to improve diagnostic accuracy and clinical decision-making for histoplasmosis in dogs.","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-7"},"PeriodicalIF":1.4,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thoracic spondylosis deformans in search-and-rescue dogs. 搜救犬的胸椎病畸形。

IF 1.4 3区农林科学

American journal of veterinary research Pub Date : 2026-03-02 DOI: 10.2460/ajvr.25.08.0309

Gretchen J Powers, Clara Wilson, Jennifer A Reetz, Amritha Mallikarjun, Tina Capparell, Cynthia M Otto

{"title":"Thoracic spondylosis deformans in search-and-rescue dogs.","authors":"Gretchen J Powers, Clara Wilson, Jennifer A Reetz, Amritha Mallikarjun, Tina Capparell, Cynthia M Otto","doi":"10.2460/ajvr.25.08.0309","DOIUrl":"10.2460/ajvr.25.08.0309","url":null,"abstract":"Objective: To describe the prevalence, age at first radiographic detection, severity, and progression of thoracic spondylosis deformans (SD) in search-and-rescue (SAR) dogs enrolled in a long-term medical surveillance program.Methods: This retrospective case series analyzed thoracic radiographs from 127 SAR dogs. All dogs participated in a 15-year medical surveillance program beginning in 2001. Thoracic radiographs and health data were submitted annually by handlers when available; however, radiographs were not submitted each year consistently, and some data points were missing. One board-certified radiologist reviewed the radiographs for the presence, severity, and progression of thoracic SD. Descriptive statistics were used to summarize signalment and radiographic findings.Results: Of the 127 dogs evaluated, 81 (63.8%) had thoracic SD identified on radiographs. The average age at first detection was 8.7 years (range, 2.0 to 15.8 years). Severity was classified as mild in 52.9% of cases, moderate in 32.8%, and severe in 14.2%. Radiographic progression occurred in 40% of affected dogs. The condition was observed across multiple breeds, including German Shepherd Dogs and Labrador Retrievers.Conclusions: Thoracic SD, an enthesopathy, is a common and sometimes progressive finding in SAR dogs.Clinical relevance: Although historically considered an incidental finding, the identification of thoracic SD may inform long-term musculoskeletal monitoring and clinical management strategies for SAR and other working dogs.","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-6"},"PeriodicalIF":1.4,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of rabbit-appeasing pheromone in mist form helps pet rabbits cope with transport. 使用雾状的兔子安抚信息素帮助宠物兔子应对运输。

IF 1.4 3区农林科学

American journal of veterinary research Pub Date : 2026-03-02 DOI: 10.2460/ajvr.25.12.0433

Elisa Codecasa, Pietro Asproni, Alessandro Cozzi, Philippe Monneret, Estelle Descout, Patrick Pageat, Miriam Marcet-Rius

{"title":"Use of rabbit-appeasing pheromone in mist form helps pet rabbits cope with transport.","authors":"Elisa Codecasa, Pietro Asproni, Alessandro Cozzi, Philippe Monneret, Estelle Descout, Patrick Pageat, Miriam Marcet-Rius","doi":"10.2460/ajvr.25.12.0433","DOIUrl":"https://doi.org/10.2460/ajvr.25.12.0433","url":null,"abstract":"Objective: To evaluate whether rabbit-appeasing pheromone (RAP) use can help pet rabbits cope with transport.Methods: This controlled experimental study was performed from April 18 through June 12, 2024. Rabbits underwent a 30-minute car trip in a crate sprayed with RAP in mist form or the control. Rabbits were video recorded to assess their behavior. Blood was sampled 2 days before transport, immediately after, 2 days after, and 8 days after to dose corticosterone. Statistical analysis was performed to assess differences between groups.Results: Twenty-four 5-month-old New Zealand white rabbits (6 castrated males, 6 entire males, and 12 entire females) were divided between RAP (n = 12) and control (12) groups. Video analysis revealed that controls kept ears pushed back longer than RAP-treated rabbits (mean difference, 512.88 seconds; 95% CI, 64.39 to 961.38 seconds), and they also tended to be more agitated (mean difference, 88.71 seconds; 95% CI, -7.62 to 185.05 seconds), whereas RAP-treated rabbits kept ears in erect position longer (mean difference, 544.47 seconds; 95% CI, 111.56 to 977.39 seconds). The RAP group tended to have higher corticosterone levels after transport compared to the controls (mean difference, 33.14 ng/mL; 95% CI, -5.64 to 71.93 ng/mL), but levels became equivalent after 2 and 8 days.Conclusions: The results indicate that RAP modified the rabbit behavior and neuroendocrine stress response, suggesting a shift toward an adaptive coping strategy in response to transport.Clinical relevance: Spraying RAP into the transport crate seems to be a promising method in helping pet rabbits cope with this event.","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-9"},"PeriodicalIF":1.4,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of botulinum toxin injection into the deep digital flexor muscle on foot biomechanics in healthy horses. 指深屈肌注射肉毒毒素对健康马足部生物力学的影响。

IF 1.4 3区农林科学

American journal of veterinary research Pub Date : 2026-02-26 Print Date: 2026-05-01 DOI: 10.2460/ajvr.25.12.0452

Kali Slavik, Claire Underwood, Caitrin Lowndes, Georgia Skelton, Andrew van Eps

{"title":"The effect of botulinum toxin injection into the deep digital flexor muscle on foot biomechanics in healthy horses.","authors":"Kali Slavik, Claire Underwood, Caitrin Lowndes, Georgia Skelton, Andrew van Eps","doi":"10.2460/ajvr.25.12.0452","DOIUrl":"10.2460/ajvr.25.12.0452","url":null,"abstract":"Objective: To examine the effects of botulinum toxin inoculation into the deep digital flexor (DDF) muscle on foot biomechanics.Methods: 6 healthy horses were injected with botulinum toxin in the DDF of 1 forelimb. The opposite forelimb was untreated. Ground reaction forces (GRF) were measured using a pressure sensor in regions of interest, including the dorsal hoof wall (toe). The location of the center of pressure (COP) was measured relative to the dorsal hoof wall during static standing and at peak stance during walking. Repeat measurements 3, 7, 14, 28, and 42 days after injection were compared to baseline (pretreatment) using Friedman tests with Dunn multiple comparisons.Results: There was a median 122-N (IQR, 66 to 254) reduction in the peak GRF at the toe at 7 days after Botox injection. The COP was shifted palmarly by 10 mm (IQR, 8 to 16) during stationary stance and by 6 mm (IQR, 3 to 7) during ambulation at day 7 compared to baseline. These changes were no longer significantly different to control by 14 days. No significant changes were seen in untreated limbs.Conclusions: Treatment with botulinum toxin transiently reduced peak GRF at the toe and caused a palmar shift in COP at rest and during ambulation.Clinical relevance: These biomechanical effects of DDF botulinum toxin inoculation would be expected to reduce mechanical stress on the dorsal lamellae and could be useful for treatment of acute laminitis to help reduce distal phalangeal rotation.","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147300836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pipettes to pets-the impact of research on clinical practice. 移液器对宠物的影响研究对临床实践的影响。

IF 1.4 3区农林科学

American journal of veterinary research Pub Date : 2026-02-26 DOI: 10.2460/ajvr.26.01.0035

Joshua T Butcher, Rudra Channappanavar, João Brandão, Giovana Catandi, Kelly A Black, Kelly S Harrison

引用次数: 0